메뉴 건너뛰기




Volumn 39, Issue 8, 2011, Pages 3350-3362

Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; MESSENGER RNA; PROTEIN BAX; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA;

EID: 79955588050     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq1277     Document Type: Article
Times cited : (113)

References (58)
  • 1
    • 0022423513 scopus 로고
    • Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin
    • Burke, J.F. and Mogg, A.E. (1985) Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Nucleic Acids Res., 13, 6265-6272.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 6265-6272
    • Burke, J.F.1    Mogg, A.E.2
  • 4
    • 54849413018 scopus 로고    scopus 로고
    • Introducing sense into nonsense in treatments of human genetic diseases
    • Linde, L. and Kerem, B. (2008) Introducing sense into nonsense in treatments of human genetic diseases. Trends Genet., 24, 552-563.
    • (2008) Trends Genet. , vol.24 , pp. 552-563
    • Linde, L.1    Kerem, B.2
  • 5
    • 33845996905 scopus 로고    scopus 로고
    • Aminoglycoside-induced translational read-through in disease: Overcoming nonsense mutations by pharmacogenetic therapy
    • DOI 10.1038/sj.clpt.6100012, PII 6100012
    • Zingman, L.V., Park, S., Olson, T.M., Alekseev, A.E. and Terzic A. (2007) Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy. Clin. Pharmacol. Ther., 81, 99-103. (Pubitemid 46050873)
    • (2007) Clinical Pharmacology and Therapeutics , vol.81 , Issue.1 , pp. 99-103
    • Zingman, L.V.1    Park, S.2    Olson, T.M.3    Alekseev, A.E.4    Terzic, A.5
  • 9
    • 0043092426 scopus 로고    scopus 로고
    • Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results
    • Politano, L., Nigro, G, Nigro, V., Piluso, G, Papparella, S., Paciello, O. and Comi, L.I. (2003) Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results. Acta Myol., 22, 15-21. (Pubitemid 36966404)
    • (2003) Acta Myologica , vol.22 , Issue.MAY , pp. 15-21
    • Politano, L.1    Nigro, G.2    Nigro, V.3    Pilus, G.4    Papparella, S.5    Paciello, O.6    Comi, L.I.7
  • 12
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A J. and Kastan, M.B. (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev., 12, 2973-2983. (Pubitemid 28469299)
    • (1998) Genes and Development , vol.12 , Issue.19 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 13
    • 0028034199 scopus 로고
    • Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability ofp53 to induce p21waf1/cip1
    • Wagner, A.J., Kokontis, J.M. and Hay, N. (1994) Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability ofp53 to induce p21waf1/cip1. Genes Dev., 8, 2817-2830.
    • (1994) Genes Dev. , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 15
    • 0345256634 scopus 로고    scopus 로고
    • The role ofp53 in chemosensitivity and radiosensitivity
    • El-Deiry, W.S. (2003) The role ofp53 in chemosensitivity and radiosensitivity. Oncogene, 22, 7486-7495.
    • (2003) Oncogene , vol.22 , pp. 7486-7495
    • El-Deiry, W.S.1
  • 16
    • 0027451668 scopus 로고
    • p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents
    • DOI 10.1016/0092-8674(93)90719-7
    • Lowe, S.W., Ruley, H.E., Jacks, T. and Housman, D.E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967. (Pubitemid 23289454)
    • (1993) Cell , vol.74 , Issue.6 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 17
    • 0026642375 scopus 로고
    • Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
    • Takahashi, T., Carbone, D., Nau, M.M., Hida, T., Linnoila, I., Ueda, R. and Minna, J.D. (1992) Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res., 52, 2340-2343.
    • (1992) Cancer Res. , vol.52 , pp. 2340-2343
    • Takahashi, T.1    Carbone, D.2    Nau, M.M.3    Hida, T.4    Linnoila, I.5    Ueda, R.6    Minna, J.D.7
  • 18
    • 0026054909 scopus 로고
    • Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene
    • Casey, G, Lo-Hsueh, M., Lopez, M.E., Vogelstein, B. and Stanbridge, E.J. (1991) Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene. Oncogene, 6, 1791-1797. (Pubitemid 21924011)
    • (1991) Oncogene , vol.6 , Issue.10 , pp. 1791-1797
    • Casey, G.1    Lo-Hsueh, M.2    Lopez, M.E.3    Vogelstein, B.4    Stanbridge, E.J.5
  • 19
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen, X., Ko, L.J., Jayaraman, L. and Prives, C. (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev., 10, 2438-2451. (Pubitemid 26341879)
    • (1996) Genes and Development , vol.10 , Issue.19 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 20
    • 30044439886 scopus 로고    scopus 로고
    • Adenovirus p53 gene therapy
    • DOI 10.1517/14712598.6.1.55
    • Roth, JA. (2006) Adenovirus p53 gene therapy. Expert. Opin. Biol. Ther., 6, 55-61. (Pubitemid 43049346)
    • (2006) Expert Opinion on Biological Therapy , vol.6 , Issue.1 , pp. 55-61
    • Roth, J.A.1
  • 21
    • 24944454988 scopus 로고    scopus 로고
    • Current status of gendicine in China: Recombinant human Ad-p53 agent for treatment of cancers
    • DOI 10.1089/hum.2005.16.1016
    • Peng, Z. (2005) Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers. Hum. Gene Ther., 16, 1016-1027. (Pubitemid 41324561)
    • (2005) Human Gene Therapy , vol.16 , Issue.9 , pp. 1016-1027
    • Peng, Z.1
  • 22
    • 77952543382 scopus 로고    scopus 로고
    • Therapeutic targeting ofp53 by small molecules
    • Selivanova, G (2010) Therapeutic targeting ofp53 by small molecules. Semin. Cancer Biol., 20, 46-56.
    • (2010) Semin. Cancer Biol. , vol.20 , pp. 46-56
    • Selivanova, G.1
  • 23
    • 77953406697 scopus 로고    scopus 로고
    • Targeting p53 for novel anticancer therapy
    • Wang, Z. and Sun, Y. (2010) Targeting p53 for novel anticancer therapy. Transl. Oncol., 3, 1-12.
    • (2010) Transl. Oncol. , vol.3 , pp. 1-12
    • Wang, Z.1    Sun, Y.2
  • 25
    • 36849084779 scopus 로고    scopus 로고
    • CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    • DOI 10.1172/JCI32481
    • Tang, X., Zhu, Y., Han, L., Kim, A.L., Kopelovich, L., Bickers, D.R. and Athar, M. (2007) CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J. Clin. Invest., 117, 3753-3764. (Pubitemid 350224086)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.12 , pp. 3753-3764
    • Tang, X.1    Zhu, Y.2    Han, L.3    Kim, A.L.4    Kopelovich, L.5    Bickers, D.R.6    Athar, M.7
  • 26
    • 49049096115 scopus 로고    scopus 로고
    • PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells
    • Magrini, R., Russo, D., Ottaggio, L., Fronza, G., Inga, A. and Menichini, P. (2008) PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells. J. Cell Biochem., 104, 2363-2373.
    • (2008) J. Cell Biochem. , vol.104 , pp. 2363-2373
    • Magrini, R.1    Russo, D.2    Ottaggio, L.3    Fronza, G.4    Inga, A.5    Menichini, P.6
  • 27
    • 52449087539 scopus 로고    scopus 로고
    • PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53
    • Zache, N., Lambert, J.M., Wiman, K.G. and Bykov, V.J. (2008) PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53. Cell Oncol., 30, 411-418.
    • (2008) Cell Oncol. , vol.30 , pp. 411-418
    • Zache, N.1    Lambert, J.M.2    Wiman, K.G.3    Bykov, V.J.4
  • 28
    • 1842586020 scopus 로고    scopus 로고
    • Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment
    • DOI 10.1038/sj.gt.3302211
    • Bidou, L., Hatin, I., Perez, N., Allamand, V., Panthier, J.J. and Rousset, J.P. (2004) Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. Gene Ther., 11, 619-627. (Pubitemid 38455980)
    • (2004) Gene Therapy , vol.11 , Issue.7 , pp. 619-627
    • Bidou, L.1    Hatin, I.2    Perez, N.3    Allamand, V.4    Panthier, J.-J.5    Rousset, J.-P.6
  • 29
    • 0034237824 scopus 로고    scopus 로고
    • Establishment and characterization of a new cell line derived from a human primary breast carcinoma
    • DOI 10.1016/S0165-4608(99)00253-8, PII S0165460899002538
    • Wang, C.S., Goulet, F., Lavoie, J., Drouin, R., Auger, F., Champetier, S., Germain, L. and Tetu, B. (2000) Establishment and characterization of a new cell line derived from a human primary breast carcinoma. Cancer Genet. Cytogenet., 120, 58-72. (Pubitemid 30410778)
    • (2000) Cancer Genetics and Cytogenetics , vol.120 , Issue.1 , pp. 58-72
    • Wang, C.S.1    Goulet, F.2    Lavoie, J.3    Drouin, R.E.4    Auger, F.5    Champetier, S.6    Germain, L.7    Tetu, B.8
  • 30
    • 0033942924 scopus 로고    scopus 로고
    • Nonsense-mediated decay mutants do not affect programmed -1 frameshifting
    • DOI 10.1017/S1355838200000443
    • Bidou, L., Stahl, G, Hatin, I., Namy, O., Rousset, J.P. and Farabaugh, P.J. (2000) Nonsense-mediated decay mutants do not affect programmed-1 frameshifting. RNA, 6, 952-961. (Pubitemid 30471133)
    • (2000) RNA , vol.6 , Issue.7 , pp. 952-961
    • Bidou, L.1    Stahl, G.2    Hatin, I.3    Namy, O.4    Rousset, J.-P.5    Farabaugh, P.J.6
  • 35
    • 2142861272 scopus 로고    scopus 로고
    • Real-time polymerase chain reaction quantitation of relative expression of genes modulated by p53 using SYBR Green i
    • Stagliano, K.E., Carchman, E. and Deb, S. (2003) Real-time polymerase chain reaction quantitation of relative expression of genes modulated by p53 using SYBR Green I. Methods Mol. Biol., 234, 73-91.
    • (2003) Methods Mol. Biol. , vol.234 , pp. 73-91
    • Stagliano, K.E.1    Carchman, E.2    Deb, S.3
  • 36
    • 68649089108 scopus 로고    scopus 로고
    • Pharmaceuticals targeting nonsense mutations in genetic diseases: Progress in development
    • Rowe, S.M. and Clancy, J.P. (2009) Pharmaceuticals targeting nonsense mutations in genetic diseases: progress in development. Bio Drugs, 23, 165-174.
    • (2009) Bio Drugs , vol.23 , pp. 165-174
    • Rowe, S.M.1    Clancy, J.P.2
  • 37
    • 0035997219 scopus 로고    scopus 로고
    • Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAS in a mammalian translation system
    • DOI 10.1007/s00109-001-0317-z
    • Keeling, K.M. and Bedwell, D.M. (2002) Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system. J. Mol. Med., 80, 367-376. (Pubitemid 34775375)
    • (2002) Journal of Molecular Medicine , vol.80 , Issue.6 , pp. 367-376
    • Keeling, K.M.1    Bedwell, D.M.2
  • 38
    • 77950837290 scopus 로고    scopus 로고
    • Restoration of APC gene function in colorectal cancer cells by aminoglycoside-and macrolide-induced read-through of premature termination codons
    • Zilberberg, A., Lahav, L. and Rosin-Arbesfeld, R. (2010) Restoration of APC gene function in colorectal cancer cells by aminoglycoside-and macrolide-induced read-through of premature termination codons. Gut, 59, 496-507.
    • (2010) Gut , vol.59 , pp. 496-507
    • Zilberberg, A.1    Lahav, L.2    Rosin-Arbesfeld, R.3
  • 39
    • 0033854425 scopus 로고    scopus 로고
    • Sequence specificity of aminoglycoside-induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy
    • DOI 10.1002/1531-8249(200008)48:2<164::AID-ANA5>3.0.CO;2-B
    • Howard, M.T., Shirts, B.H., Petros, L.M., Flanigan, K.M., Gesteland, R.F. and Atkins, J.F. (2000) Sequence specificity of aminoglycoside-induced stop condon readthrough: potential implications for treatment of Duchenne muscular dystrophy. Ann. Neurol., 48, 164-169. (Pubitemid 30617034)
    • (2000) Annals of Neurology , vol.48 , Issue.2 , pp. 164-169
    • Howard, M.T.1    Shirts, B.H.2    Petros, L.M.3    Flanigan, K.M.4    Gesteland, R.F.5    Atkins, J.F.6
  • 40
    • 0033929810 scopus 로고    scopus 로고
    • Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system
    • DOI 10.1017/S1355838200000716
    • Manuvakhova, M., Keeling, K. and Bedwell, D.M. (2000) Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system. RNA, 6, 1044-1055. (Pubitemid 30471140)
    • (2000) RNA , vol.6 , Issue.7 , pp. 1044-1055
    • Manuvakhova, M.1    Keeling, K.2    Bedwell, D.M.3
  • 41
    • 77449140016 scopus 로고    scopus 로고
    • In vitro readthrough of termination codons by gentamycin in the Stuve-Wiedemann Syndrome
    • Bellais, S., Le Goff, C., Dagoneau, N., Munnich A. and Cormier-Daire, V. (2010) In vitro readthrough of termination codons by gentamycin in the Stuve-Wiedemann Syndrome. Eur. J. Hum. Genet., 18, 130-132.
    • (2010) Eur. J. Hum. Genet. , vol.18 , pp. 130-132
    • Bellais, S.1    Le Goff, C.2    Dagoneau, N.3    Munnich, A.4    Cormier-Daire, V.5
  • 42
    • 77949904260 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in human cells: Mechanistic insights, functions beyond quality control and the double-life of NMD factors
    • Nicholson, P., Yepiskoposyan, H., Metze, S., Zamudio Orozco, R., Kleinschmidt, N. and Muhlemann, O. (2010) Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol. Life Sci., 67, 677-700.
    • (2010) Cell Mol. Life Sci. , vol.67 , pp. 677-700
    • Nicholson, P.1    Yepiskoposyan, H.2    Metze, S.3    Zamudio Orozco, R.4    Kleinschmidt, N.5    Muhlemann, O.6
  • 43
    • 33746224027 scopus 로고    scopus 로고
    • Applying nonsense-mediated mRNA decay research to the clinic: Progress and challenges
    • DOI 10.1016/j.molmed.2006.05.005, PII S1471491406001122
    • Kuzmiak, HA. and Maquat, L.E. (2006) Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges. Trends Mol. Med., 12, 306-316. (Pubitemid 44094291)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.7 , pp. 306-316
    • Kuzmiak, H.A.1    Maquat, L.E.2
  • 44
    • 45449118785 scopus 로고    scopus 로고
    • Recognition of nonsense mRNA: Towards a unified model
    • DOI 10.1042/BST0360497
    • Muhlemann, O. (2008) Recognition of nonsense mRNA: towards a unified model. Biochem. Soc Trans., 36, 497-501. (Pubitemid 351850181)
    • (2008) Biochemical Society Transactions , vol.36 , Issue.3 , pp. 497-501
    • Muhlemann, O.1
  • 46
    • 1642447080 scopus 로고    scopus 로고
    • Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae
    • DOI 10.1261/rna.5147804
    • Keeling, K.M., Lanier, J., Du, M., Salas-Marco, J., Gao, L., Kaenjak-Angeletti A. and Bedwell, D.M. (2004) Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae. RNA, 10, 691-703. (Pubitemid 38405947)
    • (2004) RNA , vol.10 , Issue.4 , pp. 691-703
    • Keeling, K.M.1    Lanier, J.2    Du, M.3    Salas-Marco, J.4    Gao, L.5    Kaenjak-Angeletti, A.6    Bedwell, D.M.7
  • 47
    • 0031896755 scopus 로고    scopus 로고
    • Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA
    • Moriarty, P.M., Reddy, C.C. and Maquat, L.E. (1998) Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol. Cell. Biol., 18, 2932-2939. (Pubitemid 28183462)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 2932-2939
    • Moriarty, P.M.1    Reddy, C.C.2    Maquat, L.E.3
  • 48
    • 0031870674 scopus 로고    scopus 로고
    • Cis-acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels
    • DOI 10.1017/S1355838298971990
    • Weiss, S.L. and Sunde, RA. (1998) Cis-acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels. RNA, 4, 816-827. (Pubitemid 28317829)
    • (1998) RNA , vol.4 , Issue.7 , pp. 816-827
    • Weiss, S.L.1    Sunde, R.A.2
  • 50
    • 46449091667 scopus 로고    scopus 로고
    • Aminoglycoside induced ototoxicity
    • Guthrie, O.W. (2008) Aminoglycoside induced ototoxicity. Toxicology, 249, 91-96.
    • (2008) Toxicology , vol.249 , pp. 91-96
    • Guthrie, O.W.1
  • 52
    • 14844364384 scopus 로고    scopus 로고
    • 1 cells against reduction in SGLT1 activity induced by gentamicin C
    • DOI 10.1016/j.bbagen.2004.12.006
    • Takamoto, K., Kawada, M., Ikeda, D. and Yoshida, M. (2005) Apolipoprotein E3 (apoE3) safeguards pig proximal tubular LLC-PK1 cells against reduction in SGLT1 activity induced by gentamicin C Biochim. Biophys. Acta, 1722, 247-253. (Pubitemid 40354163)
    • (2005) Biochimica et Biophysica Acta - General Subjects , vol.1722 , Issue.3 , pp. 247-253
    • Takamoto, K.1    Kawada, M.2    Ikeda, D.3    Yoshida, M.4
  • 53
    • 65449188724 scopus 로고    scopus 로고
    • Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model
    • Du, M., Keeling, K.M., Fan, L., Liu, X. and Bedwell, D.M. (2009) Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model. J. Biol. Chem., 284, 6885-6892.
    • (2009) J. Biol. Chem. , vol.284 , pp. 6885-6892
    • Du, M.1    Keeling, K.M.2    Fan, L.3    Liu, X.4    Bedwell, D.M.5
  • 54
    • 77953133544 scopus 로고    scopus 로고
    • Repairing faulty genes by aminoglycosides: Development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations
    • Nudelman, I., Glikin, D., Smolkin, B., Hainrichson, M., Belakhov, V. and Baasov, T. (2010) Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations. Bioorg. Med. Chem., 18, 3735-3746.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 3735-3746
    • Nudelman, I.1    Glikin, D.2    Smolkin, B.3    Hainrichson, M.4    Belakhov, V.5    Baasov, T.6
  • 57
    • 33751064254 scopus 로고    scopus 로고
    • Drug evaluation: PTC-124 - A potential treatment for cystic fibrosis and Duchenne muscular dystrophy
    • Hamed, SA. (2006) Drug evaluation: PTC-124-a potential treatment of cystic fibrosis and Duchenne muscular dystrophy. IDrugs, 9, 783-789. (Pubitemid 44756118)
    • (2006) IDrugs , vol.9 , Issue.11 , pp. 783-789
    • Hamed, S.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.