-
2
-
-
34247506387
-
Epidemiology of nonmelanoma skin cancer (NMSC) in Europe: Accurate and comparabledata are neededfor effective public health monitoring and interventions
-
Trakatelli M, Ulrich C, del Marmol V, Euvrard S, Stockfleth E, Abeni D. Epidemiology of nonmelanoma skin cancer (NMSC) in Europe: accurate and comparabledata are neededfor effective public health monitoring and interventions. Br J Dermatol 2007;156 Suppl 3:1-7.
-
(2007)
Br J Dermatol
, vol.156
, pp. 1-7
-
-
Trakatelli, M.1
Ulrich, C.2
Del Marmol, V.3
Euvrard, S.4
Stockfleth, E.5
Abeni, D.6
-
3
-
-
0028284693
-
Nonmelanoma skin cancer in the United States: Incidence
-
Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 1994;30:774-8.
-
(1994)
J Am Acad Dermatol
, vol.30
, pp. 774-778
-
-
Miller, D.L.1
Weinstock, M.A.2
-
4
-
-
31444431900
-
Non-melanoma skin cancer in Australia: The 2002 national survey and trends since 1985
-
Staples MP, Elwood M, Burton RC, Williams JL, Marks R, Giles GG. Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985. Med J Aust 2006;184:6-10.
-
(2006)
Med J Aust
, vol.184
, pp. 6-10
-
-
Staples, M.P.1
Elwood, M.2
Burton, R.C.3
Williams, J.L.4
Marks, R.5
Giles, G.G.6
-
5
-
-
84905708146
-
Update of the European guidelines for basal cell carcinoma management
-
Trakatelli M, Morton C, Nagore E, Ulrich C, Del Marmol V, Peris K, et al. Update of the European guidelines for basal cell carcinoma management. Eur J Dermatol 2014;24:312-29.
-
(2014)
Eur J Dermatol
, vol.24
, pp. 312-329
-
-
Trakatelli, M.1
Morton, C.2
Nagore, E.3
Ulrich, C.4
Del Marmol, V.5
Peris, K.6
-
6
-
-
0025019786
-
Cisplatin-based chemotherapy in advanced basal cell carcinoma and squamous cell carcinoma of the skin: Results in 28 patients including 13 patients receiving multimodality therapy
-
Guthrie TH, Porubsky ES, Luxenberg MN, Shah KJ, Wurtz KL, Watson PR. Cisplatin-based chemotherapy in advanced basal cell carcinoma and squamous cell carcinoma of the skin: results in 28 patients including 13 patients receiving multimodality therapy. J Clin Oncol 1990;8:342-6.
-
(1990)
J Clin Oncol
, vol.8
, pp. 342-346
-
-
Guthrie, T.H.1
Porubsky, E.S.2
Luxenberg, M.N.3
Shah, K.J.4
Wurtz, K.L.5
Watson, P.R.6
-
7
-
-
0028057256
-
Metastatic basal cell carcinoma. Report of five cases
-
Snow SN, Sahl W, Lo JS, Mohs FE, Warner T, Dekkinga JA, et al. Metastatic basal cell carcinoma. Report of five cases. Cancer 1994;73:328-35.
-
(1994)
Cancer
, vol.73
, pp. 328-335
-
-
Snow, S.N.1
Sahl, W.2
Lo, J.S.3
Mohs, F.E.4
Warner, T.5
Dekkinga, J.A.6
-
8
-
-
3042818253
-
Aggressive basal cell carcinoma: Presentation, pathogenesis, and management
-
Walling HW, Fosko SW, Geraminejad PA, Whitaker DC, Arpey CJ. Aggressive basal cell carcinoma: presentation, pathogenesis, and management. Cancer Metastasis Rev 2004;23:389-402.
-
(2004)
Cancer Metastasis Rev
, vol.23
, pp. 389-402
-
-
Walling, H.W.1
Fosko, S.W.2
Geraminejad, P.A.3
Whitaker, D.C.4
Arpey, C.J.5
-
9
-
-
84894065660
-
Metastatic basal cell carcinoma: Prognosis dependent on anatomic site and spread of disease
-
McCusker M, Basset-Seguin N, Dummer R, Lewis K, Schadendorf D, Sekulic A, et al. Metastatic basal cell carcinoma: prognosis dependent on anatomic site and spread of disease. Eur J Cancer 2014;50:774-83.
-
(2014)
Eur J Cancer
, vol.50
, pp. 774-783
-
-
McCusker, M.1
Basset-Seguin, N.2
Dummer, R.3
Lewis, K.4
Schadendorf, D.5
Sekulic, A.6
-
10
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
Briscoe J, Therond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 2013;14:416-29.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 416-429
-
-
Briscoe, J.1
Therond, P.P.2
-
11
-
-
77951101203
-
The primary cilium: A signalling centre during vertebrate development
-
Goetz SC, Anderson KV. The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 2010;11:331-44.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
12
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998; 391:90-2.
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
-
13
-
-
19944433687
-
Somatic mutationsinthe PTCH, SMOH, SUFUH and TP53genes in sporadic basal cell carcinomas
-
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, et al. Somatic mutationsinthe PTCH, SMOH, SUFUH and TP53genes in sporadic basal cell carcinomas. Br J Dermatol 2005;152:43-51.
-
(2005)
Br J Dermatol
, vol.152
, pp. 43-51
-
-
Reifenberger, J.1
Wolter, M.2
Knobbe, C.B.3
Kohler, B.4
Schonicke, A.5
Scharwachter, C.6
-
15
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272:1668-71.
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
-
16
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85: 841-51.
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
-
17
-
-
0031036694
-
Sporadic medulloblastomas contain PTCH mutations
-
Raffel C, Jenkins RB, Frederick L, Hebrink D, Alderete B, Fults DW, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res 1997; 57:842-5.
-
(1997)
Cancer Res
, vol.57
, pp. 842-845
-
-
Raffel, C.1
Jenkins, R.B.2
Frederick, L.3
Hebrink, D.4
Alderete, B.5
Fults, D.W.6
-
18
-
-
84864444165
-
Novel mutations target distinct subgroups of medulloblastoma
-
Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, et al. Novel mutations target distinct subgroups of medulloblastoma. Nature 2012; 488:43-8.
-
(2012)
Nature
, vol.488
, pp. 43-48
-
-
Robinson, G.1
Parker, M.2
Kranenburg, T.A.3
Lu, C.4
Chen, X.5
Ding, L.6
-
19
-
-
84874645692
-
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
-
Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, et al. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet 2013;45:285-9.
-
(2013)
Nat Genet
, vol.45
, pp. 285-289
-
-
Brastianos, P.K.1
Horowitz, P.M.2
Santagata, S.3
Jones, R.T.4
McKenna, A.5
Getz, G.6
-
20
-
-
84874372046
-
Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO
-
Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, et al. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 2013;339:1077-80.
-
(2013)
Science
, vol.339
, pp. 1077-1080
-
-
Clark, V.E.1
Erson-Omay, E.Z.2
Serin, A.3
Yin, J.4
Cotney, J.5
Ozduman, K.6
-
21
-
-
84903637379
-
Identification of recurrent SMO and BRAF mutations in ameloblastomas
-
Sweeney RT, McClary AC, Myers BR, Biscocho J, Neahring L, Kwei KA, et al. Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet 2014;46:722-5.
-
(2014)
Nat Genet
, vol.46
, pp. 722-725
-
-
Sweeney, R.T.1
McClary, A.C.2
Myers, B.R.3
Biscocho, J.4
Neahring, L.5
Kwei, K.A.6
-
22
-
-
33751549095
-
Targeting the hedgehog pathway in cancer
-
Rubin LL, de Sauvage FJ. Targeting the hedgehog pathway in cancer. Nat Rev Cancer 2006;5:1026-33.
-
(2006)
Nat Rev Cancer
, vol.5
, pp. 1026-1033
-
-
Rubin, L.L.1
De Sauvage, F.J.2
-
23
-
-
80955181031
-
The Hedgehog's tale: Developing strategies for targeting cancer
-
Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011;11:493-501.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 493-501
-
-
Ng, J.M.1
Curran, T.2
-
24
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 2009;106:4254-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
DuPree, K.J.3
Darbonne, W.C.4
Ahn, C.P.5
Scales, S.J.6
-
25
-
-
34547683699
-
Essential role of stromally induced hedgehog signaling in B-cell malignancies
-
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, et al. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med 2007;13:944-51.
-
(2007)
Nat Med
, vol.13
, pp. 944-951
-
-
Dierks, C.1
Grbic, J.2
Zirlik, K.3
Beigi, R.4
Englund, N.P.5
Guo, G.R.6
-
26
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer
-
Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008;455:406-10.
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
Gould, S.E.2
Scales, S.J.3
Tang, T.4
Tian, H.5
Ahn, C.P.6
-
27
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
28
-
-
84902435628
-
Stromal elements acttorestrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, et al. Stromal elements acttorestrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014;25:735-47.
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
Mirek, E.T.4
Palermo, C.F.5
Sastra, S.A.6
-
29
-
-
84918811818
-
Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (Vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
-
Kim EJ, Sahai V, Abel EV, Griffith KA, Greenson JK, Takebe N, et al. Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (Vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. Clin Cancer Res 2014;20:5937-45.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5937-5945
-
-
Kim, E.J.1
Sahai, V.2
Abel, E.V.3
Griffith, K.A.4
Greenson, J.K.5
Takebe, N.6
-
30
-
-
84871959114
-
A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer
-
Berlin J, Bendell JC, Hart LL, Firdaus I, Gore I, Hermann RC, et al. A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer. Clin Cancer Res 2013;19:258-67.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 258-267
-
-
Berlin, J.1
Bendell, J.C.2
Hart, L.L.3
Firdaus, I.4
Gore, I.5
Hermann, R.C.6
-
31
-
-
84870366661
-
A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
-
Kaye SB, Fehrenbacher L, Holloway R, Amit A, Karlan B, Slomovitz B, et al. A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission. Clin Cancer Res 2012;18:6509-18.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6509-6518
-
-
Kaye, S.B.1
Fehrenbacher, L.2
Holloway, R.3
Amit, A.4
Karlan, B.5
Slomovitz, B.6
-
32
-
-
0032080853
-
Missense mutations in SMOH in sporadicbasal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
-
Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P, et al. Missense mutations in SMOH in sporadicbasal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998;58:1798-803.
-
(1998)
Cancer Res
, vol.58
, pp. 1798-1803
-
-
Reifenberger, J.1
Wolter, M.2
Weber, R.G.3
Megahed, M.4
Ruzicka, T.5
Lichter, P.6
-
33
-
-
84919767719
-
Germline mutations in SUFU cause gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations
-
Smith MJ, Beetz C, Williams SG, Bhaskar SS, O'Sullivan J, Anderson B, et al. Germline mutations in SUFU cause gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations. J Clin Oncol 2014;32:4155-61.
-
(2014)
J Clin Oncol
, vol.32
, pp. 4155-4161
-
-
Smith, M.J.1
Beetz, C.2
Williams, S.G.3
Bhaskar, S.S.4
O'Sullivan, J.5
Anderson, B.6
-
34
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002;31:306-10.
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
Hui, C.C.4
Mainprize, T.G.5
Zhang, X.6
-
35
-
-
33750543972
-
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway
-
Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, et al. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res 2006;66:10171-8.
-
(2006)
Cancer Res
, vol.66
, pp. 10171-10178
-
-
Mao, J.1
Ligon, K.L.2
Rakhlin, E.Y.3
Thayer, S.P.4
Bronson, R.T.5
Rowitch, D.6
-
36
-
-
0034753859
-
A mouse model for medulloblastoma and basal cell nevus syndrome
-
Corcoran RB, Scott MP. A mouse model for medulloblastoma and basal cell nevus syndrome. J Neurooncol 2001;53:307-18.
-
(2001)
J Neurooncol
, vol.53
, pp. 307-318
-
-
Corcoran, R.B.1
Scott, M.P.2
-
37
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002;16:2743-8.
-
(2002)
Genes Dev
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
38
-
-
56249121238
-
Semisynthetic cyclopamine analogues as potent and orally bioavail-able hedgehog pathway antagonists
-
Tremblay MR, Nevalainen M, Nair SJ, Porter JR, Castro AC, Behnke ML, et al. Semisynthetic cyclopamine analogues as potent and orally bioavail-able hedgehog pathway antagonists. J Med Chem 2008;51:6646-9.
-
(2008)
J Med Chem
, vol.51
, pp. 6646-6649
-
-
Tremblay, M.R.1
Nevalainen, M.2
Nair, S.J.3
Porter, J.R.4
Castro, A.C.5
Behnke, M.L.6
-
39
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1()p53(-/-) mice
-
Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1()p53(-/-) mice. Cancer Cell 2004; 6:229-40.
-
(2004)
Cancer Cell
, Issue.6
, pp. 229-240
-
-
Romer, J.T.1
Kimura, H.2
Magdaleno, S.3
Sasai, K.4
Fuller, C.5
Baines, H.6
-
40
-
-
69949084378
-
GDC-0449-a potent inhibitor of the hedgehog pathway
-
Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, et al. GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett 2009;19:5576-81.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5576-5581
-
-
Robarge, K.D.1
Brunton, S.A.2
Castanedo, G.M.3
Cui, Y.4
Dina, M.S.5
Goldsmith, R.6
-
41
-
-
33646231995
-
Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
-
Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, et al. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 2006;66:4215-22.
-
(2006)
Cancer Res
, vol.66
, pp. 4215-4222
-
-
Sasai, K.1
Romer, J.T.2
Lee, Y.3
Finkelstein, D.4
Fuller, C.5
McKinnon, P.J.6
-
42
-
-
79960403317
-
Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation
-
Wong H, Alicke B, West KA, Pacheco P, La H, Januario T, et al. Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin Cancer Res 2011;17:4682-92.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4682-4692
-
-
Wong, H.1
Alicke, B.2
West, K.A.3
Pacheco, P.4
La Januario H, T.5
-
43
-
-
79954611501
-
Phase i trial of hedgehog pathway inhibitor vismodegib (GDC-0449) inpatients with refractory, locally advanced or metastatic solid tumors
-
LoRusso PM, Rudin CM, Reddy JC, Tibes R, Weiss GJ, Borad MJ, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) inpatients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res 2011;17:2502-11.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2502-2511
-
-
LoRusso, P.M.1
Rudin, C.M.2
Reddy, J.C.3
Tibes, R.4
Weiss, G.J.5
Borad, M.J.6
-
44
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 2012;366:2171-9.
-
(2012)
N Engl J Med
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
Dirix, L.4
Lewis, K.D.5
Hainsworth, J.D.6
-
45
-
-
84905485738
-
Clinical benefit assessment of vismodegib therapy in patients with advanced Basal cell carcinoma
-
Dreno B, Basset-Seguin N, Caro I, Yue H, Schadendorf D. Clinical benefit assessment of vismodegib therapy in patients with advanced Basal cell carcinoma. Oncologist 2014;19:790-6.
-
(2014)
Oncologist
, vol.19
, pp. 790-796
-
-
Dreno, B.1
Basset-Seguin, N.2
Caro, I.3
Yue, H.4
Schadendorf, D.5
-
46
-
-
84902811306
-
Vismodegib for advanced basal cell carcinoma: Duration of response after vismodegib discontinuation and response to vismodegib retreatment upon disease progression
-
abstr 9081
-
Sekulic A, Hainsworth JD, Lewis KD, Oro AE, Gesierich A, Mortier L, et al. Vismodegib for advanced basal cell carcinoma: Duration of response after vismodegib discontinuation and response to vismodegib retreatment upon disease progression. J Clin Oncol 32:5s, 2014 (suppl; abstr 9081).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5
-
-
Sekulic, A.1
Hainsworth, J.D.2
Lewis, K.D.3
Oro, A.E.4
Gesierich, A.5
Mortier, L.6
-
47
-
-
84891274728
-
Long term safety and Efficacy of vismodegib in patients with advanced basal cell carcinoma (aBCC): 18 months update of the pivotal ERIVANCE BCC study
-
abstr 9037
-
Sekulic A, Migden MR, Basset-Seguin N, Garbe C, Gesierich A, Lao CD, et al. Long term safety and Efficacy of vismodegib in patients with advanced basal cell carcinoma (aBCC): 18 months update of the pivotal ERIVANCE BCC study. J Clin Oncol 31:15s, 2014 (suppl; abstr 9037).
-
(2014)
J Clin Oncol
, vol.31
, pp. 15s
-
-
Sekulic, A.1
Migden, M.R.2
Basset-Seguin, N.3
Garbe, C.4
Gesierich, A.5
Lao, C.D.6
-
48
-
-
84891277504
-
Vismodegib a hedgehog pathway inhibitor (HPI) in advanced basal cell carcinoma (aBCC); Stevie study interim analysis in 300 patients
-
(suppl; abstr 9036)
-
Grob JJ, Kunstfeld R, Dreno B, Jouary T, Mortier L, Basset-Seguin N, et al. Vismodegib a hedgehog pathway inhibitor (HPI) in advanced basal cell carcinoma (aBCC); Stevie study interim analysis in 300 patients. J Clin Oncol 31, 2013 (suppl; abstr 9036).
-
(2013)
J Clin Oncol
, vol.31
-
-
Grob, J.J.1
Kunstfeld, R.2
Dreno, B.3
Jouary, T.4
Mortier, L.5
Basset-Seguin, N.6
-
49
-
-
84946907358
-
Vismodegib in thetreatment of patients with metastatic basal cell carcinoma (mBCC) and distant metastases: Survival in the pivotal phaseII and phase i studies
-
abstr 9012
-
Lewis KD, Sekulic A, Hauschild A, Migden MR, Oro AE, et al. Vismodegib in thetreatment of patients with metastatic basal cell carcinoma (mBCC) and distant metastases: Survival in the pivotal phaseII and phase I studies.J Clin Oncol 2014;32:5s (suppl; abstr 9012).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Lewis, K.D.1
Sekulic, A.2
Hauschild, A.3
Migden, M.R.4
Oro, A.E.5
-
50
-
-
84890796086
-
Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib
-
Chang AL, Solomon JA, Hainsworth JD, Goldberg L, McKenna E, Day BM, et al. Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. JAMA Derma-tol 2014;70:60-9.
-
(2014)
JAMA Derma-tol
, vol.70
, pp. 60-69
-
-
Chang, A.L.1
Solomon, J.A.2
Hainsworth, J.D.3
Goldberg, L.4
McKenna, E.5
Day, B.M.6
-
51
-
-
84861876867
-
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
-
Tang JY, Mackay-Wiggan JM, Aszterbaum M, Yauch RL, Lindgren J, Chang K, et al. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med 2012;366:2180-8.
-
(2012)
N Engl J Med
, vol.366
, pp. 2180-2188
-
-
Tang, J.Y.1
MacKay-Wiggan, J.M.2
Aszterbaum, M.3
Yauch, R.L.4
Lindgren, J.5
Chang, K.6
-
52
-
-
79960613454
-
Resolution of odontogenic keratocysts of the jaw in basal cell nevus syndrome with GDC-0449
-
Goldberg LH, Landau JM, Moody MN, Kazakevich N, Holzer AM, Myers A. Resolution of odontogenic keratocysts of the jaw in basal cell nevus syndrome with GDC-0449. Arch Dermatol 2011;147:839-41.
-
(2011)
Arch Dermatol
, vol.147
, pp. 839-841
-
-
Goldberg, L.H.1
Landau, J.M.2
Moody, M.N.3
Kazakevich, N.4
Holzer, A.M.5
Myers, A.6
-
53
-
-
84922479971
-
An investigator-initiated open-label clinical trial of vismodegib as a neoadju-vant to surgery for high-risk basal cell carcinoma
-
Ally MS, Aasi S, Wysong A, Teng C, Anderson E, Bailey-Healy I, et al. An investigator-initiated open-label clinical trial of vismodegib as a neoadju-vant to surgery for high-risk basal cell carcinoma. J Am Acad Dermatol 2014;71:904-11.
-
(2014)
J Am Acad Dermatol
, vol.71
, pp. 904-911
-
-
Ally, M.S.1
Aasi, S.2
Wysong, A.3
Teng, C.4
Anderson, E.5
Bailey-Healy, I.6
-
54
-
-
84908242161
-
Two different scenarios of squamous cell carcinoma within advanced basal cell carcinomas: Cases illustrating the importance of serial biopsy during vismodegib usage
-
Zhu GA, Sundram U, Chang AL. Two different scenarios of squamous cell carcinoma within advanced basal cell carcinomas: cases illustrating the importance of serial biopsy during vismodegib usage. JAMA Dermatol 2014;150:970-3.
-
(2014)
JAMA Dermatol
, vol.150
, pp. 970-973
-
-
Zhu, G.A.1
Sundram, U.2
Chang, A.L.3
-
55
-
-
85027924456
-
Multiple highly and moderately differentiated squamous cell carcinomas of the skin during vismodegib treatment of inoperable basal cell carcinoma
-
Orouji A, Goerdt S, Utikal J, Leverkus M. Multiple highly and moderately differentiated squamous cell carcinomas of the skin during vismodegib treatment of inoperable basal cell carcinoma. Br J Dermatol 2014;171: 431-3.
-
(2014)
Br J Dermatol
, vol.171
, pp. 431-433
-
-
Orouji, A.1
Goerdt, S.2
Utikal, J.3
Leverkus, M.4
-
56
-
-
84874225039
-
New onset of keratoacanthomas after vismodegib treatment for locally advanced basal cell carcinomas: A report of 2 cases
-
Aasi S, Silkiss R, Tang JY, Wysong A, Liu A, Epstein E, et al. New onset of keratoacanthomas after vismodegib treatment for locally advanced basal cell carcinomas: a report of 2 cases. JAMA Dermatol 2013;149:242-3.
-
(2013)
JAMA Dermatol
, vol.149
, pp. 242-243
-
-
Aasi, S.1
Silkiss, R.2
Tang, J.Y.3
Wysong, A.4
Liu, A.5
Epstein, E.6
-
57
-
-
79954620413
-
A first in human, phase i study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139) in subjects with advanced or metastatic tumors
-
abstr 2501
-
Siu LL, Pappadopoulos K, Alberts SR, Kirchoff-Ross R, Vakkalagadda B, Lang L, et al. A first in human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139) in subjects with advanced or metastatic tumors. J Clin Oncol 28:15s, 2010 (suppl; abstr 2501).
-
(2010)
J Clin Oncol
, vol.28
, pp. 15s
-
-
Siu, L.L.1
Pappadopoulos, K.2
Alberts, S.R.3
Kirchoff-Ross, R.4
Vakkalagadda, B.5
Lang, L.6
-
58
-
-
84878112106
-
Structure of the human smoothened receptor bound to an antitumour agent
-
Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature 2013;497:338-43.
-
(2013)
Nature
, vol.497
, pp. 338-343
-
-
Wang, C.1
Wu, H.2
Katritch, V.3
Han, G.W.4
Huang, X.P.5
Liu, W.6
-
59
-
-
84929458903
-
A phase i study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors
-
Nov 11. [Epub ahead of print]
-
Wagner AJ, Messersmith WA, Shaik MN, Li S, Zheng X, McLachlan KR, et al. A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2014 Nov 11. [Epub ahead of print].
-
(2014)
Clin Cancer Res.
-
-
Wagner, A.J.1
Messersmith, W.A.2
Shaik, M.N.3
Li, S.4
Zheng, X.5
McLachlan, K.R.6
-
60
-
-
84881030230
-
Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened
-
Peukert S, He F, Dai M, Zhang R, Sun Y, Miller-Moslin K, et al. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. Chem Med Chem 2013;8:1261-5.
-
(2013)
Chem Med Chem
, vol.8
, pp. 1261-1265
-
-
Peukert, S.1
He, F.2
Dai, M.3
Zhang, R.4
Sun, Y.5
Miller-Moslin, K.6
-
61
-
-
84898721363
-
A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor sonidegib (LDE225) in patients with advanced solid tumors
-
Rodon J, Tawbi HA, Thomas AL, Stoller RG, Turtschi CP, Baselga J, et al. A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor sonidegib (LDE225) in patients with advanced solid tumors. Clin Cancer Res 2014;20:1900-9.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1900-1909
-
-
Rodon, J.1
Tawbi, H.A.2
Thomas, A.L.3
Stoller, R.G.4
Turtschi, C.P.5
Baselga, J.6
-
62
-
-
84946896782
-
Randomized, double-blind study of sonidegib (LDE225) in patients (pts) with locally advanced (La) or metastatic (m) basal-cell carcinoma (BCC)
-
abstr 9009a
-
Midgen MR, Gumisnki AD, Gutzmer R, Dirix LY, Lewis KD, Combemale P, et al. Randomized, double-blind study of sonidegib (LDE225) in patients (pts) with locally advanced (La) or metastatic (m) basal-cell carcinoma (BCC). J Clin Oncol 32:5s, 2014 (suppl; abstr 9009a^).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Midgen, M.R.1
Gumisnki, A.D.2
Gutzmer, R.3
Dirix, L.Y.4
Lewis, K.D.5
Combemale, P.6
-
63
-
-
84872417679
-
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
-
Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 2013;23:23-34.
-
(2013)
Cancer Cell
, vol.23
, pp. 23-34
-
-
Kim, J.1
Aftab, B.T.2
Tang, J.Y.3
Kim, D.4
Lee, A.H.5
Rezaee, M.6
-
64
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
-
Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 2010;17:388-99.
-
(2010)
Cancer Cell
, vol.17
, pp. 388-399
-
-
Kim, J.1
Tang, J.Y.2
Gong, R.3
Kim, J.4
Lee, J.J.5
Clemons, K.V.6
-
65
-
-
84897949607
-
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma
-
Kim DJ, Kim J, Spaunhurst K, Montoya J, Khodosh R, Chandra K, et al. Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol 2014;32:745-51.
-
(2014)
J Clin Oncol
, vol.32
, pp. 745-751
-
-
Kim, D.J.1
Kim, J.2
Spaunhurst, K.3
Montoya, J.4
Khodosh, R.5
Chandra, K.6
-
66
-
-
79955990024
-
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened
-
Tang T, Tang JY, Li D, Reich M, Callahan CA, Fu L, et al. Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res 2011;17:3378-87.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3378-3387
-
-
Tang, T.1
Tang, J.Y.2
Li, D.3
Reich, M.4
Callahan, C.A.5
Fu, L.6
-
67
-
-
79960340656
-
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor
-
Skvara H, Kalthoff F, Meingassner JG, Wolff-Winiski B, Aschauer H, Kelleher JF, et al. Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol 2011;131:1735-44.
-
(2011)
J Invest Dermatol
, vol.131
, pp. 1735-1744
-
-
Skvara, H.1
Kalthoff, F.2
Meingassner, J.G.3
Wolff-Winiski, B.4
Aschauer, H.5
Kelleher, J.F.6
-
68
-
-
84896096387
-
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
-
Kool M, Jones DT, Jager N, Northcott PA, Pugh TJ, Hovestadt V, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell 2014;25: 393-405.
-
(2014)
Cancer Cell
, vol.25
, pp. 393-405
-
-
Kool, M.1
Jones, D.T.2
Jager, N.3
Northcott, P.A.4
Pugh, T.J.5
Hovestadt, V.6
-
69
-
-
70350496540
-
Smoothened mutation confers resistancetoaHedgehogpathway inhibitor in medulloblastoma
-
Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, et al. Smoothened mutation confers resistancetoaHedgehogpathway inhibitor in medulloblastoma. Science 2009;326:572-4.
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
Januario, T.4
Ahn, C.P.5
Holcomb, T.6
-
70
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009;361:1173-8.
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
Yauch, R.L.4
Callahan, C.A.5
Fu, L.6
-
71
-
-
84869131318
-
Initial assessment of tumor regrowth after vismo-degib in advanced Basal cell carcinoma
-
Chang AL, Oro AE. Initial assessment of tumor regrowth after vismo-degib in advanced Basal cell carcinoma. Arch Dermatol 2012;148: 1324-5.
-
(2012)
Arch Dermatol
, vol.148
, pp. 1324-1325
-
-
Chang, A.L.1
Oro, A.E.2
-
72
-
-
84922480709
-
Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma
-
Brinkhuizen T, Reinders MG, van Geel M, Hendriksen AJ, Paulussen AD, Winnepenninckx VJ, et al. Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma. J Am Acad Dermatol 2014;71: 1005-8.
-
(2014)
J Am Acad Dermatol
, vol.71
, pp. 1005-1008
-
-
Brinkhuizen, T.1
Reinders, M.G.2
Van Geel, M.3
Hendriksen, A.J.4
Paulussen, A.D.5
Winnepenninckx, V.J.6
-
73
-
-
77958060845
-
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
-
Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2010;2:51ra70.
-
(2010)
Sci Transl Med
, vol.2
, pp. 51ra70
-
-
Buonamici, S.1
Williams, J.2
Morrissey, M.3
Wang, A.4
Guo, R.5
Vattay, A.6
-
74
-
-
84890288884
-
PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition
-
Metcalfe C, Alicke B, Crow A, Lamoureux M, Dijkgraaf GJ, Peale F, et al. PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition. Cancer Res 2013;73:7034-42.
-
(2013)
Cancer Res
, vol.73
, pp. 7034-7042
-
-
Metcalfe, C.1
Alicke, B.2
Crow, A.3
Lamoureux, M.4
Dijkgraaf, G.J.5
Peale, F.6
-
75
-
-
84963745103
-
Open-label pilot study of LDE225 in advanced basal cell carcinoma patients who have been treated previously with a non-LDE225 Smoothened inhibitor
-
suppl; abstr 580)
-
Chang AS, Oro A. Open-label pilot study of LDE225 in advanced basal cell carcinoma patients who have been treated previously with a non-LDE225 Smoothened inhibitor. J Invest Dermatol 134:S101, 2014 (suppl; abstr 580).
-
(2014)
J Invest Dermatol
, vol.134
, pp. S101
-
-
Chang, A.S.1
Oro, A.2
-
76
-
-
84904036266
-
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
-
Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med 2014;20:732-40.
-
(2014)
Nat Med
, vol.20
, pp. 732-740
-
-
Tang, Y.1
Gholamin, S.2
Schubert, S.3
Willardson, M.I.4
Lee, A.5
Bandopadhayay, P.6
|