Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage

Journal of Biological Chemistry

Volumn 290, Issue 27, 2015, Pages 16772-16785

  Casellas, Alba ^a,b   Mallol, Cristina ^a,b   Salavert, Ariana ^a   Jimenez, Veronica ^a,b   Garcia, Miquel ^a,b   Agudo, Judith ^a,b   Obach, Mercè ^a,b   Haurigot, Virginia ^a,b   Vilà, Laia ^a,b   Molas, Maria ^a,b   Lage, Ricardo ^a,b   Morró, Meritxell ^a,b   Casana, Estefania ^a,b   Ruberte, Jesús ^a,b   Bosch, Fatima ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INSULIN;

ANIMAL STUDIES; BETA CELL; GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR 2; OVER-EXPRESSION;

CYTOLOGY;

SOMATOMEDIN B; STREPTOZOCIN; IGF2 PROTEIN, HUMAN; INSULIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEDIFFERENTIATION; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; IMMUNE RESPONSE GENE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; PANCREAS ISLET; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANIMALIA;

ANIMALS; CELL DEDIFFERENTIATION; CELL LINE, TUMOR; DIABETES MELLITUS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR II; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RATS;

EID: 84936770791     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.642041     Document Type: Article

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