Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice

Molecular and Cellular Biology

Volumn 27, Issue 8, 2007, Pages 3176-3186

  Zheng, Li ^a   Dai, Huifang ^a   Qiu, Junzhuan ^a   Huang, Qin ^a   Shen, Binghui ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DNA; FLAP ENDONUCLEASE; GLUTAMINYLGLYCYLARGINYLLEUCYLASPARTYLASPARTYLPHENYLALANYLPHENYLALANYLLYSINE; MUTANT PROTEIN; OKAZAKI FRAGMENT; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FEN1 GENE; FIBROBLAST; GENE; GENE LOCUS; GENE MUTATION; KNOCKOUT GENE; LUNG HYPOPLASIA; MALE; MOUSE; NEWBORN; NEWBORN DEATH; NONHUMAN; PANCYTOPENIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CELL PROLIFERATION; DNA MUTATIONAL ANALYSIS; DNA REPLICATION; EMBRYO; EMBRYONIC DEVELOPMENT; FIBROBLASTS; FLAP ENDONUCLEASES; HOMOZYGOTE; LUNG; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; PANCYTOPENIA; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN TRANSPORT; STILLBIRTH;

MAMMALIA; MUS;

EID: 34147209417     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01652-06     Document Type: Article

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