Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 3 56-3, 2004, Pages

  Czarny, Malgorzata ^a   Schnitzer, Jan E ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

Caveolae; Endothelium; Mechanosignal transduction; Shear stress

Indexed keywords

CERAMIDE; CERAMIDE DERIVATIVE; GENISTEIN; HERBAMYCIN A; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYLDIHYDROSPHINGOSINE; N ACETYLSPHINGOSINE; N HEXANOYLSPHINGANINE; PROTEIN TYROSINE KINASE; SCYPHOSTATIN; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; BLOOD FLOW VELOCITY; CAVEOLA; CELL CULTURE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; EXPERIMENTAL MODEL; FLOW RATE; LUNG BLOOD VESSEL; MECHANICAL STRESS; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SECOND MESSENGER; SHEAR STRESS; VASCULAR ENDOTHELIUM;

AMIDES; ANIMALS; CATTLE; CELL MEMBRANE; CELLS, CULTURED; CERAMIDES; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; LUNG; MECHANOTRANSDUCTION, CELLULAR; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEINS; PYRONES; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 4143125479     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00222.2004     Document Type: Article

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