Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus

Immunobiology

Volumn 216, Issue 6, 2011, Pages 670-677

  Huemer, Hartwig P ^a   Lassnig, Caroline ^b   Bernhard, David ^c   Sturm, Sonja ^d   Nowotny, Norbert ^b   Kitchen, Maria ^a   Pavlic, Marion ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Antibody; Cannabidiol; Cannabinol; Cannabis; Cowpox virus; Immunosuppression; Lymphocyte; Mitogen; Tetrahydrocannabinol; Vaccinia virus

Indexed keywords

CANNABIDIOL; CANNABINOID; CANNABINOL; GAMMA INTERFERON; INTERLEUKIN 4; RESIN; TETRAHYDROCANNABINOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POXVIRUS INFECTION; PRIORITY JOURNAL; SMALLPOX VIRUS; VACCINIA VIRUS; VIRUS VIRULENCE; WEIGHT REDUCTION;

ANIMALS; ANTIBODY FORMATION; APOPTOSIS; CANNABINOIDS; CELL LINE; CELL PROLIFERATION; COWPOX VIRUS; CYTOKINES; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MITOGENS; RABBITS; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES; TETRAHYDROCANNABINOL; VACCINIA; VACCINIA VIRUS; VIRULENCE;

EID: 79955532485     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2010.11.001     Document Type: Article

References (31)

1. Agurell S., Halldin M., Lindgren J.E., Ohlsson A., Widman M., Gillespie H., Hollister L. Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man. Pharmacol. Rev. 1986, 38:21-43.
2. Aleksandrova G.M., Rozhkova V.N., Borisova L.N. Comparative characteristics of the immunotropic activity of sodium diclofenac, indomethacin and sodium salicylate. Farmakol. Toksikol. 1981, 44:450-453.
3. Beaulieu P. Toxic effects of cannabis and cannabinoids: animal data. Pain Res. Manage. 2005, 10(Suppl. A):23A-26A.
4. Berhanu A., Wilson R.L., Kirkwood-Watts D.L., King D.S., Warren T.K., Lund S.A., Brown L.L., Krupkin A.K., Vandermay E., Weimers W., Honeychurch K.M., Grosenbach D.W., Jones K.F., Hruby D.E. Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L,B5R, and D8L protects mice from lethal vaccinia virus challenge. J. Virol. 2008, 82:3517-3529.
5. Bernhard D., Huck C.W., Jakschitz T., Pfister G., Henderson B., Bonn G.K., Wick G. Development and evaluation of an in vitro model for the analysis of cigarette smoke effects on cultured cells and tissues. J. Pharmacol. Toxicol. Methods 2004, 50:45-51.
6. Carayon P., Marchand J., Dussossoy D., Derocq J.M., Jbilo O., Bord A., Bouaboula M., Galiègue S., Mondière P., Pénarier G., Fur G.L., Defrance T., Casellas P. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood 1998, 92:3605-3615.
7. Chen Y., Buck J. Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism. J. Pharmacol. Exp. Ther. 2000, 293:807-812.
8. Derocq J.M., Ségui M., Marchand J., Le Fur G., Casellas P. Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS Lett. 1995, 369:177-182.
9. El-Gohary M., Eid M.A. Effect of cannabinoid ingestion (in the form of bhang) on the immune system of high school and university students. Hum. Exp. Toxicol. 2004, 23:149-156.
10. Elsohly M.A., Slade D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci. 2005, 78:539-548.
11. Froebel K.S., Pakker N.G., Aiuti F., Bofill M., Choremi-Papadopoulou H., Economidou J., Rabian C., Roos M.T.L., Ryder L.P., Miedema F. Standardization and quality assurance of lymphocyte proliferation assays for use in the assessment of immune function. J. Immunol. Methods 1999, 227:85-97.
12. Hönlinger B., Huemer H.P., Romani N., Czerny C.P., Eisendle K., Höpfl R. Generalized cowpox infection probably transmitted from a rat. Br. J. Dermatol. 2005, 153:451-453.
13. Hou J.P. The development of Chinese herbal medicine and the Pen-ts'ao. Comp. Med. East West 1977, 5:117-122.
14. Huemer H.P., Himmelreich A., Hönlinger B., Pavlic M., Eisendle K., Höpfl R., Rabl W., Czerny C.P. " Recreational" drug abuse associated with failure to mount a proper antibody response after a generalised orthopoxvirus infection. Infection 2007, 35:469-473.
15. Jan T.R., Su S.T., Wu H.Y., Liao M.H. Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice. Int. Immunopharmacol. 2007, 7:773-780.
16. Katial R.K., Hershey J., Purohit-Seth T., Belisle J.T., Brennan P.J., Spencer J.S., Engler R.J. Cell-mediated immune response to tuberculosis antigens: comparison of skin testing and measurement of in vitro gamma interferon production in whole-blood culture. Clin. Diag. Lab. Immunol. 2001, 8:339-345.
17. Klein T.W., Newton C., Zhu W., Daaka Y., Friedman H. delta 9-Tetrahydrocannabinol, cytokines, and immunity to Legionella pneumophila. Proc. Soc. Exp. Biol. Med. 1995, 209:205-212.
18. Lee C.Y., Wey S.P., Liao M.H., Hsu W.L., Wu H.Y., Jan T.R. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int. Immunopharmacol. 2008, 8:732-740.
19. Mackie K. Cannabinoid receptors as therapeutic targets. Ann. Rev. Pharmacol. Toxicol. 2006, 46:101-122.
20. McCoy K.L., Gainey D., Cabral G.A. delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages. J. Pharmacol. Exp. Ther. 1995, 273:1216-1223.
21. McKallip R.J., Lombard C., Martin B.R., Nagarkatti M., Nagarkatti P.S. Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. J. Pharmacol. Exp. Ther. 2002, 302:451-465.
22. Rachelefsky G.S., Opelz G., Mickey M.R., Lessin P., Kiuchi M., Silverstein M.J., Stiehm E.R. Intact humoral and cell-mediated immunity in chronic marijuana smoking. J. Allergy Clin. Immunol. 1976, 58:483-490.
23. Riccardi C., Nicoletti I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat. Protoc. 2006, 1:1458-1461.
24. Richter S., Huemer H.P., Revilla-Fernández S., Zenz W., Strenger V., Müller M., Ellerbrock H., Nitsche A., Allerberger F. Diagnosis of Cowpox virus in Austria, 2007. Infection 2008, 36(Suppl. I):59.
25. Rieder S.A., Chauhan A., Singh U., Nagarkatti M., Nagarkatti P. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology 2010, 215:598-605.
26. Schatz A.R., Kessler F.K., Kaminski N.E. Inhibition of adenylate cyclase by delta 9-tetrahydrocannabinol in mouse spleen cells: a potential mechanism for cannabinoid-mediated immunosuppression. Life Sci. 1992, 51:PL25-30.
27. Schwarz H., Blanco F.J., Lotz M. Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J. Neuroimmunol. 1994, 55:107-115.
28. Tashkin D.P., Baldwin G.C., Sarafian T., Dubinett S., Roth M.D. Respiratory and immunologic consequences of marijuana smoking. J. Clin. Pharmacol. 2002, 42(Suppl.):71S-81S.
29. Walter L., Stella N. Cannabinoids and neuroinflammation. Br. J. Pharmacol. 2004, 141:775-789.
30. Wu H.Y., Jan T.R. Cannabidiol hydroxyquinone-induced apoptosis of splenocytes is mediated predominantly by thiol depletion. Toxicol. Lett. 2010, 195:68-74.
31. Xu R., Johnson A.J., Liggitt D., Bevan M.J. Cellular and humoral immunity against vaccinia virus infection of mice. J. Immunol. 2004, 72:6265-6271.