Δ9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: Involvement of Bcl-2 and caspase-1

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 2, 1998, Pages 1103-1109

  Zhu, Weigang ^a   Friedman, Herman ^a   Klein, Thomas W ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLTYROSYLVALYLALANYLASPARTIC ACID ALDEHYDE; CANNABINOID; CASPASE INHIBITOR; CONCANAVALIN A; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DIMETHYL SULFOXIDE; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; DRONABINOL; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; DNA; PSYCHEDELIC AGENT; TETRAHYDROCANNABINOL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; LYMPHOCYTE; MEMBRANE DAMAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SPLEEN CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DRUG EFFECT; ENZYMOLOGY; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SPECTROFLUOROMETRY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CASPASE 1; CYSTEINE ENDOPEPTIDASES; DNA; DNA FRAGMENTATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HALLUCINOGENS; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-BCL-2; SPECTROMETRY, FLUORESCENCE; TETRAHYDROCANNABINOL;

EID: 0032219623     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornbeny NA, Wong WW and Yuan J (1996) Human ICE/CED-3 protease nomenclature. Cell 87:171.
2. Arenas MJ, Morris RG and Wyllie AH (1990) Apoptosis: the role of the endonuclease. Am J Pathol 136:593-608.
3. Black RA, Kronheim SR, Cantrell M, Deeley MC, March CJ, Prickett KS, Wignall L, Conlon PJ, Cosman D, Hopp TP and Mochizuki DY (1988) Generation of biologically active interleukin-1β by proteolytic cleavage of the inactive precursor. J Biol Chem 263:9437-9442.
4. Bouaboula M, Bourrie B, Rinaldi-Carmona M, Shire D, Le Fur G and Casellas P (1995a) Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells. J Biol Chem 270:13973-13980.
5. Bouaboula M, Poinot-Chazel C, Bourne B, Canat X, Calandra B, Rinaldi-Carmona M, Le Fur G and Casellas P (1995a) Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem J 312: 637-641.
6. Broome HE, Dargan CM, Bessent EF, Krajewski S and Reed JC (1995) Apoptosis and Bcl-2 expression in cultured murine splenic T cells. Immunology 84:375-382.
7. Cohen JJ, Duke RC, Fadok VA and Sellins KS (1992) Apoptosis and programmed cell death in immunity. Annu Rev Immunol 10:267-293.
8. Cory S (1995) Regulation of lymphocyte survival by the BCL-2 gene family. Annu Rev Immunol 13:513-543.
9. 9-tetrahydrocannabinol is mediated by nuclear factor κB and CB1 cannabinoid receptor. DNA Cell Biol 16:301-309.
10. Gavrieli Y, Sherman Y and Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
11. Hogquist KA, Nett MA, Unanue ER and Chaplin DD (1991) Interleukin-1 is processed and released during apoptosis. Proc Natl Acad Sci USA 88:8485-8489.
12. Hewlett AC, Johnson MR, Melvin LS and Milne GM (1988) Nonclassical cannabinoid analgetics inhibit adenylate cyclase: Development of a cannabinoid receptor model. Mol Pharm 33:297-302.
13. Kamesaki H, Zwiebel JA, Reed JC and Cossman J (1994) Role of Bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines. J Immunol 152:3294-3305.
14. Kaminski N, Abood M, Kessler F, Martin B and Schatz A (1992) Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol Pharm 42:736-742.
15. Klein TW, Friedman H and Specter S (1998) Marijuana, immunity and infection. J Neuroimmunol 83:102-115.
16. Kolberg R (1997) Tangled pathways: New roles for NFκB, TNFα in apoptosis. JNIH Res 9:29-32.
17. Kostura MJ, Tocci MJ, Limjuco G, Chin J, Cameron P, Hillman AG, Chartrain NA and Schmidt JA (1989) Identification of a monocyte specific pre-interleukin 1β convertase activity. Proc Natl Acad Sci USA 86:5227-5231.
18. Lee S, Christakos S and Small MB (1993) Apoptosis and signal transduction: clues to a molecular mechanism. Curr Opinion Cell Biol 5:286-291.
19. Lynn AB and Herkenham M (1994) Localization of cannabinoid receptors and non-saturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids. J Pharm Exp Ther 268:1612-1623.
20. McConkey DJ, Orrenius S and Jondal M (1990) Cellular signaling in programmed cell death (apoptosis). Immunol Today 11:120-121.
21. Nahas GG, Morishima A and Desoize B (1977) Effects of cannabinoids on macromolecular synthesis and replication of cultured lymphocytes. Fed Proc 36:1748-1752.
22. Nicholson DW (1996) ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature Biotech 14:297-301.
23. Nunez G, London L, Hockenbery D, Alexander M, McKearn JP and Korsmeyer SJ (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic ceil lines. J Immunol 144:3602-3610.
24. Schwartz L and Osborne BA (1993) Programmed cell death, apoptosis and killer genes. Immunol Today 14:582-590.
25. Schwarz H, Blanco FJ and Lotz M (1994) Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J Neuroimmunol 55:107-115.
26. Sentman CL, Shutter JR, Hochenbery D, Kanagawa O and Korsmeyer SJ (1991) Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879-888.
27. Tsujimoto Y, Finger LR, Tunis J, Nowell PC and Croce CM (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099.
28. Thomberry NA and Molineaux SM (1995) Interleukin-β converting enzyme: A nonel cysteine protease required for IL-1β production and implicated in programmed cell death. Protein Sci 4:3-12.
29. Vaux DL, Cory S and Adams JM (1988) Bcl-2 promotes the survival of hemopoietic cells and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442.
30. Veis DJ, Sentman CL, Bach EA and Korsmeyer SJ (1993) Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol 151:2546-2554.
31. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556.
32. Wyllie AH, Kerr JFR and Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306.
33. Wyllie AH, Morris RG, Smith AL and Dunlop D (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142:66-67.
34. Young RL and Korsmeyer SJ (1994) A negative regulatory element in the bcl-2 5′-untranslated region inhibits expression from an upstream promoter. Mol Cell Biol 13:3686-3697.
35. 9-Tetrahydrocannabinol enhances the secretion of interleukin-1 from endotoxin-stimulated macrophage. J Pharmacol Exp Ther 270:1334-1339.