A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 81-89

  Zhou, Zikai ^a,b   Meng, Yanghong ^a   Asrar, Suhail ^a,b   Todorovski, Zarko ^a,b   Jia, Zhengping ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Actin filaments; Dendritic spine; Hippocampal long term potentiation; Rho GTPase; ROCK2 knockout mice

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ACTIN; ACTIN BINDING PROTEIN; AMPA RECEPTOR; COFILIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PICROTOXIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RHO KINASE 2; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DENDRITIC SPINE; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MOUSE; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; SYNAPTIC TRANSMISSION;

ACTIN DEPOLYMERIZING FACTORS; ANIMALS; ANIMALS, NEWBORN; BIOPHYSICS; CELLS, CULTURED; DENDRITIC SPINES; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE EXPRESSION REGULATION; GLYCINE; GLYCINE AGENTS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; N-METHYLASPARTATE; NEURONS; PATCH-CLAMP TECHNIQUES; PHALLOIDINE; RHO-ASSOCIATED KINASES; SYNAPSES; SYNAPSINS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 58049103751     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.07.031     Document Type: Article

References (52)

1. Asrar S., Meng Y., Zhou Z., Todorovski Z., Huang W.W., and Jia Z. Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1). Neuropharmacology 56 (2009) 73-80
2. Bamburg J.R. Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu. Rev. Cell Dev. Biol. 15 (1999) 185-230
3. Bliss T.V.P., and Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361 (1993) 31-39
4. Bredt D.S., and Nicoll R.A. AMPA receptor trafficking at excitatory synapses. Neuron 40 (2003) 361-379
5. Carlisle H.J., and Kennedy M.B. Spine architecture and synaptic plasticity. Trends Neurosci. 28 (2005) 82-87
6. Chelly J., and Mandel J. Monogenic causes of X-linked mental retardation. Nat. Rev. Genet. 2 (2001) 669-680
7. Chen L.Y., Rex C.S., Casale M.S., Gall C.M., and Lynch G. Changes in synaptic morphology accompany actin signaling during LTP.J. Neuroscience 27 (2007) 5363-5372
8. Collingridge G.L., Isaac J.T., and Wang Y.T. Receptor trafficking and synaptic plasticity. Nat. Rev. Neurosci. 5 (2004) 952-962
9. Dash P.K., Orsi S.A., Moody M., and Moore A.N. A role of hippocampal Rho-ROCK pathway in long-term spatial memory. Biochem. Biophys. Res. Commun. 322 (2004) 893-898
10. Derkach V.A., Oh M.C., Guire E.S., and Soderling T.R. Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat. Rev. Neurosci. 8 (2007) 101-113
11. Diana G., Valentini G., Travaglione S., Falzano L., Massimo P., Zona C., Meschini S., Fabbri A., and Fiorentini C. Enhancement of learning and memory after activation of cerebral Rho GTPases. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 636-641
12. Dillon C., and Goda Y. The actin cytoskeleton: integration form and function at the synapse. Annu. Rev. Neurosci. 28 (2005) 25-55
13. Fukazawa Y., Saitoh Y., Ozawa F., Ohta Y., Mizuno K., and Inokuchi K. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38 (2003) 447-460
14. Govek E.E., Newey S.E., Akerman C.J., Cross J.R., Van der Veken L., and Van Aelst L. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat. Neurosci. 7 (2004) 364-372
15. Govek E.E., Newey S.E., and Van Aelst L. The role of the RHO GTPases in neuronal development. Genes Dev. 19 (2005) 1-49
16. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
17. Hering H., and Sheng M. Dendritic spine: structure, dynamics and regulation. Nat. Rev. Neurosci. 2 (2001) 880-888
18. Jia Z.P., Agopyan N., Miu P., Xiong Z., Henderson J., Gerlai R., Taverna F., Velumian A., MacDonald J.F., Carlen P., Abranow-Newerly W., and Roder J. Enhanced LTP in mice deficient in the AMPA receptor, GluR2. Neuron 17 (1996) 945-956
19. Kim C.H., and Lisman J.E. A role of actin filaments in synaptic transmission and long-term potentiation. J. Neurosci. 19 (1999) 4314-4324
20. Krucker T., Siggins G.R., and Halpain S. Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of hippocampus. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 6856-6861
21. Lamprecht R., and LeDoux J. Structural plasticity and memory. Nat. Rev. Neurosci. 5 (2004) 45-54
22. Lamprecht R., Farb C.R., and LeDoux J.E. Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex. Neuron 36 (2002) 727-738
23. Leung T., Chen X.Q., Manser E., and Lim L. The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16 (1996) 5313-5327
24. Li Z., Aizenman C.D., and Cline H.T. Regulation of rho GTPases by crosstalk and neuronal activity in vivo. Neuron 33 (2002) 741-750
25. Lin B., Kramár E.A., Bi X., Brucher F.A., Gall C.M., and Lynch G. Theta stimulation polymerizes actin in dendritic spines of hippocampus. J. Neurosci. 25 (2005) 2062-2069
26. Lisman J. Actin's action in LTP-induced synapse growth. Neuron 38 (2003) 361-365
27. Luo L. Rho GTPases in neuronal morphogenesis. Nat. Rev. Neurosci. 1 (2000) 173-180
28. Luo L. Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu. Rev. Cell Dev. Biol. 18 (2002) 601-635
29. Maekawa M., Ishizaki T., Boku S., Watanabe N., Fujita A., Iwamatsu A., Obinata T., Ohashi K., Mizuno K., and Narumiya S. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285 (1999) 895-898
30. Malenka R.C., and Nicoll R.A. Long-term potentiation-a decade of progress?. Science 285 (1999) 1870-1874
31. Malinow R., and Malenka R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25 (2002) 103-126
32. Matus A. Actin-based plasticity in dendritic spines. Science 290 (2000) 754-778
33. Meng Y.H., Zhang Y., Tregoubov V., Janus C., Cruz L., Jackson M., Lu W.Y., MacDonald J.F., Wang J.Y., Falls D.L., and Jia Z.P. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35 (2002) 121-133
34. Meng Y.H., Zhang Y., Tregoubov V., Falls D.L., and Jia Z.P. Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton. Rev. Neurosci. 14 (2003) 233-240
35. Meng Y.H., Zhang Y., and Jia Z.P. Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3. Neuron 39 (2003) 163-176
36. Meng J.S., Meng Y.H., Hanna A., Janus C., and Jia Z.P. Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J. Neurosci. 25 (2005) 6641-6650
37. Nakayama A.Y., Harms M.B., and Luo L. Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. J. Neurosci. 20 (2000) 5329-5338
38. O'Kane E.M., Stone T.W., and Morris B.J. Activation of Rho GTPases by synaptic transmission in the hippocampus. J. Neurochem. 87 (2003) 1309-1312
39. O'Kane E.M., Stone T.W., and Morris B.J. Increased long-term potentiation in the CA1 region of rat hippocampus via modulation of GTPase signaling or inhibition of Rho kinase. Neuropharmacology 46 (2004) 879-887
40. Okamoto K., Nagai T., Miyawaki A., and Hayashi Y. Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity. Nat. Neurosci. 7 (2004) 1104-1112
41. Ramakers G.J.A. Rho proteins, mental retardation and the cellular basis of cognition. Trends Neurosci. 25 (2002) 191-199
42. Riento K., and Ridley A. ROCKS: multifunctional kinases in cell behavior. Nat. Rev. Mol. Cell Biol. 4 (2003) 446-456
43. Sin W.C., Hass K., Ruthazer E.S., and Cline H.T. Dendritic growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature 419 (2002) 475-480
44. Smart F.M., and Halpain S. Regulation of dendritic spine stability. Hippocampus 10 (2000) 542-554
45. Sorra K.E., and Harris K.M. Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 10 (2000) 501-511
46. Tada T., and Sheng M. Molecular mechanisms of dendritic spine morphogenesis. Curr. Opin. Neurobiol. 16 (2006) 95-101
47. Tashiro A., Minden A., and Yuste R. Regulation of dendritic spine morphology by the Rho family small GTPases: antagonistic roles of Rac and Rho. Cereb. Cortex 10 (2000) 927-938
48. Thumkeo D., Keel J., Ishizaki T., Hirose M., Nonomura K., Oshima H., Oshima M., Taketo M.M., and Narumiya S. Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol. Cell. Biol. 23 (2003) 5043-5055
49. Van Aelst L., and Cline H.T. Rho GTPases and activity-dependent dendrite development. Curr. Opin. Neurobiol. 14 (2004) 297-304
50. Van Galen E.J., and Ramakers G.J. Rho proteins, mental retardation and the neurobiological basis of intelligence. Prog. Brain Res. 147 (2004) 295-317
51. Zhao Z.S., and Manser E. PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation. Biochem. J. 386 (2005) 201-214
52. Zito K., Knott G., Shepherd G.M., Shenolikar S., and Svoboda K. Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. Neuron 44 (2004) 321-334