Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex

EMBO Journal

Volumn 34, Issue 13, 2015, Pages 1829-1843

  Liu, Songbai ^a,b   Lu, Guojun ^b,f   Ali, Shafat ^b   Liu, Wenpeng ^a,b   Zheng, Li ^b   Dai, Huifang ^b   Li, Hongzhi ^b   Xu, Hong ^a   Hua, Yuejin ^a   Zhou, Yajing ^c   Ortega, Janice ^d   Li, Guo Min ^d   Kunkel, Thomas A ^e   Shen, Binghui ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c JIANGSU UNIVERSITY   (China)

^d UNIVERSITY OF KENTUCKY   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

DNA mismatch repair; flap endonuclease 1; MutS ; Okazaki fragment maturation; segment error editing

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; EXONUCLEASE; FLAP ENDONUCLEASE; FLAP ENDONUCLEASE 1; OKAZAKI FRAGMENT; PRIMER RNA; PROTEIN MSH2; UNCLASSIFIED DRUG; DNA; DNA DIRECTED DNA POLYMERASE BETA; OKAZAKI FRAGMENTS; PROTEIN MUTS;

ALPHA SEGMENT ERROR EDITING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CELL TRANSFORMATION; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVITY; GENE MUTATION; GENETIC PARAMETERS; GENOMIC INSTABILITY; MISMATCH REPAIR; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RNA PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CLASSIFICATION; FEMALE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HUMAN; MALE; METABOLISM; SACCHAROMYCES CEREVISIAE; TRANSGENIC MOUSE;

EUKARYOTA; MAMMALIA; MUS;

ANIMALS; CELLS, CULTURED; DNA; DNA MISMATCH REPAIR; DNA POLYMERASE I; DNA REPLICATION; EMBRYO, MAMMALIAN; FEMALE; FLAP ENDONUCLEASES; HEK293 CELLS; HELA CELLS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTS DNA MISMATCH-BINDING PROTEIN; SACCHAROMYCES CEREVISIAE;

EID: 84933674587     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201489865     Document Type: Article

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