Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

Cell Research

Volumn 21, Issue 7, 2011, Pages 1052-1067

  Zheng, Li ^a   Dai, Huifang ^a   Hegde, Muralidhar L ^b   Zhou, Mian ^a   Guo, Zhigang ^a   Wu, Xiwei ^a   Wu, Jun ^a   Su, Lei ^a   Zhong, Xueyan ^a   Mitra, Sankar ^b   Huang, Qin ^a   Kernstine, Kemp H ^a   Pfeifer, Gerd P ^a   Shen, Binghui ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

aneuploidy; cancer; FEN1; long patch base excision repair; Okazaki fragment maturation; PCNA; tetraploidy

Indexed keywords

CHECKPOINT KINASE 1; CYCLINE; DNA; FLAP ENDONUCLEASE; OKAZAKI FRAGMENTS; PROTEIN KINASE;

ANEUPLOIDY; ANIMAL; ARTICLE; CELL CULTURE; CELL TRANSFORMATION; DNA REPAIR; DNA STRAND BREAKAGE; GENETICS; HUMAN; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; POINT MUTATION;

ANEUPLOIDY; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA; DNA BREAKS; DNA REPAIR; FLAP ENDONUCLEASES; HUMANS; MICE; NEOPLASMS; POINT MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN KINASES;

MUS;

EID: 79960139957     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.35     Document Type: Article

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