Immune function alterations in mice tolerant to Δ9- tetrahydrocannabinol: Functional and biochemical parameters

Journal of Neuroimmunology

Volumn 92, Issue 1-2, 1998, Pages 60-66

  Massi, Paola ^a   Sacerdote, Paola ^a   Ponti, Wilma ^b   Fuzio, Domenica ^a   Manfredi, Barbara ^a   Viganó, Daniela ^a   Rubino, Tiziana ^a   Bardotti, Massimiliano ^b   Parolaro, Daniela ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Chronic 9 THC treatment; Cytokine levels; Cytotoxicity; Natural killer; Splenocyte composition; Splenocyte proliferation

Indexed keywords

CANNABIS; CONCANAVALIN A; DRONABINOL; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNE SYSTEM; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; CELL DIVISION; CELLS, CULTURED; CONCANAVALIN A; IMMUNE SYSTEM; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-2; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; MALE; MICE; REFERENCE VALUES; SPLEEN; T-LYMPHOCYTES; TETRAHYDROCANNABINOL;

EID: 0032428723     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00177-5     Document Type: Article

References (34)

1. Adams I.B., Martin B.R. Cannabis: pharmacology and toxicology in animals and humans. Addiction. 91:1996;1585-1614.
2. 9-tetrahydrocannabinol. Pharmacology. 52:1996;271-282.
3. Burnette-Curley, et al., 1993.
4. 9-tetrahidrocannabinol suppresses macrophage extrinsic anti-herpes virus activity. Proc. Soc. Exp. Biol. Med. 199:1992;255-263.
5. Cabral G.A., Pettit D.A. Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease. J. Neuroimmunol. 83:1998;116-123.
6. Cabral G.A., Pettit D.A., Fisher-Stenger K. Marijuana inhibition of cytotoxic T lymphocytes activity. Adv. Biosci. 86:1993;653-662.
7. Carter L.L., Dutton R.W. Type 1 and Type 2: a fundamental dichotomy for all T cell subsets. Curr. Opin. Immunol. 8:1996;336-342.
8. Charlton B., Lafferty K.J. The Th1/Th2 balance in autoimmunity. Curr. Opin. Immunol. 7:1995;793-798.
9. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:1941;74-77.
10. Dewey W.L. Cannabinoid pharmacology. Pharmacol. Rev. 38:1986;151-178.
11. 9-tetrahydrocannabinol, CP 55,940 and Win 55,212. J. Pharm. Exp. Ther. 271:1994;1383-1390.
12. 9-tetrahydrocannabinol decreases cytotoxic T lymphocyte activity to herpes simplex virus type 1-infected cells. Proc. Soc. Exp. Biol. Med. 200:1992;422-430.
13. Kaminski N.E., Koh W.S., Yang K.H., Lee M., Kessler F.K. Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G protein coupled mechanism. Biochem. Pharmacol. 48:1994;1899-1908.
14. Kawakami Y., Klein T.M., Newton C.A., Djeu J.Y., Specter S., Friedman H. Suppression of delta-9-tetrahydrocannabinol of interleukin-2 induced lymphocyte proliferation and lymphokine-activated killer cell activity. Int. J. Immunopharmacol. 10:1988;485-488.
15. Klein, T.W., Friedman, H., 1990. Modulation of murine immune cell function by marijuana components. In: Watson, R. (Ed.), Drugs of Abuse and Immune Function. CRC Press, Boca Raton, FL, pp. 87-111.
16. Klein T.W., Kawakami Y., Newton C., Friedman H. Marijuana components suppress induction and cytolytic function of murine cytotoxic T cells in vitro and in vivo. J. Toxicol. Environ. Health. 32:1991;465-477.
17. Klein T.W., Friedman H., Specter S. Marijuana, immunity and infection. J. Neuroimmunol. 83:1998;102-115.
18. Kruszewska B., Felten S.J., Moynihan A. Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice. J. Immunol. 155:1995;4613-4620.
19. Lee M., Yang K.H., Kaminski N.E. Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. J. Pharm. Exp. Ther. 275:1995;529-536.
20. Manfredi B., Sacerdote P., Bianchi M., Veljic-Radulovic J., Panerai A.E. Evidence for an opioid inhibitory effect on T cell proliferation. J. Neuroimmunol. 44:1993;43-48.
21. Newton C.A., Klein T.W., Friedman H. Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect. Immunol. 62:1994;4015-4020.
22. Panerai A.E., Manfredi B., Granucci F., Sacerdote P. The beta-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid. J. Neuroimmunol. 58:1995;71-76.
23. Patrini G., Sacerdote P., Fuzio D., Manfredi B., Parolaro D. Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound. J. Neuroimmunol. 80:1997;143-148.
24. Pertwee, R.G., 1991. Tolerance to and dependence on psychotropic cannabinoids. In: Pratt, J.A. (Ed.), The Biological Bases of Drug Tolerance and Dependence. Academic Press, London, pp. 233-236.
25. Pross S.H., Nakano Y., Widen R., McHugh S., Newton C.A., Klein T.W., Friedman H. Differing effects of delta-9-tetrahydrocannabinol (THC) on murine spleen cell populations dependent upon stimulators. Int. J. Immunopharmacol. 14:1992;1019-1027.
26. Sacerdote P., Manfredi B., Bianchi M., Panerai A.E. Intermittent but not continuous inescapable foot-shock stress affects immune responses and immunocyte beta-endorphin concentration in the rat. Brain Behav. Immunol. 8:1994;251-260.
27. 9-tetrahydrocannabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function. Immunopharmacology. 26:1993;129-137.
28. Schwarz H., Blanco F.J., Lotz M. Anandamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J. Neuroimmunol. 55:1994;107-115.
29. Specter S., Lancz G., Hazelden J. Marijuana and immunity: tetrahydrocannabinol mediated inhibition of lymphocytes blastogenesis. Int. J. Immunopharmacol. 12:1990;261-267.
30. Specter S., Lancz G., Goodfellow D. Suppression of human macrophage function in vitro by delta-9-tetrahydrocannabinol. J. Leukocyte Biol. 50:1991;423-426.
31. 9-tetrahydrocannabinol augments murine retroviral induced immunosuppression and infection. Int. J. Immunopharmacol. 13:1991;411-417.
32. Tang J., Lancz G., Specter S., Bullock H. Marijuana and immunity: tetrahydrocannabinol-mediated inhibition of growth and phagocytic activity of the murine macrophage cell line, P388D1. Int. J. Immunopharmacol. 14:1992;253-262.
33. Zhu W., Igarashi T., Qi Z.T., Newton C., Widen R.E., Friedman H., Klein T.W. Delta-9-tetrahydrocannabinol (THC) decreases the number of high and intermediate affinity IL-2 receptors of the IL-2 dependent cell line NKB61A2. Int. J. Immunopharmacol. 15:1993;401-408.
34. 9-tetrahydrocannabinol (THC) causes the variable expression of IL-2 receptor subunits. J. Pharmacol. Exp. Ther. 274:1995;1001-1007.