Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy

Kidney International

Volumn 88, Issue 1, 2015, Pages 85-94

  Cheng, Huifang ^a   Fan, Xiaofeng ^a   Lawson, William E ^a   Paueksakon, Paisit ^a   Harris, Raymond C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; MTOR; P16; Proximal tubule; Renal ischemia reperfusion; Senescence

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P16; PROTEIN P62; RAPAMYCIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MTOR PROTEIN, MOUSE; RNA; TARGET OF RAPAMYCIN KINASE; TELOMERASE RNA; TERT PROTEIN, MOUSE;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; CELL PROLIFERATION; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; IN VITRO STUDY; KIDNEY ISCHEMIA; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEINURIA; REPERFUSION INJURY; SENESCENCE; TELOMERE HOMEOSTASIS; UREMIA; ACUTE KIDNEY INJURY; AGING; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPLICATION; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; KIDNEY; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGENERATION; SIGNAL TRANSDUCTION; TELOMERE SHORTENING; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; AGING; ANIMALS; APOPTOSIS; AUTOPHAGY; BLOOD UREA NITROGEN; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; KIDNEY; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REGENERATION; REPERFUSION INJURY; RNA; SIGNAL TRANSDUCTION; SIROLIMUS; TELOMERASE; TELOMERE SHORTENING; TOR SERINE-THREONINE KINASES;

EID: 84934435476     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.69     Document Type: Article

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