Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Wang, Leilei ^a   Li, Chuanzhou ^a   Guo, Hao ^b   Kern, Timothy S ^c,d   Huang, Kun ^b   Zheng, Ling ^a  

^a WUHAN UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; BETA TUBULIN 3; CURCUMIN; I KAPPA B KINASE ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT1 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; CCL2 PROTEIN, RAT; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; STAT3 PROTEIN, RAT; TUBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME REGULATION; GLIA CELL; INTRAOCULAR PRESSURE; MALE; NERVE CELL DEGENERATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; RETINA CAPILLARY; RETINA DEGENERATION; RETINA ISCHEMIA; RETINA NERVE CELL; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; NERVE CELL; PATHOLOGY; RETINA; RETINA BLOOD VESSEL; RETINA GANGLION CELL; TIME; VASCULAR DISEASE; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BLOTTING, WESTERN; CHEMOKINE CCL2; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; NEURONS; NF-KAPPA B; RATS; RATS, WISTAR; REPERFUSION INJURY; RETINA; RETINAL GANGLION CELLS; RETINAL VESSELS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TUBULIN; VASCULAR DISEASES;

EID: 79961229847     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023194     Document Type: Article

References (41)

1. Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, et al. (2004) Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res 23: 91-147.
2. Zheng L, Gong B, Hatala DA, Kern TS, (2007) Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes. Invest Ophthalmol Vis Sci 48: 361-367.
3. Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, et al. (2008) CD40 mediates retinal inflammation and neurovascular degeneration. J Immunol 181: 8719-8726.
4. Zheng L, Szabo C, Kern TS, (2004) Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes 53: 2960-2967.
5. Kern TS, Miller CM, Du Y, Zheng L, Mohr S, et al. (2007) Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes 56: 373-379.
6. Zheng L, Du Y, Miller C, Gubitosi-Klug RA, Kern TS, et al. (2007) Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia 50: 1987-1996.
7. Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, et al. (2002) Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 16: 438-440.
8. Zheng L, Liu S, Sun MZ, Chang J, Chance MR, et al. (2009) Pharmacologic intervention targeting glycolytic-related pathways protects against retinal injury due to ischemia and reperfusion. Proteomics 9: 1869-1882.
9. Neufeld AH, Kawai S, Das S, Vora S, Gachie E, et al. (2002) Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase. Exp Eye Res 75: 521-528.
10. Pari L, Tewas D, Eckel J, (2008) Role of curcumin in health and disease. Arch Physiol Biochem 114: 127-149.
11. Aggarwal BB, Harikumar KB, (2009) Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41: 40-59.
12. Kowluru RA, Kanwar M, (2007) Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab (Lond) 4: 8.
13. Mrudula T, Suryanarayana P, Srinivas PN, Reddy GB, (2007) Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem Biophys Res Commun 361: 528-532.
14. Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, et al. (2009) Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med 46: 672-679.
15. Raymond ID, Vila A, Huynh UC, Brecha NC, (2008) Cyan fluorescent protein expression in ganglion and amacrine cells in a thy1-CFP transgenic mouse retina. Mol Vis 14: 1559-1574.
16. Pimentel B, Sanz C, Varela-Nieto I, Rapp UR, De Pablo F, et al. (2000) c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis. J Neurosci 20: 3254-3262.
17. Yin Y, Cui Q, Li Y, Irwin N, Fischer D, et al. (2003) Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci 23: 2284-2293.
18. Cui Q, Yip HK, Zhao RC, So KF, Harvey AR, (2003) Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Mol Cell Neurosci 22: 49-61.
19. Karl MO, Hayes S, Nelson BR, Tan K, Buckingham B, et al. (2008) Stimulation of neural regeneration in the mouse retina. Proc Natl Acad Sci U S A 105: 19508-19513.
20. Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, et al. (1995) The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci 15: 4762-4785.
21. Middeldorp J, Hol EM, (2011) GFAP in health and disease. Prog Neurobiol.
22. Kuroki M, O'Flaherty JT, (1999) Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines. Biochem J341 (Pt 3): 691-696.
23. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA, (1994) Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A 91: 3652-3656.
24. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB, (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4: 807-818.
25. Yu S, Zheng W, Xin N, Chi ZH, Wang NQ, et al. (2011) Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation Res 13: 55-64.
26. Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES, (2002) Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 46: 273-279.
27. Rathore P, Dohare P, Varma S, Ray A, Sharma U, et al. (2008) Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem Res 33: 1672-1682.
28. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, et al. (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21: 8370-8377.
29. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, et al. (2005) Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280: 5892-5901.
30. Hayden MS, Ghosh S, (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
31. Yamamoto Y, Gaynor RB, (2004) IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 29: 72-79.
32. Ihle JN, Kerr IM, (1995) Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11: 69-74.
33. Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, et al. (2009) Function of mitochondrial Stat3 in cellular respiration. Science 323: 793-797.
34. Bharti AC, Donato N, Aggarwal BB, (2003) Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 171: 3863-3871.
35. Atkinson GP, Nozell SE, Benveniste ET, (2011) NF-kappaB and STAT3 signaling in glioma: targets for future therapies. Expert Rev Neurother 10: 575-586.
36. Ramudo L, Yubero S, Manso MA, Vicente S, De Dios I, (2009) Signal transduction of MCP-1 expression induced by pancreatitis-associated ascitic fluid in pancreatic acinar cells. J Cell Mol Med 13: 1314-1320.
37. Broadbelt NV, Chen J, Silver RB, Poppas DP, Felsen D, (2009) Pressure activates epidermal growth factor receptor leading to the induction of iNOS via NFkappaB and STAT3 in human proximal tubule cells. Am J Physiol Renal Physiol 297: F114-124.
38. Jo N, Wu GS, Rao NA, (2003) Upregulation of chemokine expression in the retinal vasculature in ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 44: 4054-4060.
39. Newman E, Reichenbach A, (1996) The Muller cell: a functional element of the retina. Trends Neurosci 19: 307-312.
40. Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, et al. (2006) Muller cells in the healthy and diseased retina. Prog Retin Eye Res 25: 397-424.
41. Lin MS, Lee YH, Chiu WT, Hung KS, (2009) Curcumin Provides Neuroprotection After Spinal Cord Injury. J Surg Res.