Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor

Nature Structural Biology

Volumn 3, Issue 5, 1996, Pages 419-426

  McDonnell, J M ^a   Beavil, A J ^a   Mackay, G A ^a   Jameson, B A ^b   Korngold, R ^b   Gould, H J ^a   Sutton, B J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CD2 ANTIGEN; CYCLOPEPTIDE; CYSTEINE; FC RECEPTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; SYNTHETIC PEPTIDE;

ALLERGY; ANIMAL CELL; CIRCULAR DICHROISM; CONTROLLED STUDY; CYCLIZATION; DRUG DESIGN; DRUG RECEPTOR BINDING; MAST CELL DEGRANULATION; MAST CELL LEUKEMIA; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RAT; RECEPTOR AFFINITY; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; ANTI-ALLERGIC AGENTS; BIOSENSING TECHNIQUES; CELL DEGRANULATION; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; MAST CELLS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RECEPTORS, IGE;

ANIMALIA;

EID: 0029875055     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0596-419     Document Type: Review

References (19)

1. Banner, D.W. & Hadvary, P. Crystallographic analysis at 3.0-Å resolution of the binding to human thrombin of four active site-directed inhibitors. J Biol. Chem. 266, 20085-20093 (1991).
2. Navia, M.A. & Murcko, M.A. Use of structural information in drug design. Curr. Opin. Stuct. Biol. 2, 202-210 (1992).
3. Chen, S. et al. Design and synthesis of a CD4 β-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp 120 binding and infection of human lymphocytes. Proc. Natl. Acad. Sci. USA 89, 5872-5876 (1992).
4. Jameson, B.A., McDonnell, J.M., Marini, J.C. & Korngold, R. A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis. Wature 368, 744-746 (1994).
5. Nakanishi, H. et al. Peptide mimetics of the thrombin-bound structure of fibrinopeptide A. Proc. Natl. Acad. Sci. USA 89, 1705-1709 (1992).
6. Sato, M. et al. M. Design, synthesis and conformational analysis of γ-turn peptide mimetics of bradykinin. Bichem. Biophys. Res. Comm. 187, 999-1006 (1992).
7. DeGrado, W.F. Design of peptides and proteins. Adv. Prot Chem. 39, 51-124 (1988).
8. ′-methylamides of dehydroalanine and N-methyldehydroalanine. Biopolymers 19, 469-475 (1980).
9. Rose, G.D., Gierasch, L.M. & Smith, J.A. Turns in peptides and proteins. Adv. Prot. Chem. 37, 1-109 (1985).
10. Rizo, J. & Gierasch, L.M. Constrained peptides - models of bioactive peptides and protein substructures. Ann. Rev. Biochem. 61, 387-418 (1992).
11. Miklavc, A., Kocjan, D., Avbelj, F. & Hadzi, D. in QSAR in Drug Design and Toxicology, (eds D. Hadzi & B. Jerman-Blazic) 185-190. (Elsevier Science Publishers B.V., Amsterdam, 1987).
12. Riske, F. et al. High affinity human IgE receptor (FcεRI). Analysis of functional domains of the α-subunit with monoclonal antibodies. J. Biol. Chem. 266, 11245-11251 (1991).
13. Robertson, M.W. Phage and Escherichia coli expression of the human high affinity immunoglobulin E receptor α-subunit ectodomain. J. Biol. Chem. 268, 12736-12743 (1993).
14. Mallamaci, M.A. et al. Identification of sites on the human FcεRIα subunit which are involved in binding to human and rat IgE. J. Biol. Chem. 268, 22076-22083 (1993).
15. Hulett, M.D., McKenzie, I.F.C. & Hogarth, P.M. Chimeric Fc receptors identify immunoglobulin-binding regions in human FcγRII and FaRI. Cur. J. Immunol. 23, 640-645 (1993).
16. Scarselli, E., Esposito, G. & Traboni, C. Receptor phage: Display of functional domains of the high affinity IgE receptor on the M13 phage surface. FEBS Lett 329, 223-226 (1993).
17. Shimizu, A., Tepler, I., Bemfrey, P.N., Berenstein, E.H. & Leder, P. Human and rat mast-cell high-affinity immunoglobulin-E receptors characterization of putative alpha-chain gene products. Proc. Natl. Acad. Sci. USA 85, 1907-1911 (1988).
18. Sutton, B.J. & Gould, H.J. The human IgE network. Nature 366, 421-428 (1993).
19. Hogarth, P.M. et al. Identification of the immunoglobulin binding regions of Fc-gamma-RII and Fc-epsilon-RI. Immunol. Rev. 125, 21-35 (1992).