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Volumn 29, Issue 7, 2015, Pages 949-968

Pycnogenol® in Metabolic Syndrome and Related Disorders

Author keywords

clinical research; diabetes; dyslipidaemia; food supplement; hypertension; metabolic syndrome; obesity; Pycnogenol ; renal dysfunction

Indexed keywords

ALPHA GLUCOSIDASE; AUTACOID; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; LIPID; NIFEDIPINE; NITRIC OXIDE; PLACEBO; PYCNOGENOL; RAMIPRIL; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ENDOTHELIUM DERIVED RELAXING FACTOR; FLAVONOID; GLUCOSE BLOOD LEVEL; PLANT EXTRACT; PYCNOGENOLS; VASODILATOR AGENT;

EID: 84936882497     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5341     Document Type: Review
Times cited : (37)

References (130)
  • 1
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ,. 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 2
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - A new worldwide definition
    • Alberti KG, Zimmet P, Shaw J, Group IDFETFC. 2005. The metabolic syndrome-a new worldwide definition. Lancet 366: 1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 3
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; And International Association for the Study of Obesity
    • Alberti KG, Eckel RH, Grundy SM, et al., 2009. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 4
    • 0037233460 scopus 로고    scopus 로고
    • The nitric oxide-endothelin-1 connection
    • Alonso D, Radomski MW,. 2003. The nitric oxide-endothelin-1 connection. Heart Fail Rev 8: 107-115.
    • (2003) Heart Fail Rev , vol.8 , pp. 107-115
    • Alonso, D.1    Radomski, M.W.2
  • 5
    • 67349273307 scopus 로고    scopus 로고
    • Metabolic syndrome and oxidative stress
    • Ando K, Fujita T,. 2009. Metabolic syndrome and oxidative stress. Free Radic Biol Med 47: 213-218.
    • (2009) Free Radic Biol Med , vol.47 , pp. 213-218
    • Ando, K.1    Fujita, T.2
  • 7
    • 0141618410 scopus 로고    scopus 로고
    • Association between albuminuria and proteinuria in the general population: The AusDiab Study
    • Atkins RC, Briganti EM, Zimmet PZ, Chadban SJ,. 2003. Association between albuminuria and proteinuria in the general population: the AusDiab Study. Nephrol Dial Transplant 18: 2170-2174.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 2170-2174
    • Atkins, R.C.1    Briganti, E.M.2    Zimmet, P.Z.3    Chadban, S.J.4
  • 8
    • 29044440104 scopus 로고    scopus 로고
    • Venous ulcers: Microcirculatory improvement and faster healing with local use of Pycnogenol
    • Belcaro G, Cesarone MR, Errichi BM, et al., 2005. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology 56: 699-705.
    • (2005) Angiology , vol.56 , pp. 699-705
    • Belcaro, G.1    Cesarone, M.R.2    Errichi, B.M.3
  • 9
    • 33748488211 scopus 로고    scopus 로고
    • Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol
    • Belcaro G, Cesarone MR, Ricci A, et al., 2006. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost 12: 440-444.
    • (2006) Clin Appl Thromb Hemost , vol.12 , pp. 440-444
    • Belcaro, G.1    Cesarone, M.R.2    Ricci, A.3
  • 10
    • 84885578911 scopus 로고    scopus 로고
    • Pycnogenol(R) supplementation improves health risk factors in subjects with metabolic syndrome
    • Belcaro G, Cornelli U, Luzzi R, et al., 2013. Pycnogenol(R) supplementation improves health risk factors in subjects with metabolic syndrome. Phytother Res 27: 1572-1578.
    • (2013) Phytother Res , vol.27 , pp. 1572-1578
    • Belcaro, G.1    Cornelli, U.2    Luzzi, R.3
  • 11
    • 0000674730 scopus 로고
    • Anti-inflammatory and superoxide radical scavenging activities of procyanidins containing extract from the bark of Pinus pinaster sol. and its fractions
    • Blazso G, Gabor M, Sibbel R, Rohdewald P,. 1994. Anti-inflammatory and superoxide radical scavenging activities of procyanidins containing extract from the bark of Pinus pinaster sol. and its fractions. Pharm Pharmacol Lett 3: 217-220.
    • (1994) Pharm Pharmacol Lett , vol.3 , pp. 217-220
    • Blazso, G.1    Gabor, M.2    Sibbel, R.3    Rohdewald, P.4
  • 12
    • 8344279068 scopus 로고
    • Anti-inflammatory activities of procyanidin-containing extracts from Pinus pinaster sol
    • Antus S. Gabor M. Vetschera K. (eds.). Vienna, Austria
    • Blazso G, Rohdewald P, Sibbel R, Gabor M,. 1995. Anti-inflammatory activities of procyanidin-containing extracts from Pinus pinaster sol. In Proceedings of the International Bioflavonoid Symposium, Antus S, Gabor M, Vetschera K, (eds.). Vienna, Austria
    • (1995) Proceedings of the International Bioflavonoid Symposium
    • Blazso, G.1    Rohdewald, P.2    Sibbel, R.3    Gabor, M.4
  • 13
    • 0031137060 scopus 로고    scopus 로고
    • Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application
    • Blazso G, Gabor M, Rohdewald P,. 1997. Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application. Pharmazie 52: 380-382.
    • (1997) Pharmazie , vol.52 , pp. 380-382
    • Blazso, G.1    Gabor, M.2    Rohdewald, P.3
  • 14
    • 3542999226 scopus 로고    scopus 로고
    • Pycnogenol accelerates wound healing and reduces scar formation
    • Blazso G, Gabor M, Schonlau F, Rohdewald P,. 2004. Pycnogenol accelerates wound healing and reduces scar formation. Phytother Res 18: 579-581.
    • (2004) Phytother Res , vol.18 , pp. 579-581
    • Blazso, G.1    Gabor, M.2    Schonlau, F.3    Rohdewald, P.4
  • 15
    • 33845997235 scopus 로고    scopus 로고
    • Pycnogenol (french maritime pine bark extract) pinus pinaster aiton subsp. Atlantica
    • ABC: Austin, Texas USA
    • Blumenthal M,. 2003. Pycnogenol (french maritime pine bark extract) pinus pinaster aiton subsp. Atlantica. In The American Botanical Council guide to Herbs, ABC: Austin, Texas USA; 369-373.
    • (2003) The American Botanical Council Guide to Herbs , pp. 369-373
    • Blumenthal, M.1
  • 17
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG,. 2000. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 18
    • 0036141855 scopus 로고    scopus 로고
    • Pathophysiology of essential hypertension: Role of the pump, the vessel, and the kidney
    • Cain AE, Khalil RA,. 2002. Pathophysiology of essential hypertension: role of the pump, the vessel, and the kidney. Semin Nephrol 22: 3-16.
    • (2002) Semin Nephrol , vol.22 , pp. 3-16
    • Cain, A.E.1    Khalil, R.A.2
  • 19
    • 0018200009 scopus 로고
    • Effects of angiotensen antagonist in rats with acute, subacute, and chronic two-kidney renal hypertension
    • Carretero OA, Gulati OP,. 1978. Effects of angiotensen antagonist in rats with acute, subacute, and chronic two-kidney renal hypertension. J Lab Clin Med 91: 264-271.
    • (1978) J Lab Clin Med , vol.91 , pp. 264-271
    • Carretero, O.A.1    Gulati, O.P.2
  • 20
    • 0034141548 scopus 로고    scopus 로고
    • Essential hypertension: Part II: Treatment
    • Carretero OA, Oparil S,. 2000a. Essential hypertension: part II: treatment. Circulation 101: 446-453.
    • (2000) Circulation , vol.101 , pp. 446-453
    • Carretero, O.A.1    Oparil, S.2
  • 21
    • 0034711753 scopus 로고    scopus 로고
    • Essential hypertension: Part I: Definition and etiology
    • Carretero OA, Oparil S,. 2000b. Essential hypertension: Part I: definition and etiology. Circulation 101: 329-335.
    • (2000) Circulation , vol.101 , pp. 329-335
    • Carretero, O.A.1    Oparil, S.2
  • 22
    • 41149116067 scopus 로고    scopus 로고
    • Possible role of oxidative stress in the pathogenesis of hypertension
    • Ceriello A,. 2008. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 31 (Suppl 2): S181-S184.
    • (2008) Diabetes Care , vol.31 , pp. S181-S184
    • Ceriello, A.1
  • 23
    • 76749095167 scopus 로고    scopus 로고
    • Kidney flow and function in hypertension: Protective effects of pycnogenol in hypertensive participants - A controlled study
    • Cesarone MR, Belcaro G, Stuard S, et al., 2008a. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants - a controlled study. J Cardiovasc Pharmacol Ther 15: 41-46.
    • (2008) J Cardiovasc Pharmacol Ther , vol.15 , pp. 41-46
    • Cesarone, M.R.1    Belcaro, G.2    Stuard, S.3
  • 24
    • 49649089723 scopus 로고    scopus 로고
    • Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC-3
    • Cesarone MR, Di Renzo A, Errichi S, Schonlau F, Wilmer JL, Blumenfeld J,. 2008b. Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC-3. Angiology 59: 408-414.
    • (2008) Angiology , vol.59 , pp. 408-414
    • Cesarone, M.R.1    Di Renzo, A.2    Errichi, S.3    Schonlau, F.4    Wilmer, J.L.5    Blumenfeld, J.6
  • 25
    • 76749095167 scopus 로고    scopus 로고
    • Kidney flow and function in hypertension: Protective effects of pycnogenol in hypertensive participants - A controlled study
    • Cesarone MR, Belcaro G, Stuard S, et al., 2010. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants - a controlled study. J Cardiovasc Pharmacol Ther 15: 41-46.
    • (2010) J Cardiovasc Pharmacol Ther , vol.15 , pp. 41-46
    • Cesarone, M.R.1    Belcaro, G.2    Stuard, S.3
  • 26
    • 0742266631 scopus 로고    scopus 로고
    • The metabolic syndrome and chronic kidney disease in U.S. adults
    • Chen J, Muntner P, Hamm LL, et al., 2004. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 140: 167-174.
    • (2004) Ann Intern Med , vol.140 , pp. 167-174
    • Chen, J.1    Muntner, P.2    Hamm, L.L.3
  • 27
    • 0035039028 scopus 로고    scopus 로고
    • Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines
    • Cho KJ, Yun CH, Packer L, Chung AS,. 2001. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Ann N Y Acad Sci 928: 141-156.
    • (2001) Ann N Y Acad Sci , vol.928 , pp. 141-156
    • Cho, K.J.1    Yun, C.H.2    Packer, L.3    Chung, A.S.4
  • 29
    • 84862576920 scopus 로고    scopus 로고
    • Delaying progression to type 2 diabetes among high-risk Spanish individuals is feasible in real-life primary healthcare settings using intensive lifestyle intervention
    • Costa B, Barrio F, Cabre JJ, et al., 2012. Delaying progression to type 2 diabetes among high-risk Spanish individuals is feasible in real-life primary healthcare settings using intensive lifestyle intervention. Diabetologia 55: 1319-1328.
    • (2012) Diabetologia , vol.55 , pp. 1319-1328
    • Costa, B.1    Barrio, F.2    Cabre, J.J.3
  • 31
    • 0346037137 scopus 로고    scopus 로고
    • Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile
    • Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I,. 2002. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37: 931-934.
    • (2002) Lipids , vol.37 , pp. 931-934
    • Devaraj, S.1    Vega-Lopez, S.2    Kaul, N.3    Schonlau, F.4    Rohdewald, P.5    Jialal, I.6
  • 32
    • 0001899614 scopus 로고    scopus 로고
    • From ancient pine bark uses to Pycnogenol
    • Packer L. Hiramatsu M. Yoshikawa T. (eds.). Academic Press: New York, USA
    • Drehsen G, 1999. From ancient pine bark uses to Pycnogenol. In Antioxidant Food Supplements in human health, Packer L, Hiramatsu M, Yoshikawa T, (eds.). Academic Press: New York, USA; 311-322.
    • (1999) Antioxidant Food Supplements in Human Health , pp. 311-322
    • Drehsen, G.1
  • 33
    • 10744232221 scopus 로고    scopus 로고
    • Ò, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction- a pilot study
    • Ò, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction- a pilot study. Nutr Res 23: 1189-1198.
    • (2003) Nutr Res , vol.23 , pp. 1189-1198
    • Durackova, Z.1    Trebaticky, B.2    Novotny, V.3    Zitnanova, I.4    Breza, J.5
  • 34
    • 84861417811 scopus 로고    scopus 로고
    • Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: A double-blind, randomized, placebo-controlled, cross-over study
    • Enseleit F, Sudano I, Périat D, et al., 2012. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. http://www.ncbi.nlm.nih.gov/pubmed/22240497 Eur Heart J. 33 (13): 1589-1597.
    • (2012) Eur Heart J. , vol.33 , Issue.13 , pp. 1589-1597
    • Enseleit, F.1    Sudano, I.2    Périat, D.3
  • 35
    • 0034604248 scopus 로고    scopus 로고
    • Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS)
    • Festa A, D'Agostino R Jr, Howard G, Mykkanen L, Tracy RP, Haffner SM,. 2000. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-47.
    • (2000) Circulation , vol.102 , pp. 42-47
    • Festa, A.1    D'Agostino, R.2    Howard, G.3    Mykkanen, L.4    Tracy, R.P.5    Haffner, S.M.6
  • 37
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich JE,. 1998. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 19: 491-503.
    • (1998) Endocr Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 38
    • 0037417237 scopus 로고    scopus 로고
    • Treatment for patients with the metabolic syndrome
    • Ginsberg HN,. 2003. Treatment for patients with the metabolic syndrome. Am J Cardiol 91: 29E-39E.
    • (2003) Am J Cardiol , vol.91 , pp. 29E-39E
    • Ginsberg, H.N.1
  • 39
    • 84910110212 scopus 로고    scopus 로고
    • The insulin resistance syndrome: Impact on lipoprotein metabolism and atherothrombosis
    • Ginsberg HN, Huang LS,. 2000. The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis. J Cardiovasc Risk 7: 325-331.
    • (2000) J Cardiovasc Risk , vol.7 , pp. 325-331
    • Ginsberg, H.N.1    Huang, L.S.2
  • 40
    • 0037399286 scopus 로고    scopus 로고
    • The metabolic syndrome: Targeting dyslipidaemia to reduce coronary risk
    • Ginsberg HN, Stalenhoef AF,. 2003. The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk. J Cardiovasc Risk 10: 121-128.
    • (2003) J Cardiovasc Risk , vol.10 , pp. 121-128
    • Ginsberg, H.N.1    Stalenhoef, A.F.2
  • 41
    • 46749149676 scopus 로고    scopus 로고
    • Oxidative stress-induced risk factors associated with the metabolic syndrome: A unifying hypothesis
    • Grattagliano I, Palmieri VO, Portincasa P, Moschetta A, Palasciano G,. 2008. Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis. J Nutr Biochem 19: 491-504.
    • (2008) J Nutr Biochem , vol.19 , pp. 491-504
    • Grattagliano, I.1    Palmieri, V.O.2    Portincasa, P.3    Moschetta, A.4    Palasciano, G.5
  • 42
    • 1342328148 scopus 로고    scopus 로고
    • Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol)
    • Grimm T, Schafer A, Hogger P,. 2004. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med 36: 811-822.
    • (2004) Free Radic Biol Med , vol.36 , pp. 811-822
    • Grimm, T.1    Schafer, A.2    Hogger, P.3
  • 43
    • 1842842014 scopus 로고    scopus 로고
    • Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    • Grundy SM, Brewer HB Jr, Cleeman JI, et al., 2004a. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 24: e13-e18.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. e13-e18
    • Grundy, S.M.1    Brewer, H.B.2    Cleeman, J.I.3
  • 44
    • 0842285784 scopus 로고    scopus 로고
    • Clinical management of metabolic syndrome: Report of the american heart association/national heart, lung, and blood institute/american diabetes association conference on scientific issues related to management
    • Grundy SM, Hansen B, Smith SC Jr, et al., 2004b. Clinical management of metabolic syndrome: report of the american heart association/national heart, lung, and blood institute/american diabetes association conference on scientific issues related to management. Circulation 109: 551-556.
    • (2004) Circulation , vol.109 , pp. 551-556
    • Grundy, S.M.1    Hansen, B.2    Smith, S.C.3
  • 45
    • 0002521141 scopus 로고    scopus 로고
    • Pycnogenol® in venous disorders: A review
    • Gulati OP,. 1999. Pycnogenol® in venous disorders: A review. Eur Bull Drug Res 7: 8-13.
    • (1999) Eur Bull Drug Res , vol.7 , pp. 8-13
    • Gulati, O.P.1
  • 46
    • 33845971291 scopus 로고    scopus 로고
    • The Nutraceutical Pycnogenol: Its role in cardiovascular health and blood glucose control
    • Gulati OP,. 2005. The Nutraceutical Pycnogenol: its role in cardiovascular health and blood glucose control. Biomed Rev 16: 49-57.
    • (2005) Biomed Rev , vol.16 , pp. 49-57
    • Gulati, O.P.1
  • 47
    • 80051503983 scopus 로고    scopus 로고
    • Pycnogenol® - A nutraceutical for venous health
    • Gulati OP,. 2008. Pycnogenol®-a nutraceutical for venous health. Biomed Rev 19: 33-43.
    • (2008) Biomed Rev , vol.19 , pp. 33-43
    • Gulati, O.P.1
  • 48
    • 84895806058 scopus 로고    scopus 로고
    • Pycnogenol(R) in chronic venous insufficiency and related venous disorders
    • Gulati OP,. 2014. Pycnogenol(R) in chronic venous insufficiency and related venous disorders. Phytother Res 28: 348-362.
    • (2014) Phytother Res , vol.28 , pp. 348-362
    • Gulati, O.P.1
  • 49
    • 0018821707 scopus 로고
    • Effects of labetalol in chronic two-kidney Goldblatt hypertension (2-KGH) in rats
    • Gulati OP, Gulati N,. 1980. Effects of labetalol in chronic two-kidney Goldblatt hypertension (2-KGH) in rats. Arch Int Pharmacodyn Ther 243: 255-260.
    • (1980) Arch Int Pharmacodyn Ther , vol.243 , pp. 255-260
    • Gulati, O.P.1    Gulati, N.2
  • 50
    • 0018322433 scopus 로고
    • Effects of propranolol in chronic two-kidney Goldblatt hypertension in rats
    • Gulati OP, Liard JF,. 1979. Effects of propranolol in chronic two-kidney Goldblatt hypertension in rats. Arch Int Pharmacodyn Ther 240: 285-293.
    • (1979) Arch Int Pharmacodyn Ther , vol.240 , pp. 285-293
    • Gulati, O.P.1    Liard, J.F.2
  • 51
    • 0016294882 scopus 로고
    • Experimental renal hypertension in rhesus monkeys: Effect of surgical removal of ischaemic kidney on various parameters
    • Gulati OP, Chakravarti RN, Sharma PL,. 1974a. Experimental renal hypertension in rhesus monkeys: effect of surgical removal of ischaemic kidney on various parameters. Indian J Med Res 62: 736-744.
    • (1974) Indian J Med Res , vol.62 , pp. 736-744
    • Gulati, O.P.1    Chakravarti, R.N.2    Sharma, P.L.3
  • 52
    • 0016374765 scopus 로고
    • Serial study of plasma angiotensin, electrolytes and juxta-glomerular index in experimental renal hypertension of monkeys
    • Gulati OP, Chakravarti RN, Sharma PL,. 1974b. Serial study of plasma angiotensin, electrolytes and juxta-glomerular index in experimental renal hypertension of monkeys. Indian J Med Res 62: 86-92.
    • (1974) Indian J Med Res , vol.62 , pp. 86-92
    • Gulati, O.P.1    Chakravarti, R.N.2    Sharma, P.L.3
  • 54
    • 0017035560 scopus 로고
    • Urinary kallikrein and plasma renin during the reversal of renovascular hypertension in rats
    • Gulati OP, Carretero OA, Morino T, Oza NB,. 1976. Urinary kallikrein and plasma renin during the reversal of renovascular hypertension in rats. Clin Sci Mol Med 3 (Suppl 3): 263s-266s.
    • (1976) Clin Sci Mol Med , vol.3 , pp. 263s-266s
    • Gulati, O.P.1    Carretero, O.A.2    Morino, T.3    Oza, N.B.4
  • 55
    • 0017858432 scopus 로고
    • Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys
    • Gulati OP, Chakravarti RN, Sharma PL,. 1978. Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. Indian J Med Res 67: 622-631.
    • (1978) Indian J Med Res , vol.67 , pp. 622-631
    • Gulati, O.P.1    Chakravarti, R.N.2    Sharma, P.L.3
  • 56
    • 0020056887 scopus 로고
    • Effects of captopril (SQ 14225) on norepinephrine-induced vasoconstriction in the isolated perfused mesentery and hindquarters of the rat
    • Gulati N, Huggel H, Gulati OP,. 1982. Effects of captopril (SQ 14225) on norepinephrine-induced vasoconstriction in the isolated perfused mesentery and hindquarters of the rat. Arch Int Pharmacodyn Ther 255: 168-176.
    • (1982) Arch Int Pharmacodyn Ther , vol.255 , pp. 168-176
    • Gulati, N.1    Huggel, H.2    Gulati, O.P.3
  • 57
    • 0021329403 scopus 로고
    • Enalpril (MK-421) induced attenuation of norepinephrine induced responses in isolated perfused rat mesentery
    • Gulati N, Huggel H, Gulati OP,. 1984. Enalpril (MK-421) induced attenuation of norepinephrine induced responses in isolated perfused rat mesentery. Indian J Exp Biol 22: 57-58.
    • (1984) Indian J Exp Biol , vol.22 , pp. 57-58
    • Gulati, N.1    Huggel, H.2    Gulati, O.P.3
  • 59
    • 0031829004 scopus 로고    scopus 로고
    • Endothelin as a regulator of cardiovascular function in health and disease
    • Haynes WG, Webb DJ,. 1998. Endothelin as a regulator of cardiovascular function in health and disease. J Hypertens 16: 1081-1098.
    • (1998) J Hypertens , vol.16 , pp. 1081-1098
    • Haynes, W.G.1    Webb, D.J.2
  • 60
    • 11344260694 scopus 로고    scopus 로고
    • Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults
    • Heacock PM, Hertzler SR, Williams JA, Wolf BW,. 2005. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 105: 65-71.
    • (2005) J Am Diet Assoc , vol.105 , pp. 65-71
    • Heacock, P.M.1    Hertzler, S.R.2    Williams, J.A.3    Wolf, B.W.4
  • 61
    • 0021832924 scopus 로고
    • Increased plasma renin during renin inhibition. Studies with a novel immunoassay
    • Hofbauer KG, Wood JM, Gulati N, Heusser C, Menard J,. 1985. Increased plasma renin during renin inhibition. Studies with a novel immunoassay. Hypertension 7: I61-I65.
    • (1985) Hypertension , vol.7 , pp. I61-I65
    • Hofbauer, K.G.1    Wood, J.M.2    Gulati, N.3    Heusser, C.4    Menard, J.5
  • 62
    • 0027527402 scopus 로고
    • Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis
    • Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S,. 1993. Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. FEBS Lett 334: 170-174.
    • (1993) FEBS Lett , vol.334 , pp. 170-174
    • Hogg, N.1    Kalyanaraman, B.2    Joseph, J.3    Struck, A.4    Parthasarathy, S.5
  • 63
    • 0034765544 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, prospective, 16week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients
    • Hosseini S, Lee J, Sepulveda RT, Rohdewald P, Watson RR,. 2001. A randomized, double-blind, placebo-controlled, prospective, 16week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients. Nutr Res 21: 1251-1260.
    • (2001) Nutr Res , vol.21 , pp. 1251-1260
    • Hosseini, S.1    Lee, J.2    Sepulveda, R.T.3    Rohdewald, P.4    Watson, R.R.5
  • 64
    • 0034096988 scopus 로고    scopus 로고
    • Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    • Hotta K, Funahashi T, Arita Y, et al., 2000. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20: 1595-1599.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1595-1599
    • Hotta, K.1    Funahashi, T.2    Arita, Y.3
  • 65
    • 1842507337 scopus 로고    scopus 로고
    • Hypertension, hypertensive heart disease and perioperative cardiac risk
    • Howell SJ, Sear JW, Foex P,. 2004. Hypertension, hypertensive heart disease and perioperative cardiac risk. Br J Anaesth 92: 570-583.
    • (2004) Br J Anaesth , vol.92 , pp. 570-583
    • Howell, S.J.1    Sear, J.W.2    Foex, P.3
  • 66
    • 0033068813 scopus 로고    scopus 로고
    • Increased levels of factor VII, fibrinogen and activity of plasminogen activator inhibitor during postprandial triglyceridemia in patients with ischemic heart disease confirmed by angiography
    • Jastrzebska M, Przybycien K, Chelstowski K, Torbus-Lisiecka B, Kornacewicz-Jach Z, Naruszewicz M,. 1999. Increased levels of factor VII, fibrinogen and activity of plasminogen activator inhibitor during postprandial triglyceridemia in patients with ischemic heart disease confirmed by angiography. Nutr Metab Cardiovasc Dis 9: 33-40.
    • (1999) Nutr Metab Cardiovasc Dis , vol.9 , pp. 33-40
    • Jastrzebska, M.1    Przybycien, K.2    Chelstowski, K.3    Torbus-Lisiecka, B.4    Kornacewicz-Jach, Z.5    Naruszewicz, M.6
  • 67
    • 84908540207 scopus 로고    scopus 로고
    • Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome
    • Jeong HS, Hong SJ, Lee TB, et al., 2014. Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome. Phytother Res 28: 1492-1498.
    • (2014) Phytother Res , vol.28 , pp. 1492-1498
    • Jeong, H.S.1    Hong, S.J.2    Lee, T.B.3
  • 68
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE,. 2003. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46: 3-19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 69
    • 0029873574 scopus 로고    scopus 로고
    • Genetics of non-insulin-dependent (type-II) diabetes mellitus
    • Kahn CR, Vicent D, Doria A,. 1996. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu Rev Med 47: 509-531.
    • (1996) Annu Rev Med , vol.47 , pp. 509-531
    • Kahn, C.R.1    Vicent, D.2    Doria, A.3
  • 70
    • 0033676092 scopus 로고    scopus 로고
    • Effect of selected antioxidants on malondialdehyde modification of proteins
    • Kim JCJ, Pinnas JL, Mooradian AD,. 2000. Effect of selected antioxidants on malondialdehyde modification of proteins. Nutrition 16: 1079-1081.
    • (2000) Nutrition , vol.16 , pp. 1079-1081
    • Kim, J.C.J.1    Pinnas, J.L.2    Mooradian, A.D.3
  • 71
    • 19544387948 scopus 로고    scopus 로고
    • Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia
    • Kim YM, Jeong YK, Wang MH, Lee WY, Rhee HI,. 2005. Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia. Nutrition 21: 756-761.
    • (2005) Nutrition , vol.21 , pp. 756-761
    • Kim, Y.M.1    Jeong, Y.K.2    Wang, M.H.3    Lee, W.Y.4    Rhee, H.I.5
  • 72
    • 49449117005 scopus 로고    scopus 로고
    • The role of inflammatory cytokines in diabetes and its complications
    • King GL,. 2008. The role of inflammatory cytokines in diabetes and its complications. J Periodontol 79: 1527-1534.
    • (2008) J Periodontol , vol.79 , pp. 1527-1534
    • King, G.L.1
  • 73
    • 7244234583 scopus 로고    scopus 로고
    • Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: An open clinical trial
    • Kohama T, Suzuki N, Ohno S, Inoue M,. 2004. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. J Reprod Med 49: 828-832.
    • (2004) J Reprod Med , vol.49 , pp. 828-832
    • Kohama, T.1    Suzuki, N.2    Ohno, S.3    Inoue, M.4
  • 74
    • 0034851575 scopus 로고    scopus 로고
    • Therapeutic potential of anti-oxidants and diabetic retinopathy
    • Kowluru RA, Kennedy A,. 2001. Therapeutic potential of anti-oxidants and diabetic retinopathy. Expert Opin Investig Drugs 10: 1665-1676.
    • (2001) Expert Opin Investig Drugs , vol.10 , pp. 1665-1676
    • Kowluru, R.A.1    Kennedy, A.2
  • 75
    • 19944429248 scopus 로고    scopus 로고
    • Physical activity in the prevention of type 2 diabetes: The Finnish diabetes prevention study
    • Laaksonen DE, Lindstrom J, Lakka TA, et al., 2005. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes 54: 158-165.
    • (2005) Diabetes , vol.54 , pp. 158-165
    • Laaksonen, D.E.1    Lindstrom, J.2    Lakka, T.A.3
  • 78
    • 67650169799 scopus 로고    scopus 로고
    • Adiponectin levels and risk of type 2 diabetes: A systematic review and meta-analysis
    • Li S, Shin HJ, Ding EL, van Dam RM,. 2009. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302: 179-188.
    • (2009) JAMA , vol.302 , pp. 179-188
    • Li, S.1    Shin, H.J.2    Ding, E.L.3    Van Dam, R.M.4
  • 79
    • 78049437912 scopus 로고    scopus 로고
    • Reducing the risk of type 2 diabetes with nutrition and physical activity - Efficacy and implementation of lifestyle interventions in Finland
    • Lindstrom J, Absetz P, Hemio K, Peltomaki P, Peltonen M,. 2010. Reducing the risk of type 2 diabetes with nutrition and physical activity-efficacy and implementation of lifestyle interventions in Finland. Public Health Nutr 13: 993-999.
    • (2010) Public Health Nutr , vol.13 , pp. 993-999
    • Lindstrom, J.1    Absetz, P.2    Hemio, K.3    Peltomaki, P.4    Peltonen, M.5
  • 80
    • 0345059061 scopus 로고    scopus 로고
    • Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients
    • Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P,. 2004a. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 74: 855-862.
    • (2004) Life Sci , vol.74 , pp. 855-862
    • Liu, X.1    Wei, J.2    Tan, F.3    Zhou, S.4    Wurthwein, G.5    Rohdewald, P.6
  • 81
    • 4444377960 scopus 로고    scopus 로고
    • Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II
    • Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P,. 2004b. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75: 2505-2513.
    • (2004) Life Sci , vol.75 , pp. 2505-2513
    • Liu, X.1    Wei, J.2    Tan, F.3    Zhou, S.4    Wurthwein, G.5    Rohdewald, P.6
  • 82
    • 1442324389 scopus 로고    scopus 로고
    • French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients
    • Liu X, Zhou HJ, Rohdewald P,. 2004c. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839.
    • (2004) Diabetes Care , vol.27 , pp. 839
    • Liu, X.1    Zhou, H.J.2    Rohdewald, P.3
  • 83
    • 0033341628 scopus 로고    scopus 로고
    • Practical considerations of the pharmacology of angiotensin receptor blockers
    • McConnaughey MM, McConnaughey JS, Ingenito AJ,. 1999. Practical considerations of the pharmacology of angiotensin receptor blockers. J Clin Pharmacol 39: 547-559.
    • (1999) J Clin Pharmacol , vol.39 , pp. 547-559
    • McConnaughey, M.M.1    McConnaughey, J.S.2    Ingenito, A.J.3
  • 84
    • 84936867784 scopus 로고    scopus 로고
    • Executive summary of the Third Report of the National Cholesterol Education Programm (NCEP) Expert Panel on detection, evaluation and treatment of high blood cholesterol in adultss (Adult Treatment Panel III)
    • NCEP-ATP III.
    • NCEP-ATP III. 2001. Executive summary of the Third Report of The National Cholesterol Education Programm (NCEP) Expert Panel on detection, evaluation and treatment of high blood cholesterol in adultss (Adult Treatment Panel III). JAMA 16: 442-443.
    • (2001) JAMA , vol.16 , pp. 442-443
  • 85
    • 0031883856 scopus 로고    scopus 로고
    • Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage
    • Nelson AB, Lau BH, Ide N, Rong Y,. 1998. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage. Drug Dev Ind Pharm 24: 139-144.
    • (1998) Drug Dev Ind Pharm , vol.24 , pp. 139-144
    • Nelson, A.B.1    Lau, B.H.2    Ide, N.3    Rong, Y.4
  • 86
    • 0017741029 scopus 로고
    • Effects of propranolol on the development of renovascular hypertension in the rat
    • Niarchos AP, Gulati OP, Carretero OA,. 1977. Effects of propranolol on the development of renovascular hypertension in the rat. Am Heart J 94: 81-86.
    • (1977) Am Heart J , vol.94 , pp. 81-86
    • Niarchos, A.P.1    Gulati, O.P.2    Carretero, O.A.3
  • 87
    • 82055163932 scopus 로고    scopus 로고
    • Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus - Results from a randomised, controlled trial
    • Nilsen V, Bakke PS, Gallefoss F,. 2011. Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus-results from a randomised, controlled trial. BMC Public Health 11: 893.
    • (2011) BMC Public Health , vol.11 , pp. 893
    • Nilsen, V.1    Bakke, P.S.2    Gallefoss, F.3
  • 90
    • 70350653833 scopus 로고    scopus 로고
    • Protective effects of pycnogenol against ischemia reperfusion-induced oxidative renal injury in rats
    • Ozer Sehirli A, Sener G, Ercan F,. 2009. Protective effects of pycnogenol against ischemia reperfusion-induced oxidative renal injury in rats. Ren Fail 31: 690-697.
    • (2009) Ren Fail , vol.31 , pp. 690-697
    • Ozer Sehirli, A.1    Sener, G.2    Ercan, F.3
  • 91
    • 0032839592 scopus 로고    scopus 로고
    • Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol
    • Packer L, Rimbach G, Virgili F,. 1999. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol. Free Radic Biol Med 27: 704-724.
    • (1999) Free Radic Biol Med , vol.27 , pp. 704-724
    • Packer, L.1    Rimbach, G.2    Virgili, F.3
  • 92
    • 70249112934 scopus 로고    scopus 로고
    • Pycnogenol prevents potassium dichromate K2Cr2O7-induced oxidative damage and nephrotoxicity in rats
    • Parveen K, Khan MR, Siddiqui WA,. 2009. Pycnogenol prevents potassium dichromate K2Cr2O7-induced oxidative damage and nephrotoxicity in rats. Chem Biol Interact 181: 343-350.
    • (2009) Chem Biol Interact , vol.181 , pp. 343-350
    • Parveen, K.1    Khan, M.R.2    Siddiqui, W.A.3
  • 93
    • 77953540524 scopus 로고    scopus 로고
    • Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats
    • Parveen K, Khan MR, Mujeeb M, Siddiqui WA,. 2010. Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats. Chem Biol Interact 186: 219-227.
    • (2010) Chem Biol Interact , vol.186 , pp. 219-227
    • Parveen, K.1    Khan, M.R.2    Mujeeb, M.3    Siddiqui, W.A.4
  • 94
    • 0034042818 scopus 로고    scopus 로고
    • Pycnogenol inhibits tumor necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells
    • Peng Q, Wei Z, Lau BH,. 2000. Pycnogenol inhibits tumor necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells. Cell Mol Life Sci 57: 834-841.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 834-841
    • Peng, Q.1    Wei, Z.2    Lau, B.H.3
  • 95
    • 0034457608 scopus 로고    scopus 로고
    • Pathophysiology of microcirculation in venous disease
    • Puruhito,. 2000. Pathophysiology of microcirculation in venous disease. Clin Hemorheol Microcirc 23: 239-242.
    • (2000) Clin Hemorheol Microcirc , vol.23 , pp. 239-242
    • Puruhito1
  • 96
    • 0042135946 scopus 로고    scopus 로고
    • Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol
    • Putter M, Grotemeyer KH, Wurthwein G, et al., 1999. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 95: 155-161.
    • (1999) Thromb Res , vol.95 , pp. 155-161
    • Putter, M.1    Grotemeyer, K.H.2    Wurthwein, G.3
  • 97
    • 0032729205 scopus 로고    scopus 로고
    • Effect of procyanidins from Pinus maritima on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages
    • Rimbach G, Virgili F, Park YC, Packer L,. 1999. Effect of procyanidins from Pinus maritima on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4: 171-177.
    • (1999) Redox Rep , vol.4 , pp. 171-177
    • Rimbach, G.1    Virgili, F.2    Park, Y.C.3    Packer, L.4
  • 98
    • 0002821318 scopus 로고    scopus 로고
    • Pycnogenol®
    • Rice-Evans CAPacker L (ed.). Marcel Dekker Inc.: New York
    • Rohdewald P, 1998. Pycnogenol®. In Flavonoids in Health and Disease, Rice-Evans CA, Packer L, (ed.). Marcel Dekker Inc.: New York, 405-419.
    • (1998) Flavonoids in Health and Disease , pp. 405-419
    • Rohdewald, P.1
  • 99
    • 0036219486 scopus 로고    scopus 로고
    • A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology
    • Rohdewald P,. 2002. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40: 158-168.
    • (2002) Int J Clin Pharmacol Ther , vol.40 , pp. 158-168
    • Rohdewald, P.1
  • 100
    • 0028702029 scopus 로고
    • Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury
    • Rong Y, Li L, Shah V, Lau BH,. 1994-1995. Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury. Biotechnol Ther 5: 117-126.
    • (1994) Biotechnol Ther , vol.5 , pp. 117-126
    • Rong, Y.1    Li, L.2    Shah, V.3    Lau, B.H.4
  • 101
    • 0035863274 scopus 로고    scopus 로고
    • Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract
    • Saliou C, Rimbach G, Moini H, et al., 2001. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 30: 154-160.
    • (2001) Free Radic Biol Med , vol.30 , pp. 154-160
    • Saliou, C.1    Rimbach, G.2    Moini, H.3
  • 102
    • 34247159943 scopus 로고    scopus 로고
    • Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase
    • Schafer A, Hogger P,. 2007. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res Clin Pract 77: 41-46.
    • (2007) Diabetes Res Clin Pract , vol.77 , pp. 41-46
    • Schafer, A.1    Hogger, P.2
  • 103
    • 1542284225 scopus 로고    scopus 로고
    • Pathophysiology of type 2 diabetes
    • Scheen AJ,. 2003. Pathophysiology of type 2 diabetes. Acta Clin Belg 58: 335-341.
    • (2003) Acta Clin Belg , vol.58 , pp. 335-341
    • Scheen, A.J.1
  • 104
    • 36049008829 scopus 로고    scopus 로고
    • Obesity, essential hypertension and renin-angiotensin system
    • Segura J, Ruilope LM,. 2007. Obesity, essential hypertension and renin-angiotensin system. Public Health Nutr 10: 1151-1155.
    • (2007) Public Health Nutr , vol.10 , pp. 1151-1155
    • Segura, J.1    Ruilope, L.M.2
  • 105
    • 34347330354 scopus 로고    scopus 로고
    • The role of endothelin-1 in human hypertension
    • Shreenivas S, Oparil S,. 2007. The role of endothelin-1 in human hypertension. Clin Hemorheol Microcirc 37: 157-178.
    • (2007) Clin Hemorheol Microcirc , vol.37 , pp. 157-178
    • Shreenivas, S.1    Oparil, S.2
  • 106
    • 77149164750 scopus 로고    scopus 로고
    • Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy
    • Steigerwalt R, Belcaro G, Cesarone MR, et al., 2009. Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. J Ocul Pharmacol Ther 25: 537-540.
    • (2009) J Ocul Pharmacol Ther , vol.25 , pp. 537-540
    • Steigerwalt, R.1    Belcaro, G.2    Cesarone, M.R.3
  • 108
    • 79952200220 scopus 로고    scopus 로고
    • Kidney function in metabolic syndrome may be improved with Pycnogenol(R)
    • Stuard S, Belcaro G, Cesarone MR, et al., 2010. Kidney function in metabolic syndrome may be improved with Pycnogenol(R). Panminerva Med 52: 27-32.
    • (2010) Panminerva Med , vol.52 , pp. 27-32
    • Stuard, S.1    Belcaro, G.2    Cesarone, M.R.3
  • 109
    • 84888828375 scopus 로고    scopus 로고
    • Assessment of the cytotoxic, genotoxic, and antigenotoxic potential of Pycnogenol(R) in in vitro mammalian cells
    • Taner G, Aydin S, Aytac Z, Basaran AA, Basaran N,. 2013. Assessment of the cytotoxic, genotoxic, and antigenotoxic potential of Pycnogenol(R) in in vitro mammalian cells. Food Chem Toxicol 61: 203-208.
    • (2013) Food Chem Toxicol , vol.61 , pp. 203-208
    • Taner, G.1    Aydin, S.2    Aytac, Z.3    Basaran, A.A.4    Basaran, N.5
  • 110
    • 84915829390 scopus 로고    scopus 로고
    • Modulating effects of pycnogenol(R) on oxidative stress and DNA damage induced by sepsis in rats
    • Taner G, Aydin S, Bacanli M, et al., 2014. Modulating effects of pycnogenol(R) on oxidative stress and DNA damage induced by sepsis in rats. Phytother Res 28: 1692-1700.
    • (2014) Phytother Res , vol.28 , pp. 1692-1700
    • Taner, G.1    Aydin, S.2    Bacanli, M.3
  • 114
    • 33644633736 scopus 로고    scopus 로고
    • Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans
    • Vincent HK, Taylor AG,. 2006. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 30: 400-418.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 400-418
    • Vincent, H.K.1    Taylor, A.G.2
  • 115
    • 0032563263 scopus 로고    scopus 로고
    • Procyanidins extracted from pine bark protect alpha-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: Role of nitric oxide and peroxynitrite
    • Virgili F, Kim D, Packer L,. 1998. Procyanidins extracted from pine bark protect alpha-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite. FEBS Lett 431: 315-318.
    • (1998) FEBS Lett , vol.431 , pp. 315-318
    • Virgili, F.1    Kim, D.2    Packer, L.3
  • 116
    • 0342267141 scopus 로고    scopus 로고
    • Procyanidins from Pinus maritima bark: Antioxidant activity, effects on the immune system and modulation of nitrogen monoxide metabolism
    • Packer L. Hiramatsu M. Yoshikawa T. (eds.). Academic Press: New York, USA
    • Virgili F, Kobuchi H, Noda Y, Cossins E, Packer L,. 1999. Procyanidins from Pinus maritima bark: Antioxidant activity, effects on the immune system and modulation of nitrogen monoxide metabolism. In Antioxidant Food Supplements in Human Health, Packer L, Hiramatsu M, Yoshikawa T, (eds.). Academic Press: New York, USA; 323-342.
    • (1999) Antioxidant Food Supplements in Human Health , pp. 323-342
    • Virgili, F.1    Kobuchi, H.2    Noda, Y.3    Cossins, E.4    Packer, L.5
  • 117
    • 42449103122 scopus 로고    scopus 로고
    • Effect of metabolic syndrome or type II diabetes mellitus on the occurrence of recurrent vascular events in hypertensive patients
    • Vlek AL, van der Graaf Y, Spiering W, Visseren FL, group Ss. 2008. Effect of metabolic syndrome or type II diabetes mellitus on the occurrence of recurrent vascular events in hypertensive patients. J Hum Hypertens 22: 358-365.
    • (2008) J Hum Hypertens , vol.22 , pp. 358-365
    • Vlek, A.L.1    Van Der Graaf, Y.2    Spiering, W.3    Visseren, F.L.4
  • 118
    • 73649099215 scopus 로고    scopus 로고
    • Differential impact of metabolic syndrome on arterial stiffness and wave reflections: Focus on distinct definitions
    • Vyssoulis GP, Pietri PG, Karpanou EA, et al., 2010. Differential impact of metabolic syndrome on arterial stiffness and wave reflections: focus on distinct definitions. Int J Cardiol 138: 119-125.
    • (2010) Int J Cardiol , vol.138 , pp. 119-125
    • Vyssoulis, G.P.1    Pietri, P.G.2    Karpanou, E.A.3
  • 119
    • 0033047029 scopus 로고    scopus 로고
    • Reduction of cardiovascular disease risk factors by French Maritime Pine Bark Extract
    • Watson RR,. 1999. Reduction of cardiovascular disease risk factors by French Maritime Pine Bark Extract. Cardiovasc Rev Rep XX: 326-329.
    • (1999) Cardiovasc Rev Rep , vol.20 , pp. 326-329
    • Watson, R.R.1
  • 120
    • 0030714562 scopus 로고    scopus 로고
    • Pycnogenol enhances endothelial cell antioxidant defenses
    • Wei ZH, Peng QL, Lau BHS,. 1997. Pycnogenol enhances endothelial cell antioxidant defenses. Redox Rep 3: 219-224.
    • (1997) Redox Rep , vol.3 , pp. 219-224
    • Wei, Z.H.1    Peng, Q.L.2    Lau, B.H.S.3
  • 121
    • 0029928474 scopus 로고    scopus 로고
    • Salt sensitivity of blood pressure in humans
    • Weinberger MH,. 1996. Salt sensitivity of blood pressure in humans. Hypertension 27: 481-490.
    • (1996) Hypertension , vol.27 , pp. 481-490
    • Weinberger, M.H.1
  • 122
    • 33747509112 scopus 로고    scopus 로고
    • Body mass index as an indicator of obesity
    • Weisell RC,. 2002. Body mass index as an indicator of obesity. Asia Pac J Clin Nutr 11 (Suppl 8): S681-S684.
    • (2002) Asia Pac J Clin Nutr , vol.11 , pp. S681-S684
    • Weisell, R.C.1
  • 124
    • 0022706244 scopus 로고
    • Two-kidney, one clip renal hypertension in the marmoset
    • Wood JM, Gulati N, Michel JB, Hofbauer KG,. 1986a. Two-kidney, one clip renal hypertension in the marmoset. J Hypertens 4: 251-254.
    • (1986) J Hypertens , vol.4 , pp. 251-254
    • Wood, J.M.1    Gulati, N.2    Michel, J.B.3    Hofbauer, K.G.4
  • 125
    • 0022504563 scopus 로고
    • Monoclonal antibodies against human renin. Blood pressure effects in the marmoset
    • Wood JM, Heusser C, Gulati N, Forgiarini P, Hofbauer KG,. 1986b. Monoclonal antibodies against human renin. Blood pressure effects in the marmoset. Hypertension 8: 600-605.
    • (1986) Hypertension , vol.8 , pp. 600-605
    • Wood, J.M.1    Heusser, C.2    Gulati, N.3    Forgiarini, P.4    Hofbauer, K.G.5
  • 126
    • 36849054536 scopus 로고    scopus 로고
    • Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats
    • Yang YS, Ahn TH, Lee JC, et al., 2008. Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Food Chem Toxicol 46: 380-387.
    • (2008) Food Chem Toxicol , vol.46 , pp. 380-387
    • Yang, Y.S.1    Ahn, T.H.2    Lee, J.C.3
  • 127
    • 84917730756 scopus 로고    scopus 로고
    • Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial
    • Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC,. 2014. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res 28: 1770-1777.
    • (2014) Phytother Res , vol.28 , pp. 1770-1777
    • Yang, Y.S.1    Su, Y.F.2    Yang, H.W.3    Lee, Y.H.4    Chou, J.I.5    Ueng, K.C.6
  • 128
    • 0026705732 scopus 로고
    • Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries
    • Yao SK, Ober JC, Krishnaswami A, et al., 1992. Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries. Circulation 86: 1302-1309.
    • (1992) Circulation , vol.86 , pp. 1302-1309
    • Yao, S.K.1    Ober, J.C.2    Krishnaswami, A.3
  • 129
    • 42949094141 scopus 로고    scopus 로고
    • Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation
    • Zibadi S, Rohdewald PJ, Park D, Watson RR,. 2008. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res 28: 315-320.
    • (2008) Nutr Res , vol.28 , pp. 315-320
    • Zibadi, S.1    Rohdewald, P.J.2    Park, D.3    Watson, R.R.4
  • 130
    • 23844494837 scopus 로고    scopus 로고
    • Mainstreaming the metabolic syndrome: A definitive definition
    • Zimmet PZ, Alberti KG, Shaw JE,. 2005. Mainstreaming the metabolic syndrome: a definitive definition. Med J Aust 183: 175-176.
    • (2005) Med J Aust , vol.183 , pp. 175-176
    • Zimmet, P.Z.1    Alberti, K.G.2    Shaw, J.E.3


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