B-cell dedifferentiation in diabetes is important, but what is it

Islets

Volumn 5, Issue 5, 2013, Pages 233-237

  Weir, Gordon C ^a   Aguayo Mazzucato, Cristina ^a   Bonner Weir, Susan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

B cell; Dedifferentiation; Diabetes; Differentiation; Insulin secretion; Islets

Indexed keywords

GLUCOSE; INSULIN; TRANSCRIPTION FACTOR FKHR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE;

CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CELL MATURATION; DIABETES MELLITUS; DISEASE SEVERITY; DISORDERS OF CARBOHYDRATE METABOLISM; GLUCOTOXICITY; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SECRETION DYSFUNCTION; MULTIPOTENT STEM CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PHENOTYPE; REVIEW; TOXICITY; ANIMAL; CYTOLOGY; GENETICS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; DIABETES MELLITUS; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MULTIPOTENT STEM CELLS;

EID: 84922482092     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.27494     Document Type: Review

References (36)

1. Weir GC, Bonner-Weir S. Islet β cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci 2013; 1281:92-105; PMID:23363033; http://dx.doi.org/10.1111/nyas.12031
2. Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 2012; 150:1223-34; PMID:22980982; http://dx.doi.org/10.1016/j.cell.2012.07.029
3. Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patané G, Laybutt R, Bonner-Weir S, Weir GC. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999; 274:14112-21; PMID:10318828; http://dx.doi.org/10.1074/jbc.274.20.14112
4. Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, et al. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia 2011; 54:583-93; PMID:21190012; http://dx.doi.org/10.1007/s00125-010-2026-z
5. Jermendy A, Toschi E, Aye T, Koh A, AguayoMazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia 2011; 54:594-604; PMID:21240476; http://dx.doi.org/10.1007/s00125-010-2036-x
6. Bliss CR, Sharp GW. Glucose-induced insulin release in islets of young rats: time-dependent potentiation and effects of 2-bromostearate. Am J Physiol 1992; 263:E890-6; PMID:1443122
7. Bennett BD, Jetton TL, Ying G, Magnuson MA, Piston DW. Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. J Biol Chem 1996; 271:3647-51; PMID:8631975; http://dx.doi.org/10.1074/jbc.271.7. 3647 (Pubitemid 26065680)
8. Salomon D, Meda P. Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells. Exp Cell Res 1986; 162:507-20; PMID:3510882; http://dx.doi.org/10.1016/0014-4827(86)90354-X (Pubitemid 16131246)
9. Andersson A, Eizirik DL, Bremer C, Johnson RC, Pipeleers DG, Hellerstrom C. Structure and function of macroencapsulated human and rodent pancreatic islets transplanted into nude mice. Horm Metab Res 1996; 28:306-9; PMID:8811336; http://dx.doi.org/10.1055/s-2007-979800 (Pubitemid 26196027)
10. Pipeleers D, Kiekens R, Ling Z, Wilikens A, Schuit F. Physiologic relevance of heterogeneity in the pancreatic beta-cell population. Diabetologia 1994; 37(Suppl 2):S57-64; PMID:7821741; http://dx.doi.org/10.1007/BF00400827 (Pubitemid 24288793)
11. Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, et al. Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia 2010; 53:128-38; PMID:19851748; http://dx.doi.org/10.1007/s00125-009-1570-x
12. Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006; 443:453-7; PMID:16957737; http://dx.doi.org/10.1038/ nature05092 (Pubitemid 44477281)
13. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92:93637; PMID:7568133; http://dx.doi.org/10.1073/pnas.92.20.9363
14. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8:729-40; PMID:17667954; http://dx.doi.org/10.1038/nrm2233 (Pubitemid 47312822)
15. Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 2013; 201:613-29; PMID:23649808; http://dx.doi.org/10.1083/jcb.201206006
16. Olsson R, Carlsson PO. A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells. Diabetes 2011; 60:206875; PMID:21788581; http://dx.doi.org/10.2337/db09-0877
17. Brunzell JD, Robertson RP, Lerner RL, Hazzard WR, Ensinck JW, Bierman EL, Porte D Jr. Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab 1976; 42:2229; PMID:1262429; http://dx.doi.org/10.1210/jcem-42-2-222
18. Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 1983; 71:1544-53; PMID:6134752; http://dx.doi.org/10.1172/JCI110910 (Pubitemid 13056759)
19. Leahy JL, Cooper HE, Deal DA, Weir GC. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J Clin Invest 1986; 77:908-15; PMID:3512603; http://dx.doi.org/10.1172/JCI112389 (Pubitemid 16067964)
20. Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S. Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes 1981; 30:5905; PMID:6114005; http://dx.doi.org/10.2337/diab.30.7.590
21. Andersson A. Long-term effects of glucose on insulin release and glucose oxidation by mouse pancreatic islets maintained in tissue culture. Biochem J 1974; 140:377-82; PMID:4614795
22. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004; 53(Suppl 3):S16-21; PMID:15561905; http://dx.doi.org/10.2337/diabetes.53.suppl-3.S16 (Pubitemid 39564517)
23. Ward WK, Bolgiano DC, McKnight B, Halter JB, Porte D Jr. Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 1984; 74:1318-28; PMID:6384269; http://dx.doi.org/10.1172/ JCI111542 (Pubitemid 15206828)
24. Palmer JP, Benson JW, Walter RM, Ensinck JW. Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects. J Clin Invest 1976; 58:565-70; PMID:783201; http://dx.doi.org/10.1172/JCI108502
25. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52:102-10; PMID:12502499; http://dx.doi.org/10.2337/ diabetes.52.1.102 (Pubitemid 36042113)
26. Polyzogopoulou EV, Kalfarentzos F, Vagenakis AG, Alexandrides TK. Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. Diabetes 2003; 52:1098-103; PMID:12716738; http://dx.doi.org/10.2337/diabetes.52.5.1098 (Pubitemid 36523342)
27. Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, Hu Y, Zhou Z, Yan X, Tian H, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic con-trol in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008; 371:1753-60; PMID:18502299; http://dx.doi.org/10.1016/S0140-6736(08)60762-X (Pubitemid 351697950)
28. Kramer CK, Choi H, Zinman B, Retnakaran R. Determinants of reversibility of β-cell dysfunction in response to short-term intensive insulin therapy in patients with early type 2 diabetes. Am J Physiol Endocrinol Metab 2013; 305:E1398407; PMID:24129396; http://dx.doi.org/10.1152/ajpendo.00447.2013
29. Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI. Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 1995; 44:1447-57; PMID:7589853; http://dx.doi.org/10.2337/diab.44.12.1447
30. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, BonnerWeir S, Weir GC. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem 2002; 277:10912-21; PMID:11782487; http://dx.doi.org/10.1074/jbc. M111751200 (Pubitemid 34952846)
31. Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, et al. Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res 2011; 21:95105; PMID:21088282; http://dx.doi.org/10.1101/gr.109173. 110
32. Pullen TJ, Khan AM, Barton G, Butcher SA, Sun G, Rutter GA. Identification of genes selectively disallowed in the pancreatic islet. Islets 2010; 2:8995; PMID:21099300; http://dx.doi.org/10.4161/isl.2.2.11025
33. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol 2009; 23:1281-90; PMID:19407223; http://dx.doi.org/10.1210/me.2008-0482
34. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, et al. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes 2002; 51:413-23; PMID:11812749; http://dx.doi.org/10.2337/diabetes.51.2.413 (Pubitemid 34764797)
35. Guo S, Dai C, Guo M, Taylor B, Harmon JS, Sander M, Robertson RP, Powers AC, Stein R. Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest 2013; Forthcoming; PMID:23863625; http://dx.doi.org/ 10.1172/JCI65390
36. McCulloch DK, Koerker DJ, Kahn SE, Bonner-Weir S, Palmer JP. Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons. Diabetes 1991; 40:673-9; PMID:2040383; http://dx.doi.org/10.2337/diab.40.6.673