The TIGIT/CD226 axis regulates human T cell function

Journal of Immunology

Volumn 188, Issue 8, 2012, Pages 3869-3875

  Lozano, Ester ^a,b   Dominguez Villar, Margarita ^a,b   Kuchroo, Vijay ^b   Hafler, David A ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD155 LIGAND; CD226 PROTEIN; CELL RECEPTOR; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; LYMPHOCYTE ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; RETINOIC ACID RELATED ORPHAN RECEPTOR C; SHORT HAIRPIN RNA; T CELL IG AND ITIM DOMAIN PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; BINDING COMPETITION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; IMMUNE TOLERANCE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, VIRUS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS;

EID: 84860329359     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103627     Document Type: Article

References (24)

1. Sharpe, A. H. 2009. Mechanisms of costimulation. Immunol. Rev. 229: 5-11.
2. Vijayakrishnan, L., J. M. Slavik, Z. Illés, R. J. Greenwald, D. Rainbow, B. Greve, L. B. Peterson, D. A. Hafler, G. J. Freeman, A. H. Sharpe, et al. 2004. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 20: 563-575. (Pubitemid 38638126)
3. International Multiple Sclerosis Genetics Consortium and The Wellcome Trust Case Control Consortium 2. 2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214-219.
4. Maier, L. M., and D. A. Hafler. 2009. Autoimmunity risk alleles in costimulation pathways. Immunol. Rev. 229: 322-336.
5. Ueda, H., J. M. Howson, L. Esposito, J. Heward, H. Snook, G. Chamberlain, D. B. Rainbow, K. M. Hunter, A. N. Smith, G. Di Genova, et al. 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506-511. (Pubitemid 36648570)
6. Hafler, J. P., L. M. Maier, J. D. Cooper, V. Plagnol, A. Hinks, M. J. Simmonds, H. E. Stevens, N. M. Walker, B. Healy, J. M. Howson, et al. 2009. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun. 10: 5-10.
7. International Multiple Sclerosis Genetics Consortium 2009. The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun. 10: 11-14.
8. Shibuya, A., D. Campbell, C. Hannum, H. Yssel, K. Franz-Bacon, T. McClanahan, T. Kitamura, J. Nicholl, G. R. Sutherland, L. L. Lanier, and J. H. Phillips. 1996. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4: 573-581. (Pubitemid 26233311)
9. Shibuya, K., J. Shirakawa, T. Kameyama, S. Honda, S. Tahara-Hanaoka, A. Miyamoto, M. Onodera, T. Sumida, H. Nakauchi, H. Miyoshi, and A. Shibuya. 2003. CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J. Exp. Med. 198: 1829-1839. (Pubitemid 38032116)
10. Bottino, C., R. Castriconi, D. Pende, P. Rivera, M. Nanni, B. Carnemolla, C. Cantoni, J. Grassi, S. Marcenaro, N. Reymond, et al. 2003. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 198: 557-567. (Pubitemid 37040390)
11. Tahara-Hanaoka, S., K. Shibuya, Y. Onoda, H. Zhang, S. Yamazaki, A. Miyamoto, S. Honda, L. L. Lanier, and A. Shibuya. 2004. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int. Immunol. 16: 533-538. (Pubitemid 38489427)
12. Yu, X., K. Harden, L. C. Gonzalez, M. Francesco, E. Chiang, B. Irving, I. Tom, S. Ivelja, C. J. Refino, H. Clark, et al. 2009. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10: 48-57.
13. Joller, N., J. P. Hafler, B. Brynedal, N. Kassam, S. Spoerl, S. D. Levin, A. H. Sharpe, and V. K. Kuchroo. 2011. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J. Immunol. 186: 1338-1342.
14. Levin, S. D., D. W. Taft, C. S. Brandt, C. Bucher, E. D. Howard, E. M. Chadwick, J. Johnston, A. Hammond, K. Bontadelli, D. Ardourel, et al. 2011. Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur. J. Immunol. 41: 902-915.
15. Moffat, J., D. A. Grueneberg, X. Yang, S. Y. Kim, A. M. Kloepfer, G. Hinkle, B. Piqani, T. M. Eisenhaure, B. Luo, J. K. Grenier, et al. 2006. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124: 1283-1298.
16. Dominguez-Villar, M., C. M. Baecher-Allan, and D. A. Hafler. 2011. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat. Med. 17: 673-675.
17. Masson, D., A. Jarry, B. Baury, P. Blanchardie, C. Laboisse, P. Lustenberger, and M. G. Denis. 2001. Overexpression of the CD155 gene in human colorectal carcinoma. Gut 49: 236-240. (Pubitemid 32675118)
18. Tahara-Hanaoka, S., K. Shibuya, H. Kai, A. Miyamoto, Y. Morikawa, N. Ohkochi, S. Honda, and A. Shibuya. 2006. Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Blood 107: 1491-1496. (Pubitemid 43242386)
19. Castriconi, R., A. Dondero, M. V. Corrias, E. Lanino, D. Pende, L. Moretta, C. Bottino, and A. Moretta. 2004. Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Cancer Res. 64: 9180-9184. (Pubitemid 39665534)
20. Chan, C. J., D. M. Andrews, N. M. McLaughlin, H. Yagita, S. Gilfillan, M. Colonna, and M. J. Smyth. 2010. DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases. J. Immunol. 184: 902-911.
21. Stanietsky, N., H. Simic, J. Arapovic, A. Toporik, O. Levy, A. Novik, Z. Levine, M. Beiman, L. Dassa, H. Achdout, et al. 2009. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc. Natl. Acad. Sci. USA 106: 17858-17863.
22. Hodi, F. S., S. J. O'Day, D. F. McDermott, R. W. Weber, J. A. Sosman, J. B. Haanen, R. Gonzalez, C. Robert, D. Schadendorf, J. C. Hassel, et al. 2010. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363: 711-723.
23. Collins, A. V., D. W. Brodie, R. J. Gilbert, A. Iaboni, R. Manso-Sancho, B. Walse, D. I. Stuart, P. A. van der Merwe, and S. J. Davis. 2002. The interaction properties of costimulatory molecules revisited. Immunity 17: 201-210. (Pubitemid 35245962)
24. Kremer, J. M., R. Westhovens, M. Leon, E. Di Giorgio, R. Alten, S. Steinfeld, A. Russell, M. Dougados, P. Emery, I. F. Nuamah, et al. 2003. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N. Engl. J. Med. 349: 1907-1915. (Pubitemid 37409707)