Transplantation of induced pluripotent stem cells without C-Myc attenuates retinal ischemia and reperfusion injury in rats

Experimental Eye Research

Volumn 113, Issue , 2013, Pages 49-59

  Fang, I Mo ^a,b   Yang, Chung May ^b   Yang, Chang Hao ^b   Chiou, Shih Hwa ^c,d   Chen, Muh Shy ^b  

^a TAIPEI CITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d VGH Taipei   (Taiwan)

Author keywords

C Myc; Induced pluripotent stem cells; Ischemia reperfusion injury; Oxidative stress; Paracrine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR 2; MYC PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTRORETINOGRAM; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; IMMUNOHISTOCHEMISTRY; NONHUMAN; PARACRINE SIGNALING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RETINA CELL; RETINA GANGLION CELL; RETINA ISCHEMIA; RETINAL THICKNESS; STEM CELL TRANSPLANTATION;

EID: 84879436499     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.05.007     Document Type: Article

References (39)

1. Armstrong L., Tillgner K., Saretzki G., Atkinson S.P., Stojkovic M., Moreno R., Przyborski S., Lako M. Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells 2010, 28(4):661-673.
2. Carr A.J., Vugler A.A., Hikita S.T., Lawrence J.M., Gias C., Chen L.L., Buchholz D.E., Ahmado A., Semo M., Smart M.J., Hasan S., da Cruz L., Johnson L.V., Clegg D.O., Coffey P.J. Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. Plos One 2009, 4:e8152.
3. Cellerino A., Kohler K. Brain derived neurotrophic factor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebral retina. J.Comp. Neurol. 1997, 386:149-160.
4. Chen S.J., Chang C.M., Tsai S.K., Chang Y.L., Chou S.J., Huang S.S., Tai L.K., Chen Y.C., Ku H.H., Li H.Y., Chiou S.H. Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glue. Stem Cells Dev. 2010, 19:1757-1767.
5. Cheng A.S., Yau T.M. Paracrine effects of cell transplantation: strategies to augment the efficacy of cell therapies. Semin. Thorac. Cardiovasc. Surg. 2008, 20(2):94-101.
6. Cingolani C., Rogers B., Lu L., Kachi S., Shen J., Campochiaro P.A. Retinal degeneration from oxidative damage. Free Radic. Biol. Med. 15 Feb. 2006, 40(4):660-669.
7. Di-Polo A., Aigner L.J., Dunn R.J., Bray G.M., Aguayo A.J. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:3978-3983.
8. Fedak P.W. Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart. Semin. Thorac. Cardiovasc. Surg. 2008, 20(2):87-93.
9. Gerdoni E., Gallo B., Casazza S., Musio S., Bonanni I., Pedemonte E., Mantegazza R., Frassoni F., Mancardi G., Pedotti R., Uccelli A. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann. Neurol. 2007, 61(3):219-227.
10. Harper M.M., Grozdanic S.D., Blits B., Kuehn M.H., Zamzow D., Buss J.E., Kardon R.H., Sakaguchi D.S. Transplantation of BDNF-secreting mesenchymal stem cell provides neuroprotection in chronically hypertensive rat eyes. Invest. Ophthalmol. Vis. Sci. 2011, 52:4506-4515.
11. Hill D.W. Fluorescein studies in retinal vascular occlusion. Br. J. Ophthalmol. 1968, 52:1-12.
12. Kao C.L., Tai L.K., Chiou S.H., Chen Y.J., Lee K.H., Chou S.J., Chang Y.L., Chang C.M., Chen S.J., Ku H.H., Li H.Y. Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells. Stem Cells Dev. 2010, 19(11):1757-1767.
13. Kassis I., Grigoriadis N., Gowda-Kurkalli B., Mizrachi-Kol R., Ben-Hur T., Slavin S., Abramsky O., Karussis D. Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis. Arch. Neurol. 2008, 65(6):753-761.
14. Klocker N., Cellerino A., Bahr M. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells invivo. J.Neurosci. 1998, 18:1038-1046.
15. Ko M.L., Hu D.N., Ritch R., Sharma S.C. The combined effect of brain-derived neurotrophic factor and a free radical scavenger in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2000, 41:2967-2971.
16. Lam T.T., Abler A.S., Tao M.O.M. Apoptosis and caspase after ischemia-reperfusion injury in rat retina. Invest. Ophthalmol. Vis. Sci. 1999, 40:967-975.
17. Levine L.A. Models of neural injury. J.Glaucoma 2001, 10:S19-S21.
18. Lee P.Y., Chien Y., Chiou G.Y., Lin C.H., Chiou C.H., Tarng D.C. Induced pluripotent stem cells with c-Myc attenuate acute kidney injury via downregulating the signaling oxidative stress and inflammation in ischemia-reperfusion rats. Cell Transplant. 2012, 21:2569-2585.
19. Li H.Y., Chien Y., Chen Y.J., Chen S.F., Chang Y.L., Chiang C.H., Jeng S.Y., Chang C.M., Wang M.L., Chen L.K., Hung S.I., Huo T.I., Lee S.D., Chiou S.H. Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells. Biomaterials 2011, 32:5994-6005.
20. Li N., Li X.R., Yuan J.Q. Effects of bone-marrow mesenchymal stem cells transplanted into vitreous cavity of rat injured by ischemia/reperfusion. Graefes Arch. Clin. Exp. Ophthalmol. 2009, 247:503-514.
21. Mansour-Robaey S., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:1632-1636.
22. Nakagawa M., Koyanagi M., Tanabe K., Takahashi K., Ichisaka T., Aoi T., Okita K., Mochiduki Y., Takizawa N., Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 2008, 26(1):101-106.
23. Okita K., Ichisaka T., Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007, 448:313-317.
24. Osborne N.N., Casson R.J., Wood J.P., Chidlow G., Graham M., Melena J. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog. Retin. Eye Res. 2004, 23(1):91-147.
25. Pelengaris S., Khan M., Evan G. c-Myc: more than just a matter of life and death. Nat. Rev. Cancer 2002, 2(10):764-776.
26. Pellegrini-Giampietro D.E., Cherici G., Alesiani M., Carla V., Moroni F. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J.Neurosci. 1990, 10(3):1035-1041.
27. Quigley H.A., McKinnon S.J., Zack D.J., Pease M.E., Kerrigan-Baumrind L.A., Kerrigan D.F., Mitchell R.S. Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest. Ophthalmol. Vis. Sci. 2000, 41:3460-3466.
28. Stefansson E., Machemer R., de Juan E., McCuen B.W., Peterson J. Retinal oxygenation and laser treatment in patients with diabetic retinopathy. Am. J. Ophthalmol. 1992, 113:36-38.
29. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
30. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
31. Tso M.O., Jampol L.M. Pathophysiology of hypertensive retinopathy. Ophthalmology 1982, 89:1132-1145.
32. Uccelli A., Benvenuto F., Laroni A., Giunti D. Neuroprotective features of mesenchymal stem cells. Best Pract. Res. Clin. Haematol. 2011, 24(1):59-64.
33. Unoki K., la Vail M.M. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest. Ophthalmol. Vis. Sci. 1994, 35:907-915.
34. Watanabe M., Tokita Y., Kato M., Fukuda Y. Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina. Neuroscience 2003, 116:733-742.
35. Wen R., Tao W., Li Y., Sieving P.A. CNTF and retina. Prog. Retin. Eye Res. 2012, 31:136-151.
36. Wu W.C., Lai C.C., Chen S.L., Sun M.H., Xiao X., Chen T.L., Tsai R.J., Kuo S.W., Tsao Y.P. GDNF gene therapy attenuates retinal ischemic injuries in rats. Mol. Vis. 2004, 10:93-102.
37. Yang K.Y., Shih H.C., How C.K., Chen C.Y., Hsu H.S., Yang C.W., Lee Y.C., Perng R.P., Peng C.H., Li H.Y., Chang C.M., Mou C.Y., Chiou S.H. IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice. Chest 2011, 140(5):1243-1253.
38. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., Nie J., Jonsdottir G.A., Ruotti V., Stewart R., Slukvin I.I, Thomson J.A. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
39. Zheng L., Gong B., Hatala D.A., Kern T.S. Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes. Invest. Ophthalmol. Vis. Sci. 2007, 48(1):361-367.