Immune effects of autoantigen-associated RNA

Advances in Experimental Medicine and Biology

Volumn 598, Issue , 2007, Pages 293-308

  Greidinger, Eric L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; C REACTIVE PROTEIN; IMMUNOGLOBULIN; PENTRAXIN; RNA; TOLL LIKE RECEPTOR;

BONE MARROW CELL; CONFERENCE PAPER; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNITY; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 84934441476     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-71767-8_21     Document Type: Conference Paper

References (84)

1. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413, 732-738.
2. Barath S., Sipka S., Aleksza M., Szegedi A., Szodoray .P, Vegh J., Szegedi G., Bodolay E. (2006) Regulatory T cells in peripheral blood of patients with mixed connective tissue disease. Scand. J. Rheumatol. 35, 300-304.
3. Barrat F.J., Meeker T., Gregorio J., Chan J.H., Uematsu S., Akira S., Chang B., Duramad O., Coffman R.L. (2005) Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med. 202, 1131-1139.
4. Blander JM, Medzhitov R. (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808-812.
5. Bonfa E., Elkon K.B. (1986) Clinical and serologic associations of the antiribosomal P protein antibody. Arthritis Rheum. 29, 981-985.
6. Boule M.W., Broughton C., Mackay F., Akira S., Marshak-Rothstein A., Rifkin I.R. (2004) Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199, 1631-1640.
7. Branlant C., Krol A., Ebel J.P., Lazar E., Gallinaro H., Jacob M., Sri-Widada J., Jeanteur P. (1980) Nucleotide sequences of nuclear U1A RNAs from chicken, rat and man. Nucleic Acids Res. 8, 4143-4154.
8. Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., Shlomchik M.J. (2006) Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25, 417-428.
9. Cohen P.L., Caricchio R., Abraham V., Camenisch T.D., Jennette J.C., Roubey R.A., Earp H.S., Matsushima G., Reap E.A. (2002) Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J. Exp. Med. 196, 135-140.
10. de Bouteiller O., Merck E., Hasan U.A., Hubac S., Benguigui B., Trinchieri G., Bates E.E., Caux C. (2005) Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J. Biol. Chem. 280, 38133-38145.
11. Degen W.G., Aarssen Y., Pruijn G.J., Utz P.J., van Venrooij W.J. (2000) The fate of U1 snRNP during anti-Fas induced apoptosis: specific cleavage of the U1 snRNA molecule. Cell Death Differ. 7, 70-79.
12. Deshmukh U.S., Kannapell C.C., Fu S.M. (2002) Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins. J. Immunol. 168, 5326-5332.
13. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. (2001) Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med. 193, 233-238.
14. Du Clos T.W. (1989) C-reactive protein reacts with the U1 small nuclear ribonucleoprotein. J. Immunol. 143, 2553-2559.
15. Edwards A.D., Diebold S.S., Slack E.M., Tomizawa H., Hemmi H., Kaisho T., Akira S., Reis e Sousa C. (2003) Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol. 33, 827-833.
16. El-Hefnawy T., Raja S., Kelly .L, Bigbee W.L., Kirkwood J.M., Luketich J.D., Godfrey T.E. (2004) Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin. Chem. 50, 564-573.
17. Fitzgerald K.A., Rowe D.C., Barnes B.J., Caffrey D.R., Visintin A., Latz E., Monks B., Pitha P.M., Golenbock D.T. (2003) LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055.
18. Fu Y., Xie C., Chen J., Zhu J., Zhou H., Thomas J., Zhou X.J., Mohan C. (2006) Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J. Immunol. 176, 632-639.
19. Gorden K.B., Gorski K.S., Gibson S.J., Kedl R.M., Kieper W.C., Qiu X., Tomai M.A., Alkan S.S., Vasilakos J.P. (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J. Immunol. 174, 1259-1268.
20. Gorden K.K., Qiu X.X., Binsfeld C.C., Vasilakos J.P., Alkan S.S.. (2006) Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides. J. Immunol. 177, 6584-6587.
21. Gottenberg J.E., Cagnard N., Lucchesi C., Letourneur .F, Mistou S., Lazure T., Jacques S., Ba N., Ittah M., Lepajolec C., Labetoulle M., Ardizzone M., Sibilia J., Fournier C., Chiocchia G., Mariette X. (2006) Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. Proc. Natl. Acad. Sci. U S A. 103, 2770-5.
22. Greidinger E.L. (2001) Apoptosis in lupus pathogenesis. Front. Biosci. 6, D1392-D1402.
23. Greidinger E.L., Zang Y., Jaimes K., Hogenmiller S., Nassiri M., Bejarano P., Barber G.N., Hoffman R.W. (2006) A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen. Arthritis Rheum. 54, 661-669.
24. Hart O.M., Athie-Morales V., O'Connor G.M., Gardiner C.M. (2005) TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J. Immunol. 175, 1636-1642.
25. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., Bauer S. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526-1529.
26. Hewson C.A., Jardine A., Edwards M..R, Laza-Stanca V., Johnston S.L. (2005) Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells. J Virol. 79, 12273-12279.
27. Hoffman R.W., Gazitt T., Foecking M.F., Ortmann R.A., Misfeldt M., Jorgenson R., Young S.L., Greidinger E.L. (2004) U1 RNA induces innate immunity signaling. Arthritis Rheum. 50, 2891-2896.
28. Horsmans Y., Berg T., Desager J.P., Mueller T., Schott E., Fletcher S.P., Steffy K.R., Bauman L.A., Kerr B.M., Averett D.R. (2005) Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology 42, 724-7231.
29. Hubert F.X., Voisine C., Louvet C., Heslan J.M., Ouabed A., Heslan M., Josien R. (2006) Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets. J. Immunol. 177, 1007-1016.
30. Ito T., Amakawa R., Kaisho T., Hemmi H., Tajima K., Uehira K., Ozaki Y., Tomizawa H., Akira S., Fukuhara S. (2002) Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195, 1507-1512.
31. Jakymiw A., Ikeda K., Fritzler M.J., Reeves W.H., Satoh M., Chan E.K. (2006) Autoimmune targeting of key components of RNA interference. Arthritis Res. Ther. 8, R87.
32. Kao A.H., Lacomis D., Lucas M., Fertig N., Oddis C.V. (2004) Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy. Arthritis Rheum. 50, 209-215.
33. Kariko K., Buckstein M, Ni H., Weissman D. (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175.
34. Kariko K., Ni H., Capodici J., Lamphier M., Weissman D. (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J. Biol. Chem. 279, 12542-12550.
35. Kato H., Takeuchi O., Sato S., Yoneyama M., Yamamoto M., Matsui K., Uematsu S., Jung A., Kawai T., Ishii K.J., Yamaguchi O., Otsu K., Tsujimura T., Koh C.S., Reis e Sousa C., Matsuura Y., Fujita T., Akira S. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105.
36. Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH. (2006) "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60. Arthritis Rheum. 54, 1557-1567.
37. Kirou K.A., Lee C., George S., Louca K., Peterson M.G., Crow M.K. (2005) Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis Rheum. 52, 1491-1503.
38. Koffler D., Faiferman I., Gerber M.A. (1977) Radioimmunoassay for antibodies to cytoplasmic ribosomes in human serum. Science 198, 741-3.
39. Laderach D., Koutouzov S., Bach J.F., Yamamoto A.M. (2003) Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice. J. Autoimmun. 20, 161-170.
40. Lau C.M., Broughton C., Tabor A.S., Akira S., Flavell R.A., Mamula M.J., Christensen S.R., Shlomchik M.J., Viglianti G.A., Rifkin I.R., Marshak-Rothstein A. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202, 1171-1177.
41. Le Goffic R, Balloy V, Lagranderie M, Alexopoulou L, Escriou N, Flavell R, Chignard M, Si-Tahar M. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog. 2, e53.
42. Lovgren T., Eloranta M.L., Kastner B., Wahren-Herlenius M., Alm G.V., Ronnblom L. (2006) Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjogren's syndrome autoantigen-associated RNA. Arthritis Rheum. 54, 1917-1927.
43. Marguerie C., Bunn C.C., Beynon H.L., Bernstein R.M., Hughes J.M., So A.K., Walport M.J. (1990) Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q. J. Med. 77, 1019-1038.
44. Marshall B.C., McPherson R.A., Greidinger E., Hoffman R., Adler S.P. (2002) Lack of autoantibody production associated with cytomegalovirus infection. Arthritis Res. 4, R6.
45. Mathews M.B., Bernstein R.M. (1983) Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity. Nature 304, 177-179.
46. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293, 1364-1369.
47. McClain M.T., Heinlen L.D., Dennis G.J., Roebuck J., Harley J.B., James J.A. (2005) Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat. Med. 11, 85-89.
48. McGaha T.L., Sorrentino B., Ravetch J.V.. (2005) Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science 307, 590-593.
49. Mineo C., Gormley A.K., Yuhanna I.S., Osborne-Lawrence S., Gibson L.L., Hahner L., Shohet R.V., Black S., Salmon J.E., Samols D., Karp D.R., Thomas G.D., Shaul P.W. (2005) FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res. 97, 1124-1131.
50. Mold C., Du Clos T.W. (2006) C-reactive protein increases cytokine responses to Streptococcus pneumoniae through interactions with Fc gamma receptors. J Immunol 176, 7598-604.
51. Monneaux F., Briand J.P., Muller S. (2000) B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Eur. J. Immunol. 30, 2191-2200.
52. Monneaux F., Dumortier H., Steiner G., Briand J.P., Muller S. (2001) Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB x NZW)F(1) lupus mice. Int Immunol. 13, 1155-1163.
53. O'Hanlon T.P., Carrick D.M., Targoff I.N., Arnett F.C., Reveille J.D., Carrington M., Gao X., Oddis C.V., Morel P.A., Malley J.D., Malley K., Shamim E.A., Rider L.G., Chanock S.J., Foster C.B., Bunch T., Blackshear P.J., Plotz P.H., Love L.A., Miller F.W. (2006) Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. Medicine (Baltimore). 85, 111-127.
54. Pasare C., Medzhitov R. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 2003 Feb 14;299(5609):1033-1036.
55. Pasare C., Medzhitov R. (2005) Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560:11-18.
56. Potter P.K., Cortes-Hernandez J., Quartier P., Botto M., Walport M.J. (2003) Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells. J. Immunol. 170, 3223-3232.
57. Raijmakers R., Renz M., Wiemann C., Egberts W.V., Seelig H.P., van Venrooij W.J., Pruijn G.J. (2004) PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. Arthritis Rheum. 50, 565-569.
58. Reichlin M, Van Venrooij WJ. (1991) Autoantibodies to the URNP particles: relationship to clinical diagnosis and nephritis. Clin. Exp. Immunol. 83, 286-290.
59. Rodriguez W., Mold C., Marnell L.L., Hutt J., Silverman G.J., Tran D., Du Clos T.W.. Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein. Arthritis Rheum. 54, 325-335.
60. Rothenfusser S., Goutagny N., DiPerna G., Gong M., Monks B.G., Schoenemeyer A., Yamamoto M., Akira S., Fitzgerald K.A. (2005) The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol. 175, 5260-5268.
61. Scalapino K.J., Tang Q., Bluestone J.A., Bonyhadi M.L., Daikh D.I. (2006) Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J. Immunol. 177, 1451-1459.
62. Schlaepfer E., Audige A., Joller H., Speck R.F. (2006) TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection. J Immunol. 2006 Mar 1;176(5):2888-95.
63. Schoenemeyer A., Barnes B.J., Mancl M.E., Latz E., Goutagny N., Pitha P.M., Fitzgerald K.A., Golenbock D.T. (2005) The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J. Biol. Chem. 280, 17005-17012.
64. Schur, P.H. and Monroe, M. (1969) Antibodies to ribonucleic acid in systemic lupus erythematosus. Proc. Natl. Acad. Sci. U S A. 63, 1108-1112.
65. Setty Y.N., Pittman C.B., Mahale A.S., Greidinger E.L., Hoffman R.W. (2002) Sicca symptoms and anti-SSA/Ro antibodies are common in mixed connective tissue disease. J. Rheumatol. 29, 487-9.
66. Sharp G.C., Irvin W.S., LaRoque R.L., Velez C., Daly V., Kaiser A.D., and Holman H.R. (1971) Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy. J. Clin. Invest. 50, 350-359.
67. Sjoberg A.P., Trouw L.A., McGrath F.D., Hack C.E., Blom A.M. (2006) Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. J. Immunol. 176, 7612-7620.
68. Skriner K, Sommergruber WH, Tremmel V, Fischer I, Barta A, Smolen JS, Steiner G. (1997) Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. J. Clin. Invest. 100, 127-135.
69. Stein A.J., Fuchs G., Fu C., Wolin S.L., Reinisch K.M. (2005) Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell. 121, 529-539.
70. Szalai A.J., Weaver C.T., McCrory M.A., van Ginkel F.W., Reiman R.M., Kearney J.F., Marion T.N., Volanakis J.E. (2003) Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum. 48, 1602-1611.
71. Tan E.M., Feltkamp T.E., Smolen J.S., Butcher B., Dawkins R., Fritzler M.J., Gordon T., Hardin J.A., Kalden J.R., Lahita R.G., Maini R.N., McDougal J.S., Rothfield N.F., Smeenk R.J., Takasaki Y., Wiik A., Wilson M.R., Koziol J.A. (1997) Range of antinuclear antibodies in "healthy" individuals. Arthritis Rheum. 40, 1601-1611.
72. Triantafilou K., Orthopoulos G., Vakakis E., Ahmed M.A., Golenbock D.T., Lepper P.M., Triantafilou M. (2005) Cell Microbiol. 7, 1117-1126.
73. Van Eenennaam H., Vogelzangs J.H., Lugtenberg D., Van Den Hoogen F.H., Van Venrooij W.J., Pruijn G.J. (2002) Identity of the RNase MRP- and RNase P-associated Th/To autoantigen. Arthritis Rheum. 46, 3266-3272.
74. Vollmer J., Tluk S., Schmitz C., Hamm S., Jurk M., Forsbach A., Akira S., Kelly K.M., Reeves W.H., Bauer S., Krieg A.M. (2005) Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med. 202, 1575-1585.
75. Walter P., Blobel G. (1983) Disassembly and reconstitution of signal recognition particle. Cell. 34:525-533.
76. Wang J, Shao Y, Bennett TA, Shankar RA, Wightman PD, Reddy LG. (2006) The functional effects of physical interactions among toll-like receptors 7, 8 and 9. J. Biol. Chem. Oct 13; [Epub ahead of print].
77. Wang Z., Xiang L., Shao J., Yuan Z. (2006) The 3′ CCACCA sequence of tRNAAla(UGC) is the motif that is important in inducing Th1-like immune response, and this motif can be recognized by Toll-like receptor 3. Clin. Vaccine Immunol. 13, 733-739.
78. Warner N.Z, Greidinger E.L. (2004) Patients with antibodies to both PmScl and dsDNA. J. Rheumatol. 31, 2169-2174.
79. Weickmann J.L., Glitz D.G. (1982) Human ribonucleases. Quantitation of pancreatic-like enzymes in serum, urine, and organ preparations. J. Biol. Chem. 257(15):8705-8710.
80. Yamasaki Y., Honkanen-Scott M., Hernandez L., Ikeda K., Barker T., Bubb M.R., Narain S., Richards H.B., Chan E.K., Reeves W.H., Satoh M. (2006) Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies. Arthritis Rheum. 54:3051-6.
81. Yang J.M., Hildebrandt B., Luderschmidt C., Pollard K.M. (2003) Human scleroderma sera contain autoantibodies to protein components specific to the U3 small nucleolar RNP complex. Arthritis Rheum. 48, 210-217.
82. Yoneyama M., Kikuchi M., Matsumoto K., Imaizumi T., Miyagishi M., Taira K., Foy E., Loo Y.M., Gale M. Jr., Akira S., Yonehara S., Kato A., Fujita T. (2005) Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175, 2851-2858.
83. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., Fujita T. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737.
84. Young S.L., Lyddon T.D., Jorgenson R.L., Misfeldt M.L. (2004) Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. Am J Reprod Immunol. 52, 67-73.