Venous ulcers: Microcirculatory improvement and faster healing with local use of Pycnogenol®

Angiology

Volumn 56, Issue 6, 2005, Pages 699-705

  Belcaro, Gianni ^a,b   Cesarone, M R ^a   Errichi, B M ^a   Ledda, A ^a   Di Renzo, A ^a   Stuard, S ^a   Dugall, M ^a   Pellegrini, L ^a   Rohdewald, P ^a   Ippolito, E ^a   Ricci, A ^a   Cacchio, M ^a   Ruffini, I ^a   Fano, F ^a   Hosoi, M ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PYCNOGENOL;

ADULT; ARTICLE; CAPILLARY PRESSURE; CHRONIC VEIN INSUFFICIENCY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; LEG EDEMA; MALE; MICROANGIOPATHY; MICROCIRCULATION; ULCER; ULCER HEALING; VENOUS HYPERTENSIVE MICROANGIOPATHY;

EID: 29044440104     PISSN: 00033197     EISSN: None     Source Type: Journal    
DOI: 10.1177/000331970505600607     Document Type: Article

References (35)

1. Belcaro G, Nicolaides AN, Stansby G (eds): The Venous Clinic. London: Imperial College Press, 1999.
2. De Sanctis MT, Cesarone MR, Incandela L, et al: Methods of evaluation and quantification of microangiopathy in high perfusion microangiopathy (chronic venous insufficiency and diabetic microangiopathy). J Cardiovasc Pharmacol Ther 7(suppl I):S3-5, 2002.
3. Belcaro G, Nicolaides AN (eds): Noninvasive Investigations in Vascular Disease. London: Imperial College press, 2001.
4. Almond NE: A laser Doppler blood flowmeter used to detect thermal entrainment in normal persons and patients with Raynaud's phenomenon. In: Practical Aspects of Skin Blood Flow Measurement, ed. by Spence VA, Sheldon CD. London: Biological Engineering Society, 1985, pp 14-28.
5. Anning ST: The cause and treatment of leg ulcers. Lancet ii:789-791, 1952.
6. Anning ST: Leg ulcers. Their Causes and Treatment. London: J & A Churchill Ltd, 1954.
7. Anning ST: The historical aspect. In: The pathology and Surgery of the Veins of the Lower Limb, ed. by Dodd H, Cockett FB. Edinburgh: Churchill-Livingstone, 1976, pp 29-37.
8. 2 measurements in association with laser Doppler flowmetry in venous hypertension. Phlebology 3:189-193, 1988.
9. Belcaro G, Grigg M, Rulo A, et al: Blood flow in the perimalleolar skin in relation to posture in patients with venous hypertension. Ann Vasc Surg 1:5-8, 1989a.
10. Belcaro G, Christopoulos D, Nicolaides AN: Skin flow and swelling in postphlebitic limbs. Vasa 18:136-138, 1989b.
11. Belcaro G, Nicolaides AN, Volteas N, et al: Skin flow, the venoarteriolar response and capillary filtration in diabetics. A three-year follow-up study. Angiology 43:490-494, 1992a.
12. Belcaro G, Bollinger A, Hoffman U, et al (eds): Laser Doppler Flowmetry. London: Med-Orion, 1994.
13. Fagrell B: Local microcirculation in chronic venous incompetence and leg ulcers. Vasc Surg 13:217-219, 1979.
14. Fagrell B: Microcirculatory disturbances-the final cause for venous leg ulcers? Vasa 11:101-103, 1982.
15. Franzeck U, Bollinger A, Huch R, et al: Transcutaneous oxygen tension and capillary morphologic characteristics and density in patients with chronic venous incompetence. Circulation 70:806-809, 1984.
16. Hendriksen O: Local reflex in microcirculation in human subcutaneous tissue. Acta Physiol Scand 97:446-449, 1976.
17. Rayman G, Hassan A, Tooke JE: Blood flow in the skin of the foot related to posture in patients with diabetes mellitus. Br Med J 292:87-91, 1986.
18. Thulesius O: Capillary filtration under normal and pathological conditions. Angiologia 10:198-201, 1973.
19. Bollinger A, Jager K, Geser A, et al: Transcapillary and interstitial diffusion of Na-Fluorescein in chronic venous insufficiency with white atrophy. Int J Microcirc 1:5-8, 1982b.
20. Belcaro G, Nicolaides AN, Veller M: Venous Disorders. A Manual of Diagnosis and Treatment. Cambridge: Saunders, 1995.
21. Belcaro G: Laser Doppler in venous hypertension. PhD thesis, University of London. UCL, 1996.
22. Bollinger A, Leu AJ, Hoffman U, et al: Microvascular changes in venous disease: An update. Angiology 48:27-32, 1997.
23. Nicolaides AN, Abenhaim L, Akeson H, et al: Investigation of chronic venous insufficiency. A consensus statement. Circulation 102:e126-163, 2000.
24. Rohdewald P: A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-168, 2002.
25. Petrassi C, Mastromarino A, Spartera C: Pycnogenol® in chronic venous insufficiency. Phytomedicine 7:383-388, 2000.
26. Schmidtke I, Schoop W: Le pycnogénol: Thérapeutique médicamenteuse de l'œdème statique. J Suisse de médecine globale 3:114-115, 1995.
27. Putter M, Grotemeyer KHM, Wurthwein G, et al: Inhibition of smoking-induced platelet aggregation by aspirin and Pycnogenol. Thromb Res 95:155-161, 1999.
28. Wang S, Tan D, Zhao Y, et al: The effect of Pycnogenol® on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 7:19-25, 1999.
29. Blasó G, Gábor M, Schönlau F, et al: Pycnogenol® accelerates wound healing and reduces scar formation. Phytother Res 18:579-581, 2004.
30. Packer L, Cho K-J, Yun C-H, et al: Effects of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production lipopolysaccharide-stimulated RAW 264,7. Toxicol Appl Pharmacol 168:64-71, 2000.
31. Högger P, Schäfer A, Chovanová Z, et al: Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomedicine and Pharmacotherapy, in print.
32. Saliou C, Rimbach G, Moni H, et al: Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Rad Biol Med 30:154-160, 2001.
33. Peng Q, Wei Z, Lau BHS: Pycnogenol® inhibits tumor necrosis factor-a-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells. Cell Mol Life Sci 57:834-841, 2000.
34. Calvo Torras MA, Adelantado Faura C, Schönlau F, Rohdewald P: Antimicrobial Activity of Pycnogenol. Phytotherapy Research 19:647-648, 2005.
35. Cesarone MR, Belcaro G, Rohdewald P, et al: Prevention of edema in long flights with Pycnogenol®. Clin Appl Thrombosis/Hemostasis 11:289-294, 2005.