Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation

Neuroscience

Volumn 301, Issue , 2015, Pages 542-552

  Lavich, I C ^a   de Freitas, B S ^a   Kist, L W ^a   Falavigna, L ^a   Dargel V A ^a   Kobe L M ^a   Aguzzoli, C ^a   Piffero, B ^a   Florian, P Z ^a   Bogo, M R ^a,b   de Lima, M N M ^a,b   Schroder N ^a,b  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b National Institute for Translational Medicine (INCT TM)   (Brazil)

Author keywords

Iron; Mitochondria; Neurodegenerative disorders; Recognition memory; Sulforaphane; Synapse

Indexed keywords

BIOLOGICAL MARKER; CARBONYL IRON; HYBRID PROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN DNM1L; PROTEIN OPA1; SODIUM CHLORIDE; SULFORAPHANE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CATALASE; DRP1 PROTEIN, RAT; DYNAMIN; GLUTATHIONE PEROXIDASE; GUANOSINE TRIPHOSPHATASE; IRON; IRON DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; NQO1 PROTEIN, RAT; OPA1 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAFAN;

ADULTHOOD; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; HIPPOCAMPUS; MALE; MEMORY DISORDER; NEUROPROTECTION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SINGLE DRUG DOSE; TASK PERFORMANCE; WESTERN BLOTTING; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MEMORY DISORDERS; METABOLISM; MITOCHONDRION; PATHOLOGY; PREGNANCY; RECOGNITION; SYNAPSE; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; ANTICARCINOGENIC AGENTS; BRAIN; CATALASE; DISEASE MODELS, ANIMAL; DYNAMINS; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTATHIONE PEROXIDASE; GTP PHOSPHOHYDROLASES; IRON; IRON COMPOUNDS; ISOTHIOCYANATES; MALE; MEMORY DISORDERS; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); PREGNANCY; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY); SYNAPSES;

EID: 84934324781     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.06.025     Document Type: Article

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