Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats

European Journal of Pharmacology

Volumn 691, Issue 1-3, 2012, Pages 297-306

  Inaba, Wataru ^a   Mizukami, Hiroki ^a   Kamata, Kosuke ^a   Takahashi, Kazunori ^a   Tsuboi, Kentaro ^a   Yagihashi, Soroku ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

cells; cells; (GK rat); Dipeptidyl peptidase 4 inhibitor; Glucagon like peptide 1; Type 2 diabetes

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FORKHEAD TRANSCRIPTION FACTOR; FORKHEAD TRANSCRIPTION FACTOR O1; GLUCAGON LIKE PEPTIDE 1; HOMEOBOX 1 PROTEIN; HOMEODOMAIN PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN S6; UNCLASSIFIED DRUG; VILDAGLIPTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD GLUCOSE MONITORING; CELL COUNT; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GLUCAGON LIKE PEPTIDE 1 BLOOD LEVEL; GLUCOSE TOLERANCE; GOTO KAKIZAKI RAT; HYPERGLUCAGONEMIA; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; LONG TERM CARE; MACROPHAGE MIGRATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STRUCTURE ANALYSIS; WISTAR RAT;

ADAMANTANE; ANIMALS; APOPTOSIS; CELL PROLIFERATION; DEOXYGUANOSINE; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; EATING; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE INTOLERANCE; INSULIN; INSULIN-SECRETING CELLS; MALE; NITRILES; PYRROLIDINES; RATS; TIME FACTORS;

EID: 84865007305     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.030     Document Type: Article

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