A novel human immunoglobulin Fcγ-Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation

Nature Medicine

Volumn 8, Issue 5, 2002, Pages 518-521

  Zhu, Daocheng ^a   Kepley, Christopher L ^b   Zhang, Min ^a   Zhang, Ke ^a   Saxon, Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 IODO 5 NITROPHENYLACETIC ACID; FC RECEPTOR; HISTAMINE; HYBRID PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN FC EPSILON FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN FC GAMMA FRAGMENT; PROTEIN; PROTEIN KINASE SYK; TYROSINE; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOPHIL; BASOPHIL DEGRANULATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; MAST CELL; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SKIN ANAPHYLAXIS; TRANSGENIC MOUSE; TREATMENT OUTCOME;

ANIMALS; BASOPHIL DEGRANULATION TEST; BASOPHILS; CELL DEGRANULATION; HUMANS; HYPERSENSITIVITY; MAST CELLS; MICE; MICE, TRANSGENIC; RECEPTORS, IGE; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0036100524     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0502-518     Document Type: Article

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