Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion

Acta Pharmacologica Sinica

Volumn 27, Issue 7, 2006, Pages 919-926

  Yu, Jie ^a   Zhang, Hai Feng ^a   Wu, Feng ^a   Li, Qiu Xia ^a   Ma, Heng ^a   Guo, Wen Yi ^a   Wang, Hai Chang ^a   Gao, Feng ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Akt; Calcium transients; Cardiomyocyte; Contraction; Insulin; Ischemia reperfusion; SERCA2a

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); DRUG VEHICLE; INSULIN; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN SERCA2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOXIA; ARTICLE; CALCIUM CELL LEVEL; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; FLUORESCENCE ANALYSIS; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE; MALE; MUSCLE CONTRACTILITY; MUSCLE FUNCTION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; RAT; SARCOPLASMIC RETICULUM; SOLUTION AND SOLUBILITY;

ANIMALS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELL SEPARATION; HEART VENTRICLES; INSULIN; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION;

EID: 33748543968     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00388.x     Document Type: Article

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