Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives

Journal of Medicinal Chemistry

Volumn 58, Issue 11, 2015, Pages 4529-4549

  Wong, Iris L K ^a   Wang, Bao Chao ^b   Yuan, Jian ^b   Duan, Liang Xing ^b   Liu, Zhen ^b   Liu, Tao ^b   Li, Xue Min ^b   Hu, Xuesen ^a   Zhang, Xiao Yu ^b   Jiang, Tao ^b   Wan, Sheng Biao ^b   Chow, Larry M C ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHROMANONE DERIVATIVE; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; DIHYDROMYRICETIN DERIVATIVE; EPIGALLOCATECHIN; GALLOCATECHIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MYRICETIN; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; CATECHIN; DIHYDROMYRICETIN; EPIGALLOCATECHIN GALLATE; FLAVONOL DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; TUMOR PROTEIN;

ARTICLE; CANCER RESISTANCE; CELLULAR DISTRIBUTION; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; IC50; MULTIDRUG RESISTANCE; NEOPLASM; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; EVALUATION STUDY; HUMAN; METABOLISM; METHYLATION; NEOPLASMS; PATHOLOGY; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CATECHIN; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLAVONOLS; HUMANS; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; NEOPLASMS; P-GLYCOPROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84935847040     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00085     Document Type: Article

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