PDX1 binds and repreßes hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells

Stem Cell Reports

Volumn 4, Issue 4, 2015, Pages 578-590

  Teo, Adrian Kee Keong ^e   Tsuneyoshi, Norihiro ^a   Hoon, Shawn ^b   Tan, Ee Kim ^a   Stanton, Lawrence W ^c   Wright, Christopher V E ^d   Ray Dunn, N ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c GENOME INSTITUTE OF SINGAPORE   (Singapore)

^d VANDERBILT UNIVERSITY   (United States)

^e INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR PDX 1; BIOLOGICAL MARKER; HOMEODOMAIN PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; PROTEIN BINDING; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL POPULATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DEVELOPMENTAL GENE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; FOREGUT; GENE EXPRESSION; GENE REPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER; MICROARRAY ANALYSIS; MIDGUT; MOUSE; NONHUMAN; PANCREAS; PANCREAS CELL; PANCREATIC PROGENITOR CELL; PRIORITY JOURNAL; STEM CELL; TRANSCRIPTION REGULATION; ANTIBODY SPECIFICITY; BINDING SITE; BIOLOGY; CELL LINE; CLUSTER ANALYSIS; CYTOLOGY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN EMBRYONIC STEM CELL; METABOLISM; NUCLEOTIDE MOTIF; ORGANOGENESIS; POSITION WEIGHT MATRIX;

BINDING SITES; BIOMARKERS; CELL DIFFERENTIATION; CELL LINE; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMAN EMBRYONIC STEM CELLS; HUMANS; LIVER; NUCLEOTIDE MOTIFS; ORGAN SPECIFICITY; ORGANOGENESIS; PANCREAS; POSITION-SPECIFIC SCORING MATRICES; PROTEIN BINDING; RESPONSE ELEMENTS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 84933678295     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.02.015     Document Type: Article

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