Δ9-Tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 451-465

  McKallip, Robert J ^a,b,c   Lombard, Catherine ^a,b,c   Martin, Billy R ^a,b,c   Nagarkatti, Mitzi ^a,b,c   Nagarkatti, Prakash S ^a,b,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Departments of Pharmacology and Toxicology   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CANNABIS; CASPASE INHIBITOR; CONCANAVALIN A; DRONABINOL; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY CD3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATROPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOTOXICITY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SPLEEN ATROPHY; SPLEEN CELL; THYMOCYTE; THYMUS; THYMUS ATROPHY;

ANIMALS; APOPTOSIS; BORNANES; CONCANAVALIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PIPERIDINES; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SPLEEN; TETRAHYDROCANNABINOL; THYMUS GLAND;

EID: 0036074054     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.033506     Document Type: Article

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