Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier

Journal of Medicinal Chemistry

Volumn 52, Issue 19, 2009, Pages 6073-6082

  Dörner, Bernd ^a   Kuntner, Claudia ^b   Bankstahl, Jens P ^c   Bankstahl, Marion ^c   Stanek, Johann ^b   Wanek, Thomas ^b   Stundner, Gloria ^b   Mairinger, Severin ^a,b,d   Löscher, Wolfgang ^c   Müller, Markus ^d   Langer, Oliver ^b,d   Erker, Thomas ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b AIT AUSTRIAN INSTITUTE OF TECHNOLOGY   (Austria)

^c UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; ELACRIDAR; GLYCOPROTEIN P; O DESMETHYL ELACRIDAR; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD BRAIN BARRIER; DRUG SYNTHESIS; ISOTOPE LABELING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ACRIDINES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; AUTORADIOGRAPHY; BLOOD-BRAIN BARRIER; CARBON RADIOISOTOPES; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; P-GLYCOPROTEINS; POSITRON-EMISSION TOMOGRAPHY; RATS; TETRAHYDROISOQUINOLINES; TISSUE DISTRIBUTION;

EID: 70349643109     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900940f     Document Type: Article

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