-
1
-
-
84875758730
-
Lessons from the cancer genome
-
Garraway LA, Lander ES. Lessons from the cancer genome. Cell 2013; 153: 17-37.
-
(2013)
Cell
, vol.153
, pp. 17-37
-
-
Garraway, L.A.1
Lander, E.S.2
-
2
-
-
84884826911
-
The next-generation sequencing revolution and its impact on genomics
-
Koboldt DC, Steinberg KM, Larson DE, Wilson RK, Mardis ER. The next-generation sequencing revolution and its impact on genomics. Cell 2013; 155: 27-38.
-
(2013)
Cell
, vol.155
, pp. 27-38
-
-
Koboldt, D.C.1
Steinberg, K.M.2
Larson, D.E.3
Wilson, R.K.4
Mardis, E.R.5
-
3
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C et al. Mutational landscape and significance across 12 major cancer types. Nature 2013; 502: 333-339.
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
Lu, C.6
-
4
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LAJ, Kinzler KW. Cancer genome landscapes. Science 2013; 339: 1546-1558.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, L.A.J.5
Kinzler, K.W.6
-
5
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 2013; 499: 214-218.
-
(2013)
Nature
, vol.499
, pp. 214-218
-
-
Lawrence, M.S.1
Stojanov, P.2
Polak, P.3
Kryukov, G.V.4
Cibulskis, K.5
Sivachenko, A.6
-
6
-
-
79953158399
-
Exploring the genomes of cancer cells: Progress and promise
-
Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science 2011; 331: 1553-1558.
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
8
-
-
0014692015
-
Suppression of malignancy by cell fusion
-
Harris H, Miller OJ, Klein G, Worst P, Tachibana T. Suppression of malignancy by cell fusion. Nature 1969; 223: 363-368.
-
(1969)
Nature
, vol.223
, pp. 363-368
-
-
Harris, H.1
Miller, O.J.2
Klein, G.3
Worst, P.4
Tachibana, T.5
-
9
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
Knudson A. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971; 68: 820-823.
-
(1971)
Proc Natl Acad Sci USA
, vol.68
, pp. 820-823
-
-
Knudson, A.1
-
10
-
-
0020518746
-
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
-
Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL et al. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 1983; 305: 779-784.
-
(1983)
Nature
, vol.305
, pp. 779-784
-
-
Cavenee, W.K.1
Dryja, T.P.2
Phillips, R.A.3
Benedict, W.F.4
Godbout, R.5
Gallie, B.L.6
-
11
-
-
0030839584
-
Tumour-suppressor genes: Evolving definitions in the genomic age
-
Haber D, Harlow E. Tumour-suppressor genes: evolving definitions in the genomic age. Nat Genet 1997; 16: 320-322.
-
(1997)
Nat Genet
, vol.16
, pp. 320-322
-
-
Haber, D.1
Harlow, E.2
-
12
-
-
0030932869
-
Cancer-susceptibility genes. Gatekeepers and caretakers
-
Kinzler KW, Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997; 386: 763.
-
(1997)
Nature
, vol.386
, pp. 763
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
13
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269-271.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
-
14
-
-
0037370310
-
Notch1 functions as a tumor suppressor in mouse skin
-
Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 2003; 33: 416-421.
-
(2003)
Nat Genet
, vol.33
, pp. 416-421
-
-
Nicolas, M.1
Wolfer, A.2
Raj, K.3
Kummer, J.A.4
Mill, P.5
Van Noort6
-
15
-
-
0024536654
-
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
-
Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989; 244: 217-221.
-
(1989)
Science
, vol.244
, pp. 217-221
-
-
Baker, S.J.1
Fearon, E.R.2
Nigro, J.M.3
Hamilton, S.R.4
Preisinger, A.C.5
Jessup, J.M.6
-
16
-
-
0024452546
-
P53: A frequent target for genetic abnormalities in lung cancer
-
Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour et al. p53: a frequent target for genetic abnormalities in lung cancer. Science 1989; 246: 491-494.
-
(1989)
Science
, vol.246
, pp. 491-494
-
-
Takahashi, T.1
Nau, M.M.2
Chiba, I.3
Birrer, M.J.4
Rosenberg, R.K.5
Vinocour6
-
17
-
-
35148826938
-
Shaping genetic alterations in human cancer: The p53 mutation paradigm
-
Soussi T, Wiman KG. Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell 2007; 12: 303-312.
-
(2007)
Cancer Cell
, vol.12
, pp. 303-312
-
-
Soussi, T.1
Wiman, K.G.2
-
18
-
-
84862636275
-
Mutant p53: One name, many proteins
-
Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev 2012; 26: 1268-1286.
-
(2012)
Genes Dev
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
19
-
-
84901054744
-
TP53 mutations in human cancer: Database reassessment and prospects for the next decade
-
Leroy B, Anderson M, Soussi T. TP53 mutations in human cancer: database reassessment and prospects for the next decade. Hum Mutat 2014; 35: 672-688.
-
(2014)
Hum Mutat
, vol.35
, pp. 672-688
-
-
Leroy, B.1
Anderson, M.2
Soussi, T.3
-
20
-
-
79961110903
-
Advances in carcinogenesis: A historical perspective from observational studies to tumor genome sequencing and TP53 mutation spectrum analysis
-
Soussi T. Advances in carcinogenesis: a historical perspective from observational studies to tumor genome sequencing and TP53 mutation spectrum analysis. Biochim Biophys Acta 2011; 1816: 199-208.
-
(2011)
Biochim Biophys Acta
, vol.1816
, pp. 199-208
-
-
Soussi, T.1
-
21
-
-
77956400377
-
The tumor suppressor p53: From structures to drug discovery
-
Joerger AC, Fersht AR. The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol 2010; 2: a000919.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
, pp. a000919
-
-
Joerger, A.C.1
Fersht, A.R.2
-
22
-
-
84884994218
-
The Cancer Genome Atlas Pan-Cancer analysis project
-
Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 2013; 45: 1113-1120.
-
(2013)
Nat Genet
, vol.45
, pp. 1113-1120
-
-
Weinstein, J.N.1
Collisson, E.A.2
Mills, G.B.3
Shaw, K.R.4
Ozenberger, B.A.5
Ellrott, K.6
-
24
-
-
0029956081
-
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
-
Aas T, Borresen AL, Geisler S, Smith-Sorensen B, Johnsen H, Varhaug JE et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996; 2: 811-814.
-
(1996)
Nat Med
, vol.2
, pp. 811-814
-
-
Aas, T.1
Borresen, A.L.2
Geisler, S.3
Smith-Sorensen, B.4
Johnsen, H.5
Varhaug, J.E.6
-
25
-
-
78650307334
-
TP53 mutation profile in chronic lymphocytic leukemia: Evidence for a disease specific profile from a comprehensive analysis of 268 mutations
-
Zenz T, Vollmer D, Trbusek M, Smardova J, Benner A, Soussi T et al. TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. Leukemia 2010; 24: 2072-2079.
-
(2010)
Leukemia
, vol.24
, pp. 2072-2079
-
-
Zenz, T.1
Vollmer, D.2
Trbusek, M.3
Smardova, J.4
Benner, A.5
Soussi, T.6
-
26
-
-
0025879530
-
Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies
-
Bartek J, Bartkova J, Vojtesek B, Staskova Z, Lukas J, Rejthar A et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991; 6: 1699-1703.
-
(1991)
Oncogene
, vol.6
, pp. 1699-1703
-
-
Bartek, J.1
Bartkova, J.2
Vojtesek, B.3
Staskova, Z.4
Lukas, J.5
Rejthar, A.6
-
27
-
-
0020339943
-
Radioimmunoassay of the cellular protein p53 in mouse and human cell lines
-
Benchimol S, Pim D, Crawford L. Radioimmunoassay of the cellular protein p53 in mouse and human cell lines. EMBO J 1982; 1: 1055-1062.
-
(1982)
EMBO J
, vol.1
, pp. 1055-1062
-
-
Benchimol, S.1
Pim, D.2
Crawford, L.3
-
28
-
-
44149121239
-
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
-
Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA et al. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev 2008; 22: 1337-1344.
-
(2008)
Genes Dev
, vol.22
, pp. 1337-1344
-
-
Terzian, T.1
Suh, Y.A.2
Iwakuma, T.3
Post, S.M.4
Neumann, M.5
Lang, G.A.6
-
29
-
-
84890200628
-
The role of ubiquitin modification in the regulation of p53
-
Hock AK, Vousden KH. The role of ubiquitin modification in the regulation of p53. Biochim Biophys Acta 2014; 1843: 137-149.
-
(2014)
Biochim Biophys Acta
, vol.1843
, pp. 137-149
-
-
Hock, A.K.1
Vousden, K.H.2
-
30
-
-
84906084536
-
Limiting the power of p53 through the ubiquitin proteasome pathway
-
Pant V, Lozano G. Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev 2014; 28: 1739-1751.
-
(2014)
Genes Dev
, vol.28
, pp. 1739-1751
-
-
Pant, V.1
Lozano, G.2
-
31
-
-
79956017927
-
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells
-
Li D, Marchenko ND, Schulz R, Fischer V, Velasco-Hernandez T, Talos F et al. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res 2011; 9: 577-588.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 577-588
-
-
Li, D.1
Marchenko, N.D.2
Schulz, R.3
Fischer, V.4
Velasco-Hernandez, T.5
Talos, F.6
-
32
-
-
0025248598
-
Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
-
Gannon JV, Greaves R, Iggo R, Lane DP. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J 1990; 9: 1595-1602.
-
(1990)
EMBO J
, vol.9
, pp. 1595-1602
-
-
Gannon, J.V.1
Greaves, R.2
Iggo, R.3
Lane, D.P.4
-
33
-
-
0025618980
-
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: A comparison of the 'hot spot' mutant phenotypes
-
Hinds PW, Finlay CA, Quartin RS, Baker SJ, Fearon ER, Vogelstein B et al. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the 'hot spot' mutant phenotypes. Cell Growth Differ 1990; 1: 571-580.
-
(1990)
Cell Growth Differ
, vol.1
, pp. 571-580
-
-
Hinds, P.W.1
Finlay, C.A.2
Quartin, R.S.3
Baker, S.J.4
Fearon, E.R.5
Vogelstein, B.6
-
34
-
-
0027994037
-
Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation
-
Ory K, Legros Y, Auguin C, Soussi T. Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J 1994; 13: 3496-3504.
-
(1994)
EMBO J
, vol.13
, pp. 3496-3504
-
-
Ory, K.1
Legros, Y.2
Auguin, C.3
Soussi, T.4
-
35
-
-
0025858155
-
A conformation hypothesis for the suppressor and promoter functions of p53 in cell growth control and in cancer
-
Milner J. A conformation hypothesis for the suppressor and promoter functions of p53 in cell growth control and in cancer. Proc Biol Sci 1991; 245: 139-145.
-
(1991)
Proc Biol Sci
, vol.245
, pp. 139-145
-
-
Milner, J.1
-
36
-
-
0033587701
-
Hot-spot mutants of p53 core domain evince characteristic local structural changes
-
Wong KB, DeDecker BS, Freund SM, Proctor MR, Bycroft M, Fersht AR. Hot-spot mutants of p53 core domain evince characteristic local structural changes. Proc Natl Acad Sci USA 1999; 96: 8438-8442.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8438-8442
-
-
Wong, K.B.1
Dedecker, B.S.2
Freund, S.M.3
Proctor, M.R.4
Bycroft, M.5
Fersht, A.R.6
-
37
-
-
0031447171
-
Thermodynamic stability of wild-type and mutant p53 core domain
-
Bullock AN, Henckel J, DeDecker BS, Johnson CM, Nikolova PV, Proctor MR et al. Thermodynamic stability of wild-type and mutant p53 core domain. Proc Natl Acad Sci USA 1997; 94: 14338-14342.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14338-14342
-
-
Bullock, A.N.1
Henckel, J.2
Dedecker, B.S.3
Johnson, C.M.4
Nikolova, P.V.5
Proctor, M.R.6
-
38
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
-
Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 1994; 265: 346-355.
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
39
-
-
0025085667
-
Different tumor-derived p53 mutants exhibit distinct biological activities
-
Halevy O, Michalovitz D, Oren M. Different tumor-derived p53 mutants exhibit distinct biological activities. Science 1990; 250: 113-116.
-
(1990)
Science
, vol.250
, pp. 113-116
-
-
Halevy, O.1
Michalovitz, D.2
Oren, M.3
-
40
-
-
27144509290
-
The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library
-
Kawaguchi T, Kato S, Otsuka K, Watanabe G, Kumabe T, Tominaga T et al. The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library. Oncogene 2005; 24: 6976-6981.
-
(2005)
Oncogene
, vol.24
, pp. 6976-6981
-
-
Kawaguchi, T.1
Kato, S.2
Otsuka, K.3
Watanabe, G.4
Kumabe, T.5
Tominaga, T.6
-
41
-
-
16844362817
-
Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s
-
Kakudo Y, Shibata H, Otsuka K, Kato S, Ishioka C. Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s. Cancer Res 2005; 65: 2108-2114.
-
(2005)
Cancer Res
, vol.65
, pp. 2108-2114
-
-
Kakudo, Y.1
Shibata, H.2
Otsuka, K.3
Kato, S.4
Ishioka, C.5
-
42
-
-
9144273328
-
Isolation of temperaturesensitive p53 mutations from a comprehensive missense mutation library
-
Shiraishi K, Kato S, Han SY, Liu W, Otsuka K, Sakayori et al. Isolation of temperaturesensitive p53 mutations from a comprehensive missense mutation library. J Biol Chem 2004; 279: 348-355.
-
(2004)
J Biol Chem
, vol.279
, pp. 348-355
-
-
Shiraishi, K.1
Kato, S.2
Han, S.Y.3
Liu, W.4
Otsuka, K.5
Sakayori6
-
43
-
-
0037816165
-
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
-
Kato S, Han SY, Liu W, Otsuka K, Shibata H, Kanamaru R et al. Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci USA 2003; 100: 8424-8429.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8424-8429
-
-
Kato, S.1
Han, S.Y.2
Liu, W.3
Otsuka, K.4
Shibata, H.5
Kanamaru, R.6
-
46
-
-
46049118428
-
Oncogenomic approaches in exploring gain of function of mutant p53
-
Donzelli S, Biagioni F, Fausti F, Strano S, Fontemaggi G, Blandino G. Oncogenomic approaches in exploring gain of function of mutant p53. Curr Genomics 2008; 9: 200-207.
-
(2008)
Curr Genomics
, vol.9
, pp. 200-207
-
-
Donzelli, S.1
Biagioni, F.2
Fausti, F.3
Strano, S.4
Fontemaggi, G.5
Blandino, G.6
-
47
-
-
84899622427
-
Unravelling mechanisms of p53-mediated tumour suppression
-
Bieging KT, Mello SS, Attardi LD. Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer 2014; 14: 359-370.
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 359-370
-
-
Bieging, K.T.1
Mello, S.S.2
Attardi, L.D.3
-
48
-
-
0027210981
-
Gain of function mutations in p53
-
Dittmer D, Pati S, Zambetti G, Chu S, Teresky AK, Moore et al. Gain of function mutations in p53. Nat Genet 1993; 4: 42-46.
-
(1993)
Nat Genet
, vol.4
, pp. 42-46
-
-
Dittmer, D.1
Pati, S.2
Zambetti, G.3
Chu, S.4
Teresky, A.K.5
Moore6
-
49
-
-
84884997982
-
Emerging landscape of oncogenic signatures across human cancers
-
Ciriello G, Miller ML, Aksoy BA, Senbabaoglu Y, Schultz N, Sander C. Emerging landscape of oncogenic signatures across human cancers. Nat Genet 2013; 45: 1127-1133.
-
(2013)
Nat Genet
, vol.45
, pp. 1127-1133
-
-
Ciriello, G.1
Miller, M.L.2
Aksoy, B.A.3
Senbabaoglu, Y.4
Schultz, N.5
Sander, C.6
-
50
-
-
77649298024
-
Modulation of the vitamin D3 response by cancer-associated mutant p53
-
Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z et al. Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell 2010; 17: 273-285.
-
(2010)
Cancer Cell
, vol.17
, pp. 273-285
-
-
Stambolsky, P.1
Tabach, Y.2
Fontemaggi, G.3
Weisz, L.4
Maor-Aloni, R.5
Siegfried, Z.6
-
51
-
-
79956139237
-
ChIP-on-Chip analysis of in vivo mutant p53 binding to selected gene promoters
-
Dell'orso S, Fontemaggi G, Stambolsky P, Goeman F, Voellenkle C, Levrero et al. ChIP-on-Chip analysis of in vivo mutant p53 binding to selected gene promoters. OMICS 2011; 15: 305-312.
-
(2011)
OMICS
, vol.15
, pp. 305-312
-
-
Dell'Orso, S.1
Fontemaggi, G.2
Stambolsky, P.3
Goeman, F.4
Voellenkle, C.5
Levrero6
-
52
-
-
84880298880
-
Mutant p53 gain-offunction induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
-
Dong P, Karaayvaz M, Jia N, Kaneuchi M, Hamada J, Watari H et al. Mutant p53 gain-offunction induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis. Oncogene 2013; 32: 3286-3295.
-
(2013)
Oncogene
, vol.32
, pp. 3286-3295
-
-
Dong, P.1
Karaayvaz, M.2
Jia, N.3
Kaneuchi, M.4
Hamada, J.5
Watari, H.6
-
53
-
-
84922391998
-
Transcriptional regulation by mutant p53 and oncogenesis
-
Santoro R, Strano S, Blandino G. Transcriptional regulation by mutant p53 and oncogenesis. Subcell Biochem 2014; 85: 91-103.
-
(2014)
Subcell Biochem
, vol.85
, pp. 91-103
-
-
Santoro, R.1
Strano, S.2
Blandino, G.3
-
54
-
-
84903627732
-
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation
-
Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D et al. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell 2014; 54: 960-974.
-
(2014)
Mol Cell
, vol.54
, pp. 960-974
-
-
Zhou, G.1
Wang, J.2
Zhao, M.3
Xie, T.X.4
Tanaka, N.5
Sano, D.6
-
55
-
-
84890695935
-
Tumour-associated mutant p53 drives the Warburg effect
-
Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X et al. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun 2013; 4: 2935.
-
(2013)
Nat Commun
, vol.4
, pp. 2935
-
-
Zhang, C.1
Liu, J.2
Liang, Y.3
Wu, R.4
Zhao, Y.5
Hong, X.6
-
56
-
-
0032161624
-
P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominantnegative activities
-
Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominantnegative activities. Mol Cell 1998; 2: 305-316.
-
(1998)
Mol Cell
, vol.2
, pp. 305-316
-
-
Yang, A.1
Kaghad, M.2
Wang, Y.3
Gillett, E.4
Fleming, M.D.5
Dotsch, V.6
-
57
-
-
0030812331
-
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
-
Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997; 90: 809-819.
-
(1997)
Cell
, vol.90
, pp. 809-819
-
-
Kaghad, M.1
Bonnet, H.2
Yang, A.3
Creancier, L.4
Biscan, J.C.5
Valent, A.6
-
58
-
-
0032951530
-
P73 function is inhibited by tumor-derived p53 mutants in mammalian cells
-
Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol 1999; 19: 1438-1449.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1438-1449
-
-
Di Como, C.J.1
Gaiddon, C.2
Prives, C.3
-
59
-
-
10744230945
-
P53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
-
Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003; 3: 387-402.
-
(2003)
Cancer Cell
, vol.3
, pp. 387-402
-
-
Bergamaschi, D.1
Gasco, M.2
Hiller, L.3
Sullivan, A.4
Syed, N.5
Trigiante, G.6
-
60
-
-
0035131701
-
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
-
Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001; 21: 1874-1887.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1874-1887
-
-
Gaiddon, C.1
Lokshin, M.2
Ahn, J.3
Zhang, T.4
Prives, C.5
-
61
-
-
34047223196
-
Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?
-
Li Y, Prives C. Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function? Oncogene 2007; 26: 2220-2225.
-
(2007)
Oncogene
, vol.26
, pp. 2220-2225
-
-
Li, Y.1
Prives, C.2
-
62
-
-
84861973567
-
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
-
Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 2012; 149: 1269-1283.
-
(2012)
Cell
, vol.149
, pp. 1269-1283
-
-
Li, T.1
Kon, N.2
Jiang, L.3
Tan, M.4
Ludwig, T.5
Zhao, Y.6
-
63
-
-
79955795151
-
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
-
Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM et al. Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 2011; 145: 571-583.
-
(2011)
Cell
, vol.145
, pp. 571-583
-
-
Brady, C.A.1
Jiang, D.2
Mello, S.S.3
Johnson, T.M.4
Jarvis, L.A.5
Kozak, M.M.6
-
64
-
-
84878546043
-
P53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa
-
Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL et al. p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep 2013; 3: 1339-1345.
-
(2013)
Cell Rep
, vol.3
, pp. 1339-1345
-
-
Valente, L.J.1
Gray, D.H.2
Michalak, E.M.3
Pinon-Hofbauer, J.4
Egle, A.5
Scott, C.L.6
-
65
-
-
84861987695
-
Tumor suppression by p53: Fall of the triumvirate?
-
Hock AK, Vousden KH. Tumor suppression by p53: fall of the triumvirate? Cell 2012; 149: 1183-1185.
-
(2012)
Cell
, vol.149
, pp. 1183-1185
-
-
Hock, A.K.1
Vousden, K.H.2
-
66
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CAJ, Butel JS et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356: 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery, C.A.J.5
Butel, J.S.6
-
67
-
-
70350567735
-
20 years studying p53 functions in genetically engineered mice
-
Donehower LA, Lozano G. 20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer 2009; 9: 831-841.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 831-841
-
-
Donehower, L.A.1
Lozano, G.2
-
68
-
-
77955354374
-
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
-
Kenzelmann Broz D, Attardi LD. In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis 2010; 31: 1311-1318.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1311-1318
-
-
Kenzelmann Broz, D.1
Attardi, L.D.2
-
69
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 2004; 119: 861-872.
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.A.3
Liu, G.4
Rao, V.A.5
Parant, J.M.6
-
70
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004; 119: 847-860.
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
Yin, B.4
Willis, N.A.5
Bronson, R.T.6
-
71
-
-
0029742781
-
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
-
Ludwig RL, Bates S, Vousden KH. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol 1996; 16: 4952-4960.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4952-4960
-
-
Ludwig, R.L.1
Bates, S.2
Vousden, K.H.3
-
72
-
-
0346455759
-
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
-
Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK et al. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 2004; 36: 63-68.
-
(2004)
Nat Genet
, vol.36
, pp. 63-68
-
-
Liu, G.1
Parant, J.M.2
Lang, G.3
Chau, P.4
Chavez-Reyes, A.5
El-Naggar, A.K.6
-
73
-
-
84895779578
-
Drugging the p53 pathway: Understanding the route to clinical efficacy
-
Khoo KH, Verma CS, Lane DP. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov 2014; 13: 217-236.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 217-236
-
-
Khoo, K.H.1
Verma, C.S.2
Lane, D.P.3
-
74
-
-
84905124070
-
Mutant p53 reactivation by small molecules makes its way to the clinic
-
Bykov VJ, Wiman KG. Mutant p53 reactivation by small molecules makes its way to the clinic. FEBS Lett 2014; 588: 2622-2627.
-
(2014)
FEBS Lett
, vol.588
, pp. 2622-2627
-
-
Bykov, V.J.1
Wiman, K.G.2
-
75
-
-
84865281347
-
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
-
Wilcken R, Wang G, Boeckler FM, Fersht AR. Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition. Proc Natl Acad Sci USA 2012; 109: 13584-13589.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 13584-13589
-
-
Wilcken, R.1
Wang, G.2
Boeckler, F.M.3
Fersht, A.R.4
-
76
-
-
48749103325
-
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
-
Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci USA 2008; 105: 10360-10365.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10360-10365
-
-
Boeckler, F.M.1
Joerger, A.C.2
Jaggi, G.3
Rutherford, T.J.4
Veprintsev, D.B.5
Fersht, A.R.6
-
77
-
-
84880234835
-
Small molecule induced reactivation of mutant p53 in cancer cells
-
Liu X, Wilcken R, Joerger AC, Chuckowree IS, Amin J, Spencer J et al. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res 2013; 41: 6034-6044.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 6034-6044
-
-
Liu, X.1
Wilcken, R.2
Joerger, A.C.3
Chuckowree, I.S.4
Amin, J.5
Spencer, J.6
-
79
-
-
84910072506
-
Small molecule restoration of wildtype structure and function of mutant p53 using a novel zincmetallochaperone based mechanism
-
Yu X, Blanden AR, Narayanan S, Jayakumar L, Lubin D, Augeri D et al. Small molecule restoration of wildtype structure and function of mutant p53 using a novel zincmetallochaperone based mechanism. Oncotarget 2014; 5: 8879-8892.
-
(2014)
Oncotarget
, vol.5
, pp. 8879-8892
-
-
Yu, X.1
Blanden, A.R.2
Narayanan, S.3
Jayakumar, L.4
Lubin, D.5
Augeri, D.6
-
80
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 2002; 8: 282-288.
-
(2002)
Nat Med
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
Issaeva, N.2
Shilov, A.3
Hultcrantz, M.4
Pugacheva, E.5
Chumakov, P.6
-
81
-
-
24044466754
-
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs
-
Bykov VJ, Issaeva N, Zache N, Shilov A, Hultcrantz M, Bergman J et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J Biol Chem 2005; 280: 30384-30391.
-
(2005)
J Biol Chem
, vol.280
, pp. 30384-30391
-
-
Bykov, V.J.1
Issaeva, N.2
Zache, N.3
Shilov, A.4
Hultcrantz, M.5
Bergman, J.6
-
82
-
-
19444387176
-
PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis
-
Bykov VJ, Zache N, Stridh H, Westman J, Bergman J, Selivanova G et al. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 2005; 24: 3484-3491.
-
(2005)
Oncogene
, vol.24
, pp. 3484-3491
-
-
Bykov, V.J.1
Zache, N.2
Stridh, H.3
Westman, J.4
Bergman, J.5
Selivanova, G.6
-
83
-
-
77949267055
-
Mutant p53 reactivation by PRIMA-1(MET) induces multiple signaling pathways converging on apoptosis
-
Lambert JM, Moshfegh A, Hainaut P, Wiman KG, Bykov VJ. Mutant p53 reactivation by PRIMA-1(MET) induces multiple signaling pathways converging on apoptosis. Oncogene 2009; 29: 1329-1338.
-
(2009)
Oncogene
, vol.29
, pp. 1329-1338
-
-
Lambert, J.M.1
Moshfegh, A.2
Hainaut, P.3
Wiman, K.G.4
Bykov, V.J.5
-
84
-
-
84879147794
-
Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53
-
Wassman CD, Baronio R, Demir O, Wallentine BD, Chen CK, Hall LV et al. Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53. Nat Commun 2013; 4: 1407.
-
(2013)
Nat Commun
, vol.4
, pp. 1407
-
-
Wassman, C.D.1
Baronio, R.2
Demir, O.3
Wallentine, B.D.4
Chen, C.K.5
Hall, L.V.6
-
85
-
-
84867615093
-
Targeting p53 in vivo: A first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
-
Lehmann S, Bykov VJ, Ali D, Andren O, Cherif H, Tidefelt U et al. Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. J Clin Oncol 2012; 30: 3633-3639.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3633-3639
-
-
Lehmann, S.1
Bykov, V.J.2
Ali, D.3
Andren, O.4
Cherif, H.5
Tidefelt, U.6
-
86
-
-
84887417425
-
APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
-
Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ et al. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis 2013; 4: e881.
-
(2013)
Cell Death Dis
, vol.4
, pp. e881
-
-
Peng, X.1
Zhang, M.Q.2
Conserva, F.3
Hosny, G.4
Selivanova, G.5
Bykov, V.J.6
-
87
-
-
84907007279
-
PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance
-
Tessoulin B, Descamps G, Moreau P, Maiga S, Lode L, Godon C et al. PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance. Blood 2014; 124: 1626-1636.
-
(2014)
Blood
, vol.124
, pp. 1626-1636
-
-
Tessoulin, B.1
Descamps, G.2
Moreau, P.3
Maiga, S.4
Lode, L.5
Godon, C.6
-
88
-
-
44049091429
-
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
-
Kravchenko JE, Ilyinskaya GV, Komarov PG, Agapova LS, Kochetkov DV, Strom E et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci USA 2008; 105: 6302-6307.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6302-6307
-
-
Kravchenko, J.E.1
Ilyinskaya, G.V.2
Komarov, P.G.3
Agapova, L.S.4
Kochetkov, D.V.5
Strom, E.6
-
89
-
-
79955588050
-
Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides
-
Floquet C, Deforges J, Rousset JP, Bidou L. Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides. Nucleic Acids Res 2011; 39: 3350-3362.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3350-3362
-
-
Floquet, C.1
Deforges, J.2
Rousset, J.P.3
Bidou, L.4
-
90
-
-
0000822580
-
Further studies on the nature and causes of gene mutations
-
Muller HJ. Further studies on the nature and causes of gene mutations. Int Congr Genet 1932; 6: 231-255.
-
(1932)
Int Congr Genet
, vol.6
, pp. 231-255
-
-
Muller, H.J.1
-
91
-
-
20144370942
-
A survey of homozygous deletions in human cancer genomes
-
Cox C, Bignell G, Greenman C, Stabenau A, Warren W, Stephens P et al. A survey of homozygous deletions in human cancer genomes. Proc Natl Acad Sci USA 2005; 102: 4542-4547.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4542-4547
-
-
Cox, C.1
Bignell, G.2
Greenman, C.3
Stabenau, A.4
Warren, W.5
Stephens, P.6
-
92
-
-
0034724186
-
APC mutations in sporadic colorectal tumors: A mutational 'hotspot' and interdependence of the 'two hits'
-
Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A et al. APC mutations in sporadic colorectal tumors: A mutational 'hotspot' and interdependence of the 'two hits'. Proc Natl Acad Sci USA 2000; 97: 3352-3357.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3352-3357
-
-
Rowan, A.J.1
Lamlum, H.2
Ilyas, M.3
Wheeler, J.4
Straub, J.5
Papadopoulou, A.6
-
93
-
-
0023239517
-
Functional inactivation of genes by dominant negative mutations
-
Herskowitz I. Functional inactivation of genes by dominant negative mutations. Nature 1987; 329: 219-222.
-
(1987)
Nature
, vol.329
, pp. 219-222
-
-
Herskowitz, I.1
-
94
-
-
70149100002
-
Ultraslow oligomerization equilibria of p53 and its implications
-
Natan E, Hirschberg D, Morgner N, Robinson CV, Fersht AR. Ultraslow oligomerization equilibria of p53 and its implications. Proc Natl Acad Sci USA 2009; 106: 14327-14332.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14327-14332
-
-
Natan, E.1
Hirschberg, D.2
Morgner, N.3
Robinson, C.V.4
Fersht, A.R.5
-
95
-
-
79952234403
-
Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
-
Wang Y, Suh YA, Fuller MY, Jackson JG, Xiong S, Terzian T et al. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest 2011; 121: 893-904.
-
(2011)
J Clin Invest
, vol.121
, pp. 893-904
-
-
Wang, Y.1
Suh, Y.A.2
Fuller, M.Y.3
Jackson, J.G.4
Xiong, S.5
Terzian, T.6
-
96
-
-
84863720872
-
A tumour suppressor network relying on the polyamine-hypusine axis
-
Scuoppo C, Miething C, Lindqvist L, Reyes J, Ruse C, Appelmann I et al. A tumour suppressor network relying on the polyamine-hypusine axis. Nature 2012; 487: 244-248.
-
(2012)
Nature
, vol.487
, pp. 244-248
-
-
Scuoppo, C.1
Miething, C.2
Lindqvist, L.3
Reyes, J.4
Ruse, C.5
Appelmann, I.6
-
97
-
-
34248369435
-
Rare cancer-specific mutations in PIK3CA show gain of function
-
Gymnopoulos M, Elsliger MA, Vogt PK. Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 2007; 104: 5569-5574.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5569-5574
-
-
Gymnopoulos, M.1
Elsliger, M.A.2
Vogt, P.K.3
-
98
-
-
84871533576
-
Diverging gain-offunction mechanisms of two novel KRAS mutations associated with Noonan and cardiofacio-cutaneous syndromes
-
Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker et al. Diverging gain-offunction mechanisms of two novel KRAS mutations associated with Noonan and cardiofacio-cutaneous syndromes. Hum Mol Genet 2013; 22: 262-270.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 262-270
-
-
Cirstea, I.C.1
Gremer, L.2
Dvorsky, R.3
Zhang, S.C.4
Piekorz, R.P.5
Zenker6
-
99
-
-
77953702324
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2010; 465: 966.
-
(2010)
Nature
, vol.465
, pp. 966
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
100
-
-
84896098750
-
Mutant p53 in cancer: New functions and therapeutic opportunities
-
Muller PA, Vousden KH. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell 2014; 25: 304-317.
-
(2014)
Cancer Cell
, vol.25
, pp. 304-317
-
-
Muller, P.A.1
Vousden, K.H.2
|