Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease

Radiology

Volumn 253, Issue 2, 2009, Pages 497-504

  Zhu, Wen Zhen ^a   Zhong, Wei De ^b   Wang, Wei ^c   Zhan, Chuan Jia ^a   Wang, Cheng Yuan ^a   Qi, Jian Pin ^a   Wang, Jian Zhi ^c   Lei, Ting ^c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IRON;

ADULT; AGED; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ARTICLE; BRAIN IRON DEPOSITION; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; CHINA; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DENTATE NUCLEUS; DISEASE COURSE; DISEASE SEVERITY; EVALUATION; FEMALE; HUMAN; INFORMED CONSENT; IRON STORAGE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PRIORITY JOURNAL; PUTAMEN; RED NUCLEUS; STATISTICAL SIGNIFICANCE; STUDENT T TEST; SUBSTANTIA NIGRA; THALAMUS; TWO TAILED TEST; VOLUNTEER; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; BRAIN; COGNITION; FEMALE; HUMANS; IRON; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED;

EID: 77950118979     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.2532082324     Document Type: Article

References (36)

1. Jack CR Jr, Marjanska M, Wengenack TM, et al. Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research. Neuroscientist 2007;13:38-48.
2. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-259.
3. Deibel MA, Ehmann WD, Markesbery WR. Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress. J Neurol Sci 1996;143:137-142.
4. Lovell MA, Robertson JD, Teesdale WJ, Campbell JL, Markesbery WR. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 1998;158:47-52.
5. Berg D, Youdim MB. Role of iron in neurodegenerative disorders. Top Magn Reson Imaging 2006;17:5-17.
6. Haacke EM, Cheng NY, House MJ, et al. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 2005;23:1-25.
7. Gutteridge JM. Iron and oxygen radicals in brain. Ann Neurol 1992;32(suppl):S16-S21.
8. Bartzokis G, Sultzer D, Cummings J, et al. In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging. Arch Gen Psychiatry 2000;57:47-53.
9. Thomas M, Jankovic J. Neurodegenerative disease and iron storage in the brain. Curr Opin Neurol 2004;17:437-442.
10. El Tannir El Tayara N, Delatour B, Le Cudennec C, Guégan M, Volk A, Dhenain M. Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2006;22:199-208.
11. Bartzokis G, Tishler TA. MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntington's disease. Cell Mol Biol (Noisy-le-grand) 2000;46:821-833.
12. Bartzokis G, Sultzer D, Mintz J, et al. In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI. Biol Psychiatry 1994;35:480-487.
13. Connor JR, Snyder BS, Arosio P, Loeffler DA, LeWitt P. A quantitative analysis of isoferritins in selected regions of aged, parkinsonian and Alzheimer's diseased brains. J Neurochem 1995;65:717-724.
14. Loeffler DA, Connor JR, Juneau PL, et al. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J Neurochem 1995;65:710-724.
15. Casadesus G, Smith MA, Zhu X, et al. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J Alzheimers Dis 2004;6:165-169.
16. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 2004;5:863-873.
17. Richardson DR. Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions. Ann N Y Acad Sci 2004;1012:326-341.
18. Rottkamp CA, Raina AK, Zhu X, et al. Redox-active iron mediates amyloid-beta toxicity. Free Radic Biol Med 2001;30:447-450.
19. Honda K, Casadesus G, Petersen RB, Perry G, Smith MA. Oxidative stress and redoxactive iron in Alzheimer's disease. Ann N Y Acad Sci 2004;1012:179-182.
20. Santhosh K, Kesavadas C, Thomas B, Gupta AK, Thamburaj K, Kapilamoorthy TR. Susceptibility weighted imaging: a new tool in magnetic resonance imaging of stroke. Clin Radiol 2009;64:74-83.
21. Rauscher A, Barth M, Reichenbach JR, Stollberger R, Moser E. Automated unwrapping of MR phase images applied to BOLD MR-venography at 3 Tesla. J Magn Reson Imaging 2003;18:175-180.
22. Haacke EM, Xu Y, Cheng YC, Reichenbach JR. Susceptibility weighted imaging (SWI). Magn Reson Med 2004;52:612-618.
23. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
24. Xu X, Wang Q, Zhang M. Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study. Neuroimage 2008;40:35-42.
25. Hallgren B, Sourander P. The effect of age on the non-haemin iron in the human brain. J Neurochem 1958;3:41-51.
26. Schenck JF. Magnetic resonance imaging of brain iron. J Neurol Sci 2003;207:99-102.
27. Pankhurst Q, Hautot D, Khan N, Dobson J. Increased levels of magnetic iron compounds in Alzheimer's disease. J Alzheimers Dis 2008;13:49-52.
28. Abduljalil AM, Schmalbrock P, Novak V, Chakeres DW. Enhanced gray and white matter contrast of phase susceptibility-weighted images in ultra-high-field magnetic resonance imaging. J Magn Reson Imaging 2003;18:284-290.
29. Ogg RJ, Langston JW, Haacke EM, Steen RG, Taylor JS. The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 1999;17:1141-1148.
30. McCrea RP, Harder SL, Martin M, Buist R, Nichol H. A comparison of rapid-scanning X-ray fluorescence mapping and magnetic resonance imaging to localize brain iron distribution. Eur J Radiol 2008;68(suppl 3):S109-S113.
31. Nakada T, Matsuzawa H, Igarashi H, Fujii Y, Kwee IL. In vivo visualization of senile-plaque-like pathology in Alzheimer's disease patients by MR microscopy on a 7T system. J Neuroimaging 2008;18:125-129.
32. Harder SL, Hopp KM, Ward H, Neglio H, Gitlin J, Kido D. Mineralization of the deep gray matter with age: a retrospective review with susceptibility- weighted MR imaging. AJNR Am J Neuroradiol 2008;29:176-183.
33. Bartzokis G, Tishler TA, Shin IS, Lu PH, Cummings JL. Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases. Ann N Y Acad Sci 2004;1012:224-236.
34. House MJ, St Pierre TG, Foster JK, Martins RN, Clarnette R. Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss. AJNR Am J Neuroradiol 2006;27:430-439.
35. Raz N, Rodrigue KM, Kennedy KM, Head D, Gunning-Dixon F, Acker JD. Differential aging of the human striatum: longitudinal evidence. AJNR Am J Neuroradiol 2003;24:1849-1856.
36. Schenck JF, Zimmerman EA. High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed 2004;17:433-445.