Δ9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB2, disrupting early activation events

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 4, 2012, Pages 843-855

  Karmaus, Peer W F ^a   Chen, Weimin ^a,b   Kaplan, Barbara L F ^a,c   Kaminski, Norbert E ^a,c  

^a Center for Integrative Toxicology   (United States)

^b Microbiology and Molecular Genetics   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

9 tetrahydrocannabinol; Ca2+; Cannabinoid receptors; Cytotoxic T lymphocytes; Immune modulation; T cell activation

Indexed keywords

CALCIUM IONOPHORE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CD69 ANTIGEN; DRONABINOL; IONOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; INFLUENZA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CALCIUM SIGNALING; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHROMIUM RADIOISOTOPES; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; INTERFERON-GAMMA; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; T-LYMPHOCYTES, CYTOTOXIC; TETRAHYDROCANNABINOL;

EID: 84875859193     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9293-4     Document Type: Article

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