Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

EMBO Reports

Volumn 6, Issue 1, 2005, Pages 83-89

  Zheng, Li ^a   Zhou, Mian ^a   Chai, Qing ^a   Parrish, Jay ^b   Xue, Ding ^b   Patrick, Steve M ^c   Turchi, John J ^c   Yannone, Steven M ^d   Chen, David ^d   Shen, Binghui ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c WRIGHT STATE UNIVERSITY   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

DNA replication fork; Flap endonuclease 1; Werner syndrome protein

Indexed keywords

CAMPTOTHECIN; FLAP ENDONUCLEASE; REPLICATION PROTEIN A; WERNER SYNDROME PROTEIN; CELL EXTRACT; DNA; FLAP ENDONUCLEASE 1, HUMAN; FLAP ENDONUCLEASE-1, HUMAN;

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; TEMPERATURE SENSITIVITY; ULTRAVIOLET RADIATION; CELL NUCLEUS; GENETICS; HELA CELL; METABOLISM; MUTATION; WERNER SYNDROME;

EUKARYOTA;

CELL EXTRACTS; CELL NUCLEUS; DNA; DNA REPLICATION; FLAP ENDONUCLEASES; HELA CELLS; HUMANS; MUTATION; WERNER SYNDROME;

EID: 21444436726     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400313     Document Type: Article

References (26)

1. Brosh Jr RM, von Kobbe C, Sommers JA, Karmakar P, Opresko PL, Piotrowski J, Dianova I, Dianov GL, Bohr VA (2001) Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J 20: 5791-5801
2. Cox MM (2001) Recombinational DNA repair of damaged replication forks in Escherichia coli: questions. Annu Rev Genet 35: 53-82
3. Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B (1998) Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates. J Biol Chem 273: 33064-33072
4. Gangloff S, Soustelle C, Fabre F (2000) Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases. Nat Genet 25: 192-194
5. Harmon FG, Kowalczykowski SC (1998) RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination. Genes Dev 12: 1134-1144
6. Hsiang YH, Hertzberg R, Hecht S, Liu LF (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260: 14873-14878
7. Kaliraman V, Mullen JR, Fricke WM, Bastin-Shanower SA, Brill SJ (2001) Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev 15: 2730-2740
8. Khlimankov D, Rechkunova NI, Khodyreva SN, Petruseva IO, Nazarkina Zh K, Belousova EA, Lavrik OI (2002) Interaction of replication protein A and flap endonuclease 1 with DNA duplexes containing a nick or flap. Mol Biol (Mosk) 36: 1044-1053
9. Limoli CL, Laposa R, Cleaver JE (2002) DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin. Mutat Res 510: 121-129
10. Liu Y, Masson JY, Shah R, O'Regan P, West SC (2004) RAD51C is required for Holliday junction processing in mammalian cells. Science 303: 243-246
11. Michel B (2000) Replication fork arrest and DNA recombination. Trends Biochem Sci 25: 173-178
12. Murante RS, Rust L, Bambara RA (1995) Calf 5′ to 3′ exo/endonuclease must slide from a 5′ end of the substrate to perform structure-specific cleavage. J Biol Chem 270: 30377-30383
13. Oakley GG, Patrick SM, Yao J, Carty MP, Turchi JJ, Dixon K (2003) RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry 42: 3255-3264
14. Parrish JZ, Yang C, Shen B, Xue D (2003) CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J 22: 3451-3460
15. Partridge JJ, Lopreiato Jr JO, Latterich M, Indig FE (2003) DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP. Mol Biol Cell 14: 4221-4229
16. Pouliot JJ, Yao KC, Robertson CA, Nash HA (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286: 552-555
17. Ramilo C, Gu L, Guo S, Zhang X, Patrick SM, Turchi JJ, Li G-M (2002) Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A. Mol Cell Biol 22: 2037-2046
18. Reagan MS, Pittenger C, Siede W, Friedberg EC (1995) Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene. J Bacteriol 177: 364-371
19. Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y (1999) Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J 18: 1397-1406
20. Sharma S, Otterlei M, Sommers JA, Driscoll HC, Dianov GL, Kao HI, Bambara RA, Brosh Jr RM (2004) WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell 15: 734-750
21. Sogo JM, Lopes M, Foiani M (2002) Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297: 599-602
22. Tishkoff DX, Filosi N, Gaida CM, Kolodner RD (1997) A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88: 253-263
23. Tong AH eta/(2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294: 2364-2368
24. Wu L, Hickson ID (2002) RecQ helicases and cellular responses to DNA damage. Mutat Res 509: 35-47
25. Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi J, Chen DJ (2001) Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem 276: 38242-38248
26. 2+ binding sites in regulation of murine flap endonuclease-1 activities. Biochemistry 41: 10323-10331