Therapeutic potential of anti-oxidants and diabetic retinopathy

Expert Opinion on Investigational Drugs

Volumn 10, Issue 9, 2001, Pages 1665-1676

  Kowluru, R A ^a   Kennedy, A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Anti oxidants; Diabetes; Diabetic complications; Oxidative stress; Retinal cell death; Retinopathy

Indexed keywords

ACETYLCYSTEINE; ADVANCED GLYCATION END PRODUCT; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; C REACTIVE PROTEIN; CASPASE 3; FREE RADICAL; GLUCOSE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPID HYDROPEROXIDE; NICANARTINE; POLYOL; PROBUCOL; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER; SELENIUM; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOCTIC ACID; TROLOX C; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ATTENUATION; BLINDNESS; CELL DEATH; CELL TYPE; CONTROLLED STUDY; DEVELOPED COUNTRY; DIABETES MELLITUS; DIABETIC RETINOPATHY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE COURSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LIPID PEROXIDATION; METABOLIC REGULATION; NONHUMAN; OXIDATIVE STRESS; RAT; RAT STRAIN; RETINA; RETINA CELL; REVIEW; VISION;

ANIMALS; ANTIOXIDANTS; DIABETIC RETINOPATHY; HUMANS;

EID: 0034851575     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.10.9.1665     Document Type: Review

References (123)

1. Retinopathy in experimental diabetes: Its relevance to diabetic retinopathy in man
2. Pathogenesis of diabetic retinopathy and cataract
3. Diabetic retinopathy
4. Studies of retinal vascular patterns: I. Normal architecture
5. Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy
6. High-dose vitamin E supplementation normalizes retinal blood flow and creatine clearance in patients with type 1 diabetes
7. Vitamin E and heart disease: Basic science to clinical intervention trials
8. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-src) kinase activation and death of ht4 neuronal cells
9. The effect of intensive treatment of diabetes on the development of long-term complications in insulin-dependent diabetes mellitus
10. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
11. Early worsening of diabetic retinopathy in the diabetes control and complication trial
12. Progression of incipient diabetic retinopathy during good glycemic control
13. Islet transplantation inhibits diabetic retinopathy in the sucrose-fed diabetic Cohen diabetic rat
14. Diabetic-like retinopathy: Early and late intervention therapies in galactose-fed rats
15. Relationship of lipid peroxides to diabetic complications
16. Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system
17. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy
18. Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats
19. Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors
20. Characterization of the mechanism for the chronic activation of DAG-PKC pathway in diabetes and hypergalactosemia
21. Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and ATPases
22. Role of vascular endothelial growth factor in diabetic vascular complications
23. Role of oxidative stress in development of complications in diabetes
24. Chronic N-acetyl-L-cysteine treatment prevents impaired endothelium-dependent relaxation and improves peripheral nerve blood flow and conduction in diabetic rats
25. Ascorbic acid supplementation prevents hyperlipidemia and improves myocardial performance in streptozotocin-diabetic rats
26. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
27. Alterations in free radical tissue-defense mechanisms in streptozotocin-induced diabetes
28. Lipoperoxide levels and scavenging enzyme activities in the diabetic albino rabbit retina
29. Lipid peroxidation, oxygen radicals, cell damage and antioxidant therapy
30. Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells
31. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus
32. Lipid peroxidation and retinal degeneration
33. Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age
34. Lipid peroxidation and retinopathy in streptozotocin-induced diabetes
35. Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas
36. Retinal vascular changes induced by the oxidative stress of alpha-tocopherol deficiency contrasted with diabetic microangiography
37. Abnormalities of retinal metabolism in diabetes or galactosemia II. Comparison of gamma-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy
38. Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: Effect of DL-alpha-lipoic acid
39. Abnormalities of retinal metabolism in diabetes or experimental galactosemia VI. Comparison of retinal and cerebral cortex metabolism, and effects of antioxidant therapy
40. Multiple NADPH-producing pathways control glutathione (GSH) content in retina
41. 2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat
42. Involvement of cell-cell interactions in the pathogenesis of diabetic retinopathy
43. Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage
44. Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension
45. Role of nitric oxide in retinal cell death
46. DNA strand breakage and activation of poly-ADP ribotransferase: A cytotoxic pathway triggered by peroxynitrite
47. Peroxynitrite cytotoxicity on bovine retinal pigmented epithelial cells in culture
48. Aldose reductase inhibitors: Therapeutic implications for diabetic complications
49. Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients
50. Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
51. Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats
52. Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor
53. Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs
54. A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
55. Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats
56. Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine
57. The effect of aminoguanidine and tolrestat on glucose toxicity in bovine retinal capillary pericytes
58. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: An exploratory study
59. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
60. Advanced glycation end product, oxidant stress and vascular lesions
61. Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products
62. Aminoguanidine inhibits oxidative modification of low density lipoprotein and the subsequent increase in uptake by macrophage scavenger receptors
63. Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation
64. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia
65. Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine
66. Correlation of diacylglycerol and protein kinase C in rat retina to retinal circulation
67. Fas mediated apoptosis of human Jurkat T-cells: Intracellular events and potentiation by redox-active alpha-lipoic acid
68. Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates
69. Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and D-α-tocopherol in vascular smooth muscles
70. Protein kinase C signalling and oxidative stress
71. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications?
72. High glucose can induce lipid peroxidation in the isolated rat glomeruli
73. Oxidative stress and protein kinase C are inter-related in retinas of diabetic rats and galactose-fed rats
74. D-α-tocopherol prevents the hyperglycemia induced activation of diacylglycerol protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity
75. Localization of vascular endothelial growth factor in human retina and choroid
76. Advanced glycation end products increase retinal vascular endothelial growth factor expression
77. Cell turnover of capillaries
78. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
79. Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro
80. Antioxidants inhibit hyperglycemia-induced activation of caspase-3 in the retina
81. Programmed cell death and the control of cell survival: Lessons from the nervous system
82. Integrin overexpression induced by high glucose and by human diabetes: Potential pathway to cell dysfunction in diabetic microangiopathy
83. Patterns of ischemia in diabetic retinopathy
84. 2 and nitric oxide-mediated oxidative stress induce apoptosis in rat skeletal muscle myoblasts
85. Oxidative stress and apoptosis
86. High-glucose-triggered apoptosis in cultured endothelial cells
87. Redox regulation of apoptotic cell death in the immune system
88. Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation
89. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activation of c-Jun NH(2)-terminal kinase and caspase-3
90. Modulation of chromatin structure by poly ADP ribosylation
91. Glutathione metabolism and its selective modification
92. Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics
93. The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat
94. Oxidative damage and age-related macular degeneration
95. Prooxidant and antioxidant properties of Trolox C, analogue of vitamin E, in oxidation of low-density lipoprotein
96. Interaction of peroxynitrite with carotenoids in human low density lipoproteins
97. Neuroprotection by the metabolic antioxidant alpha lipoic acid
98. Ascorbate-dependent recycling of the vitamin E homologue Trolox by dihydrolipoate and glutathione in murine skin homogenates
99. N-acetylcysteine for lung cancer prevention
100. Dietary modulation of endothelial function: Implications for cardiovascular disease
101. Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy
102. Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats
103. Dietary supplementation of a natural isomer mixture of beta-carotene inhibits oxidation of LDL derived from patients with diabetes mellitus
104. Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients
105. Effects of ramipril and vitamin E on atherosclerosis: The study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE)
106. Diabetes-induced metabolic abnormalities in myocardium: Effect of antioxidant therapy
107. Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive, patients with non-insulin-dependent diabetes
108. Vitamin C: An aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus
109. Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations
110. Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes
111. Selenium-deficient diet induces renal oxidative stress and injury via TGF-beta1 in normal and diabetic rats
112. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus
113. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy
114. Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids
115. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy
116. Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes
117. Influence of selenium on the microvasculature of the retina
118. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
119. Retinal glutamate in diabetes and effect of antioxidants
120. Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine
121. Prevention of pericyte loss by Trolox in diabetic rat retina
122. Antioxidant nutrient intake and diabetic retinopathy: The San Luis Vally diabetes study
123. Multiple antioxidants protect against heme protein and lipid oxidation in kidney tissue