Tripartite structure of Saccharomyces cerevisiae Dna2 helicase/endonuclease

Nucleic Acids Research

Volumn 29, Issue 14, 2001, Pages 3069-3079

  Bae, Sung Ho ^a   Kim, Jung Ae ^a   Choi, Eunju ^a   Lee, Kyoung Hwa ^a   Kang, Ho Young ^a   Kim, Hee Dai ^a   Kim, Jae Hoon ^a   Bae, Kwang Hee ^a   Cho, Yunje ^b   Park, Chankyu ^c   Seo, Yeon Soo ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DEOXYRIBONUCLEASE; DNA FRAGMENT; HELICASE; MONOMER; MUTANT PROTEIN; POLYPEPTIDE; REPLICATION PROTEIN A; SUBTILISIN;

ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; BIOPHYSICS; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; GENETIC ANALYSIS; GROWTH DISORDER; HYDRODYNAMICS; IN VIVO STUDY; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; TEMPERATURE;

ANIMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0035878722     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.14.3069     Document Type: Article

References (21)

1. Characterization of the enzymatic properties of the yeast dna2 helicase/endonuclease suggests a new model for Okazaki fragment processing
2. A yeast gene required for DNA replication encodes a protein with homology to DNA helicases
3. The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways
4. Dna2 mutants reveal interactions with DNA polymerase alpha and Ctf4, a Pol alpha accessory factor and show that full Dna2 helicase activity is not essential for growth
5. + reveal that Dna2 plays an essential role in Okazaki fragment metabolism
6. Identification of the Xenopus laevis homolog of Saccharomyces cerevisiae DNA2 and its role in DNA replication
7. Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP
8. Conserved domains in DNA repair proteins and evolution of repair systems
9. The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo
10. The endonuclease activity of the yeast Dna2 enzyme is essential in vivo
11. A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nucleases in carrying out its essential function
12. Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template
13. Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase
14. Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27
15. Identification of high copy disruptors of telomeric silencing in Saccharomyces cerevisiae
16. A DNA helicase from Schizosaccharomyces pombe stimulated by single-stranded DNA-binding protein at low ATP concentration
17. In vitro evidence that purified yeast Rad27 and Dna2 are not stably associated with each other suggests that an additional protein(s) is required for a complex formation
18. Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases
19. DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes
20. RPA-governed endonuclease switching during Okazaki fragment processing
21. + encodes a novel replication factor required for chromosome integrity