메뉴 건너뛰기




Volumn 14, Issue 1, 2015, Pages

Sphingolipids in cardiovascular diseases and metabolic disorders

Author keywords

Cardiovascular diseases; Ceramide; Metabolic disorders; Sphingolipids; Sphingosine 1 phosphate

Indexed keywords

CERAMIDE; FINGOLIMOD; HYDRALAZINE; LOSARTAN; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE;

EID: 84935883118     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-015-0053-y     Document Type: Review
Times cited : (124)

References (70)
  • 1
    • 84872432559 scopus 로고    scopus 로고
    • Sphingolipids in apoptosis
    • 1:CAS:528:DC%2BC38XhvFSiu7vI 23070008
    • Tirodkar TS, Voelkel-Johnson C. Sphingolipids in apoptosis. Exp Oncol. 2012;34:231-42.
    • (2012) Exp Oncol , vol.34 , pp. 231-242
    • Tirodkar, T.S.1    Voelkel-Johnson, C.2
  • 2
    • 50049090026 scopus 로고    scopus 로고
    • Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
    • 1:CAS:528:DC%2BD1cXhtVKjtbrM 2614331 18619555
    • Mao C, Obeid LM. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta. 2008;1781:424-34.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 424-434
    • Mao, C.1    Obeid, L.M.2
  • 3
    • 51649122574 scopus 로고    scopus 로고
    • A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
    • 1:CAS:528:DC%2BD1cXpvVOktLc%3D 2515133 18511810
    • Paugh SW, Paugh BS, Rahmani M, Kapitonov D, Almenara JA, Kordula T, et al. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. 2008;112:1382-91.
    • (2008) Blood , vol.112 , pp. 1382-1391
    • Paugh, S.W.1    Paugh, B.S.2    Rahmani, M.3    Kapitonov, D.4    Almenara, J.A.5    Kordula, T.6
  • 4
    • 33644840772 scopus 로고    scopus 로고
    • Physiological and pathophysiological aspects of ceramide
    • 1:CAS:528:DC%2BD28XhsVKisL4%3D 16352856
    • Gulbins E, Li PL. Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol. 2006;290:R11-26.
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290 , pp. 11-26
    • Gulbins, E.1    Li, P.L.2
  • 7
    • 78149426794 scopus 로고    scopus 로고
    • Sphingolipids and cancer: Ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
    • 1:CAS:528:DC%2BC3cXhtl2rsbjJ 3071292 21062159
    • Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, et al. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol. 2010;6:1603-24.
    • (2010) Future Oncol , vol.6 , pp. 1603-1624
    • Ponnusamy, S.1    Meyers-Needham, M.2    Senkal, C.E.3    Saddoughi, S.A.4    Sentelle, D.5    Selvam, S.P.6
  • 9
    • 66349086742 scopus 로고    scopus 로고
    • Bioactive sphingolipids: Metabolism and function
    • 2674734 19017611
    • Bartke N, Hannun YA. Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009;50(Suppl):S91-6.
    • (2009) J Lipid Res , vol.50 , pp. 91-96
    • Bartke, N.1    Hannun, Y.A.2
  • 10
    • 77956395451 scopus 로고    scopus 로고
    • Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease
    • 1:CAS:528:DC%2BC3cXhtFWqsLvL 20193711
    • Gangoiti P, Camacho L, Arana L, Ouro A, Granado MH, Brizuela L, et al. Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Prog Lipid Res. 2010;49:316-34.
    • (2010) Prog Lipid Res , vol.49 , pp. 316-334
    • Gangoiti, P.1    Camacho, L.2    Arana, L.3    Ouro, A.4    Granado, M.H.5    Brizuela, L.6    Casas, J.7
  • 12
    • 84866729965 scopus 로고    scopus 로고
    • Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat
    • 1:CAS:528:DC%2BC38XhtFShu7zJ 22833182
    • Knapp M, Zendzian-Piotrowska M, Kurek K, Błachnio-Zabielska A. Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. Lipids. 2012;47:847-53.
    • (2012) Lipids , vol.47 , pp. 847-853
    • Knapp, M.1    Zendzian-Piotrowska, M.2    Kurek, K.3    Błachnio-Zabielska, A.4
  • 13
    • 0033135379 scopus 로고    scopus 로고
    • FK506 prevents stroke-induced generation of ceramide and apoptosis signaling
    • 1:CAS:528:DyaK1MXjt1Shtbo%3D 10224298
    • Herr I, Martin-Villalba A, Kurz E, Roncaioli P, Schenkel J, Cifone MG, et al. FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res. 1999;826:210-9.
    • (1999) Brain Res , vol.826 , pp. 210-219
    • Herr, I.1    Martin-Villalba, A.2    Kurz, E.3    Roncaioli, P.4    Schenkel, J.5    Cifone, M.G.6
  • 14
    • 10044232741 scopus 로고    scopus 로고
    • Sphingolipids and atherosclerosis: A mechanistic connection? A therapeutic opportunity?
    • 15569847
    • Tabas I. Sphingolipids and atherosclerosis: a mechanistic connection? A therapeutic opportunity? Circulation. 2004;110:3400-1.
    • (2004) Circulation , vol.110 , pp. 3400-3401
    • Tabas, I.1
  • 15
    • 15744398177 scopus 로고    scopus 로고
    • Ceramide and other sphingolipids in cellular responses
    • 1:CAS:528:DC%2BD2cXmslKhsLk%3D 15211031
    • Yang J, Yu Y, Sun S, Duerksen-Hughes PJ. Ceramide and other sphingolipids in cellular responses. Cell Biochem Biophys. 2004;40:323-50.
    • (2004) Cell Biochem Biophys , vol.40 , pp. 323-350
    • Yang, J.1    Yu, Y.2    Sun, S.3    Duerksen-Hughes, P.J.4
  • 16
    • 0034717184 scopus 로고    scopus 로고
    • Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
    • 1:CAS:528:DC%2BD3cXjvFaju7k%3D 10747891
    • Cuvillier O, Edsall L, Spiegel S. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J Biol Chem. 2000;275:15691-700.
    • (2000) J Biol Chem , vol.275 , pp. 15691-15700
    • Cuvillier, O.1    Edsall, L.2    Spiegel, S.3
  • 17
    • 0030062206 scopus 로고    scopus 로고
    • Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity
    • 1:CAS:528:DyaK28XkvFeisLw%3D 8752836
    • Tokura Y, Wakita H, Yagi H, Nishimura K, Furukawa F, Takigawa M. Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity. J Invest Dermatol. 1996;107:34-40.
    • (1996) J Invest Dermatol , vol.107 , pp. 34-40
    • Tokura, Y.1    Wakita, H.2    Yagi, H.3    Nishimura, K.4    Furukawa, F.5    Takigawa, M.6
  • 18
    • 0030899436 scopus 로고    scopus 로고
    • Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes
    • 1:CAS:528:DyaK2sXhvVarsL4%3D 9058737
    • Suchard SJ, Hinkovska-Galcheva V, Mansfield PJ, Boxer LA, Shayman JA. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. Blood. 1997;89:2139-47.
    • (1997) Blood , vol.89 , pp. 2139-2147
    • Suchard, S.J.1    Hinkovska-Galcheva, V.2    Mansfield, P.J.3    Boxer, L.A.4    Shayman, J.A.5
  • 19
    • 70350376864 scopus 로고    scopus 로고
    • Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis
    • 1:CAS:528:DC%2BD1MXhtFCgs7fL 2785377 19632995
    • Lamour NF, Subramanian P, Wijesinghe DS, Stahelin RV, Bonventre JV, Chalfant CE. Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis. J Biol Chem. 2009;284:26897-907.
    • (2009) J Biol Chem , vol.284 , pp. 26897-26907
    • Lamour, N.F.1    Subramanian, P.2    Wijesinghe, D.S.3    Stahelin, R.V.4    Bonventre, J.V.5    Chalfant, C.E.6
  • 20
    • 0033526803 scopus 로고    scopus 로고
    • The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor i triggering
    • 1:CAS:528:DyaK1MXksVeiurw%3D 2195554 10429665
    • Prieschl EE. The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. J Exp Med. 1999;190:1-8.
    • (1999) J Exp Med , vol.190 , pp. 1-8
    • Prieschl, E.E.1
  • 21
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • 1:CAS:528:DC%2BC2cXhtFygs77L 4320971 24899305
    • Maceyka M, Spiegel S. Sphingolipid metabolites in inflammatory disease. Nature. 2014;510:58-67.
    • (2014) Nature , vol.510 , pp. 58-67
    • Maceyka, M.1    Spiegel, S.2
  • 22
    • 0035665449 scopus 로고    scopus 로고
    • Angiotensin receptors: Signaling, vascular pathophysiology, and interactions with ceramide
    • 1:CAS:528:DC%2BD3MXptlKgu78%3D 11709400
    • Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am J Physiol Heart Circ Physiol. 2001;281:H2337-65.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , pp. 2337-2365
    • Berry, C.1    Touyz, R.2    Dominiczak, A.F.3    Webb, R.C.4    Johns, D.G.5
  • 23
    • 53749104902 scopus 로고    scopus 로고
    • Fabry's disease
    • 1:CAS:528:DC%2BD1cXht1KntLvL 18940466
    • Zarate YA, Hopkin RJ. Fabry's disease. Lancet. 2008;372:1427-35.
    • (2008) Lancet , vol.372 , pp. 1427-1435
    • Zarate, Y.A.1    Hopkin, R.J.2
  • 24
    • 0034457799 scopus 로고    scopus 로고
    • Metabolic cardiomyopathies
    • 1:CAS:528:DC%2BD3MXjtFWhtLk%3D 2517748 11298185
    • Guertl B, Noehammer C, Hoefler G. Metabolic cardiomyopathies. Int J Exp Pathol. 2000;81:349-72.
    • (2000) Int J Exp Pathol , vol.81 , pp. 349-372
    • Guertl, B.1    Noehammer, C.2    Hoefler, G.3
  • 26
    • 0030473287 scopus 로고    scopus 로고
    • Sphingomyelin breakdown and cell fate
    • 1:CAS:528:DyaK2sXhtlOmsg%3D%3D 9009829
    • Testi R. Sphingomyelin breakdown and cell fate. Trends Biochem Sci. 1996;21:468-71.
    • (1996) Trends Biochem Sci , vol.21 , pp. 468-471
    • Testi, R.1
  • 29
    • 0036083489 scopus 로고    scopus 로고
    • Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts
    • 1:CAS:528:DC%2BD38Xks12ns7w%3D 12003800
    • Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, et al. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol. 2002;282:H1970-7.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282 , pp. 1970-1977
    • Jin, Z.Q.1    Zhou, H.Z.2    Zhu, P.3    Honbo, N.4    Mochly-Rosen, D.5    Messing, R.O.6
  • 30
    • 84921438461 scopus 로고
    • Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress
    • Karliner JS. Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Biochim Biophys Acta. 1831;2013:203-12.
    • (1831) Biochim Biophys Acta , vol.2013 , pp. 203-212
    • Karliner, J.S.1
  • 31
    • 0032032901 scopus 로고    scopus 로고
    • HPTLC analysis of sphingomyelin, ceramide and sphingosine in ischemic/reperfused rat heart
    • 1:CAS:528:DyaK1cXit1egt7k%3D 9571536
    • Cordis GA, Yoshida T, Das DK. HPTLC analysis of sphingomyelin, ceramide and sphingosine in ischemic/reperfused rat heart. J Pharm Biomed Anal. 1998;16:1189-93.
    • (1998) J Pharm Biomed Anal , vol.16 , pp. 1189-1193
    • Cordis, G.A.1    Yoshida, T.2    Das, D.K.3
  • 32
    • 0035040978 scopus 로고    scopus 로고
    • Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats
    • 1:CAS:528:DC%2BD3MXkt1Omtbg%3D 11403420
    • Zhang DX, Fryer RM, Hsu AK, Zou AP, Gross GJ, Campbell WB, et al. Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats. Basic Res Cardiol. 2001;96:267-74.
    • (2001) Basic Res Cardiol , vol.96 , pp. 267-274
    • Zhang, D.X.1    Fryer, R.M.2    Hsu, A.K.3    Zou, A.P.4    Gross, G.J.5    Campbell, W.B.6
  • 33
    • 0037485571 scopus 로고    scopus 로고
    • Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate
    • 1:CAS:528:DC%2BD3sXltF2ju7s%3D 12851609
    • Deutschman DH, Carstens JS, Klepper RL, Smith WS, Page MT, Young TR, et al. Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. Am Heart J. 2003;146(1):62-8.
    • (2003) Am Heart J , vol.146 , Issue.1 , pp. 62-68
    • Deutschman, D.H.1    Carstens, J.S.2    Klepper, R.L.3    Smith, W.S.4    Page, M.T.5    Young, T.R.6
  • 34
    • 84884575993 scopus 로고    scopus 로고
    • Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury
    • 1:CAS:528:DC%2BC3sXht1ajtbvF 3680707 23781203
    • Egom EE, Mamas MA, Chacko S, Stringer SE, Charlton-Menys V, El-Omar M, et al. Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury. Front Physiol. 2013;4:130.
    • (2013) Front Physiol , vol.4 , pp. 130
    • Egom, E.E.1    Mamas, M.A.2    Chacko, S.3    Stringer, S.E.4    Charlton-Menys, V.5    El-Omar, M.6
  • 35
    • 4944246652 scopus 로고    scopus 로고
    • Sphingosine kinase activation mediates ischemic preconditioning in murine heart
    • 1:CAS:528:DC%2BD2cXnvFams78%3D 15451787
    • Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation. 2004;110:1980-9.
    • (2004) Circulation , vol.110 , pp. 1980-1989
    • Jin, Z.Q.1    Goetzl, E.J.2    Karliner, J.S.3
  • 36
    • 84898539271 scopus 로고    scopus 로고
    • Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes
    • 24589572
    • Pan W, Yu J, Shi R, Yan L, Yang T, Li Y, et al. Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes. Coron Artery Dis. 2014;25(3):230-5.
    • (2014) Coron Artery Dis , vol.25 , Issue.3 , pp. 230-235
    • Pan, W.1    Yu, J.2    Shi, R.3    Yan, L.4    Yang, T.5    Li, Y.6
  • 37
    • 70349908135 scopus 로고    scopus 로고
    • Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction
    • 1:CAS:528:DC%2BD1MXht12htbbI 19721401
    • Knapp M, Baranowski M, Czarnowski D, Lisowska A, Zabielski P, Górski J, et al. Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. Med Sci Monit. 2009;15:CR490-3.
    • (2009) Med Sci Monit , vol.15 , pp. 490-493
    • Knapp, M.1    Baranowski, M.2    Czarnowski, D.3    Lisowska, A.4    Zabielski, P.5    Górski, J.6
  • 38
    • 84887040330 scopus 로고    scopus 로고
    • Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction
    • 1:CAS:528:DC%2BC3sXhvV2ru7zI 24120760
    • Knapp M, Lisowska A, Zabielski P, Musiał W, Baranowski M. Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. Prostaglandins Other Lipid Mediat. 2013;106:53-61.
    • (2013) Prostaglandins Other Lipid Mediat , vol.106 , pp. 53-61
    • Knapp, M.1    Lisowska, A.2    Zabielski, P.3    Musiał, W.4    Baranowski, M.5
  • 39
    • 79960449880 scopus 로고    scopus 로고
    • Hypertension is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide
    • 1:CAS:528:DC%2BC3MXhtVehtL7J 3139577 21818267
    • Spijkers LJA, van den Akker RFP, Janssen BJA, Debets JJ, De Mey JG, Stroes ES, et al. Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide. PLoS ONE. 2011;6:e21817.
    • (2011) PLoS ONE , vol.6 , pp. 21817
    • Spijkers, L.J.A.1    Van Den Akker, R.F.P.2    Janssen, B.J.A.3    Debets, J.J.4    De Mey, J.G.5    Stroes, E.S.6
  • 40
    • 67449152428 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and modulation of vascular tone
    • 1:CAS:528:DC%2BD1MXksVakt74%3D 2674011 19233865
    • Igarashi J, Michel T. Sphingosine-1-phosphate and modulation of vascular tone. Cardiovasc Res. 2009;82:212-20.
    • (2009) Cardiovasc Res , vol.82 , pp. 212-220
    • Igarashi, J.1    Michel, T.2
  • 42
    • 83455205960 scopus 로고    scopus 로고
    • Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats
    • 1:CAS:528:DC%2BC38Xis1WqtA%3D%3D 3240660 22195025
    • Spijkers LJA, Janssen BJA, Nelissen J, Meens MJ, Wijesinghe D, Chalfant CE, et al. Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. PLoS ONE. 2011;6:e29222.
    • (2011) PLoS ONE , vol.6 , pp. 29222
    • Spijkers, L.J.A.1    Janssen, B.J.A.2    Nelissen, J.3    Meens, M.J.4    Wijesinghe, D.5    Chalfant, C.E.6
  • 43
    • 4143125479 scopus 로고    scopus 로고
    • Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium
    • 1:CAS:528:DC%2BD2cXnvVaqtrs%3D 15142848
    • Czarny M, Schnitzer JE. Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium. Am J Physiol Heart Circ Physiol. 2004;287:H1344-52.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , pp. 1344-1352
    • Czarny, M.1    Schnitzer, J.E.2
  • 44
    • 78650873412 scopus 로고    scopus 로고
    • Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death
    • 21081127
    • Agudo-López A, Miguel BG, Fernández I, Martínez AM. Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death. FEBS Lett. 2011;585:99-103.
    • (2011) FEBS Lett , vol.585 , pp. 99-103
    • Agudo-López, A.1    Miguel, B.G.2    Fernández, I.3    Martínez, A.M.4
  • 45
    • 0034704409 scopus 로고    scopus 로고
    • Lethal fore-brain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus
    • 1:CAS:528:DC%2BD3cXosFCjsLo%3D 11108988
    • Nakane M, Kubota M, Nakagomi T, Tamura A, Hisaki H, Shimasaki H, et al. Lethal fore-brain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus. Neurosci Lett. 2000;296:89-92.
    • (2000) Neurosci Lett , vol.296 , pp. 89-92
    • Nakane, M.1    Kubota, M.2    Nakagomi, T.3    Tamura, A.4    Hisaki, H.5    Shimasaki, H.6
  • 46
    • 0029780817 scopus 로고    scopus 로고
    • Sphingomyelin changes in rat cerebral cortex during focal ischemia
    • 1:CAS:528:DyaK28XlslKhs70%3D 8875452
    • Kubota M, Narita K, Nakagomi T, Tamura A, Shimasaki H, Ueta N, et al. Sphingomyelin changes in rat cerebral cortex during focal ischemia. Neurol Res. 1996;18:337-41.
    • (1996) Neurol Res , vol.18 , pp. 337-341
    • Kubota, M.1    Narita, K.2    Nakagomi, T.3    Tamura, A.4    Shimasaki, H.5    Ueta, N.6
  • 47
    • 2642521387 scopus 로고    scopus 로고
    • Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning
    • 1:CAS:528:DC%2BD2cXksF2ltb8%3D 15181369
    • Takahashi K, Ginis I, Nishioka R, Klimanis D, Barone FC, White RF, et al. Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning. J Cereb Blood Flow Metab. 2004;24:623-37.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 623-637
    • Takahashi, K.1    Ginis, I.2    Nishioka, R.3    Klimanis, D.4    Barone, F.C.5    White, R.F.6
  • 48
    • 0034488193 scopus 로고    scopus 로고
    • Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
    • 1:CAS:528:DC%2BD3MXht1Gqsb0%3D 11220788
    • Yu ZF, Nikolova-Karakashian M, Zhou D, Cheng G, Schuchman EH, Mattson MP. Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J Mol Neurosci. 2000;15:85-97.
    • (2000) J Mol Neurosci , vol.15 , pp. 85-97
    • Yu, Z.F.1    Nikolova-Karakashian, M.2    Zhou, D.3    Cheng, G.4    Schuchman, E.H.5    Mattson, M.P.6
  • 49
    • 3042599022 scopus 로고    scopus 로고
    • Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress
    • 1:CAS:528:DC%2BD2cXlsVartro%3D 15234103
    • Soeda S, Tsuji Y, Ochiai T, Mishima K, Iwasaki K, Fujiwara M, et al. Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress. Neurochem Int. 2004;45:619-26.
    • (2004) Neurochem Int , vol.45 , pp. 619-626
    • Soeda, S.1    Tsuji, Y.2    Ochiai, T.3    Mishima, K.4    Iwasaki, K.5    Fujiwara, M.6
  • 50
    • 33846021925 scopus 로고    scopus 로고
    • Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury
    • 1:CAS:528:DC%2BD2sXhvVGjt7w%3D 16990586
    • Kimura A, Ohmori T, Ohkawa R, Madoiwa S, Mimuro J, Murakami T, et al. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells. 2007;25:115-24.
    • (2007) Stem Cells , vol.25 , pp. 115-124
    • Kimura, A.1    Ohmori, T.2    Ohkawa, R.3    Madoiwa, S.4    Mimuro, J.5    Murakami, T.6
  • 51
    • 58149345610 scopus 로고    scopus 로고
    • Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain
    • 1:CAS:528:DC%2BD1cXhtlylt7nP 18757288
    • Kimura A, Ohmori T, Kashiwakura Y, Ohkawa R, Madoiwa S, Mimuro J, et al. Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. Stroke. 2008;39:3411-7.
    • (2008) Stroke , vol.39 , pp. 3411-3417
    • Kimura, A.1    Ohmori, T.2    Kashiwakura, Y.3    Ohkawa, R.4    Madoiwa, S.5    Mimuro, J.6
  • 52
    • 77449106966 scopus 로고    scopus 로고
    • Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
    • 1:CAS:528:DC%2BC3cXps1SnsQ%3D%3D 2811754 19940275
    • Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH. Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke. 2010;41:368-74.
    • (2010) Stroke , vol.41 , pp. 368-374
    • Hasegawa, Y.1    Suzuki, H.2    Sozen, T.3    Rolland, W.4    Zhang, J.H.5
  • 53
    • 0024405793 scopus 로고
    • Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion
    • 1:STN:280:DyaL1Mzht1Squw%3D%3D 2746971
    • Kubota M, Kitahara S, Shimasaki H, Ueta N. Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion. Jpn J Exp Med. 1989;59:59-64.
    • (1989) Jpn J Exp Med , vol.59 , pp. 59-64
    • Kubota, M.1    Kitahara, S.2    Shimasaki, H.3    Ueta, N.4
  • 54
    • 80053060999 scopus 로고    scopus 로고
    • Structures, biosynthesis, and functions of gangliosides - An overview
    • 1:CAS:528:DC%2BC3MXht1Gns7jK 3684167 21937853
    • Yu RK, Tsai YT, Ariga T, Yanagisawa M. Structures, biosynthesis, and functions of gangliosides - an overview. J Oleo Sci. 2011;60:537-44.
    • (2011) J Oleo Sci , vol.60 , pp. 537-544
    • Yu, R.K.1    Tsai, Y.T.2    Ariga, T.3    Yanagisawa, M.4
  • 55
    • 67649613308 scopus 로고    scopus 로고
    • Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP
    • 1:CAS:528:DC%2BD1MXns1eqs74%3D 19488858
    • Zhang Y, Ranta F, Tang C, Shumilina E, Mahmud H, Föller M, et al. Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP. Apoptosis. 2009;14:878-89.
    • (2009) Apoptosis , vol.14 , pp. 878-889
    • Zhang, Y.1    Ranta, F.2    Tang, C.3    Shumilina, E.4    Mahmud, H.5    Föller, M.6
  • 56
    • 34548418170 scopus 로고    scopus 로고
    • Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models
    • 1:CAS:528:DC%2BD2sXhtV2gs7fO 17563067
    • Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, et al. Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. Diabetes. 2007;56:2302-11.
    • (2007) Diabetes , vol.56 , pp. 2302-2311
    • Liadis, N.1    Salmena, L.2    Kwan, E.3    Tajmir, P.4    Schroer, S.A.5    Radziszewska, A.6
  • 57
    • 0037230114 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1
    • 1:CAS:528:DC%2BD3sXhtFSlug%3D%3D 12488362
    • Maestre I, Jordan J, Calvo S, Reig JA, Ceña V, Soria B, et al. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology. 2003;144:335-45.
    • (2003) Endocrinology , vol.144 , pp. 335-345
    • Maestre, I.1    Jordan, J.2    Calvo, S.3    Reig, J.A.4    Ceña, V.5    Soria, B.6
  • 58
    • 15944425766 scopus 로고    scopus 로고
    • A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria
    • 1:CAS:528:DC%2BD2MXitVegs7g%3D 1134862 15516208
    • Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM. A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005;386:445-51.
    • (2005) Biochem J , vol.386 , pp. 445-451
    • Birbes, H.1    Luberto, C.2    Hsu, Y.T.3    El Bawab, S.4    Hannun, Y.A.5    Obeid, L.M.6
  • 59
    • 0034612304 scopus 로고    scopus 로고
    • Ceramide interaction with the respiratory chain of heart mitochondria
    • 10828984
    • Di Paola M, Cocco T, Lorusso M. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry. 2000;39:6660-8.
    • (2000) Biochemistry , vol.39 , pp. 6660-6668
    • Di Paola, M.1    Cocco, T.2    Lorusso, M.3
  • 60
    • 0030856714 scopus 로고    scopus 로고
    • Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
    • 1:CAS:528:DyaK2sXmsFanurc%3D 9305864
    • Gudz TI, Tserng KY, Hoppel CL. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J Biol Chem. 1997;272:24154-8.
    • (1997) J Biol Chem , vol.272 , pp. 24154-24158
    • Gudz, T.I.1    Tserng, K.Y.2    Hoppel, C.L.3
  • 61
    • 84860323080 scopus 로고    scopus 로고
    • Ceramide kinase deficiency improves diet-induced obesity and insulin resistance
    • 1:CAS:528:DC%2BC38Xltl2ksLs%3D 22465662
    • Mitsutake S, Date T, Yokota H, Sugiura M, Kohama T, Igarashi Y. Ceramide kinase deficiency improves diet-induced obesity and insulin resistance. FEBS Lett. 2012;586(9):1300-5.
    • (2012) FEBS Lett , vol.586 , Issue.9 , pp. 1300-1305
    • Mitsutake, S.1    Date, T.2    Yokota, H.3    Sugiura, M.4    Kohama, T.5    Igarashi, Y.6
  • 62
    • 84873029099 scopus 로고    scopus 로고
    • Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance
    • 1:CAS:528:DC%2BC3sXhvFOnsrw%3D 3554351 23139352
    • Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, et al. Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes. 2013;62(2):401-10.
    • (2013) Diabetes , vol.62 , Issue.2 , pp. 401-410
    • Boon, J.1    Hoy, A.J.2    Stark, R.3    Brown, R.D.4    Meex, R.C.5    Henstridge, D.C.6
  • 63
    • 84877294515 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in female children and adolescents with type 2 diabetes
    • 1:CAS:528:DC%2BC2cXmsVKhtL0%3D 23612696
    • Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer PE. Plasma ceramides are elevated in female children and adolescents with type 2 diabetes. J Pediatr Endocrinol Metab. 2013;26((9-10)):995-8.
    • (2013) J Pediatr Endocrinol Metab , vol.26 , Issue.9-10 , pp. 995-998
    • Lopez, X.1    Goldfine, A.B.2    Holland, W.L.3    Gordillo, R.4    Scherer, P.E.5
  • 64
    • 80055030207 scopus 로고    scopus 로고
    • Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients
    • 1:CAS:528:DC%2BC3MXhtlyjs7fO
    • Huang H, Kasumov T, Gatmaitan P. Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients. Obesity (Silver Spring). 2011;19(11):2235-40.
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.11 , pp. 2235-2240
    • Huang, H.1    Kasumov, T.2    Gatmaitan, P.3
  • 65
    • 0042531617 scopus 로고    scopus 로고
    • Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
    • 1:CAS:528:DC%2BD3sXlvFOnt74%3D 12771145
    • Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem. 2003;278:30015-21.
    • (2003) J Biol Chem , vol.278 , pp. 30015-30021
    • Kelpe, C.L.1    Moore, P.C.2    Parazzoli, S.D.3    Wicksteed, B.4    Rhodes, C.J.5    Poitout, V.6
  • 66
    • 84863129902 scopus 로고    scopus 로고
    • FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2)
    • 1:CAS:528:DC%2BC38XisVyltLw%3D 3285331 22194608
    • Zhao Z, Choi J, Zhao C, Ma ZA. FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2). J Biol Chem. 2012;287:5562-73.
    • (2012) J Biol Chem , vol.287 , pp. 5562-5573
    • Zhao, Z.1    Choi, J.2    Zhao, C.3    Ma, Z.A.4
  • 67
    • 84885160207 scopus 로고    scopus 로고
    • Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice
    • 1:CAS:528:DC%2BC3sXhs1SqtLzK 23839933
    • Qi Y, Chen J, Lay A, Don A, Vadas M, Xia P. Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice. FASEB J. 2013;27(10):4294-304.
    • (2013) FASEB J , vol.27 , Issue.10 , pp. 4294-4304
    • Qi, Y.1    Chen, J.2    Lay, A.3    Don, A.4    Vadas, M.5    Xia, P.6
  • 68
    • 84862791207 scopus 로고    scopus 로고
    • S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition
    • 1:CAS:528:DC%2BC38XktFGhur0%3D 22406263
    • Liu W, Lan T, Xie X, Huang K, Peng J, Huang J, et al. S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. Exp Cell Res. 2012;318(8):936-43.
    • (2012) Exp Cell Res , vol.318 , Issue.8 , pp. 936-943
    • Liu, W.1    Lan, T.2    Xie, X.3    Huang, K.4    Peng, J.5    Huang, J.6
  • 69
    • 34447136081 scopus 로고    scopus 로고
    • Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720
    • 1:CAS:528:DC%2BD2sXpt1eju7g%3D 17617868
    • Truong W, Emamaullee JA, Merani S, Anderson CC, James Shapiro AM. Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. Am J Transplant. 2007;7:2031-8.
    • (2007) Am J Transplant , vol.7 , pp. 2031-2038
    • Truong, W.1    Emamaullee, J.A.2    Merani, S.3    Anderson, C.C.4    James Shapiro, A.M.5
  • 70
    • 84908248738 scopus 로고    scopus 로고
    • Decreased plasma levels of select very long chain ceramide species are associated with the development of nephropathy in type 1 diabetes
    • 1:CAS:528:DC%2BC2cXht1Ojs77L 25088746
    • Klein RL, Hammad SM, Baker NL, Hunt KJ, Al Gadban MM, Cleary PA, et al. Decreased plasma levels of select very long chain ceramide species are associated with the development of nephropathy in type 1 diabetes. Metabolism. 2014;63:1287-95.
    • (2014) Metabolism , vol.63 , pp. 1287-1295
    • Klein, R.L.1    Hammad, S.M.2    Baker, N.L.3    Hunt, K.J.4    Al Gadban, M.M.5    Cleary, P.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.