The high-affinity immunoglobulin e receptor as pharmacological target

European Journal of Pharmacology

Volumn 778, Issue , 2016, Pages 24-32

  Blank, Ulrich ^a   Charles, Nicolas ^a   Benhamou, Marc ^a  

^a CENTRE DE RECHERCHE SUR L INFLAMMATION   (France)

Author keywords

Allergy; Auto immune diseases; Cancer; High affinity receptor for IgE

Indexed keywords

ANTIHISTAMINIC AGENT; B CELL ACTIVATING FACTOR; CHIMERIC PROTEIN; CORTICOSTEROID; DESIGNED ANKYRIN REPEAT PROTEIN; FC EPSILON RECEPTOR 1; FC RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E RECEPTOR; MAST CELL FUNCTION ASSOCIATED ANTIGEN; OMALIZUMAB; PEPTIDE; PEPTIDE MCD7; PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ANTIGEN FUNCTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BULLOUS PEMPHIGOID; CELL SPECIFICITY; CHRONIC URTICARIA; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; IMMUNOGLOBULIN DEFICIENCY; IMMUNORECEPTOR TYROSINE BASED INHIBITION MOTIF; INNATE IMMUNITY; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; METABOLISM; MOLECULARLY TARGETED THERAPY; PROCEDURES;

ANIMALS; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTORS, IGE;

EID: 84935476572     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.05.070     Document Type: Article

References (174)

1. J. Abramson, and I. Pecht Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle Immunol. Lett. 82 2002 23 28
2. J. Allegra, A. Lipton, H. Harvey, J. Luderer, D. Brenner, R. Mortel, L. Demers, M. Gillin, D. White, and J. Trautlein Decreased prevalence of immediate hypersensitivity (atopy) in a cancer population Cancer Res. 36 1976 3225 3226
3. M. Aloulou, S. Ben Mkaddem, M. Biarnes-Pelicot, T. Boussetta, H. Souchet, E. Rossato, M. Benhamou, B. Crestani, Z. Zhu, U. Blank, P. Launay, and R.C. Monteiro IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses Blood 119 2012 3084 3096
4. M. Andrasfalvy, H. Peterfy, G. Toth, J. Matko, J. Abramson, K. Kerekes, G. Vamosi, I. Pecht, and A. Erdei The beta subunit of the type I Fcepsilon receptor is a target for peptides inhibiting IgE-mediated secretory response of mast cells J. Immunol. 175 2005 2801 2806
5. K. Asai, J. Kitaura, Y. Kawakami, N. Yamagata, M. Tsai, D.P. Carbone, F.T. Liu, S.J. Galli, and T. Kawakami Regulation of mast cell survival by IgE Immunity 14 2001 791 800
6. I. Bachelet, A. Munitz, and F. Levi-Schaffer Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a J. Allergy Clin. Immunol. 117 2006 1314 1320
7. C. Barone, C. Bartoloni, N. Gentiloni, A. Grieco, and G. Flamini Systemic lupus erythematosus with only IgE-class antinuclear antibodies Arthritis Rheumatol. 24 1981 1441 1443
8. W.N. Bartholomaeus, and D. Keast Reaginic antibody to tumour and alloantigens in mice Nat. New Biol. 239 1972 206 207
9. M.J. Baumann, A. Eggel, P. Amstutz, B.M. Stadler, and M. Vogel DARPins against a functional IgE epitope Immunol. Lett. 133 2010 78 84
10. L.A. Beck, G.V. Marcotte, D. MacGlashan, A. Togias, and S. Saini Omalizumab-induced reductions in mast cell Fce psilon RI expression and function J. Allergy Clin. Immunol. 114 2004 527 530
11. S. Ben Mkaddem, G. Hayem, F. Jonsson, E. Rossato, E. Boedec, T. Boussetta, J. El Benna, P. Launay, J.M. Goujon, M. Benhamou, P. Bruhns, and R.C. Monteiro Shifting FcgammaRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis J. Clin. Investig. 124 2014 3945 3959
12. M. Benhamou, N.J. Ryba, H. Kihara, H. Nishikata, and R.P. Siraganian Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation J. Biol. Chem. 268 1993 23318 23324
13. I. Berczi, V. Holford-Strevens, Z.H. Warsi, L.S. McMorris, R.H. Thorlakson, T.K. Thorlakson, and A.H. Sehon Tumor-reactive IgE antibodies in plasma of patients with gastrointestinal carcinomas Cancer Immunol. Immunother. 14 1983 180 184
14. T. Bieber, H. de la Salle, A. Wollenberg, J. Hakimi, R. Chizzonite, J. Ring, D. Hanau, and C. de la Salle Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI) J. Exp. Med. 175 1992 1285 1290
15. H.K. Binz, P. Amstutz, A. Kohl, M.T. Stumpp, C. Briand, P. Forrer, M.G. Grutter, and A. Pluckthun High-affinity binders selected from designed ankyrin repeat protein libraries Nat. Biotechnol. 22 2004 575 582
16. U. Blank, F.H. Falcone, and G. Nilsson The history of mast cell and basophil research - some lessons learnt from the last century Allergy 68 2013 1093 1101
17. U. Blank, P. Launay, M. Benhamou, and R.C. Monteiro Inhibitory ITAMs as novel regulators of immunity Immunol. Rev. 232 2009 59 71
18. J. Boesiger, M. Tsai, M. Maurer, M. Yamaguchi, L.F. Brown, K.P. Claffey, H.F. Dvorak, and S.J. Galli Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression J. Exp. Med. 188 1998 1135 1145
19. J. Bousquet, P. Cabrera, N. Berkman, R. Buhl, S. Holgate, S. Wenzel, H. Fox, S. Hedgecock, M. Blogg, and G.D. Cioppa The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma Allergy 60 2005 302 308
20. M. Brodlie, M.C. McKean, S. Moss, and D.A. Spencer The oral corticosteroid-sparing effect of omalizumab in children with severe asthma Arch. Dis. Child. 97 2012 604 609
21. B.C. Broom, and P. Alexander Rat tumour allografts evoke anaphylactic antibody responses Immunology 28 1975 1033 1040
22. A. Buku, I. Keselman, D. Lupyan, M. Mezei, and J.A. Price Effective mast cell degranulating peptide inhibitors of the IgE/Fc epsilonRI receptor interaction Chem. Biol. Drug Des. 72 2008 133 139
23. D.S. Burt, and D.R. Stanworth Inhibition of binding of rat IgE to rat mast cells by synthetic IgE peptides Eur. J. Immunol. 17 1987 437 440
24. C. Burtin, C. Ponvert, A. Fray, P. Scheinmann, G. Lespinats, B. Loridon, P. Canu, and J. Paupe Inverse correlation between tumor incidence and tissue histamine levels in W/WV, WV/+, and +/+ mice J. Natl. Cancer Inst. 74 1985 671 674
25. O.T. Burton, S.L. Logsdon, J.S. Zhou, J. Medina-Tamayo, A. Abdel-Gadir, M. Noval Rivas, K.J. Koleoglou, T.A. Chatila, L.C. Schneider, R. Rachid, D.T. Umetsu, and H.C. Oettgen Oral immunotherapy induces IgG antibodies that act through FcgammaRIIb to suppress IgE-mediated hypersensitivity J. Allergy Clin. Immunol. 134 2014 1310 1317 e1316
26. O.T. Burton, M. Noval Rivas, J.S. Zhou, S.L. Logsdon, A.R. Darling, K.J. Koleoglou, A. Roers, H. Houshyar, M.A. Crackower, T.A. Chatila, and H.C. Oettgen Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells Immunity 41 2014 141 151
27. P. Buschor, A. Eggel, F. Zellweger, B.M. Stadler, and M. Vogel Improved FcgammaRIIb targeting functionally translates into enhanced inhibition of basophil activation Int. Arch. Allergy Immunol. 163 2014 206 214
28. C.T. Cady, M.S. Powell, R.J. Harbeck, P.C. Giclas, J.R. Murphy, R.K. Katial, R.W. Weber, P.M. Hogarth, S. Johnson, E. Bonvini, S. Koenig, and J.C. Cambier IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB Immunol. Lett. 130 2010 57 65
29. L. Cassard, F. Jonsson, S. Arnaud, and M. Daeron Fcgamma receptors inhibit mouse and human basophil activation J. Immunol. 189 2012 2995 3006
30. S. Cemerski, S.Y. Chu, G.L. Moore, U.S. Muchhal, J.R. Desjarlais, and D.E. Szymkowski Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcgammaRIIb Immunol. Lett. 143 2012 34 43
31. N. Charles, D. Hardwick, E. Daugas, G.G. Illei, and J. Rivera Basophils and the T helper 2 environment can promote the development of lupus nephritis Nat. Med. 16 2010 701 707
32. N. Charles, and J. Rivera Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus Curr. Allergy Asthma Rep. 11 2011 378 387
33. W.S. Choi, T. Hiragun, J.H. Lee, Y.M. Kim, H.P. Kim, A. Chahdi, E. Her, J.W. Han, and M.A. Beaven Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr Mol. Cell. Biol. 24 2004 6980 6992
34. J. Corne, R. Djukanovic, L. Thomas, J. Warner, L. Botta, B. Grandordy, D. Gygax, C. Heusser, F. Patalano, W. Richardson, E. Kilchherr, T. Staehelin, F. Davis, W. Gordon, L. Sun, R. Liou, G. Wang, T.W. Chang, and S. Holgate The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics J. Clin. Investig. 99 1997 879 887
35. J. Corren, G. Shapiro, J. Reimann, Y. Deniz, D. Wong, D. Adelman, and A. Togias Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy J. Allergy Clin. Immunol. 121 2008 506 511
36. L. D'Auria, M. Pietravalle, P. Cordiali-Fei, and F. Ameglio Increased tryptase and myeloperoxidase levels in blister fluids of patients with bullous pemphigoid: correlations with cytokines, adhesion molecules and anti-basement membrane zone antibodies Exp. Dermatol. 9 2000 131 137
37. M. Daeron, O. Malbec, S. Latour, M. Arock, and W.H. Fridman Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors J. Clin. Investig. 95 1995 577 585
38. M. Daeron, and E. Vivier Biology of immunoreceptor tyrosine-based inhibition motif-bearing molecules Curr. Top. Microbiol. Immunol. 244 1999 1 12
39. T.R. Daniels-Wells, G. Helguera, R.K. Leuchter, R. Quintero, M. Kozman, J.A. Rodriguez, E. Ortiz-Sanchez, O. Martinez-Maza, B.C. Schultes, C.F. Nicodemus, and M.L. Penichet A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy BMC Cancer 13 2013 195
40. R.O. de Castro, J. Zhang, J.R. Groves, E.A. Barbu, and R.P. Siraganian Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation J. Biol. Chem. 287 2012 8194 8204
41. B. Dema, N. Charles, C. Pellefigues, T.K. Ricks, R. Suzuki, C. Jiang, J. Scheffel, S. Hasni, V. Hoffman, M. Jablonski, K. Sacre, D. Gobert, T. Papo, E. Daugas, S. Crampton, S. Bolland, and J. Rivera Immunoglobulin E plays an immunoregulatory role in lupus J. Exp. Med. 211 2014 2159 2168
42. B. Dema, C. Pellefigues, S. Hasni, N. Gault, C. Jiang, T.K. Ricks, M.M. Bonelli, J. Scheffel, K. Sacre, M. Jablonski, D. Gobert, T. Papo, E. Daugas, G. Illei, N. Charles, and J. Rivera Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis PLoS One 9 2014 e90424
43. O.G. Dimson, G.J. Giudice, C.L. Fu, F. Van den Bergh, S.J. Warren, M.M. Janson, and J.A. Fairley Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid J. Investig. Dermatol. 120 2003 784 788
44. D. Dombrowicz, S. Lin, V. Flamand, A.T. Brini, B.H. Koller, and J.P. Kinet Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses Immunity 8 1998 517 529
45. E. Donnadieu, M.H. Jouvin, and J.P. Kinet A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunit Immunity 12 2000 515 523
46. A.M. Dvorak, M.C. Mihm Jr., J.E. Osage, T.H. Kwan, K.F. Austen, and B.U. Wintroub Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient J. Investig. Dermatol. 78 1982 91 101
47. A. Eggel, G. Baravalle, G. Hobi, B. Kim, P. Buschor, P. Forrer, J.S. Shin, M. Vogel, B.M. Stadler, C.A. Dahinden, and T.S. Jardetzky Accelerated dissociation of IgE-FcepsilonRI complexes by disruptive inhibitors actively desensitizes allergic effector cells J. Allergy Clin. Immunol. 133 2014 1709 1719 e1708
48. A. Eggel, M.J. Baumann, P. Amstutz, B.M. Stadler, and M. Vogel DARPins as bispecific receptor antagonists analyzed for immunoglobulin E receptor blockage J. Mol. Biol. 393 2009 598 607
49. A. Eggel, P. Buschor, M.J. Baumann, P. Amstutz, B.M. Stadler, and M. Vogel Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein Allergy 66 2011 961 968
50. E. Eiseman, and J.B. Bolen Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases Nature 355 1992 78 80
51. J.A. Fairley, C.T. Burnett, C.L. Fu, D.L. Larson, M.G. Fleming, and G.J. Giudice A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice J. Investig. Dermatol. 127 2007 2605 2611
52. E. Fiebiger, F. Hammerschmid, G. Stingl, and D. Maurer Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship J. Clin. Investig. 101 1998 243 251
53. E. Fiebiger, D. Maurer, H. Holub, B. Reininger, G. Hartmann, M. Woisetschlager, J.P. Kinet, and G. Stingl Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J. Clin. Investig. 96 1995 2606 2612
54. E.W. Fisherman Does the allergic diathesis influence malignancy? J. Allergy 31 1960 74 78
55. S.L. Fu, J. Pierre, T.A. Smith-Norowitz, M. Hagler, W. Bowne, M.R. Pincus, C.M. Mueller, M.E. Zenilman, and M.H. Bluth Immunoglobulin E antibodies from pancreatic cancer patients mediate antibody-dependent cell-mediated cytotoxicity against pancreatic cancer cells Clin. Exp. Immunol. 153 2008 401 409
56. K. Furuichi, J. Rivera, and C. Isersky The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression Proc. Natl. Acad. Sci. USA 82 1985 1522 1525
57. S.J. Galli, and M. Tsai IgE and mast cells in allergic disease Nat. Med. 18 2012 693 704
58. P. Gevaert, L. Calus, T. Van Zele, K. Blomme, N. De Ruyck, W. Bauters, P. Hellings, G. Brusselle, D. De Bacquer, P. van Cauwenberge, and C. Bachert Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma J. Allergy Clin. Immunol. 131 2013 110 116 e111
59. G.J. Gleich, E.M. Zimmermann, L.L. Henderson, and J.W. Yunginger Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study J. Allergy Clin. Immunol. 70 1982 261 271
60. A.S. Gounni, B. Lamkhioued, L. Koussih, C. Ra, P.M. Renzi, and Q. Hamid Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc epsilon RI): role in asthma FASEB J. 15 2001 940 949
61. A.S. Gounni, V. Wellemans, J. Yang, F. Bellesort, K. Kassiri, S. Gangloff, M. Guenounou, A.J. Halayko, Q. Hamid, and B. Lamkhioued Human airway smooth muscle cells express the high affinity receptor for IgE (Fc epsilon RI): a critical role of Fc epsilon RI in human airway smooth muscle cell function J. Immunol. 175 2005 2613 2621
62. A.M. Greer, N. Wu, A.L. Putnam, P.G. Woodruff, P. Wolters, J.P. Kinet, and J.S. Shin Serum IgE clearance is facilitated by human FcepsilonRI internalization J. Clin. Investig. 124 2014 1187 1198
63. B.L. Gruber, M.L. Baeza, M.J. Marchese, V. Agnello, and A.P. Kaplan Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes J. Investig. Dermatol. 90 1988 213 217
64. B.L. Gruber, L.D. Kaufman, M.J. Marchese, W. Roth, and A.P. Kaplan Anti-IgE autoantibodies in systemic lupus erythematosus. Prevalence and biologic activity Arthritis Rheumatol. 31 1988 1000 1006
65. K. Hitomi, S. Tahara-Hanaoka, S. Someya, A. Fujiki, H. Tada, T. Sugiyama, S. Shibayama, K. Shibuya, and A. Shibuya An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions Nat. Immunol. 11 2010 601 607
66. H. Hong, J. Kitaura, W. Xiao, V. Horejsi, C. Ra, C.A. Lowell, Y. Kawakami, and T. Kawakami The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn Blood 110 2007 2511 2519
67. M. Humbert, R. Beasley, J. Ayres, R. Slavin, J. Hebert, J. Bousquet, K.M. Beeh, S. Ramos, G.W. Canonica, S. Hedgecock, H. Fox, M. Blogg, and K. Surrey Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE Allergy 60 2005 309 316
68. T. Ishizuka, F. Okajima, M. Ishiwara, K. Iizuka, I. Ichimonji, T. Kawata, H. Tsukagoshi, K. Dobashi, T. Nakazawa, and M. Mori Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase J. Immunol. 167 2001 2298 2304
69. Y. Iwata, K. Komura, M. Kodera, T. Usuda, Y. Yokoyama, T. Hara, E. Muroi, F. Ogawa, M. Takenaka, and S. Sato Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid Arch. Dermatol. 144 2008 41 48
70. E. Jensen-Jarolim, and G. Pawelec The nascent field of AllergoOncology Cancer Immunol. Immunother. 61 2012 1355 1357
71. S.G. Johansson Serum IgND levels in healthy children and adults Int. Arch. Allergy Appl. Immunol. 34 1968 1 8
72. S.G. Johansson, H. Bennich, and L. Wide A new class of immunoglobulin in human serum Immunology 14 1968 265 272
73. M. Joseph, A.S. Gounni, J.P. Kusnierz, H. Vorng, M. Sarfati, J.P. Kinet, A.B. Tonnel, A. Capron, and M. Capron Expression and functions of the high-affinity IgE receptor on human platelets and megakaryocyte precursors Eur. J. Immunol. 27 1997 2212 2218
74. D.H. Josephs, J.F. Spicer, P. Karagiannis, H.J. Gould, and S.N. Karagiannis IgE immunotherapy: a novel concept with promise for the treatment of cancer MAbs 6 2014 54 72
75. M.H. Jouvin, M. Adamczewski, R. Numerof, O. Letourneur, A. Valle, and J.P. Kinet Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor J. Biol. Chem. 269 1994 5918 5925
76. J. Kalesnikoff, M. Huber, V. Lam, J.E. Damen, J. Zhang, R.P. Siraganian, and G. Krystal Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival Immunity 14 2001 801 811
77. Y. Kanamaru, S. Pfirsch, M. Aloulou, F. Vrtovsnik, M. Essig, C. Loirat, G. Deschenes, C. Guerin-Marchand, U. Blank, and R.C. Monteiro Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation J. Immunol. 180 2008 2669 2678
78. A. Kaplan, D. Ledford, M. Ashby, J. Canvin, J.L. Zazzali, E. Conner, J. Veith, N. Kamath, P. Staubach, T. Jakob, R.G. Stirling, P. Kuna, W. Berger, M. Maurer, and K. Rosen Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy J. Allergy Clin. Immunol. 132 2013 101 109
79. A.P. Kaplan, K. Joseph, R.J. Maykut, G.P. Geba, and R.K. Zeldin Treatment of chronic autoimmune urticaria with omalizumab J. Allergy Clin. Immunol. 122 2008 569 573
80. P. Karagiannis, J. Singer, J. Hunt, S.K. Gan, S.M. Rudman, D. Mechtcheriakova, R. Knittelfelder, T.R. Daniels, P.S. Hobson, A.J. Beavil, J. Spicer, F.O. Nestle, M.L. Penichet, H.J. Gould, E. Jensen-Jarolim, and S.N. Karagiannis Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells Cancer Immunol. Immunother. 58 2009 915 930
81. S.N. Karagiannis, M.G. Bracher, J. Hunt, N. McCloskey, R.L. Beavil, A.J. Beavil, D.J. Fear, R.G. Thompson, N. East, F. Burke, R.J. Moore, D.D. Dombrowicz, F.R. Balkwill, and H.J. Gould IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells J. Immunol. 179 2007 2832 2843
82. H.R. Katz, E. Vivier, M.C. Castells, M.J. McCormick, J.M. Chambers, and K.F. Austen Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE Proc. Natl. Acad. Sci. USA 93 1996 10809 10814
83. C.L. Kepley, S. Taghavi, G. Mackay, D. Zhu, P.A. Morel, K. Zhang, J.J. Ryan, L.S. Satin, M. Zhang, P.P. Pandolfi, and A. Saxon Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes J. Biol. Chem. 279 2004 35139 35149
84. M.H. Kershaw, P.K. Darcy, J.A. Trapani, D. MacGregor, and M.J. Smyth Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth Oncol. Res. 10 1998 133 142
85. R. Kershenovich, E. Hodak, and D. Mimouni Diagnosis and classification of pemphigus and bullous pemphigoid Autoimmun. Rev. 13 2014 477 481
86. B. Kim, A. Eggel, S.S. Tarchevskaya, M. Vogel, H. Prinz, and T.S. Jardetzky Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor Nature 491 2012 613 617
87. D.H. Kim, K.Y. Park, B.J. Kim, M.N. Kim, and S.K. Mun Anti-immunoglobulin E in the treatment of refractory atopic dermatitis Clin. Exp. Dermatol. 38 2013 496 500
88. M. Kohno, S. Yamasaki, V.L. Tybulewicz, and T. Saito Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen Blood 105 2005 2059 2065
89. S. Kraft, and J.P. Kinet New developments in FcepsilonRI regulation, function and inhibition Nat. Rev. Immunol. 7 2007 365 378
90. A. Kulczycki Jr., and H. Metzger The interaction of IgE with rat basophilic leukemia cells. II. Quantitative aspects of the binding reaction J. Exp. Med. 140 1974 1676 1695
91. M.H. Lafeuille, J. Dean, J. Zhang, M.S. Duh, B. Gorsh, and P. Lefebvre Impact of omalizumab on emergency-department visits, hospitalizations, and corticosteroid use among patients with uncontrolled asthma Ann. Allergy Asthma Immunol. 109 2012 59 64
92. J.H. Lee, J.W. Kim, K. Kim do, H.S. Kim, H.J. Park, D.K. Park, A.R. Kim, B. Kim, M.A. Beaven, K.L. Park, Y.M. Kim, and W.S. Choi The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice J. Immunol. 187 2011 1807 1815
93. H. Lienard, P. Bruhns, O. Malbec, W.H. Fridman, and M. Daeron Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation J. Biol. Chem. 274 1999 32493 32499
94. H. Lin, K.M. Boesel, D.T. Griffith, C. Prussin, B. Foster, F.A. Romero, R. Townley, and T.B. Casale Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils J. Allergy Clin. Immunol. 113 2004 297 302
95. S. Lin, C. Cicala, A.M. Scharenberg, and J.P. Kinet The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals Cell 85 1996 985 995
96. J.M. Lu-Kuo, D.M. Joyal, K.F. Austen, and H.R. Katz gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization J. Biol. Chem. 274 1999 5791 5796
97. D. MacGlashan Jr. Facilitated dissociation of IgE versus cell replacement J. Allergy Clin. Immunol. 135 2015 294 295
98. D.W. MacGlashan Jr., B.S. Bochner, D.C. Adelman, P.M. Jardieu, A. Togias, J. McKenzie-White, S.A. Sterbinsky, R.G. Hamilton, and L.M. Lichtenstein Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody J. Immunol. 158 1997 1438 1445
99. D.W. Macglashan Jr., and S.S. Saini Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation J. Allergy Clin. Immunol. 132 2013 906 911 e901-904
100. J.J. Machiels, P.M. Lebrun, M.G. Jacquemin, and J.M. Saint-Remy Significant reduction of nonspecific bronchial reactivity in patients with Dermatophagoides pteronyssinus-sensitive allergic asthma under therapy with allergen-antibody complexes Am. Rev. Respir. Dis. 147 1993 1407 1412
101. J.J. Machiels, M.A. Somville, M.G. Jacquemin, and J.M. Saint-Remy Allergen-antibody complexes can efficiently prevent seasonal rhinitis and asthma in grass pollen hypersensitive patients. Allergen-antibody complex immunotherapy Allergy 46 1991 335 348
102. W.D. Mackay The incidence of allergic disorders and cancer Br. J. Cancer 20 1966 434 437
103. D. Maurer, E. Fiebiger, B. Reininger, B. Wolff-Winiski, M.H. Jouvin, O. Kilgus, J.P. Kinet, and G. Stingl Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals J. Exp. Med. 179 1994 745 750
104. D. Maurer, S. Fiebiger, C. Ebner, B. Reininger, G.F. Fischer, S. Wichlas, M.H. Jouvin, M. Schmitt-Egenolf, D. Kraft, J.P. Kinet, and G. Stingl Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation J. Immunol. 157 1996 607 616
105. M. Maurer, K. Rosen, H.J. Hsieh, S. Saini, C. Grattan, A. Gimenez-Arnau, S. Agarwal, R. Doyle, J. Canvin, A. Kaplan, and T. Casale Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria N. Engl. J. Med. 368 2013 924 935
106. J.M. McDonnell, A.J. Beavil, G.A. Mackay, B.A. Jameson, R. Korngold, H.J. Gould, and B.J. Sutton Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor Nat. Struct. Biol. 3 1996 419 426
107. P.D. Meers Allergy and cancer Lancet 1 1973 884 885
108. E. Mertsching, L. Bafetti, H. Hess, S. Perper, K. Giza, L.C. Allen, E. Negrou, K. Hathaway, J. Hopp, J. Chung, D. Perret, M. Shields, A. Saxon, and M.R. Kehry A mouse Fcgamma-Fcepsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases J. Allergy Clin. Immunol. 121 2008 441 447 e445
109. K.N. Messingham, H.M. Holahan, A.S. Frydman, C. Fullenkamp, R. Srikantha, and J.A. Fairley Human eosinophils express the high affinity IgE receptor, FcepsilonRI, in bullous pemphigoid PLoS One 9 2014 e107725
110. S. Miyawaki, and R.F. Ritchie Heterogeneity of antinucleolar antibody and IgE antinuclear antibody in patients with systemic rheumatic diseases J. Immunol. 113 1974 1346 1352
111. M. Molimard, L. Mala, I. Bourdeix, and V. Le Gros Observational study in severe asthmatic patients after discontinuation of omalizumab for good asthma control Respir. Med. 108 2014 571 576
112. K. Moriya, J. Rivera, S. Odom, Y. Sakuma, K. Muramato, T. Yoshiuchi, M. Miyamoto, and K. Yamada ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk Proc. Natl. Acad. Sci. USA 94 1997 12539 12544
113. K.C. Nadeau, L.C. Schneider, L. Hoyte, I. Borras, and D.T. Umetsu Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy J. Allergy Clin. Immunol. 127 2011 1622 1624
114. K. Nagai, S. Tahara-Hanaoka, Y. Morishima, T. Tokunaga, Y. Imoto, E. Noguchi, K. Kanemaru, M. Imai, S. Shibayama, N. Hizawa, S. Fujieda, K. Yamagata, and A. Shibuya Expression and function of Allergin-1 on human primary mast cells PLoS One 8 2013 e76160
115. A. Nagel, A. Lang, D. Engel, E. Podstawa, N. Hunzelmann, O. de Pita, L. Borradori, W. Uter, and M. Hertl Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3 Clin. Immunol. 134 2010 320 330
116. E. Nagy, I. Berczi, and A.H. Sehon Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus Cancer Immunol. Immunother. 34 1991 63 69
117. G.R. Nakamura, M.E. Reynolds, Y.M. Chen, M.A. Starovasnik, and H.B. Lowman Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor Proc. Natl. Acad. Sci. USA 99 2002 1303 1308
118. G.R. Nakamura, M.A. Starovasnik, M.E. Reynolds, and H.B. Lowman A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor Biochemistry 40 2001 9828 9835
119. E.A. Nigro, A.T. Brini, E. Soprana, A. Ambrosi, D. Dombrowicz, A.G. Siccardi, and L. Vangelista Antitumor IgE adjuvanticity: key role of Fc epsilon RI J. Immunol. 183 2009 4530 4536
120. D.A. Offermann, J.E. McKendrick, J.J. Sejberg, B. Mo, M.D. Holdom, B.A. Helm, R.J. Leatherbarrow, A.J. Beavil, B.J. Sutton, and A.C. Spivey Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cepsilon3 domain of human IgE J. Org. Chem. 77 2012 3197 3214
121. N.W. Palm, R.K. Rosenstein, and R. Medzhitov Allergic host defences Nature 484 2012 465 472
122. V. Parravicini, M. Gadina, M. Kovarova, S. Odom, C. Gonzalez-Espinosa, Y. Furumoto, S. Saitoh, L.E. Samelson, J.J. O'Shea, and J. Rivera Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation Nat. Immunol. 3 2002 741 748
123. B. Pasquier, P. Launay, Y. Kanamaru, I.C. Moura, S. Pfirsch, C. Ruffie, D. Henin, M. Benhamou, M. Pretolani, U. Blank, and R.C. Monteiro Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM Immunity 22 2005 31 42
124. H. Permin, and A. Wiik The prevalence of IgE antinuclear antibodies in rheumatoid arthritis and systemic lupus erythematosus Acta Pathol. Microbiol. Scand. C 86C 1978 245 249
125. H. Peterfy, G. Toth, I. Pecht, and A. Erdei C3a-derived peptide binds to the type I FcepsilonR and inhibits proximal-coupling signal processes and cytokine secretion by mast cells Int. Immunol. 20 2008 1239 1245
126. L. Pierini, D. Holowka, and B. Baird Fc epsilon RI-mediated association of 6-micron beads with RBL-2H3 mast cells results in exclusion of signaling proteins from the forming phagosome and abrogation of normal downstream signaling J. Cell Biol. 134 1996 1427 1439
127. F. Pinheiro da Silva, M. Aloulou, M. Benhamou, and R.C. Monteiro Inhibitory ITAMs: a matter of life and death Trends Immunol 29 2008 366 373
128. F. Pinheiro da Silva, M. Aloulou, D. Skurnik, M. Benhamou, A. Andremont, I.T. Velasco, M. Chiamolera, J.S. Verbeek, P. Launay, and R.C. Monteiro CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation Nat. Med. 13 2007 1368 1374
129. C. Ponvert, L. Galoppin, P. Scheinmann, P. Canu, and C. Burtin Tissue histamine levels in male and female mast cell deficient mice (W/Wv) and in their littermates (Wv/+, W/+ and +/+) Agents Actions 17 1985 1 4
130. C. Prussin, D.T. Griffith, K.M. Boesel, H. Lin, B. Foster, and T.B. Casale Omalizumab treatment downregulates dendritic cell FcepsilonRI expression J. Allergy Clin. Immunol. 112 2003 1147 1154
131. C.X. Qiao, M. Lv, L.M. Guo, M. Yu, Y. Li, Z. Lin, X.L. Hua, C.M. Hou, J.N. Feng, and B.F. Shen Inhibition of IgE activity to bind its high affinity receptor (FcepsilonRIalpha) by mouse anti-IgE Cepsilon3 approximately 4 monoclonal antibody (QME5) Int. J. Biomed. Sci. 5 2009 336 344
132. K. Rajakulasingam, S. Till, S. Ying, M. Humbert, J. Barkans, M. Sullivan, Q. Meng, C.J. Corrigan, J. Bungre, J.A. Grant, A.B. Kay, and S.R. Durham Increased expression of high affinity IgE (FcepsilonRI) receptor-alpha chain mRNA and protein-bearing eosinophils in human allergen-induced atopic asthma Am. J. Respir. Crit. Care Med. 158 1998 233 240
133. A.B. Riemer, E. Untersmayr, R. Knittelfelder, A. Duschl, H. Pehamberger, C.C. Zielinski, O. Scheiner, and E. Jensen-Jarolim Active induction of tumor-specific IgE antibodies by oral mimotope vaccination Cancer Res. 67 2007 3406 3411
134. M. Rossi, M. Ruvo, D. Marasco, M. Colombo, G. Cassani, and A. Verdoliva Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide Mol. Immunol. 45 2008 226 234
135. S.M. Rudman, D.H. Josephs, H. Cambrook, P. Karagiannis, A.E. Gilbert, T. Dodev, J. Hunt, A. Koers, A. Montes, L. Taams, S. Canevari, M. Figini, P.J. Blower, A.J. Beavil, C.F. Nicodemus, C. Corrigan, S.B. Kaye, F.O. Nestle, H.J. Gould, J.F. Spicer, and S.N. Karagiannis Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity Clin. Exp. Allergy 41 2011 1400 1413
136. R.A. Sabroe, E. Fiebiger, D.M. Francis, D. Maurer, P.T. Seed, C.E. Grattan, A.K. Black, G. Stingl, M.W. Greaves, and R.M. Barr Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity J. Allergy Clin. Immunol. 110 2002 492 499
137. A.S. Saffar, M.P. Alphonse, L. Shan, K.T. Hayglass, F.E. Simons, and A.S. Gounni IgE modulates neutrophil survival in asthma: role of mitochondrial pathway J. Immunol. 178 2007 2535 2541
138. L.A. Samayawardhena, and C.J. Pallen PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses J. Immunol. 185 2010 5993 6002
139. S. Sanchez-Ramon, I. Eguiluz-Gracia, M.E. Rodriguez-Mazariego, A. Paravisini, J.M. Zubeldia-Ortuno, J. Gil-Herrera, E. Fernandez-Cruz, and R. Suarez-Fernandez Sequential combined therapy with omalizumab and rituximab: a new approach to severe atopic dermatitis J. Investig. Allergol. Clin. Immunol. 23 2013 190 196
140. A. Sandomenico, S.M. Monti, D. Marasco, N. Dathan, R. Palumbo, M. Saviano, and M. Ruvo IgE-binding properties and selectivity of peptide mimics of the FcvarepsilonRI binding site Mol. Immunol. 46 2009 3300 3309
141. A. Sandomenico, S.M. Monti, R. Palumbo, and M. Ruvo A new FcepsilonRI receptor-mimetic peptide (PepE) that blocks IgE binding to its high affinity receptor and prevents mediator release from RBL 2H3 cells J. Pept. Sci. 17 2011 604 609
142. L.C. Schneider, R. Rachid, J. LeBovidge, E. Blood, M. Mittal, and D.T. Umetsu A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients J. Allergy Clin. Immunol. 132 2013 1368 1374
143. G. Sellge, M. Barkowsky, S. Kramer, T. Gebhardt, L.E. Sander, A. Lorentz, and S.C. Bischoff Interferon-gamma regulates growth and controls Fcgamma receptor expression and activation in human intestinal mast cells BMC Immunol. 15 2014 27
144. R.L. Shields, W.R. Whether, K. Zioncheck, L. O'Connell, B. Fendly, L.G. Presta, D. Thomas, R. Saban, and P. Jardieu Inhibition of allergic reactions with antibodies to IgE Int. Arch. Allergy Immunol. 107 1995 308 312
145. J.S. Shin, C.P. Shelburne, C. Jin, E.A. LeFurgey, and S.N. Abraham Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis J. Immunol. 177 2006 5791 5800
146. V.R. Simhadri, J.F. Andersen, E. Calvo, S.C. Choi, J.E. Coligan, and F. Borrego Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells Blood 119 2012 2799 2809
147. J. Singer, and E. Jensen-Jarolim IgE-based immunotherapy of cancer: challenges and chances Allergy 69 2014 137 149
148. R.P. Siraganian, R.O. de Castro, E.A. Barbu, and J. Zhang Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants FEBS Lett. 584 2010 4933 4940
149. J. Song, G. Hagen, S.M. Smith, D.A. Roess, I. Pecht, and B.G. Barisas Interactions of the mast cell function-associated antigen with the type I Fcepsilon receptor Mol. Immunol. 38 2002 1315 1321
150. J. Song, G.M. Hagen, D.A. Roess, I. Pecht, and B.G. Barisas The mast cell function-associated antigen and its interactions with the type I Fcepsilon receptor Biochemistry 41 2002 881 889
151. S. Spaeth, R. Riechers, L. Borradori, D. Zillikens, L. Budinger, and M. Hertl IgG, IgA and IgE autoantibodies against the ectodomain of desmoglein 3 in active pemphigus vulgaris Br. J. Dermatol. 144 2001 1183 1188
152. J. Stamos, C. Eigenbrot, G.R. Nakamura, M.E. Reynolds, J. Yin, H.B. Lowman, W.J. Fairbrother, and M.A. Starovasnik Convergent recognition of the IgE binding site on the high-affinity IgE receptor Structure 12 2004 1289 1301
153. R.T. Strait, S.C. Morris, and F.D. Finkelman IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking J. Clin. Investig. 116 2006 833 841
154. L. Sun, K. Erxun, J. Li, J. Yang, and C. Han Correlations between anti-mast cell autoantibodies and chronic idiopathic urticaria Ann. Dermatol. 26 2014 145 149
155. W.T. Sweeney, and H.R. Seibel Histamine release from peritoneal mast cells of tumor susceptible rats following periods of tumor growth and sensitization with tumor antigens and B. pertussis Int. Arch. Allergy Appl. Immunol. 45 1973 789 794
156. S.W. Tam, S. Demissie, D. Thomas, and M. Daeron A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils Allergy 59 2004 772 780
157. C. Tkaczyk, I. Villa, R. Peronet, B. David, and S. Mecheri FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells Immunology 97 1999 333 340
158. F. Toledo, J.F. Silvestre, and C. Munoz Combined therapy with low-dose omalizumab and intravenous immunoglobulin for severe atopic dermatitis. Report of four cases J. Eur. Acad. Dermatol. Venereol. 26 2012 1325 1327
159. I.M. Tomlinson Next-generation protein drugs Nat. Biotechnol. 22 2004 521 522
160. T. Uehara, M. Blery, D.W. Kang, C.C. Chen, L.H. Ho, G.L. Gartland, F.T. Liu, E. Vivier, M.D. Cooper, and H. Kubagawa Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B J. Clin. Investig. 108 2001 1041 1050
161. C. Uermosi, R.R. Beerli, M. Bauer, V. Manolova, K. Dietmeier, R.B. Buser, T.M. Kundig, P. Saudan, and M.F. Bachmann Mechanisms of allergen-specific desensitization J. Allergy Clin. Immunol. 126 2010 375 383
162. H. van der Kleij, N. Charles, K. Karimi, Y.K. Mao, J. Foster, L. Janssen, P. Chang Yang, W. Kunze, J. Rivera, and J. Bienenstock Evidence for neuronal expression of functional Fc (epsilon and gamma) receptors J. Allergy Clin. Immunol. 125 2010 757 760
163. B.M. Vonakis, H. Chen, H. Haleem-Smith, and H. Metzger The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE J. Biol. Chem. 272 1997 24072 24080
164. B. Wang, A. Rieger, O. Kilgus, K. Ochiai, D. Maurer, D. Fodinger, J.P. Kinet, and G. Stingl Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI J. Exp. Med. 175 1992 1353 1365
165. B.U. Wintroub, M.C. Mihm Jr., E.J. Goetzl, N.A. Soter, and K.F. Austen Morphologic and functional evidence for release of mast-cell products in bullous pemphigoid N. Engl. J. Med. 298 1978 417 421
166. M. Yamaguchi, C.S. Lantz, H.C. Oettgen, I.M. Katona, T. Fleming, I. Miyajima, J.P. Kinet, and S.J. Galli IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions J. Exp. Med. 185 1997 663 672
167. M. Yamaguchi, K. Sayama, K. Yano, C.S. Lantz, N. Noben-Trauth, C. Ra, J.J. Costa, and S.J. Galli IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release J. Immunol. 162 1999 5455 5465
168. T. Yamashita, S.Y. Mao, and H. Metzger Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase Proc. Natl. Acad. Sci. USA 91 1994 11251 11255
169. Y.M. Ye, E.M. Yang, H.S. Yoo, Y.S. Shin, S.H. Kim, and H.S. Park Increased level of basophil CD203c expression predicts severe chronic urticaria J. Korean Med. Sci. 29 2014 43 47
170. J. Zhang, E.H. Berenstein, R.L. Evans, and R.P. Siraganian Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells J. Exp. Med. 184 1996 71 79
171. W. Zhao, C.L. Kepley, P.A. Morel, L.M. Okumoto, Y. Fukuoka, and L.B. Schwartz Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells J. Immunol. 177 2006 694 701
172. J.S. Zhou, A. Sandomenico, V. Severino, O.T. Burton, A. Darling, H.C. Oettgen, and M. Ruvo An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis Mol. Biosyst. 9 2013 2853 2859
173. D. Zhu, C.L. Kepley, K. Zhang, T. Terada, T. Yamada, and A. Saxon A chimeric human-cat fusion protein blocks cat-induced allergy Nat. Med. 11 2005 446 449
174. D. Zhu, C.L. Kepley, M. Zhang, K. Zhang, and A. Saxon A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation Nat. Med. 8 2002 518 521