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Volumn 10, Issue 2, 2015, Pages 204-216

Effects of Cannabinoids on T-cell Function and Resistance to Infection

Author keywords

CB2 agonist; Infection; T cells; 9 THC

Indexed keywords

CANNABINOID; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CANNABINOID RECEPTOR; CANNABIS; DRONABINOL; IMMUNOSUPPRESSIVE AGENT;

EID: 84931005805     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-015-9603-3     Document Type: Review
Times cited : (83)

References (87)
  • 2
    • 0020655612 scopus 로고
    • 9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system of mice. I. in vivo investigation of the primary and secondary immune response
    • COI: 1:CAS:528:DyaL38XmtVyhur0%3D, PID: 6298841
    • 9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system of mice. I. in vivo investigation of the primary and secondary immune response. Pharmacology 26:1–11
    • (1983) Pharmacology , vol.26
    • Baczynsky, W.O.1    Zimmerman, A.M.2
  • 3
    • 80053571291 scopus 로고    scopus 로고
    • Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease
    • COI: 1:CAS:528:DC%2BC3MXht1KjtrzK, PID: 21626285
    • Basu S, Dittel BN (2011) Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease. Immunol Res 51:26–38
    • (2011) Immunol Res , vol.51 , pp. 26-38
    • Basu, S.1    Dittel, B.N.2
  • 4
    • 44349140740 scopus 로고    scopus 로고
    • Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription
    • Börner C, Höllt V, Kraus J (2007) Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription. Neuroimmunemodulation 14:281–286
    • (2007) Neuroimmunemodulation , vol.14 , pp. 281-286
    • Börner, C.1    Höllt, V.2    Kraus, J.3
  • 5
    • 72149116426 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling
    • Börner C, Smida M, Höllt V, Schraven B, Kraus J (2009) Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. J Biol Chem 284:35450–35460
    • (2009) J Biol Chem , vol.284 , pp. 35450-35460
    • Börner, C.1    Smida, M.2    Höllt, V.3    Schraven, B.4    Kraus, J.5
  • 9
    • 0034685707 scopus 로고    scopus 로고
    • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    • COI: 1:CAS:528:DC%2BD3cXjsVGntro%3D, PID: 10822068
    • Buckley NE, McCoy KL, Mezey E, Bonner T, Zimmer A, Felder CC, Glass M (2000) Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur J Pharmacol 396:141–149
    • (2000) Eur J Pharmacol , vol.396 , pp. 141-149
    • Buckley, N.E.1    McCoy, K.L.2    Mezey, E.3    Bonner, T.4    Zimmer, A.5    Felder, C.C.6    Glass, M.7
  • 10
    • 1642493025 scopus 로고    scopus 로고
    • Cannabinoid-mediated exacerbation of brain infection by opportunistic amebae
    • COI: 1:CAS:528:DC%2BD2cXltVOlsg%3D%3D, PID: 14741443
    • Cabral GA, Marciano-Cabral F (2004) Cannabinoid-mediated exacerbation of brain infection by opportunistic amebae. J Neuroimmunol 147:127–130
    • (2004) J Neuroimmunol , vol.147 , pp. 127-130
    • Cabral, G.A.1    Marciano-Cabral, F.2
  • 11
    • 0022539248 scopus 로고
    • Effect of delta-9-tetrahydrocannabinol on herpes simplex virus type 2 vaginal infections in the guinea pig
    • COI: 1:CAS:528:DyaL28XktFygsLs%3D, PID: 3010327
    • Cabral GA, Mishkin EM, Marciano-Cabral F, Coleman P, Harris L, Munson AE (1986) Effect of delta-9-tetrahydrocannabinol on herpes simplex virus type 2 vaginal infections in the guinea pig. Proc Soc Exp Biol Med 182:181–186
    • (1986) Proc Soc Exp Biol Med , vol.182 , pp. 181-186
    • Cabral, G.A.1    Mishkin, E.M.2    Marciano-Cabral, F.3    Coleman, P.4    Harris, L.5    Munson, A.E.6
  • 12
    • 84874648902 scopus 로고    scopus 로고
    • Differential expression of intracellular and extracellular CB2 cannabinoid receptor protein by human peripheral blood leukocytes
    • Castaneda JT, Harui A, Kiertscher SM, Roth JD, Roth MD (2013) Differential expression of intracellular and extracellular CB2 cannabinoid receptor protein by human peripheral blood leukocytes. J Neuroimm Pharmacol 8:323–332
    • (2013) J Neuroimm Pharmacol , vol.8 , pp. 323-332
    • Castaneda, J.T.1    Harui, A.2    Kiertscher, S.M.3    Roth, J.D.4    Roth, M.D.5
  • 13
    • 77952493930 scopus 로고    scopus 로고
    • Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors
    • PID: 20098669, [Electronic Resource]
    • Cencioni MT, Chiurchiu V, Catanzaro G, Borsellino G, Bernardi G, Battistini L, Maccarrone M (2010) Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS ONE 5:e8688 [Electronic Resource]
    • (2010) PLoS ONE , vol.5 , pp. e8688
    • Cencioni, M.T.1    Chiurchiu, V.2    Catanzaro, G.3    Borsellino, G.4    Bernardi, G.5    Battistini, L.6    Maccarrone, M.7
  • 14
    • 17544371574 scopus 로고    scopus 로고
    • Cannabinoid inhibition of adenlate cyclase-mediated signal transduction and IL-2 expression in the murine T-cell line, EL4.IL-2
    • COI: 1:CAS:528:DyaK28XjtlGisL0%3D, PID: 8662742
    • Condie R, Herring A, Koh WS, Lee M, Kaminski NE (1996) Cannabinoid inhibition of adenlate cyclase-mediated signal transduction and IL-2 expression in the murine T-cell line, EL4.IL-2. J Biol Chem 271:13175–13183
    • (1996) J Biol Chem , vol.271 , pp. 13175-13183
    • Condie, R.1    Herring, A.2    Koh, W.S.3    Lee, M.4    Kaminski, N.E.5
  • 15
    • 33846583671 scopus 로고    scopus 로고
    • Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis
    • COI: 1:CAS:528:DC%2BD2sXhtlSltLc%3D, PID: 17276894
    • Coopman K, Smith LD, Wright KL, Ward SG (2007) Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. Int Immunopharmacol 7:360–371
    • (2007) Int Immunopharmacol , vol.7 , pp. 360-371
    • Coopman, K.1    Smith, L.D.2    Wright, K.L.3    Ward, S.G.4
  • 16
    • 84863354586 scopus 로고    scopus 로고
    • Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells
    • COI: 1:CAS:528:DC%2BC38XltVyntLk%3D, PID: 22448282, [Electronic Resource]
    • Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA, Chen BK (2012) Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells. PLoS ONE 7:e33961 [Electronic Resource]
    • (2012) PLoS ONE , vol.7 , pp. e33961
    • Costantino, C.M.1    Gupta, A.2    Yewdall, A.W.3    Dale, B.M.4    Devi, L.A.5    Chen, B.K.6
  • 17
    • 23044486763 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: potential for the treatment of inflammatory diseases?
    • COI: 1:CAS:528:DC%2BD2MXntVCrurw%3D, PID: 16023222
    • Croxford JL, Yamamura T (2005) Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? J Neuroimmunol 166:3–18
    • (2005) J Neuroimmunol , vol.166 , pp. 3-18
    • Croxford, J.L.1    Yamamura, T.2
  • 18
    • 0030087688 scopus 로고    scopus 로고
    • Cannabinoid receptor proteins are increased in jurkat, human T-cell line after mitogen activation
    • COI: 1:CAS:528:DyaK28XhtFaktb4%3D, PID: 8632350
    • Daaka Y, Friedman H, Klein TW (1996) Cannabinoid receptor proteins are increased in jurkat, human T-cell line after mitogen activation. J Pharmacol Exp Ther 276:776–783
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 776-783
    • Daaka, Y.1    Friedman, H.2    Klein, T.W.3
  • 22
    • 0037396943 scopus 로고    scopus 로고
    • Microbial infections, immunomodulation, and drugs of abuse
    • COI: 1:CAS:528:DC%2BD3sXjsF2gtrY%3D, PID: 12692094
    • Friedman H, Newton C, Klein TW (2003) Microbial infections, immunomodulation, and drugs of abuse. Clin Micro Rev 16:209–219
    • (2003) Clin Micro Rev , vol.16 , pp. 209-219
    • Friedman, H.1    Newton, C.2    Klein, T.W.3
  • 25
    • 33744827120 scopus 로고    scopus 로고
    • Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes
    • COI: 1:CAS:528:DC%2BD28XlsFCns7c%3D, PID: 16503355
    • Ghosh S, Preet A, Groopman JE, Ganju RK (2006) Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes. Mol Immunol 43:2169–2179
    • (2006) Mol Immunol , vol.43 , pp. 2169-2179
    • Ghosh, S.1    Preet, A.2    Groopman, J.E.3    Ganju, R.K.4
  • 28
    • 45749086074 scopus 로고    scopus 로고
    • Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells
    • COI: 1:CAS:528:DC%2BD1cXot1aksLw%3D, PID: 18388242
    • Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, Nagarkatti PS (2008) Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells. Mol Pharmacol 74:20–33
    • (2008) Mol Pharmacol , vol.74 , pp. 20-33
    • Hegde, V.L.1    Hegde, S.2    Cravatt, B.F.3    Hofseth, L.J.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 29
    • 79955532485 scopus 로고    scopus 로고
    • Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus
    • COI: 1:CAS:528:DC%2BC3MXlvVWgsLk%3D, PID: 21131094
    • Huemer HP, Lassnig C, Bernhard D, Sturm S, Nowotny N, Kitchen M, Pavlic M (2011) Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus. Immunobiology 216:670–677
    • (2011) Immunobiology , vol.216 , pp. 670-677
    • Huemer, H.P.1    Lassnig, C.2    Bernhard, D.3    Sturm, S.4    Nowotny, N.5    Kitchen, M.6    Pavlic, M.7
  • 30
    • 0029846519 scopus 로고    scopus 로고
    • Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor
    • COI: 1:CAS:528:DyaK28XlsVCisLg%3D, PID: 8831752
    • Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH (1996) Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. J Med Chem 39:3875–3877
    • (1996) J Med Chem , vol.39 , pp. 3875-3877
    • Huffman, J.W.1    Yu, S.2    Showalter, V.3    Abood, M.E.4    Wiley, J.L.5    Compton, D.R.6    Martin, B.R.7    Bramblett, R.D.8    Reggio, P.H.9
  • 31
    • 0033381793 scopus 로고    scopus 로고
    • 3-(1′,1′-dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor
    • COI: 1:CAS:528:DC%2BD3cXntFCnsA%3D%3D, PID: 10658595
    • Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR (1999) 3-(1′,1′-dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg Med Chem 7:2905–2914
    • (1999) Bioorg Med Chem , vol.7 , pp. 2905-2914
    • Huffman, J.W.1    Liddle, J.2    Yu, S.3    Aung, M.M.4    Abood, M.E.5    Wiley, J.L.6    Martin, B.R.7
  • 32
    • 0029955788 scopus 로고    scopus 로고
    • Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression
    • COI: 1:CAS:528:DyaK28Xms1SntLY%3D, PID: 8937419
    • Kaminski NE (1996) Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression. Biochem Pharmacol 52:1133–1140
    • (1996) Biochem Pharmacol , vol.52 , pp. 1133-1140
    • Kaminski, N.E.1
  • 33
    • 0027103851 scopus 로고
    • Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation
    • COI: 1:CAS:528:DyaK3sXjt1ynsA%3D%3D, PID: 1279376
    • Kaminski NE, Abood ME, Kessler FK, Martin BR, Schatz AR (1992) Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol Pharmacol 42:736–742
    • (1992) Mol Pharmacol , vol.42 , pp. 736-742
    • Kaminski, N.E.1    Abood, M.E.2    Kessler, F.K.3    Martin, B.R.4    Schatz, A.R.5
  • 34
    • 80055070153 scopus 로고    scopus 로고
    • Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection
    • COI: 1:CAS:528:DC%2BC3MXhsFSjsr%2FL, PID: 21873455
    • Karmaus PWF, Chen W, Crawford RB, Harkema JR, Kaplan BLF, Kaminski NE (2011) Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection. J Leukoc Biol 90:983–995
    • (2011) J Leukoc Biol , vol.90 , pp. 983-995
    • Karmaus, P.W.F.1    Chen, W.2    Crawford, R.B.3    Harkema, J.R.4    Kaplan, B.L.F.5    Kaminski, N.E.6
  • 35
    • 84875859193 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB 2, disrupting early activation events
    • PID: 21789506
    • 9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB 2, disrupting early activation events. J Neuroimmune Pharmacol 7:843–855
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 843-855
    • Karmaus, P.W.1    Chen, W.2    Kaplan, B.L.3    Kaminski, N.E.4
  • 36
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • COI: 1:CAS:528:DC%2BD2MXjs1Okurg%3D, PID: 15864274
    • Klein TW (2005) Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 5:400–411
    • (2005) Nat Rev Immunol , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 37
    • 84907112385 scopus 로고
    • The effect of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9-tetrahydrocannabinol on T-lymphocyte and B-lymphocyte mitogen responses
    • COI: 1:CAS:528:DyaL28XotlWrsA%3D%3D, PID: 3003204
    • Klein TW, Newton CA, Widen R, Friedman H (1985) The effect of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9-tetrahydrocannabinol on T-lymphocyte and B-lymphocyte mitogen responses. J Immunopharmacol 7:451–466
    • (1985) J Immunopharmacol , vol.7 , pp. 451-466
    • Klein, T.W.1    Newton, C.A.2    Widen, R.3    Friedman, H.4
  • 38
    • 0025865796 scopus 로고
    • Marijuana components suppress inducion and cytolytic function of murine cytotoxic T-cells in vitro and in vivo
    • COI: 1:CAS:528:DyaK3MXit1Wgsr0%3D, PID: 1850002
    • Klein TW, Kawakami Y, Newton C, Friedman H (1991) Marijuana components suppress inducion and cytolytic function of murine cytotoxic T-cells in vitro and in vivo. J Toxicol Environ Health 32:465–477
    • (1991) J Toxicol Environ Health , vol.32 , pp. 465-477
    • Klein, T.W.1    Kawakami, Y.2    Newton, C.3    Friedman, H.4
  • 39
    • 0032520698 scopus 로고    scopus 로고
    • Marijuana, immunity and infection
    • COI: 1:CAS:528:DyaK1cXitlSru7w%3D, PID: 9610678
    • Klein TW, Friedman H, Specter S (1998) Marijuana, immunity and infection. J Neuroimmunol 83:102–115
    • (1998) J Neuroimmunol , vol.83 , pp. 102-115
    • Klein, T.W.1    Friedman, H.2    Specter, S.3
  • 40
    • 0034660138 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-γ, IL-12 and IL-12 receptor β2 responses to legionella pneumophila infection
    • COI: 1:CAS:528:DC%2BD3cXktFWltLY%3D, PID: 10843702
    • 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-γ, IL-12 and IL-12 receptor β2 responses to legionella pneumophila infection. J Immunol 164:6461–6466
    • (2000) J Immunol , vol.164 , pp. 6461-6466
    • Klein, T.W.1    Newton, C.A.2    Nakachi, N.3    Friedman, H.4
  • 42
    • 0035816415 scopus 로고    scopus 로고
    • Differential expression of cannabinoid CB2 receptor mRNA in mouse immune cells subpopulations and following B cell stimulation
    • COI: 1:CAS:528:DC%2BD3MXltVGjsL0%3D, PID: 11448490
    • Lee SF, Newton C, Widen R, Friedman H, Klein TW (2001) Differential expression of cannabinoid CB2 receptor mRNA in mouse immune cells subpopulations and following B cell stimulation. Eur J Pharmacol 423:235–241
    • (2001) Eur J Pharmacol , vol.423 , pp. 235-241
    • Lee, S.F.1    Newton, C.2    Widen, R.3    Friedman, H.4    Klein, T.W.5
  • 43
    • 0018198489 scopus 로고
    • 9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes
    • COI: 1:CAS:528:DyaE1MXhs1aksw%3D%3D, PID: 359460
    • 9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes. Immunol Commun 7:557–566
    • (1978) Immunol Commun , vol.7 , pp. 557-566
    • Lefkowitz, S.1    Klager, K.2
  • 44
    • 0035102203 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes
    • COI: 1:CAS:528:DC%2BD3MXit1OhsLc%3D, PID: 11357882
    • 9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes. Int Immunopharmacol 1:699–712
    • (2001) Int Immunopharmacol , vol.1 , pp. 699-712
    • Li, X.1    Kaminsky, N.E.2    Fischer, L.J.3
  • 45
    • 33846828655 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: Potential role for CB2-selective ligands as immunosuppressive agents
    • COI: 1:CAS:528:DC%2BD2sXhs1Chu7k%3D, PID: 17185040
    • Lombard C, Nagarkatti M, Nagarkatti P (2007) CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: Potential role for CB2-selective ligands as immunosuppressive agents. Clin Immunol 122:259–270
    • (2007) Clin Immunol , vol.122 , pp. 259-270
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.3
  • 46
    • 80054782506 scopus 로고    scopus 로고
    • 9-tetrahydorcannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens
    • COI: 1:CAS:528:DC%2BC3MXhsFehtbrF, PID: 21831965
    • 9-tetrahydorcannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens. J Pharmacol Exp Ther 339:607–317
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 317-607
    • Lombard, C.1    Hegde, V.L.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 47
    • 59649122396 scopus 로고    scopus 로고
    • Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol
    • COI: 1:CAS:528:DC%2BD1MXhslelu70%3D, PID: 18988696
    • Lu H, Kaplan BL, Ngaotepprutaram T, Kaminski NE (2009) Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol. J Leukoc Biol 85:322–329
    • (2009) J Leukoc Biol , vol.85 , pp. 322-329
    • Lu, H.1    Kaplan, B.L.2    Ngaotepprutaram, T.3    Kaminski, N.E.4
  • 48
    • 0026526910 scopus 로고
    • Effects of cannabinoids and cocaine on the mitogen-induced transformations of lymphocytes of human and mouse origins
    • COI: 1:CAS:528:DyaK38XhsVeltLg%3D, PID: 1316319
    • Luo YD, Patel MK, Wiederhold MD, Ou DW (1992) Effects of cannabinoids and cocaine on the mitogen-induced transformations of lymphocytes of human and mouse origins. Int J Immunopharmacol 14:49–56
    • (1992) Int J Immunopharmacol , vol.14 , pp. 49-56
    • Luo, Y.D.1    Patel, M.K.2    Wiederhold, M.D.3    Ou, D.W.4
  • 51
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • COI: 1:CAS:528:DyaK3cXls1Ghu7w%3D, PID: 2165569
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561–564
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 52
    • 0036074054 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD38Xls1OgsLc%3D, PID: 12130702
    • 9-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. J Pharmacol Exp Ther 302:451–465
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 451-465
    • McKallip, R.J.1    Lombard, C.2    Martin, B.R.3    Nagarkatti, M.4    Nagarkatti, P.S.5
  • 54
    • 0022348142 scopus 로고
    • Delta-9-tetrahydrocannabinol decreases host resistance to herpes simplex virus type 2 vaginal infection in the B6C3F1 mouse
    • COI: 1:CAS:528:DyaL28XhtVansrc%3D, PID: 2999306
    • Mishkin EM, Cabral GA (1985) Delta-9-tetrahydrocannabinol decreases host resistance to herpes simplex virus type 2 vaginal infection in the B6C3F1 mouse. J Gen Virol 66:2539–2549
    • (1985) J Gen Virol , vol.66 , pp. 2539-2549
    • Mishkin, E.M.1    Cabral, G.A.2
  • 57
    • 0018411107 scopus 로고
    • Effects of cannabinoids of host resistance to Listeria monocytogenes and herpes simples virus
    • Morahan PS, Klykken PC, Smith SH, Harris LS, Munson AE (1979) Effects of cannabinoids of host resistance to Listeria monocytogenes and herpes simples virus. Infect Immun 23:670–674
    • (1979) Infect Immun , vol.23 , pp. 670-674
    • Morahan, P.S.1    Klykken, P.C.2    Smith, S.H.3    Harris, L.S.4    Munson, A.E.5
  • 58
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • COI: 1:CAS:528:DyaK3sXmsVWiurk%3D, PID: 7689702
    • Munro S, Thomas KK, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61–65
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.K.2    Abu-Shaar, M.3
  • 59
    • 0027235311 scopus 로고
    • Contrasting effect of delta-9-tetrahydrocannabinol on IL-2 activity in spleen and lymph node cells of mice of different ages
    • Nakano Y, Pross S, Friedman H (1992) Contrasting effect of delta-9-tetrahydrocannabinol on IL-2 activity in spleen and lymph node cells of mice of different ages. Life Sci 52:41–51
    • (1992) Life Sci , vol.52 , pp. 41-51
    • Nakano, Y.1    Pross, S.2    Friedman, H.3
  • 60
    • 0028065110 scopus 로고
    • Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection
    • Newton CA, Klein TW, Friedman H (1994) Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect Immun 62:4015–4020
    • (1994) Infect Immun , vol.62 , pp. 4015-4020
    • Newton, C.A.1    Klein, T.W.2    Friedman, H.3
  • 61
    • 60549114334 scopus 로고    scopus 로고
    • CB1 and CB2 cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection
    • Newton CA, Chou P, Perkins I, Klein TW (2009) CB1 and CB2 cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection. J Neuroimmune Pharmacol 4:92–102
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 92-102
    • Newton, C.A.1    Chou, P.2    Perkins, I.3    Klein, T.W.4
  • 63
    • 38349158960 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin
    • COI: 1:CAS:528:DC%2BD1cXovFCkuw%3D%3D, PID: 17828291
    • 9-tetrahydrocannabivarin. Br J Pharmacol 153:199–215
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 64
    • 0025152963 scopus 로고
    • Differential suppression of T-cell subpopulations by THC (delta-9-tetrahydrocannabinol)
    • COI: 1:CAS:528:DyaK3cXls1Ggs70%3D, PID: 2170281
    • Pross SH, Klein TW, Newton CA, Smith J, Widen R, Friedman H (1990) Differential suppression of T-cell subpopulations by THC (delta-9-tetrahydrocannabinol). Int J Immunopharmacol 12:539–544
    • (1990) Int J Immunopharmacol , vol.12 , pp. 539-544
    • Pross, S.H.1    Klein, T.W.2    Newton, C.A.3    Smith, J.4    Widen, R.5    Friedman, H.6
  • 65
    • 84906343750 scopus 로고    scopus 로고
    • Cannabinoid receptor-2 and HIV-associated neurocognitive disorders
    • PID: 25015040
    • Purohit V, Rapaka RS, Rutter J (2014) Cannabinoid receptor-2 and HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol 9:447–453
    • (2014) J Neuroimmune Pharmacol , vol.9 , pp. 447-453
    • Purohit, V.1    Rapaka, R.S.2    Rutter, J.3
  • 67
    • 77954175124 scopus 로고    scopus 로고
    • Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
    • COI: 1:CAS:528:DC%2BC3cXpsVCks70%3D, PID: 19457575
    • Rieder SA, Chauhan A, Singh U, Nagarkatti M, Nagarkatti P (2010) Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology 215:598–605
    • (2010) Immunobiology , vol.215 , pp. 598-605
    • Rieder, S.A.1    Chauhan, A.2    Singh, U.3    Nagarkatti, M.4    Nagarkatti, P.5
  • 68
    • 84891371881 scopus 로고    scopus 로고
    • Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction
    • Robinson RH,Meisser JJ, Breslow-Deckman JM,Gaughan J,AdlerMW, Eisenstein TK (2013) Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction. J Neuroimmune Pharmacol 8:1239–1250
    • (2013) J Neuroimmune Pharmacol , vol.8 , pp. 1239-1250
  • 69
    • 23044432045 scopus 로고    scopus 로고
    • Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse
    • COI: 1:CAS:528:DC%2BD2MXmvVGitL8%3D, PID: 15964028
    • Roth MD, Tashkin DP, Whittaker KM, Choi R, Baldwin GC (2005) Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse. Life Sci 77:1711–1722
    • (2005) Life Sci , vol.77 , pp. 1711-1722
    • Roth, M.D.1    Tashkin, D.P.2    Whittaker, K.M.3    Choi, R.4    Baldwin, G.C.5
  • 70
    • 0027166278 scopus 로고
    • Δ9-tetrahydrocannabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function
    • COI: 1:CAS:528:DyaK3sXms1agtr0%3D, PID: 8282537
    • Schatz AR, Koh WS, Kaminski NE (1993) Δ9-tetrahydrocannabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function. Immunopharmacology 26:129–137
    • (1993) Immunopharmacology , vol.26 , pp. 129-137
    • Schatz, A.R.1    Koh, W.S.2    Kaminski, N.E.3
  • 71
    • 0027999501 scopus 로고
    • Anandamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis
    • COI: 1:CAS:528:DyaK2MXitlams7o%3D, PID: 7962480
    • Schwarz H, Blanco FJ, Lotz M (1994) Anandamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J Neuroimmunol 55:107–115
    • (1994) J Neuroimmunol , vol.55 , pp. 107-115
    • Schwarz, H.1    Blanco, F.J.2    Lotz, M.3
  • 73
    • 84855765207 scopus 로고    scopus 로고
    • Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(−/−) mice by attenuating the activation of T cells and promoting their apoptosis
    • COI: 1:CAS:528:DC%2BC38XosFOqtg%3D%3D, PID: 22119709
    • Singh UP, Singh NP, Singh B, Price RL, Nagarkatti M, Nagarkatti PS (2012) Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(−/−) mice by attenuating the activation of T cells and promoting their apoptosis. Toxicol Appl Pharmacol 258:256–267
    • (2012) Toxicol Appl Pharmacol , vol.258 , pp. 256-267
    • Singh, U.P.1    Singh, N.P.2    Singh, B.3    Price, R.L.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 74
    • 0018092009 scopus 로고
    • Structure-activity relationships of natural and synthetic cannabinoids in suppression of humoral and cell-mediated immunity
    • COI: 1:CAS:528:DyaE1MXotVOntA%3D%3D, PID: 702337
    • Smith SH, Harris LS, Uwayday IM, Munson AE (1978) Structure-activity relationships of natural and synthetic cannabinoids in suppression of humoral and cell-mediated immunity. J Pharmacol Exp Ther 207:165–170
    • (1978) J Pharmacol Exp Ther , vol.207 , pp. 165-170
    • Smith, S.H.1    Harris, L.S.2    Uwayday, I.M.3    Munson, A.E.4
  • 75
    • 0025870036 scopus 로고
    • Delta-9-tetrahydrocannabinol augments murine retroviral induced immunosuppression and infection
    • COI: 1:CAS:528:DyaK3MXks1Cmu70%3D, PID: 1646773
    • Specter S, Lancz G, Westrich G, Friedman H (1991) Delta-9-tetrahydrocannabinol augments murine retroviral induced immunosuppression and infection. Int J Immunopharmacol 13:411–417
    • (1991) Int J Immunopharmacol , vol.13 , pp. 411-417
    • Specter, S.1    Lancz, G.2    Westrich, G.3    Friedman, H.4
  • 80
    • 34548446421 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis
    • COI: 1:CAS:528:DC%2BD2sXhtValu7rM, PID: 17537989
    • Xu H, Cheng CL, Chen M, Manivannan A, Cabay L, Pertwee RG, Coutts A, Forrester JV (2007) Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol 82:532–541
    • (2007) J Leukoc Biol , vol.82 , pp. 532-541
    • Xu, H.1    Cheng, C.L.2    Chen, M.3    Manivannan, A.4    Cabay, L.5    Pertwee, R.G.6    Coutts, A.7    Forrester, J.V.8
  • 83
    • 67349193286 scopus 로고    scopus 로고
    • CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury
    • COI: 1:CAS:528:DC%2BD1MXnt1Ggs78%3D, PID: 19332079
    • Zhang M, Adler MW, Abood ME, Ganea D, Jallo J, Tuma RF (2009a) CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. Microvasc Res 78:86–94
    • (2009) Microvasc Res , vol.78 , pp. 86-94
    • Zhang, M.1    Adler, M.W.2    Abood, M.E.3    Ganea, D.4    Jallo, J.5    Tuma, R.F.6
  • 85
    • 0032219623 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of bcl-2 and capsase-1
    • COI: 1:CAS:528:DyaK1cXlsVWhtr4%3D, PID: 9694974
    • 9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of bcl-2 and capsase-1. J Pharmacol Exp Ther 286:1103–1109
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1103-1109
    • Zhu, W.1    Friedman, H.2    Klein, T.W.3
  • 87
    • 33748420226 scopus 로고    scopus 로고
    • Formation of B and T cell subsets require the cannabinoid receptor CB2
    • COI: 1:CAS:528:DC%2BD28XptVGqtbg%3D, PID: 16924491
    • Ziring D, Wei B, Velazquez P, Schrage M, Buckley NE, Braun J (2006) Formation of B and T cell subsets require the cannabinoid receptor CB2. Immunogenetics 58:714–725
    • (2006) Immunogenetics , vol.58 , pp. 714-725
    • Ziring, D.1    Wei, B.2    Velazquez, P.3    Schrage, M.4    Buckley, N.E.5    Braun, J.6


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