-
1
-
-
79953054421
-
Strategies to improve radiotherapy with targeted drugs
-
Begg A.C., Stewart F.A., Vens C. Strategies to improve radiotherapy with targeted drugs. Nat. Rev. Cancer 2011, 11:239-253.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 239-253
-
-
Begg, A.C.1
Stewart, F.A.2
Vens, C.3
-
2
-
-
84864405467
-
An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses
-
Lee S., Lim M.J., Kim M.H., Yu C.H., Yun Y.S., Ahn J., Song J.Y. An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses. Free Radical Biol. Med. 2012, 53:807-816.
-
(2012)
Free Radical Biol. Med.
, vol.53
, pp. 807-816
-
-
Lee, S.1
Lim, M.J.2
Kim, M.H.3
Yu, C.H.4
Yun, Y.S.5
Ahn, J.6
Song, J.Y.7
-
3
-
-
84890940231
-
Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1
-
Na H.K., Surh Y.J. Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1. Free Radical Biol. Med. 2014, 67:353-365.
-
(2014)
Free Radical Biol. Med.
, vol.67
, pp. 353-365
-
-
Na, H.K.1
Surh, Y.J.2
-
4
-
-
77958125017
-
Discovery of the negative regulator of Nrf2, Keap1: a historical overview
-
Itoh K., Mimura J., Yamamoto M. Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid. Redox Signal. 2010, 13:1665-1678.
-
(2010)
Antioxid. Redox Signal.
, vol.13
, pp. 1665-1678
-
-
Itoh, K.1
Mimura, J.2
Yamamoto, M.3
-
6
-
-
67649402187
-
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
-
Nguyen T., Nioi P., Pickett C.B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 2009, 284:13291-13295.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13291-13295
-
-
Nguyen, T.1
Nioi, P.2
Pickett, C.B.3
-
7
-
-
77954695549
-
Wistuba, II Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
-
Solis L.M., Behrens C., Dong W., Suraokar M., Ozburn N.C., Moran C.A., Corvalan A.H., Biswal S., Swisher S.G., Bekele B.N., Minna J.D., Stewart D.J. Wistuba, II Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin. Cancer Res. 2010, 16:3743-3753.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3743-3753
-
-
Solis, L.M.1
Behrens, C.2
Dong, W.3
Suraokar, M.4
Ozburn, N.C.5
Moran, C.A.6
Corvalan, A.H.7
Biswal, S.8
Swisher, S.G.9
Bekele, B.N.10
Minna, J.D.11
Stewart, D.J.12
-
8
-
-
84886082476
-
Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: role of reactive oxygen species, GSH and Nrf2 in radiosensitivity
-
Jayakumar S., Kunwar A., Sandur S.K., Pandey B.N., Chaubey R.C. Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: role of reactive oxygen species, GSH and Nrf2 in radiosensitivity. Biochim. Biophys. Acta 2014, 1840:485-494.
-
(2014)
Biochim. Biophys. Acta
, vol.1840
, pp. 485-494
-
-
Jayakumar, S.1
Kunwar, A.2
Sandur, S.K.3
Pandey, B.N.4
Chaubey, R.C.5
-
9
-
-
80053439769
-
NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer
-
Shibata T., Kokubu A., Saito S., Narisawa-Saito M., Sasaki H., Aoyagi K., Yoshimatsu Y., Tachimori Y., Kushima R., Kiyono T., Yamamoto M. NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer. Neoplasia 2011, 13:864-873.
-
(2011)
Neoplasia
, vol.13
, pp. 864-873
-
-
Shibata, T.1
Kokubu, A.2
Saito, S.3
Narisawa-Saito, M.4
Sasaki, H.5
Aoyagi, K.6
Yoshimatsu, Y.7
Tachimori, Y.8
Kushima, R.9
Kiyono, T.10
Yamamoto, M.11
-
10
-
-
77958129306
-
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
-
Singh A., Bodas M., Wakabayashi N., Bunz F., Biswal S. Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid. Redox Signal. 2010, 13:1627-1637.
-
(2010)
Antioxid. Redox Signal.
, vol.13
, pp. 1627-1637
-
-
Singh, A.1
Bodas, M.2
Wakabayashi, N.3
Bunz, F.4
Biswal, S.5
-
11
-
-
84888300793
-
Nrf2 is a potential therapeutic target in radioresistance in human cancer
-
Zhou S., Ye W., Shao Q., Zhang M., Liang J. Nrf2 is a potential therapeutic target in radioresistance in human cancer. Crit. Rev. Oncol. Hematol. 2013, 88:706-715.
-
(2013)
Crit. Rev. Oncol. Hematol.
, vol.88
, pp. 706-715
-
-
Zhou, S.1
Ye, W.2
Shao, Q.3
Zhang, M.4
Liang, J.5
-
12
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia A., Elledge S.J. The DNA damage response: making it safe to play with knives. Mol. Cell 2010, 40:179-204.
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
13
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411:366-374.
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
14
-
-
0031663617
-
ATM: from gene to function
-
Rotman G., Shiloh Y. ATM: from gene to function. Hum. Mol. Genet. 1998, 7:1555-1563.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1555-1563
-
-
Rotman, G.1
Shiloh, Y.2
-
15
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 2000, 10:886-895.
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
16
-
-
0035093737
-
DNA double-strand breaks: signaling, repair and the cancer connection
-
Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 2001, 27:247-254.
-
(2001)
Nat. Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
17
-
-
0035105999
-
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
-
Davies A.A., Masson J.Y., McIlwraith M.J., Stasiak A.Z., Stasiak A., Venkitaraman A.R., West S.C. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol. Cell 2001, 7:273-282.
-
(2001)
Mol. Cell
, vol.7
, pp. 273-282
-
-
Davies, A.A.1
Masson, J.Y.2
McIlwraith, M.J.3
Stasiak, A.Z.4
Stasiak, A.5
Venkitaraman, A.R.6
West, S.C.7
-
18
-
-
24044554210
-
Human DNA repair genes, 2005
-
Wood R.D., Mitchell M., Lindahl T. Human DNA repair genes, 2005. Mutat. Res. 2005, 577:275-283.
-
(2005)
Mutat. Res.
, vol.577
, pp. 275-283
-
-
Wood, R.D.1
Mitchell, M.2
Lindahl, T.3
-
19
-
-
0141619287
-
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
-
Veuger S.J., Curtin N.J., Richardson C.J., Smith G.C., Durkacz B.W. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 2003, 63:6008-6015.
-
(2003)
Cancer Res.
, vol.63
, pp. 6008-6015
-
-
Veuger, S.J.1
Curtin, N.J.2
Richardson, C.J.3
Smith, G.C.4
Durkacz, B.W.5
-
20
-
-
84918799959
-
Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51
-
Ward A., Khanna K.K., Wiegmans A.P. Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51. Cancer Treat. Rev. 2015, 41:35-45.
-
(2015)
Cancer Treat. Rev.
, vol.41
, pp. 35-45
-
-
Ward, A.1
Khanna, K.K.2
Wiegmans, A.P.3
-
21
-
-
84925664415
-
ATM and ATR as therapeutic targets in cancer
-
Weber A.M., Ryan A.J. ATM and ATR as therapeutic targets in cancer. Pharmacol. Ther. 2015, 149:124-138.
-
(2015)
Pharmacol. Ther.
, vol.149
, pp. 124-138
-
-
Weber, A.M.1
Ryan, A.J.2
-
22
-
-
84867917942
-
Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation
-
Kim S.B., Pandita R.K., Eskiocak U., Ly P., Kaisani A., Kumar R., Cornelius C., Wright W.E., Pandita T.K., Shay J.W. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:e2949-e2955.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. e2949-e2955
-
-
Kim, S.B.1
Pandita, R.K.2
Eskiocak, U.3
Ly, P.4
Kaisani, A.5
Kumar, R.6
Cornelius, C.7
Wright, W.E.8
Pandita, T.K.9
Shay, J.W.10
-
23
-
-
0036581160
-
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
-
Pfaffl M.W., Horgan G.W., Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002, 30:e36.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. e36
-
-
Pfaffl, M.W.1
Horgan, G.W.2
Dempfle, L.3
-
24
-
-
84865044015
-
The potential value of the neutral comet assay and the expression of genes associated with DNA damage in assessing the radiosensitivity of tumor cells
-
Jayakumar S., Bhilwade H.N., Pandey B.N., Sandur S.K., Chaubey R.C. The potential value of the neutral comet assay and the expression of genes associated with DNA damage in assessing the radiosensitivity of tumor cells. Mutat. Res. 2012, 748:52-59.
-
(2012)
Mutat. Res.
, vol.748
, pp. 52-59
-
-
Jayakumar, S.1
Bhilwade, H.N.2
Pandey, B.N.3
Sandur, S.K.4
Chaubey, R.C.5
-
25
-
-
78449270816
-
Ionizing radiation activates the Nrf2 antioxidant response
-
McDonald J.T., Kim K., Norris A.J., Vlashi E., Phillips T.M., Lagadec C., Della Donna L., Ratikan J., Szelag H., Hlatky L., McBride W.H. Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res. 2010, 70:8886-8895.
-
(2010)
Cancer Res.
, vol.70
, pp. 8886-8895
-
-
McDonald, J.T.1
Kim, K.2
Norris, A.J.3
Vlashi, E.4
Phillips, T.M.5
Lagadec, C.6
Della Donna, L.7
Ratikan, J.8
Szelag, H.9
Hlatky, L.10
McBride, W.H.11
-
26
-
-
84867034260
-
Role of nrf2 in oxidative stress and toxicity
-
Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 2013, 53:401-426.
-
(2013)
Annu. Rev. Pharmacol. Toxicol.
, vol.53
, pp. 401-426
-
-
Ma, Q.1
-
27
-
-
84885944468
-
The emerging role of the Nrf2-Keap1 signaling pathway in cancer
-
Jaramillo M.C., Zhang D.D. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev. 2013, 27:2179-2191.
-
(2013)
Genes Dev.
, vol.27
, pp. 2179-2191
-
-
Jaramillo, M.C.1
Zhang, D.D.2
-
28
-
-
84903514856
-
Concerted action of Nrf2-ARE pathway MRN, complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage
-
Anuranjani, Bala M. Concerted action of Nrf2-ARE pathway MRN, complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage. Redox Biol. 2014, 2:832-846.
-
(2014)
Redox Biol.
, vol.2
, pp. 832-846
-
-
Anuranjani1
Bala, M.2
-
29
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler T.W., Wakabayashi N., Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47:89-116.
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
30
-
-
84878009975
-
Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer
-
Singh B., Chatterjee A., Ronghe A.M., Bhat N.K., Bhat H.K. Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer. BMC Cancer 2013, 13:253.
-
(2013)
BMC Cancer
, vol.13
, pp. 253
-
-
Singh, B.1
Chatterjee, A.2
Ronghe, A.M.3
Bhat, N.K.4
Bhat, H.K.5
-
31
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting S.F., Callen E., Wong N., Chen H.T., Polato F., Gunn A., Bothmer A., Feldhahn N., Fernandez-Capetillo O., Cao L., Xu X., Deng C.X., Finkel T., Nussenzweig M., Stark J.M., Nussenzweig A. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010, 141:243-254.
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callen, E.2
Wong, N.3
Chen, H.T.4
Polato, F.5
Gunn, A.6
Bothmer, A.7
Feldhahn, N.8
Fernandez-Capetillo, O.9
Cao, L.10
Xu, X.11
Deng, C.X.12
Finkel, T.13
Nussenzweig, M.14
Stark, J.M.15
Nussenzweig, A.16
-
32
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
-
Fernandez-Capetillo O., Chen H.T., Celeste A., Ward I., Romanienko P.J., Morales J.C., Naka K., Xia Z., Camerini-Otero R.D., Motoyama N., Carpenter P.B., Bonner W.M., Chen J., Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 2002, 4:993-997.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
Chen, H.T.2
Celeste, A.3
Ward, I.4
Romanienko, P.J.5
Morales, J.C.6
Naka, K.7
Xia, Z.8
Camerini-Otero, R.D.9
Motoyama, N.10
Carpenter, P.B.11
Bonner, W.M.12
Chen, J.13
Nussenzweig, A.14
-
33
-
-
70350228784
-
Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels
-
Villeneuve N.F., Sun Z., Chen W., Zhang D.D. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell cycle 2009, 8:3255-3256.
-
(2009)
Cell cycle
, vol.8
, pp. 3255-3256
-
-
Villeneuve, N.F.1
Sun, Z.2
Chen, W.3
Zhang, D.D.4
-
34
-
-
84856563780
-
Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells
-
Urbin S.S., Elvers I., Hinz J.M., Helleday T., Thompson L.H. Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells. Environ. Mol. Mutagen. 2012, 53:114-124.
-
(2012)
Environ. Mol. Mutagen.
, vol.53
, pp. 114-124
-
-
Urbin, S.S.1
Elvers, I.2
Hinz, J.M.3
Helleday, T.4
Thompson, L.H.5
-
35
-
-
84884215156
-
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
-
Gorrini C., Baniasadi P.S., Harris I.S., Silvester J., Inoue S., Snow B., Joshi P.A., Wakeham A., Molyneux S.D., Martin B., Bouwman P., Cescon D.W., Elia A.J., Winterton-Perks Z., Cruickshank J., Brenner D., Tseng A., Musgrave M., Berman H.K., Khokha R., Jonkers J., Mak T.W., Gauthier M.L. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J. Exp. Med. 2013, 210:1529-1544.
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1529-1544
-
-
Gorrini, C.1
Baniasadi, P.S.2
Harris, I.S.3
Silvester, J.4
Inoue, S.5
Snow, B.6
Joshi, P.A.7
Wakeham, A.8
Molyneux, S.D.9
Martin, B.10
Bouwman, P.11
Cescon, D.W.12
Elia, A.J.13
Winterton-Perks, Z.14
Cruickshank, J.15
Brenner, D.16
Tseng, A.17
Musgrave, M.18
Berman, H.K.19
Khokha, R.20
Jonkers, J.21
Mak, T.W.22
Gauthier, M.L.23
more..
|