Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage

Drug Development and Industrial Pharmacy

Volumn 24, Issue 2, 1998, Pages 139-144

  Nelson, Audwin B ^a   Lau, Benjamin H S ^a   Ide, Nagatoshi ^a   Rong, Yongqi ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; COPPER SULFATE; DNA; HYDROXYL RADICAL; IRON; LIPOPROTEIN; PLASMID DNA; PROCYANIDIN; PYCNOGENOL; TERT BUTYL HYDROPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; ZYMOSAN;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DRUG EFFECT; FLUORESCENCE; LIPOPROTEIN METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; RESPIRATORY BURST; VASCULAR ENDOTHELIUM;

EID: 0031883856     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.3109/03639049809085598     Document Type: Article

References (23)

1. H. Sies, Oxidative Stress: Oxidants and Antioxidants, Academic Press, London, 1991.
2. L. Spatz and A. D. Bloom, Biological Consequences of Oxidative Stress-Implications for Cardiovascular Disease and Carcinogenesis, Oxford University Press, New York, 1992.
3. J. Masquelier, Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenging effect and use thereof, United States Patent #4,698,360, 1987.
4. R. A. Passwater, The New Superantioxidant-Plus, Keats Publishing Inc., New Canaan, CT 1992, p. 23.
5. R. A. Passwater and C. Kandaswami, Pycnogenol: The Super "Protector" Nutrient, Keats Publishing Inc., New Canaan, CT 1994, p. 9.
6. Y. Rong, L. Li, S. Vandana, and B. H. S. Lau, Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury, Biotech Therapeut., 5, 117-126 (1995).
7. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, Protein measurement with the folin phenol reagent, J. Biol. Chem., 193, 265-275 (1951).
8. B. H. S. Lau, P. Ong, and J. Tosk, Macrophage chemiluminescence modulated by Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum, Phytother. Res., 3, 148-153 (1989).
9. B. H. S. Lau, T. Yamasaki, and D. S. Gridley, Garlic compounds modulate macrophage and T-lymphocyte functions, Mol. Biother., 3, 103-107 (1991).
10. J. R. Rittenhouse, P. D. Lui, and B. H. S. Lau, Chinese medicinal herbs reverse macrophage suppression induced by urological tumors, J. Urol., 146, 486-490 (1991).
11. C. P. Wan, E. Myung, and B. H. S. Lau, An automated micro-fluorometric assay for monitoring oxidative burst activity of phagocytes, J. Immunol. Methods, 159, 131-138 (1993).
12. 2+ mediated oxidative modification of low density lipoprotein, Biol. Pharm. Bull., 17, 1567-1572 (1994).
13. 2+-induced oxidative modification of low density lipoprotein, Planta Med., 63, 263-264 (1997).
14. J. E. Schneider, M. M. Browning, X. Zhu, K. L. Eneff, and R. A. Floyd, Characterization of hydroxyl free radical mediated damage to plasmid pBR322 DNA, Mut. Res., 214, 23-31 (1989).
15. 2+ ions, Biochim. Biophys. Acta, 1225, 259-263 (1994).
16. S. M. Lynch, and B. Frei, Mechanisms of copper- and iron-dependent oxidative modification of human low density lipoprotein, J. Lipid Res., 34, 1745-1753 (1993).
17. S. M. Lynch and B. Frei, Mechanisms of metal ion-dependent oxidation of human low density lipoprotein, J. Nutr., 126, 1063S-1066S (1996).
18. D. Steinberg, S. Parthasarathy, T. E. Carew, and J. L. Witztum, Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity, N. Engl. J. Med., 320, 915-924 (1989).
19. S. Yla-Herttuala, W. Palinki, M. E. Rosenfeld, D. Steinberg, and J. L. Witztum, Lipoproteins in normal and atherosclerotic aorta, Eur. Heart J., 11, 88-99 (1990).
20. D. Steinberg, Modified forms of low-density lipoprotein and atherosclerosis, J. Int. Med., 233, 227-232 (1993).
21. P. Hochstein, S. K. Jani, and C. Rice-Evans, The physiological significance of oxidative perturbation in erythrocyte membrane lipids and proteins, Prog. Clin. Biol. Res., 55, 449-459 (1981).
22. J. M. Tixier, G. Godeau, A. M. Robert, and W. Hornebeck, Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affect its rate of degradation by elastases, Biochem. Pharmacol., 33, 3933-3939, 1984.
23. C. L. Yu and B. Swaminathan, Mutagenicity of proanthocyanidins, Food Chem. Toxicol. 25, 135-139 (1987).