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Volumn 10, Issue 6, 2015, Pages

Septic shock in advanced age: Transcriptome analysis reveals altered molecular signatures in neutrophil granulocytes

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; RNA;

EID: 84935019559     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128341     Document Type: Article
Times cited : (29)

References (89)
  • 1
    • 84880950517 scopus 로고    scopus 로고
    • Sepsis: Multiple abnormalities, heterogeneous responses, and evolving understanding
    • Epub 2013/08/01 PMID: 23899564; PubMed Central PMCID: PMC3962548
    • Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiological reviews. 2013; 93(3):1247-88. Epub 2013/08/01. doi: 10.1152/physrev.00037.2012 PMID: 23899564; PubMed Central PMCID: PMC3962548.
    • (2013) Physiological Reviews , vol.93 , Issue.3 , pp. 1247-1288
    • Iskander, K.N.1    Osuchowski, M.F.2    Stearns-Kurosawa, D.J.3    Kurosawa, S.4    Stepien, D.5    Valentine, C.6
  • 2
    • 63049100253 scopus 로고    scopus 로고
    • Pathophysiology of sepsis in the elderly: Clinical impact and therapeutic considerations
    • Epub 2009/01/20 PMID: 19149537
    • De Gaudio AR, Rinaldi S, Chelazzi C, Borracci T. Pathophysiology of sepsis in the elderly: clinical impact and therapeutic considerations. Current drug targets. 2009; 10(1):60-70. Epub 2009/01/20 PMID: 19149537.
    • (2009) Current Drug Targets , vol.10 , Issue.1 , pp. 60-70
    • De Gaudio, A.R.1    Rinaldi, S.2    Chelazzi, C.3    Borracci, T.4
  • 4
    • 84880014614 scopus 로고    scopus 로고
    • Infections in the elderly
    • Epub 2013/07/09 PMID: 23830661
    • Heppner HJ, Cornel S, Peter W, Philipp B, Katrin S. Infections in the elderly. Critical care clinics. 2013; 29(3):757-74. Epub 2013/07/09. doi: 10.1016/j.ccc.2013.03.016 PMID: 23830661.
    • (2013) Critical Care Clinics , vol.29 , Issue.3 , pp. 757-774
    • Heppner, H.J.1    Cornel, S.2    Peter, W.3    Philipp, B.4    Katrin, S.5
  • 5
    • 84893139550 scopus 로고    scopus 로고
    • Severe sepsis and septic shock in the elderly: An overview
    • Epub 2012/02/04 PMID: 24701398; PubMed Central PMCID: PMC3956061
    • Nasa P, Juneja D, Singh O. Severe sepsis and septic shock in the elderly: An overview. World journal of critical care medicine. 2012; 1(1):23-30. Epub 2012/02/04. doi: 10.5492/wjccm.v1.i1.23 PMID: 24701398; PubMed Central PMCID: PMC3956061.
    • (2012) World Journal of Critical Care Medicine , vol.1 , Issue.1 , pp. 23-30
    • Nasa, P.1    Juneja, D.2    Singh, O.3
  • 7
    • 0036017470 scopus 로고    scopus 로고
    • The aging of the immune system
    • Epub 2002/06/25 PMID: 12078483
    • Grubeck-Loebenstein B, Wick G. The aging of the immune system. Advances in immunology. 2002; 80:243-84. Epub 2002/06/25 PMID: 12078483.
    • (2002) Advances in Immunology , vol.80 , pp. 243-284
    • Grubeck-Loebenstein, B.1    Wick, G.2
  • 9
    • 0034991099 scopus 로고    scopus 로고
    • Age-related changes in cytokine production by leukocytes in rhesus monkeys
    • Epub 2001/06/19 PMID: 11405390
    • Mascarucci P, Taub D, Saccani S, Paloma MA, Dawson H, Roth GS, et al. Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging. 2001; 13(2):85-94. Epub 2001/06/19 PMID: 11405390.
    • (2001) Aging , vol.13 , Issue.2 , pp. 85-94
    • Mascarucci, P.1    Taub, D.2    Saccani, S.3    Paloma, M.A.4    Dawson, H.5    Roth, G.S.6
  • 10
    • 0036197729 scopus 로고    scopus 로고
    • The effect of age on B cell development and humoral immunity
    • Epub 2002/04/27 PMID: 11974580
    • Weksler ME, Goodhardt M, Szabo P. The effect of age on B cell development and humoral immunity. Springer seminars in immunopathology. 2002; 24(1):35-52. Epub 2002/04/27 PMID: 11974580.
    • (2002) Springer Seminars in Immunopathology , vol.24 , Issue.1 , pp. 35-52
    • Weksler, M.E.1    Goodhardt, M.2    Szabo, P.3
  • 12
    • 0036838909 scopus 로고    scopus 로고
    • Cutting edge: Impaired Toll-like receptor expression and function in aging
    • Epub 2002/10/23 PMID: 12391175
    • Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J, Sambhara S. Cutting edge: impaired Toll-like receptor expression and function in aging. Journal of immunology. 2002; 169(9):4697-701. Epub 2002/10/23 PMID: 12391175.
    • (2002) Journal of Immunology , vol.169 , Issue.9 , pp. 4697-4701
    • Renshaw, M.1    Rockwell, J.2    Engleman, C.3    Gewirtz, A.4    Katz, J.5    Sambhara, S.6
  • 13
    • 84888320636 scopus 로고    scopus 로고
    • Age-dependent dysregulation of innate immunity
    • Epub 2013/10/26 PMID: 24157572; PubMed Central PMCID: PMC4096436
    • Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nature reviews Immunology. 2013; 13(12):875-87. Epub 2013/10/26. doi: 10.1038/nri3547 PMID: 24157572; PubMed Central PMCID: PMC4096436.
    • (2013) Nature Reviews Immunology , vol.13 , Issue.12 , pp. 875-887
    • Shaw, A.C.1    Goldstein, D.R.2    Montgomery, R.R.3
  • 14
    • 84874999665 scopus 로고    scopus 로고
    • The role of inflammation in age-related disease
    • Epub 2013/03/12 PMID: 23474627; PubMed Central PMCID: PMC3616233
    • Howcroft TK, Campisi J, Louis GB, Smith MT, Wise B, Wyss-Coray T, et al. The role of inflammation in age-related disease. Aging (Albany NY). 2013; 5(1):84-93. Epub 2013/03/12 PMID: 23474627; PubMed Central PMCID: PMC3616233.
    • (2013) Aging (Albany NY) , vol.5 , Issue.1 , pp. 84-93
    • Howcroft, T.K.1    Campisi, J.2    Louis, G.B.3    Smith, M.T.4    Wise, B.5    Wyss-Coray, T.6
  • 15
    • 0842309938 scopus 로고    scopus 로고
    • Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
    • Epub 2003/11/25 PMID: 14634059
    • Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. Journal of leukocyte biology. 2004; 75(2):342-9. Epub 2003/11/25. doi: 10.1189/jlb.0803389 PMID: 14634059.
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.2 , pp. 342-349
    • Boehmer, E.D.1    Goral, J.2    Faunce, D.E.3    Kovacs, E.J.4
  • 17
    • 0033975581 scopus 로고    scopus 로고
    • Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    • Epub 2000/02/26 PMID: 10689155
    • Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 2000; 18(16):1717-20. Epub 2000/02/26 PMID: 10689155.
    • (2000) Vaccine , vol.18 , Issue.16 , pp. 1717-1720
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 18
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • Epub 1993/09/01 PMID: 8370415
    • Fagiolo U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E, et al. Increased cytokine production in mononuclear cells of healthy elderly people. European journal of immunology. 1993; 23 (9):2375-8. Epub 1993/09/01. doi: 10.1002/eji.1830230950 PMID: 8370415.
    • (1993) European Journal of Immunology , vol.23 , Issue.9 , pp. 2375-2378
    • Fagiolo, U.1    Cossarizza, A.2    Scala, E.3    Fanales-Belasio, E.4    Ortolani, C.5    Cozzi, E.6
  • 19
    • 0028998934 scopus 로고
    • Hypercoagulability in centenarians: The paradox of successful aging
    • Epub 1995/06/01 PMID: 7756646
    • Mari D, Mannucci PM, Coppola R, Bottasso B, Bauer KA, Rosenberg RD. Hypercoagulability in centenarians: the paradox of successful aging. Blood. 1995; 85(11):3144-9. Epub 1995/06/01 PMID: 7756646.
    • (1995) Blood , vol.85 , Issue.11 , pp. 3144-3149
    • Mari, D.1    Mannucci, P.M.2    Coppola, R.3    Bottasso, B.4    Bauer, K.A.5    Rosenberg, R.D.6
  • 21
    • 84910682303 scopus 로고    scopus 로고
    • Sepsis in old age: Review of human and animal studies
    • Epub 2014/04/15 PMID: 24729938; PubMed Central PMCID: PMC3966671
    • Starr ME, Saito H. Sepsis in old age: review of human and animal studies. Aging and disease. 2014; 5(2):126-36. Epub 2014/04/15. doi: 10.14336/AD.2014.0500126 PMID: 24729938; PubMed Central PMCID: PMC3966671.
    • (2014) Aging and Disease , vol.5 , Issue.2 , pp. 126-136
    • Starr, M.E.1    Saito, H.2
  • 22
    • 0030038450 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced lethality and cytokine production in aged mice
    • Epub 1996/03/01 PMID: 8641780; PubMed Central PMCID: PMC173836
    • Tateda K, Matsumoto T, Miyazaki S, Yamaguchi K. Lipopolysaccharide-induced lethality and cytokine production in aged mice. Infection and immunity. 1996; 64(3):769-74. Epub 1996/03/01 PMID: 8641780; PubMed Central PMCID: PMC173836.
    • (1996) Infection and Immunity , vol.64 , Issue.3 , pp. 769-774
    • Tateda, K.1    Matsumoto, T.2    Miyazaki, S.3    Yamaguchi, K.4
  • 23
    • 0037775931 scopus 로고    scopus 로고
    • Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture
    • Epub 2003/04/12 PMID: 12688540
    • Turnbull IR, Wlzorek JJ, Osborne D, Hotchkiss RS, Coopersmith CM, Buchman TG. Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock. 2003; 19(4):310-3. Epub 2003/04/12 PMID: 12688540.
    • (2003) Shock , vol.19 , Issue.4 , pp. 310-313
    • Turnbull, I.R.1    Wlzorek, J.J.2    Osborne, D.3    Hotchkiss, R.S.4    Coopersmith, C.M.5    Buchman, T.G.6
  • 25
    • 78249282915 scopus 로고    scopus 로고
    • The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia
    • Epub 2010/11/19 PMID: 21085465; PubMed Central PMCID: PMC2973976
    • Kale S, Yende S, Kong L, Perkins A, Kellum JA, Newman AB, et al. The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia. PloS one. 2010; 5(11): e13852. Epub 2010/11/19. doi: 10.1371/journal.pone.0013852 PMID: 21085465; PubMed Central PMCID: PMC2973976.
    • (2010) PloS One , vol.5 , Issue.11
    • Kale, S.1    Yende, S.2    Kong, L.3    Perkins, A.4    Kellum, J.A.5    Newman, A.B.6
  • 26
    • 61349152991 scopus 로고    scopus 로고
    • Community-acquired pneumonia in older patients: Does age influence systemic cytokine levels in community-acquired pneumonia?
    • Epub 2009/03/11 PMID: 19272082
    • Kelly E, MacRedmond RE, Cullen G, Greene CM, McElvaney NG, O'Neill SJ. Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia? Respirology. 2009; 14(2):210-6. Epub 2009/03/11. doi: 10.1111/j.1440-1843.2008.01423.x PMID: 19272082.
    • (2009) Respirology , vol.14 , Issue.2 , pp. 210-216
    • Kelly, E.1    MacRedmond, R.E.2    Cullen, G.3    Greene, C.M.4    McElvaney, N.G.5    O'Neill, S.J.6
  • 27
    • 84879247972 scopus 로고    scopus 로고
    • Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness
    • Epub 2012/03/08 PMID: 22396897; PubMed Central PMCID: PMC3295067
    • Kale SS, Yende S. Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness. Aging and disease. 2011; 2(6):501-11. Epub 2012/03/08 PMID: 22396897; PubMed Central PMCID: PMC3295067.
    • (2011) Aging and Disease , vol.2 , Issue.6 , pp. 501-511
    • Kale, S.S.1    Yende, S.2
  • 28
    • 84900395915 scopus 로고    scopus 로고
    • Expanding roles of neutrophils in aging hosts
    • Epub 2014/04/30 PMID: 24776646
    • Tseng CW, Liu GY. Expanding roles of neutrophils in aging hosts. Current opinion in immunology. 2014; 29C:43-8. Epub 2014/04/30. doi: 10.1016/j.coi.2014.03.009 PMID: 24776646.
    • (2014) Current Opinion in Immunology , vol.29 C , pp. 43-48
    • Tseng, C.W.1    Liu, G.Y.2
  • 29
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Epub 1992/06/01 1303622
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992; 101(6):1644-55. Epub 1992/06/01 1303622.
    • (1992) Chest , vol.101 , Issue.6 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6
  • 30
    • 0036898577 scopus 로고    scopus 로고
    • Microarray data normalization and transformation
    • Epub 2002/11/28 PMID: 12454644
    • Quackenbush J. Microarray data normalization and transformation. Nature genetics. 2002; 32 Suppl:496-501. Epub 2002/11/28. doi: 10.1038/ng1032 PMID: 12454644.
    • (2002) Nature Genetics , vol.32 , pp. 496-501
    • Quackenbush, J.1
  • 31
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Epub 2001/04/20 PMID: 11309499; PubMed Central PMCID: PMC33173
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(9):5116-21. Epub 2001/04/20. doi: 10.1073/pnas.091062498 PMID: 11309499; PubMed Central PMCID: PMC33173.
    • Proceedings of the National Academy of Sciences of the United States of America. 2001 , vol.98 , Issue.9 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 32
    • 33751006151 scopus 로고    scopus 로고
    • RankProd: A bioconductor package for detecting differentially expressed genes in meta-analysis
    • Epub 2006/09/20 PMID: 16982708
    • Hong F, Breitling R, McEntee CW, Wittner BS, Nemhauser JL, Chory J. RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis. Bioinformatics. 2006; 22(22):2825-7. Epub 2006/09/20. doi: 10.1093/bioinformatics/btl476 PMID: 16982708.
    • (2006) Bioinformatics , vol.22 , Issue.22 , pp. 2825-2827
    • Hong, F.1    Breitling, R.2    McEntee, C.W.3    Wittner, B.S.4    Nemhauser, J.L.5    Chory, J.6
  • 33
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Epub 2004/10/06 PMID: 15461798; PubMed Central PMCID: PMC545600
    • Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome biology. 2004; 5(10):R80. Epub 2004/10/06. doi: 10.1186/gb-2004-5-10-r80 PMID: 15461798; PubMed Central PMCID: PMC545600.
    • (2004) Genome Biology , vol.5 , Issue.10 , pp. R80
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5    Dudoit, S.6
  • 34
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Epub 2002/02/16 PMID: 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25(4):402-8. Epub 2002/02/16. doi: 10.1006/meth.2001.1262 PMID: 11846609.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 35
    • 34250189924 scopus 로고    scopus 로고
    • Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription
    • Epub 2007/03/28 PMID: 17386095; PubMed Central PMCID: PMC1868932
    • Nakaya HI, Amaral PP, Louro R, Lopes A, Fachel AA, Moreira YB, et al. Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. Genome biology. 2007; 8(3):R43. Epub 2007/03/28. doi: 10.1186/gb-2007-8-3-r43 PMID: 17386095; PubMed Central PMCID: PMC1868932.
    • (2007) Genome Biology , vol.8 , Issue.3 , pp. R43
    • Nakaya, H.I.1    Amaral, P.P.2    Louro, R.3    Lopes, A.4    Fachel, A.A.5    Moreira, Y.B.6
  • 36
    • 84865727393 scopus 로고    scopus 로고
    • The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
    • Epub 2012/09/08 PMID: 22955988; PubMed Central PMCID: PMC3431493
    • Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome research. 2012; 22(9):1775-89. Epub 2012/09/08. doi: 10.1101/gr.132159.111 PMID: 22955988; PubMed Central PMCID: PMC3431493.
    • (2012) Genome Research , vol.22 , Issue.9 , pp. 1775-1789
    • Derrien, T.1    Johnson, R.2    Bussotti, G.3    Tanzer, A.4    Djebali, S.5    Tilgner, H.6
  • 38
    • 84864801367 scopus 로고    scopus 로고
    • Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis
    • Epub 2012/07/17 PMID: 22798676
    • Kim SD, Kim HJ, Shim JW, Lee HY, Lee SK, Kwon S, et al. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. Journal of immunology. 2012; 189(4):2000-5. Epub 2012/07/17. doi: 10.4049/jimmunol.1200635 PMID: 22798676.
    • (2012) Journal of Immunology , vol.189 , Issue.4 , pp. 2000-2005
    • Kim, S.D.1    Kim, H.J.2    Shim, J.W.3    Lee, H.Y.4    Lee, S.K.5    Kwon, S.6
  • 39
    • 84887606966 scopus 로고    scopus 로고
    • Therapeutic potential of targeting IL-17 and IL-23 in sepsis
    • Epub 2013/02/02 PMID: 23369364; PubMed Central PMCID: PMC3552565
    • Bosmann M, Ward PA. Therapeutic potential of targeting IL-17 and IL-23 in sepsis. Clinical and translational medicine. 2012; 1(1):4. Epub 2013/02/02. doi: 10.1186/2001-1326-1-4 PMID: 23369364; PubMed Central PMCID: PMC3552565.
    • (2012) Clinical and Translational Medicine , vol.1 , Issue.1 , pp. 4
    • Bosmann, M.1    Ward, P.A.2
  • 40
    • 84877973388 scopus 로고    scopus 로고
    • Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3
    • Epub 2013/05/16 PMID: 23674823
    • Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, et al. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Science signaling. 2013; 6(275):ra35. Epub 2013/05/16. doi: 10.1126/scisignal.2003708 PMID: 23674823.
    • (2013) Science Signaling , vol.6 , Issue.275 , pp. ra35
    • Zhong, B.1    Liu, X.2    Wang, X.3    Liu, X.4    Li, H.5    Darnay, B.G.6
  • 41
    • 84879768651 scopus 로고    scopus 로고
    • Steroid responses in sepsis: Some novel thinking that may provide new insight
    • Epub 2013/07/06 PMID: 23826670; PubMed Central PMCID: PMC3706853
    • Deutschman CS. Steroid responses in sepsis: some novel thinking that may provide new insight. Critical care. 2013; 17(3):147. Epub 2013/07/06. doi: 10.1186/cc12723 PMID: 23826670; PubMed Central PMCID: PMC3706853.
    • (2013) Critical Care , vol.17 , Issue.3 , pp. 147
    • Deutschman, C.S.1
  • 42
    • 84863936555 scopus 로고    scopus 로고
    • p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
    • Epub 2012/06/27 PMID: 22733747; PubMed Central PMCID: PMC3396476
    • Risco A, del Fresno C, Mambol A, Alsina-Beauchamp D, MacKenzie KF, Yang HT, et al. p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(28):11200-5. Epub 2012/06/27. doi: 10.1073/pnas.1207290109 PMID: 22733747; PubMed Central PMCID: PMC3396476.
    • (2012) Proceedings of the National Academy of Sciences of the United States of America , vol.109 , Issue.28 , pp. 11200-11205
    • Risco, A.1    Del Fresno, C.2    Mambol, A.3    Alsina-Beauchamp, D.4    MacKenzie, K.F.5    Yang, H.T.6
  • 43
    • 77954384233 scopus 로고    scopus 로고
    • Assessing the human immune system through blood transcriptomics
    • Epub 2010/07/14 PMID: 20619006; PubMed Central PMCID: PMC2895587
    • Chaussabel D, Pascual V, Banchereau J. Assessing the human immune system through blood transcriptomics. BMC biology. 2010; 8:84. Epub 2010/07/14. doi: 10.1186/1741-7007-8-84 PMID: 20619006; PubMed Central PMCID: PMC2895587.
    • (2010) BMC Biology , vol.8 , pp. 84
    • Chaussabel, D.1    Pascual, V.2    Banchereau, J.3
  • 44
    • 28944431651 scopus 로고    scopus 로고
    • Microarrays
    • Epub 2005/12/13 PMID: 16340418
    • Christie JD. Microarrays. Critical care medicine. 2005; 33(12 Suppl):S449-52. Epub 2005/12/13 PMID: 16340418.
    • (2005) Critical Care Medicine , vol.33 , Issue.12 , pp. S449-S452
    • Christie, J.D.1
  • 45
    • 67650470273 scopus 로고    scopus 로고
    • Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum
    • Epub 2009/03/28 PMID: 19325468; PubMed Central PMCID: PMC2747356
    • Wong HR, Cvijanovich N, Allen GL, Lin R, Anas N, Meyer K, et al. Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Critical care medicine. 2009; 37(5):1558-66. Epub 2009/03/28. doi: 10.1097/CCM.0b013e31819fcc08 PMID: 19325468; PubMed Central PMCID: PMC2747356.
    • (2009) Critical Care Medicine , vol.37 , Issue.5 , pp. 1558-1566
    • Wong, H.R.1    Cvijanovich, N.2    Allen, G.L.3    Lin, R.4    Anas, N.5    Meyer, K.6
  • 47
    • 47249122242 scopus 로고    scopus 로고
    • Validating the genomic signature of pediatric septic shock
    • Epub 2008/05/08 PMID: 18460642; PubMed Central PMCID: PMC2440641
    • Cvijanovich N, Shanley TP, Lin R, Allen GL, Thomas NJ, Checchia P, et al. Validating the genomic signature of pediatric septic shock. Physiological genomics. 2008; 34(1):127-34. Epub 2008/05/08. doi: 10.1152/physiolgenomics.00025.2008 PMID: 18460642; PubMed Central PMCID: PMC2440641.
    • (2008) Physiological Genomics , vol.34 , Issue.1 , pp. 127-134
    • Cvijanovich, N.1    Shanley, T.P.2    Lin, R.3    Allen, G.L.4    Thomas, N.J.5    Checchia, P.6
  • 48
    • 35348925444 scopus 로고    scopus 로고
    • Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock
    • Epub 2007/10/13 PMID: 17932561; PubMed Central PMCID: PMC2014731
    • Shanley TP, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, et al. Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Molecular medicine. 2007; 13(9-10):495-508. Epub 2007/10/13. doi: 10.2119/2007-00065.Shanley PMID: 17932561; PubMed Central PMCID: PMC2014731.
    • (2007) Molecular Medicine , vol.13 , Issue.9-10 , pp. 495-508
    • Shanley, T.P.1    Cvijanovich, N.2    Lin, R.3    Allen, G.L.4    Thomas, N.J.5    Doctor, A.6
  • 49
    • 67650683145 scopus 로고    scopus 로고
    • Gene-expression profiling of peripheral blood mononuclear cells in sepsis
    • Epub 2009/02/25 PMID: 19237892
    • Tang BM, McLean AS, Dawes IW, Huang SJ, Lin RC. Gene-expression profiling of peripheral blood mononuclear cells in sepsis. Critical care medicine. 2009; 37(3):882-8. Epub 2009/02/25. doi: 10.1097/CCM.0b013e31819b52fd PMID: 19237892.
    • (2009) Critical Care Medicine , vol.37 , Issue.3 , pp. 882-888
    • Tang, B.M.1    McLean, A.S.2    Dawes, I.W.3    Huang, S.J.4    Lin, R.C.5
  • 50
    • 84862908403 scopus 로고    scopus 로고
    • A genomic storm in critically injured humans
    • Epub 2011/11/24 PMID: 22110166; PubMed Central PMCID: PMC3244029
    • Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, et al. A genomic storm in critically injured humans. The Journal of experimental medicine. 2011; 208(13):2581-90. Epub 2011/11/24. doi: 10.1084/jem.20111354 PMID: 22110166; PubMed Central PMCID: PMC3244029.
    • (2011) The Journal of Experimental Medicine , vol.208 , Issue.13 , pp. 2581-2590
    • Xiao, W.1    Mindrinos, M.N.2    Seok, J.3    Cuschieri, J.4    Cuenca, A.G.5    Gao, H.6
  • 51
    • 0029903114 scopus 로고    scopus 로고
    • Sir Isaac Newton, sepsis, SIRS, and CARS
    • Epub 1996/07/01 PMID: 8674323
    • Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS. Critical care medicine. 1996; 24(7):1125-8. Epub 1996/07/01 PMID: 8674323.
    • (1996) Critical Care Medicine , vol.24 , Issue.7 , pp. 1125-1128
    • Bone, R.C.1
  • 53
    • 0030843156 scopus 로고    scopus 로고
    • Sepsis: A new hypothesis for pathogenesis of the disease process
    • Epub 1997/07/01 PMID: 9228382
    • Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 1997; 112(1):235-43. Epub 1997/07/01 PMID: 9228382.
    • (1997) Chest , vol.112 , Issue.1 , pp. 235-243
    • Bone, R.C.1    Grodzin, C.J.2    Balk, R.A.3
  • 54
    • 84897456058 scopus 로고    scopus 로고
    • Gene expression profiling in sepsis: Timing, tissue, and translational considerations
    • Epub 2014/02/20 PMID: 24548661; PubMed Central PMCID: PMC3976710
    • Maslove DM, Wong HR. Gene expression profiling in sepsis: timing, tissue, and translational considerations. Trends in molecular medicine. 2014; 20(4):204-13. Epub 2014/02/20. doi: 10.1016/j.molmed.2014.01.006 PMID: 24548661; PubMed Central PMCID: PMC3976710.
    • (2014) Trends in Molecular Medicine , vol.20 , Issue.4 , pp. 204-213
    • Maslove, D.M.1    Wong, H.R.2
  • 55
    • 84866908879 scopus 로고    scopus 로고
    • Identification of sepsis subtypes in critically ill adults using gene expression profiling
    • Epub 2012/10/06 PMID: 23036193; PubMed Central PMCID: PMC3682285
    • Maslove DM, Tang BM, McLean AS. Identification of sepsis subtypes in critically ill adults using gene expression profiling. Critical care. 2012; 16(5):R183. Epub 2012/10/06. doi: 10.1186/cc11667 PMID: 23036193; PubMed Central PMCID: PMC3682285.
    • (2012) Critical Care , vol.16 , Issue.5 , pp. R183
    • Maslove, D.M.1    Tang, B.M.2    McLean, A.S.3
  • 56
    • 84899853408 scopus 로고    scopus 로고
    • Patterns of gene expression in peripheral blood mononuclear cells and outcomes from patients with sepsis secondary to community acquired pneumonia
    • Epub 2014/03/29 PMID: 24667684; PubMed Central PMCID: PMC3965402
    • Severino P, Silva E, Baggio-Zappia GL, Brunialti MK, Nucci LA, Rigato O Jr., et al. Patterns of gene expression in peripheral blood mononuclear cells and outcomes from patients with sepsis secondary to community acquired pneumonia. PloS one. 2014; 9(3):e91886. Epub 2014/03/29. doi: 10.1371/journal.pone.0091886 PMID: 24667684; PubMed Central PMCID: PMC3965402.
    • (2014) PloS One , vol.9 , Issue.3
    • Severino, P.1    Silva, E.2    Baggio-Zappia, G.L.3    Brunialti, M.K.4    Nucci, L.A.5    Rigato, O.6
  • 57
    • 78650624395 scopus 로고    scopus 로고
    • Genome-wide transcription profiling of human sepsis: A systematic review
    • Epub 2010/12/31 PMID: 21190579; PubMed Central PMCID: PMC3219990
    • Tang BM, Huang SJ, McLean AS. Genome-wide transcription profiling of human sepsis: a systematic review. Critical care. 2010; 14(6):R237. Epub 2010/12/31. doi: 10.1186/cc9392 PMID: 21190579; PubMed Central PMCID: PMC3219990.
    • (2010) Critical Care , vol.14 , Issue.6 , pp. R237
    • Tang, B.M.1    Huang, S.J.2    McLean, A.S.3
  • 58
    • 34848876366 scopus 로고    scopus 로고
    • The use of gene-expression profiling to identify candidate genes in human sepsis
    • Epub 2007/06/19 PMID: 17575094
    • Tang BM, McLean AS, Dawes IW, Huang SJ, Lin RC. The use of gene-expression profiling to identify candidate genes in human sepsis. American journal of respiratory and critical care medicine. 2007; 176(7):676-84. Epub 2007/06/19. doi: 10.1164/rccm.200612-1819OC PMID: 17575094.
    • (2007) American Journal of Respiratory and Critical Care Medicine , vol.176 , Issue.7 , pp. 676-684
    • Tang, B.M.1    McLean, A.S.2    Dawes, I.W.3    Huang, S.J.4    Lin, R.C.5
  • 59
    • 77952495086 scopus 로고    scopus 로고
    • Mitochondrial function and dysfunction in sepsis
    • Epub 2010/04/07 PMID: 20364414
    • Wendel M, Heller AR. Mitochondrial function and dysfunction in sepsis. Wiener medizinische Wochenschrift. 2010; 160(5-6):118-23. Epub 2010/04/07. doi: 10.1007/s10354-010-0766-5 PMID: 20364414.
    • (2010) Wiener Medizinische Wochenschrift , vol.160 , Issue.5-6 , pp. 118-123
    • Wendel, M.1    Heller, A.R.2
  • 61
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • Epub 1997/04/25 PMID: 9111045
    • Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. The Journal of biological chemistry. 1997; 272(17):11369-77. Epub 1997/04/25 PMID: 9111045.
    • (1997) The Journal of Biological Chemistry , vol.272 , Issue.17 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 62
    • 79959412738 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in sepsis
    • Epub 2011/05/21 PMID: 21596843
    • Galley HF. Oxidative stress and mitochondrial dysfunction in sepsis. British journal of anaesthesia. 2011; 107(1):57-64. Epub 2011/05/21. doi: 10.1093/bja/aer093 PMID: 21596843.
    • (2011) British Journal of Anaesthesia , vol.107 , Issue.1 , pp. 57-64
    • Galley, H.F.1
  • 63
    • 80054852150 scopus 로고    scopus 로고
    • Oxidative stress, inflamm-aging and immunosenescence
    • Epub 2011/07/02 PMID: 21718814
    • Cannizzo ES, Clement CC, Sahu R, Follo C, Santambrogio L. Oxidative stress, inflamm-aging and immunosenescence. Journal of proteomics. 2011; 74(11):2313-23. Epub 2011/07/02. doi: 10.1016/j.jprot.2011.06.005 PMID: 21718814.
    • (2011) Journal of Proteomics , vol.74 , Issue.11 , pp. 2313-2323
    • Cannizzo, E.S.1    Clement, C.C.2    Sahu, R.3    Follo, C.4    Santambrogio, L.5
  • 64
    • 80051669923 scopus 로고    scopus 로고
    • Translational research involving oxidative stress and diseases of aging
    • Epub 2011/05/10 PMID: 21549833; PubMed Central PMCID: PMC3156308
    • Floyd RA, Towner RA, He T, Hensley K, Maples KR. Translational research involving oxidative stress and diseases of aging. Free radical biology & medicine. 2011; 51(5):931-41. Epub 2011/05/10. doi: 10.1016/j.freeradbiomed.2011.04.014 PMID: 21549833; PubMed Central PMCID: PMC3156308.
    • (2011) Free Radical Biology & Medicine , vol.51 , Issue.5 , pp. 931-941
    • Floyd, R.A.1    Towner, R.A.2    He, T.3    Hensley, K.4    Maples, K.R.5
  • 65
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Epub 2004/05/28 PMID: 15164064
    • Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004; 429(6990):417-23. Epub 2004/05/28. doi: 10.1038/nature02517 PMID: 15164064.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3    Spelbrink, J.N.4    Rovio, A.T.5    Bruder, C.E.6
  • 66
    • 84885457151 scopus 로고    scopus 로고
    • TGF-beta: Guardian of T cell function
    • Epub 2013/10/08 PMID: 24098055; PubMed Central PMCID: PMC3856438
    • Oh SA, Li MO. TGF-beta: guardian of T cell function. Journal of immunology. 2013; 191(8):3973-9. Epub 2013/10/08. doi: 10.4049/jimmunol.1301843 PMID: 24098055; PubMed Central PMCID: PMC3856438.
    • (2013) Journal of Immunology , vol.191 , Issue.8 , pp. 3973-3979
    • Oh, S.A.1    Li, M.O.2
  • 67
    • 84907998323 scopus 로고    scopus 로고
    • TGFbeta in T cell biology and tumor immunity: Angel or devil?
    • Epub 2014/08/27 PMID: 25156420
    • Tu E, Chia PZ, Chen W. TGFbeta in T cell biology and tumor immunity: Angel or devil? Cytokine &growth factor reviews. 2014. Epub 2014/08/27. doi: 10.1016/j.cytogfr.2014.07.014 PMID: 25156420.
    • (2014) Cytokine &growth Factor Reviews
    • Tu, E.1    Chia, P.Z.2    Chen, W.3
  • 68
    • 84855782582 scopus 로고    scopus 로고
    • Neutralization of interleukin-10 or transforming growth factor-beta decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival
    • Epub 2011/10/11 PMID: 21982068
    • Hiraki S, Ono S, Tsujimoto H, Kinoshita M, Takahata R, Miyazaki H, et al. Neutralization of interleukin-10 or transforming growth factor-beta decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival. Surgery. 2012; 151(2):313-22. Epub 2011/10/11. doi: 10.1016/j.surg.2011.07.019 PMID: 21982068.
    • (2012) Surgery , vol.151 , Issue.2 , pp. 313-322
    • Hiraki, S.1    Ono, S.2    Tsujimoto, H.3    Kinoshita, M.4    Takahata, R.5    Miyazaki, H.6
  • 69
    • 84896973126 scopus 로고    scopus 로고
    • TGF-beta activation and function in immunity
    • Epub 2013/12/10 PMID: 24313777; PubMed Central PMCID: PMC4010192
    • Travis MA, Sheppard D. TGF-beta activation and function in immunity. Annual review of immunology. 2014; 32:51-82. Epub 2013/12/10. doi: 10.1146/annurev-immunol-032713-120257 PMID: 24313777; PubMed Central PMCID: PMC4010192.
    • (2014) Annual Review of Immunology , vol.32 , pp. 51-82
    • Travis, M.A.1    Sheppard, D.2
  • 70
    • 84922480864 scopus 로고    scopus 로고
    • Assessment of phagocytic activity of cultured macrophages using fluorescence microscopy and flow cytometry
    • Epub 2014/06/09 PMID: 24908301
    • Sharma L, Wu W, Dholakiya SL, Gorasiya S, Wu J, Sitapara R, et al. Assessment of phagocytic activity of cultured macrophages using fluorescence microscopy and flow cytometry. Methods in molecular biology. 2014; 1172:137-45. Epub 2014/06/09. doi: 10.1007/978-1-4939-0928-5-12 PMID: 24908301.
    • (2014) Methods in Molecular Biology , vol.1172 , pp. 137-145
    • Sharma, L.1    Wu, W.2    Dholakiya, S.L.3    Gorasiya, S.4    Wu, J.5    Sitapara, R.6
  • 71
    • 84897413809 scopus 로고    scopus 로고
    • Wnt signaling and the control of human stem cell fate
    • Epub 2013/12/11 PMID: 24323281
    • Van Camp JK, Beckers S, Zegers D, Van Hul W. Wnt signaling and the control of human stem cell fate. Stem cell reviews. 2014; 10(2):207-29. Epub 2013/12/11. doi: 10.1007/s12015-013-9486-8 PMID: 24323281.
    • (2014) Stem Cell Reviews , vol.10 , Issue.2 , pp. 207-229
    • Van Camp, J.K.1    Beckers, S.2    Zegers, D.3    Van Hul, W.4
  • 73
    • 0036230333 scopus 로고    scopus 로고
    • The aging of lympho-hematopoietic stem cells
    • Epub 2002/03/29 PMID: 11919569
    • Geiger H, Van Zant G. The aging of lympho-hematopoietic stem cells. Nature immunology. 2002; 3 (4):329-33. Epub 2002/03/29. doi: 10.1038/ni0402-329 PMID: 11919569.
    • (2002) Nature Immunology , vol.3 , Issue.4 , pp. 329-333
    • Geiger, H.1    Van Zant, G.2
  • 74
    • 84888021623 scopus 로고    scopus 로고
    • A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
    • Epub 2013/10/22 PMID: 24141946; PubMed Central PMCID: PMC4078992
    • Florian MC, Nattamai KJ, Dorr K, Marka G, Uberle B, Vas V, et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature. 2013; 503(7476):392-6. Epub 2013/10/22. doi: 10.1038/nature12631 PMID: 24141946; PubMed Central PMCID: PMC4078992.
    • (2013) Nature , vol.503 , Issue.7476 , pp. 392-396
    • Florian, M.C.1    Nattamai, K.J.2    Dorr, K.3    Marka, G.4    Uberle, B.5    Vas, V.6
  • 75
    • 84871994057 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production
    • Epub 2012/11/06 PMID: 23124852
    • Zhang DY, Pan Y, Zhang C, Yan BX, Yu SS, Wu DL, et al. Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production. Molecular and cellular biochemistry. 2013; 374(1-2):13-20. Epub 2012/11/06. doi: 10.1007/s11010-012-1498-1 PMID: 23124852.
    • (2013) Molecular and Cellular Biochemistry , vol.374 , Issue.1-2 , pp. 13-20
    • Zhang, D.Y.1    Pan, Y.2    Zhang, C.3    Yan, B.X.4    Yu, S.S.5    Wu, D.L.6
  • 76
    • 80054730000 scopus 로고    scopus 로고
    • Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features
    • Epub 2011/09/16 PMID: 21918189
    • Valencia J, Hernandez-Lopez C, Martinez VG, Hidalgo L, Zapata AG, Vicente A, et al. Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features. Journal of immunology. 2011; 187(8):4129-39. Epub 2011/09/16. doi: 10.4049/jimmunol.1101243 PMID: 21918189.
    • (2011) Journal of Immunology , vol.187 , Issue.8 , pp. 4129-4139
    • Valencia, J.1    Hernandez-Lopez, C.2    Martinez, V.G.3    Hidalgo, L.4    Zapata, A.G.5    Vicente, A.6
  • 77
    • 84904967098 scopus 로고    scopus 로고
    • Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells
    • Epub 2014/06/04 PMID: 24889652
    • Khoo ML, Carlin SM, Lutherborrow MA, Jayaswal V, Ma DD, Moore JJ. Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells. Aging cell. 2014; 13(4):744-54. Epub 2014/06/04. doi: 10.1111/acel.12229 PMID: 24889652.
    • (2014) Aging Cell , vol.13 , Issue.4 , pp. 744-754
    • Khoo, M.L.1    Carlin, S.M.2    Lutherborrow, M.A.3    Jayaswal, V.4    Ma, D.D.5    Moore, J.J.6
  • 78
    • 84922373615 scopus 로고    scopus 로고
    • The Wnt/-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
    • Epub 2014/08/20 PMID: 25136145; PubMed Central PMCID: PMC4127235
    • Silva-Garcia O, Valdez-Alarcon JJ, Baizabal-Aguirre VM. The Wnt/-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria. Mediators of inflammation. 2014; 2014:310183. Epub 2014/08/20. doi: 10.1155/2014/310183 PMID: 25136145; PubMed Central PMCID: PMC4127235.
    • (2014) Mediators of Inflammation , vol.2014 , pp. 310183
    • Silva-Garcia, O.1    Valdez-Alarcon, J.J.2    Baizabal-Aguirre, V.M.3
  • 79
    • 84877012460 scopus 로고    scopus 로고
    • Neuropeptides in sepsis: From brain pathology to systemic inflammation
    • Epub 2013/04/16 PMID: 23583479
    • Pinheiro da Silva F, Machado MC, Velasco IT. Neuropeptides in sepsis: from brain pathology to systemic inflammation. Peptides. 2013; 44:135-8. Epub 2013/04/16. doi: 10.1016/j.peptides.2013.03.029 PMID: 23583479.
    • (2013) Peptides , vol.44 , pp. 135-138
    • Pinheiro Da Silva, F.1    Machado, M.C.2    Velasco, I.T.3
  • 80
    • 84870056899 scopus 로고    scopus 로고
    • Nerve growth factor: From the early discoveries to the potential clinical use
    • Epub 2012/11/30 PMID: 23190582; PubMed Central PMCID: PMC3543237
    • Aloe L, Rocco ML, Bianchi P, Manni L. Nerve growth factor: from the early discoveries to the potential clinical use. Journal of translational medicine. 2012; 10:239. Epub 2012/11/30. doi: 10.1186/1479-5876-10-239 PMID: 23190582; PubMed Central PMCID: PMC3543237.
    • (2012) Journal of Translational Medicine , vol.10 , pp. 239
    • Aloe, L.1    Rocco, M.L.2    Bianchi, P.3    Manni, L.4
  • 81
    • 84872171095 scopus 로고    scopus 로고
    • Blockage of nerve growth factor modulates T cell responses and inhibits allergic inflammation in a mouse model of asthma
    • Epub 2012/08/09 PMID: 22871964
    • Shi Y, Jin Y, Guo W, Chen L, Liu C, Lv X. Blockage of nerve growth factor modulates T cell responses and inhibits allergic inflammation in a mouse model of asthma. Inflammation research: official journal of the European Histamine Research Society [et al]. 2012; 61(12):1369-78. Epub 2012/08/09. doi: 10.1007/s00011-012-0538-3 PMID: 22871964.
    • (2012) Inflammation Research: Official Journal of the European Histamine Research Society [Et Al] , vol.61 , Issue.12 , pp. 1369-1378
    • Shi, Y.1    Jin, Y.2    Guo, W.3    Chen, L.4    Liu, C.5    Lv, X.6
  • 82
    • 84881107305 scopus 로고    scopus 로고
    • Nerve growth factor: Basic studies and possible therapeutic applications
    • Epub 2013/06/20 PMID: 23777359
    • Manni L, Rocco ML, Bianchi P, Soligo M, Guaragna M, Barbaro SP, et al. Nerve growth factor: basic studies and possible therapeutic applications. Growth factors. 2013; 31(4):115-22. Epub 2013/06/20. doi: 10.3109/08977194.2013.804073 PMID: 23777359.
    • (2013) Growth Factors , vol.31 , Issue.4 , pp. 115-122
    • Manni, L.1    Rocco, M.L.2    Bianchi, P.3    Soligo, M.4    Guaragna, M.5    Barbaro, S.P.6
  • 84
    • 37149029370 scopus 로고    scopus 로고
    • Calcium signaling
    • Epub 2007/12/18 PMID: 18083096
    • Clapham DE. Calcium signaling. Cell. 2007; 131(6):1047-58. Epub 2007/12/18. doi: 10.1016/j.cell.2007.11.028 PMID: 18083096.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1047-1058
    • Clapham, D.E.1
  • 85
    • 84884169197 scopus 로고    scopus 로고
    • Immunosenescence: A product of the environment?
    • Epub 2013/07/03 PMID: 23809359
    • Su DM, Aw D, Palmer DB. Immunosenescence: a product of the environment? Current opinion in immunology. 2013; 25(4):498-503. Epub 2013/07/03. doi: 10.1016/j.coi.2013.05.018 PMID: 23809359.
    • (2013) Current Opinion in Immunology , vol.25 , Issue.4 , pp. 498-503
    • Su, D.M.1    Aw, D.2    Palmer, D.B.3
  • 86
    • 84902344060 scopus 로고    scopus 로고
    • Aging and immunity - Impact of behavioral intervention
    • Epub 2013/12/10 PMID: 24315935
    • Muller L, Pawelec G. Aging and immunity - impact of behavioral intervention. Brain, behavior, and immunity. 2014; 39:8-22. Epub 2013/12/10. doi: 10.1016/j.bbi.2013.11.015 PMID: 24315935.
    • (2014) Brain, Behavior, and Immunity , vol.39 , pp. 8-22
    • Muller, L.1    Pawelec, G.2
  • 87
    • 84910073163 scopus 로고    scopus 로고
    • MicroRNAs as Mediators of the Ageing Process
    • Epub 2014/08/21 PMID: 25140888
    • Harries LW. MicroRNAs as Mediators of the Ageing Process. Genes. 2014; 5(3):656-70. Epub 2014/08/21. doi: 10.3390/genes5030656 PMID: 25140888.
    • (2014) Genes , vol.5 , Issue.3 , pp. 656-670
    • Harries, L.W.1
  • 88
    • 84907653055 scopus 로고    scopus 로고
    • The epigenetic tracks of aging
    • Epub 2014/09/11 PMID: 25205717
    • Weidner CI, Wagner W. The epigenetic tracks of aging. Biological chemistry. 2014. Epub 2014/09/11. doi: 10.1515/hsz-2014-0180 PMID: 25205717.
    • (2014) Biological Chemistry
    • Weidner, C.I.1    Wagner, W.2
  • 89
    • 63549135460 scopus 로고    scopus 로고
    • Meta-analysis of age-related gene expression profiles identifies common signatures of aging
    • Epub 2009/02/05 PMID: 19189975; PubMed Central PMCID: PMC2732303
    • de Magalhaes JP, Curado J, Church GM. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics. 2009; 25(7):875-81. Epub 2009/02/05. doi: 10.1093/bioinformatics/btp073 PMID: 19189975; PubMed Central PMCID: PMC2732303.
    • (2009) Bioinformatics , vol.25 , Issue.7 , pp. 875-881
    • De Magalhaes, J.P.1    Curado, J.2    Church, G.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.