Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 309, Issue 1, 2015, Pages H70-H81

  Soliman, Hesham ^a,b   Nyamandi, Vongai ^a   Garcia Patino, Marysol ^a   Varela, Julia Nogueira ^a   Bankar, Girish ^a   Lin, Guorong ^a   Jia, Zhengping ^c   MacLeod, Kathleen M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MINIA UNIVERSITY   (Egypt)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Heart; Insulin receptor substrate phosphorylation; Insulin signaling; ROCK2

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE; PROTEIN KINASE B; PROTEIN ROCK1; PROTEIN ROCK2; RHO KINASE; SERINE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; ROCK1 PROTEIN, MOUSE; ROCK2 PROTEIN, MOUSE; SLC2A4 PROTEIN, MOUSE; TBC1D4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLE; ENZYME ACTIVITY; HEART FAILURE; HEART LEFT VENTRICLE WALL MOTION; HEART PERFORMANCE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPECKLE TRACKING ECHOCARDIOGRAPHY; SYSTOLE; ANIMAL; ECHOCARDIOGRAPHY; GENE DELETION; GENETICS; HEART CONTRACTION; METABOLISM; PHOSPHORYLATION;

ANIMALS; DIET, HIGH-FAT; ECHOCARDIOGRAPHY; GENE DELETION; GLUCOSE TRANSPORTER TYPE 4; GTPASE-ACTIVATING PROTEINS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; MYOCARDIAL CONTRACTION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RHO-ASSOCIATED KINASES;

EID: 84935513575     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00664.2014     Document Type: Article

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