메뉴 건너뛰기




Volumn 294, Issue 2, 2015, Pages 102-110

Sex, the aging immune system, and chronic disease

Author keywords

Aging; Atherosclerosis; Autoimmunity; Chronic inflammatory diseases; Immune system; Sex hormones; Type 2 diabetes

Indexed keywords

ANDROGEN; ESTROGEN; SEX HORMONE;

EID: 84930911630     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2015.02.002     Document Type: Review
Times cited : (247)

References (129)
  • 1
    • 82155184479 scopus 로고    scopus 로고
    • Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice
    • R.S. Scotland, M.J. Stables, S. Madalli, P. Watson, D.W. Gilroy, Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice, Blood 118 (2011) 5918-5927, http://dx.doi.org/10.1182/blood-2011-03-340281.
    • (2011) Blood , vol.118 , pp. 5918-5927
    • Scotland, R.S.1    Stables, M.J.2    Madalli, S.3    Watson, P.4    Gilroy, D.W.5
  • 2
    • 38549139609 scopus 로고    scopus 로고
    • Identification of candidate genes that influence sex hormone-dependent disease phenotypes in mouse lupus
    • M.R. Gubbels Bupp, T.N. Jørgensen, B.L. Kotzin, Identification of candidate genes that influence sex hormone-dependent disease phenotypes in mouse lupus, Genes Immun. 9 (2008) 47-56, http://dx.doi.org/10.1038/sj.gene.6364447.
    • (2008) Genes Immun. , vol.9 , pp. 47-56
    • Gubbels Bupp, M.R.1    Jørgensen, T.N.2    Kotzin, B.L.3
  • 3
    • 0021351590 scopus 로고
    • Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse
    • Y. Weinstein, S. Ran, S. Segal, Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse, J. Immunol. (Baltim. Md 1950) 132 (1984) 656-661.
    • (1984) J. Immunol. (Baltim. Md 1950) , vol.132 , pp. 656-661
    • Weinstein, Y.1    Ran, S.2    Segal, S.3
  • 5
    • 79952111785 scopus 로고    scopus 로고
    • Interleukin-12 as an adjuvant for induction of protective antibody responses
    • D.W. Metzger, Interleukin-12 as an adjuvant for induction of protective antibody responses, Cytokine 52 (2010) 102-107, http://dx.doi.org/10.1016/j.cyto.2010.06.011.
    • (2010) Cytokine , vol.52 , pp. 102-107
    • Metzger, D.W.1
  • 7
    • 77951936101 scopus 로고    scopus 로고
    • The Xs and Y of immune responses to viral vaccines
    • S.L. Klein, A. Jedlicka, A. Pekosz, The Xs and Y of immune responses to viral vaccines, Lancet Infect. Dis. 10 (2010) 338-349, http://dx.doi.org/10.1016/S1473-3099(10)70049-9.
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 338-349
    • Klein, S.L.1    Jedlicka, A.2    Pekosz, A.3
  • 9
    • 3543083877 scopus 로고    scopus 로고
    • Gender difference in the non-specific and specific immune response in humans
    • (New York, NY) 1989
    • A. Bouman, M. Schipper, M.J. Heineman, M.M. Faas, Gender difference in the non-specific and specific immune response in humans, Am. J. Reprod. Immunol. (New York, NY) 1989 (52) (2004) 19-26, http://dx.doi.org/10.1111/j.1600-0897.2004.00177.x.
    • (2004) Am. J. Reprod. Immunol , Issue.52 , pp. 19-26
    • Bouman, A.1    Schipper, M.2    Heineman, M.J.3    Faas, M.M.4
  • 10
    • 77951157657 scopus 로고    scopus 로고
    • Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
    • S. Kume, T. Uzu, K. Horiike, M. Chin-Kanasaki, K. Isshiki, S. Araki, et al., Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney, J. Clin. Invest. 120 (2010) 1043-1055.
    • (2010) J. Clin. Invest. , vol.120 , pp. 1043-1055
    • Kume, S.1    Uzu, T.2    Horiike, K.3    Chin-Kanasaki, M.4    Isshiki, K.5    Araki, S.6
  • 11
    • 0025034650 scopus 로고
    • Effects of gender and sex steroids on the immune response
    • A.H. Schuurs, H.A. Verheul, Effects of gender and sex steroids on the immune response, J. Steroid Biochem. 35 (1990) 157-172.
    • (1990) J. Steroid Biochem. , vol.35 , pp. 157-172
    • Schuurs, A.H.1    Verheul, H.A.2
  • 12
    • 33645102445 scopus 로고    scopus 로고
    • Sex hormones and the genesis of autoimmunity
    • L.S. Ackerman, Sex hormones and the genesis of autoimmunity, Arch. Dermatol. 142 (2006) 371-376, http://dx.doi.org/10.1001/archderm.142.3.371.
    • (2006) Arch. Dermatol. , vol.142 , pp. 371-376
    • Ackerman, L.S.1
  • 15
    • 67849128689 scopus 로고    scopus 로고
    • Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis
    • A. Hewagama, D. Patel, S. Yarlagadda, F.M. Strickland, B.C. Richardson, Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis, Genes Immun. 10 (2009) 509-516, http://dx.doi.org/10.1038/gene.2009.12.
    • (2009) Genes Immun. , vol.10 , pp. 509-516
    • Hewagama, A.1    Patel, D.2    Yarlagadda, S.3    Strickland, F.M.4    Richardson, B.C.5
  • 16
    • 0034947253 scopus 로고    scopus 로고
    • Sex-associated hormones and immunity to protozoan parasites
    • C.W. Roberts, W. Walker, J. Alexander, Sex-associated hormones and immunity to protozoan parasites, Clin. Microbiol. Rev. 14 (2001) 476-488, http://dx.doi.org/10.1128/CMR.14.3.476-488.2001.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 476-488
    • Roberts, C.W.1    Walker, W.2    Alexander, J.3
  • 17
    • 77957353834 scopus 로고    scopus 로고
    • Changes in the immune system during menopause and aging
    • C. Gameiro, F. Romao, Changes in the immune system during menopause and aging, Front. Biosci. Elite Ed. 2 (2010) 1299-1303.
    • (2010) Front. Biosci. Elite Ed. , vol.2 , pp. 1299-1303
    • Gameiro, C.1    Romao, F.2
  • 19
    • 0029970280 scopus 로고    scopus 로고
    • Characterization of reproductive hormonal dynamics in the perimenopause
    • N. Santoro, J.R. Brown, T. Adel, J.H. Skurnick, Characterization of reproductive hormonal dynamics in the perimenopause, J. Clin. Endocrinol. Metab. 81 (1996) 1495-1501, http://dx.doi.org/10.1210/jcem.81.4.8636357.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1495-1501
    • Santoro, N.1    Brown, J.R.2    Adel, T.3    Skurnick, J.H.4
  • 21
    • 84858752881 scopus 로고    scopus 로고
    • Sex affects immunity
    • L.M. Pennell, C.L. Galligan, E.N. Fish, Sex affects immunity, J. Autoimmun. 38 (2012) J282-J291, http://dx.doi.org/10.1016/j.jaut.2011.11.013.
    • (2012) J. Autoimmun. , vol.38 , pp. J282-J291
    • Pennell, L.M.1    Galligan, C.L.2    Fish, E.N.3
  • 22
    • 0032488877 scopus 로고    scopus 로고
    • Estradiol binding to cell surface raises cytosolic free calcium in T cells
    • W.P. Benten, M. Lieberherr, G. Giese, F. Wunderlich, Estradiol binding to cell surface raises cytosolic free calcium in T cells, FEBS Lett. 422 (1998) 349-353.
    • (1998) FEBS Lett. , vol.422 , pp. 349-353
    • Benten, W.P.1    Lieberherr, M.2    Giese, G.3    Wunderlich, F.4
  • 23
    • 0037151242 scopus 로고    scopus 로고
    • Estrogen receptor alpha in mouse splenic lymphocytes: possible involvement in immunity
    • H. Sakazaki, H. Ueno, K. Nakamuro, Estrogen receptor alpha in mouse splenic lymphocytes: possible involvement in immunity, Toxicol. Lett. 133 (2002) 221-229.
    • (2002) Toxicol. Lett. , vol.133 , pp. 221-229
    • Sakazaki, H.1    Ueno, H.2    Nakamuro, K.3
  • 24
    • 79951681964 scopus 로고    scopus 로고
    • Estrogen receptors in immunity and autoimmunity
    • M. Cunningham, G. Gilkeson, Estrogen receptors in immunity and autoimmunity, Clin. Rev. Allergy Immunol. 40 (2011) 66-73, http://dx.doi.org/10.1007/s12016-010-8203-5.
    • (2011) Clin. Rev. Allergy Immunol. , vol.40 , pp. 66-73
    • Cunningham, M.1    Gilkeson, G.2
  • 25
    • 0030639842 scopus 로고    scopus 로고
    • Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects
    • W. Gilmore, L.P. Weiner, J. Correale, Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects, J. Immunol. (Baltim. Md 1950) 158 (1997) 446-451.
    • (1997) J. Immunol. (Baltim. Md 1950) , vol.158 , pp. 446-451
    • Gilmore, W.1    Weiner, L.P.2    Correale, J.3
  • 26
    • 79951680196 scopus 로고    scopus 로고
    • The multi-faceted influences of estrogen on lymphocytes: toward novel immuno-interventions strategies for autoimmunity management
    • E. Karpuzoglu, M. Zouali, The multi-faceted influences of estrogen on lymphocytes: toward novel immuno-interventions strategies for autoimmunity management, Clin. Rev. Allergy Immunol. 40 (2011) 16-26, http://dx.doi.org/10.1007/s12016-009-8188-0.
    • (2011) Clin. Rev. Allergy Immunol. , vol.40 , pp. 16-26
    • Karpuzoglu, E.1    Zouali, M.2
  • 27
    • 34547792318 scopus 로고    scopus 로고
    • The complex role of estrogens in inflammation
    • R.H. Straub, The complex role of estrogens in inflammation, Endocr. Rev. 28 (2007) 521-574, http://dx.doi.org/10.1210/er.2007-0001.
    • (2007) Endocr. Rev. , vol.28 , pp. 521-574
    • Straub, R.H.1
  • 28
    • 79952843357 scopus 로고    scopus 로고
    • Differential roles of estrogen receptors α and β in control of B-cell maturation and selection
    • L. Hill, V. Jeganathan, P. Chinnasamy, C. Grimaldi, B. Diamond, Differential roles of estrogen receptors α and β in control of B-cell maturation and selection, Mol. Med. (Camb. Mass.) 17 (2011) 211-220, http://dx.doi.org/10.2119/molmed.2010.00172.
    • (2011) Mol. Med. (Camb. Mass.) , vol.17 , pp. 211-220
    • Hill, L.1    Jeganathan, V.2    Chinnasamy, P.3    Grimaldi, C.4    Diamond, B.5
  • 29
    • 0026507212 scopus 로고
    • Estrogen administration activates extrathymic T cell differentiation in the liver
    • R. Okuyama, T. Abo, S. Seki, T. Ohteki, K. Sugiura, A. Kusumi, et al., Estrogen administration activates extrathymic T cell differentiation in the liver, J. Exp. Med. 175 (1992) 661-669.
    • (1992) J. Exp. Med. , vol.175 , pp. 661-669
    • Okuyama, R.1    Abo, T.2    Seki, S.3    Ohteki, T.4    Sugiura, K.5    Kusumi, A.6
  • 31
    • 0035026467 scopus 로고    scopus 로고
    • Sex hormones as immunomodulators in health and disease
    • D. Verthelyi, Sex hormones as immunomodulators in health and disease, Int. Immunopharmacol. 1 (2001) 983-993.
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 983-993
    • Verthelyi, D.1
  • 33
    • 0025903735 scopus 로고
    • In vivo modulation of the distribution of thymocyte subsets: effects of estrogen on the expression of different T cell receptor V beta gene families in CD4-, CD8-thymocytes
    • I. Screpanti, D. Meco, S. Morrone, A. Gulino, B.J. Mathieson, L. Frati, In vivo modulation of the distribution of thymocyte subsets: effects of estrogen on the expression of different T cell receptor V beta gene families in CD4-, CD8-thymocytes, Cell. Immunol. 134 (1991) 414-426.
    • (1991) Cell. Immunol. , vol.134 , pp. 414-426
    • Screpanti, I.1    Meco, D.2    Morrone, S.3    Gulino, A.4    Mathieson, B.J.5    Frati, L.6
  • 34
    • 45449085637 scopus 로고    scopus 로고
    • Sexual dimorphism of humoral immunity with human vaccines
    • I.F. Cook, Sexual dimorphism of humoral immunity with human vaccines, Vaccine 26 (2008) 3551-3555, http://dx.doi.org/10.1016/j.vaccine.2008. 04.054.
    • (2008) Vaccine , vol.26 , pp. 3551-3555
    • Cook, I.F.1
  • 35
    • 51349089115 scopus 로고    scopus 로고
    • Sex differences in autoimmune disease from a pathological perspective
    • D. Fairweather, S. Frisancho-Kiss, N.R. Rose, Sex differences in autoimmune disease from a pathological perspective, Am. J. Pathol. 173 (2008) 600-609, http://dx.doi.org/10.2353/ajpath.2008.071008.
    • (2008) Am. J. Pathol. , vol.173 , pp. 600-609
    • Fairweather, D.1    Frisancho-Kiss, S.2    Rose, N.R.3
  • 36
    • 0032971797 scopus 로고    scopus 로고
    • Estrogen enhances immunoglobulin production by human PBMCs
    • N. Kanda, K. Tamaki, Estrogen enhances immunoglobulin production by human PBMCs, J. Allergy Clin. Immunol. 103 (1999) 282-288.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 282-288
    • Kanda, N.1    Tamaki, K.2
  • 37
    • 33745063218 scopus 로고    scopus 로고
    • Sexual dimorphism in immune response genes as a function of puberty
    • R. Lamason, P. Zhao, R. Rawat, A. Davis, J.C. Hall, J.J. Chae, et al., Sexual dimorphism in immune response genes as a function of puberty, BMC Immunol. 7 (2006) 2, http://dx.doi.org/10.1186/1471-2172-7-2.
    • (2006) BMC Immunol. , vol.7 , pp. 2
    • Lamason, R.1    Zhao, P.2    Rawat, R.3    Davis, A.4    Hall, J.C.5    Chae, J.J.6
  • 38
    • 0027937803 scopus 로고
    • Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation
    • N. Nilsson, H. Carlsten, Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation, Cell. Immunol. 158 (1994) 131-139, http://dx.doi.org/10.1006/cimm.1994.1262.
    • (1994) Cell. Immunol. , vol.158 , pp. 131-139
    • Nilsson, N.1    Carlsten, H.2
  • 39
    • 0019791230 scopus 로고
    • Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures
    • T. Paavonen, L.C. Andersson, H. Adlercreutz, Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures, J. Exp. Med. 154 (1981) 1935-1945.
    • (1981) J. Exp. Med. , vol.154 , pp. 1935-1945
    • Paavonen, T.1    Andersson, L.C.2    Adlercreutz, H.3
  • 40
    • 0023778073 scopus 로고
    • Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation
    • Z.M. Sthoeger, N. Chiorazzi, R.G. Lahita, Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation, J. Immunol. (Baltim. Md 1950) 141 (1988) 91-98.
    • (1988) J. Immunol. (Baltim. Md 1950) , vol.141 , pp. 91-98
    • Sthoeger, Z.M.1    Chiorazzi, N.2    Lahita, R.G.3
  • 41
    • 80051560339 scopus 로고    scopus 로고
    • Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    • S. Bhasin, M. Pencina, G.K. Jasuja, T.G. Travison, A. Coviello, E. Orwoll, et al., Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts, J. Clin. Endocrinol. Metab. 96 (2011) 2430-2439, http://dx.doi.org/10.1210/jc.2010-3012.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 2430-2439
    • Bhasin, S.1    Pencina, M.2    Jasuja, G.K.3    Travison, T.G.4    Coviello, A.5    Orwoll, E.6
  • 42
    • 84896750181 scopus 로고    scopus 로고
    • Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment
    • I. Huhtaniemi, Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment, Asian J. Androl. 16 (2014) 192-202, http://dx.doi.org/10.4103/1008-682X.122336.
    • (2014) Asian J. Androl. , vol.16 , pp. 192-202
    • Huhtaniemi, I.1
  • 43
    • 0034453155 scopus 로고    scopus 로고
    • Hysterectomy, oophorectomy and endogenous sex hormone levels in older women: the Rancho Bernardo Study
    • G.A. Laughlin, E. Barrett-Connor, D. Kritz-Silverstein, D. von Mühlen, Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study, J. Clin. Endocrinol. Metab. 85 (2000) 645-651, http://dx.doi.org/10.1210/jcem.85.2.6405.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 645-651
    • Laughlin, G.A.1    Barrett-Connor, E.2    Kritz-Silverstein, D.3    von Mühlen, D.4
  • 45
    • 84869458989 scopus 로고    scopus 로고
    • Sex and gender differences in myocarditis and dilated cardiomyopathy
    • D. Fairweather, L.T. Cooper Jr, L.A. Blauwet, Sex and gender differences in myocarditis and dilated cardiomyopathy, Curr. Probl. Cardiol. 38 (2013) 7-46, http://dx.doi.org/10.1016/j.cpcardiol.2012.07.003.
    • (2013) Curr. Probl. Cardiol. , vol.38 , pp. 7-46
    • Fairweather, D.1    Cooper, L.T.2    Blauwet, L.A.3
  • 46
    • 0035881678 scopus 로고    scopus 로고
    • Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production
    • S.M. Liva, R.R. Voskuhl, Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production, J. Immunol. (Baltim. Md 1950) 167 (2001) 2060-2067.
    • (2001) J. Immunol. (Baltim. Md 1950) , vol.167 , pp. 2060-2067
    • Liva, S.M.1    Voskuhl, R.R.2
  • 47
    • 0035098105 scopus 로고    scopus 로고
    • Androgen receptors in thymic epithelium modulate thymus size and thymocyte development
    • N.J. Olsen, G. Olson, S.M. Viselli, X. Gu, W.J. Kovacs, Androgen receptors in thymic epithelium modulate thymus size and thymocyte development, Endocrinology 142 (2001) 1278-1283, http://dx.doi.org/10.1210/endo.142.3.8032.
    • (2001) Endocrinology , vol.142 , pp. 1278-1283
    • Olsen, N.J.1    Olson, G.2    Viselli, S.M.3    Gu, X.4    Kovacs, W.J.5
  • 49
    • 84907424837 scopus 로고    scopus 로고
    • Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells
    • C. Chang, S. Yeh, S.O. Lee, T. Chang, Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells, Nucl. Recept. Signal. 11 (2013), http://dx.doi.org/10.1621/nrs.11001.
    • (2013) Nucl. Recept. Signal , vol.11
    • Chang, C.1    Yeh, S.2    Lee, S.O.3    Chang, T.4
  • 50
    • 0026055146 scopus 로고
    • Effects of castration, Depotestosterone and cyproterone acetate on lymphocyte T subsets in mouse thymus and spleen
    • S. Aboudkhil, J.P. Bureau, L. Garrelly, P. Vago, Effects of castration, Depotestosterone and cyproterone acetate on lymphocyte T subsets in mouse thymus and spleen, Scand. J. Immunol. 34 (1991) 647-653.
    • (1991) Scand. J. Immunol. , vol.34 , pp. 647-653
    • Aboudkhil, S.1    Bureau, J.P.2    Garrelly, L.3    Vago, P.4
  • 51
    • 0025723435 scopus 로고
    • Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice
    • N.J. Olsen, M.B. Watson, G.S. Henderson, W.J. Kovacs, Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice, Endocrinology 129 (1991) 2471-2476, http://dx.doi.org/10.1210/endo-129-5-2471.
    • (1991) Endocrinology , vol.129 , pp. 2471-2476
    • Olsen, N.J.1    Watson, M.B.2    Henderson, G.S.3    Kovacs, W.J.4
  • 52
    • 0028107235 scopus 로고
    • Induction of immature thymocyte proliferation after castration of normal male mice
    • N.J. Olsen, S.M. Viselli, K. Shults, G. Stelzer, W.J. Kovacs, Induction of immature thymocyte proliferation after castration of normal male mice, Endocrinology 134 (1994) 107-113, http://dx.doi.org/10.1210/endo.134.1. 8275924.
    • (1994) Endocrinology , vol.134 , pp. 107-113
    • Olsen, N.J.1    Viselli, S.M.2    Shults, K.3    Stelzer, G.4    Kovacs, W.J.5
  • 53
    • 0031765773 scopus 로고    scopus 로고
    • Androgens accelerate thymocyte apoptosis
    • N.J. Olsen, S.M. Viselli, J. Fan, W.J. Kovacs, Androgens accelerate thymocyte apoptosis, Endocrinology 139 (1998) 748-752, http://dx.doi.org/10.1210/endo.139.2.5729.
    • (1998) Endocrinology , vol.139 , pp. 748-752
    • Olsen, N.J.1    Viselli, S.M.2    Fan, J.3    Kovacs, W.J.4
  • 54
    • 0035071529 scopus 로고    scopus 로고
    • Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice
    • T.M. Ellis, M.T. Moser, P.T. Le, R.C. Flanigan, E.D. Kwon, Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice, Int. Immunol. 13 (2001) 553-558.
    • (2001) Int. Immunol. , vol.13 , pp. 553-558
    • Ellis, T.M.1    Moser, M.T.2    Le, P.T.3    Flanigan, R.C.4    Kwon, E.D.5
  • 55
  • 56
    • 0028962781 scopus 로고
    • Enhanced production of B lymphocytes after castration
    • C.A. Wilson, S.A. Mrose, D.W. Thomas, Enhanced production of B lymphocytes after castration, Blood 85 (1995) 1535-1539.
    • (1995) Blood , vol.85 , pp. 1535-1539
    • Wilson, C.A.1    Mrose, S.A.2    Thomas, D.W.3
  • 57
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • G.S. Ashcroft, X. Yang, A.B. Glick, M. Weinstein, J.L. Letterio, D.E. Mizel, et al., Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response, Nat. Cell Biol. 1 (1999) 260-266, http://dx.doi.org/10.1038/12971.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 260-266
    • Ashcroft, G.S.1    Yang, X.2    Glick, A.B.3    Weinstein, M.4    Letterio, J.L.5    Mizel, D.E.6
  • 58
    • 0034671664 scopus 로고    scopus 로고
    • Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages
    • R. Friedl, M. Brunner, T. Moeslinger, P.G. Spieckermann, Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages, Life Sci. 68 (2000) 417-429.
    • (2000) Life Sci. , vol.68 , pp. 417-429
    • Friedl, R.1    Brunner, M.2    Moeslinger, T.3    Spieckermann, P.G.4
  • 61
    • 77954948753 scopus 로고    scopus 로고
    • The X chromosome in immune functions: when a chromosome makes the difference
    • C. Libert, L. Dejager, I. Pinheiro, The X chromosome in immune functions: when a chromosome makes the difference, Nat. Rev. Immunol. 10 (2010) 594-604, http://dx.doi.org/10.1038/nri2815.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 594-604
    • Libert, C.1    Dejager, L.2    Pinheiro, I.3
  • 62
    • 80054694532 scopus 로고    scopus 로고
    • X-chromosome-located microRNAs in immunity: might they explain male/female differences? The X chromosomegenomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females
    • I. Pinheiro, L. Dejager, C. Libert, X-chromosome-located microRNAs in immunity: might they explain male/female differences? The X chromosomegenomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females, BioEssays 33 (2011) 791-802, http://dx.doi.org/10.1002/bies.201100047.
    • (2011) BioEssays , vol.33 , pp. 791-802
    • Pinheiro, I.1    Dejager, L.2    Libert, C.3
  • 63
    • 84858447329 scopus 로고    scopus 로고
    • The influence of sex and gender on the immune response
    • S. Oertelt-Prigione, The influence of sex and gender on the immune response, Autoimmun. Rev. 11 (2012) A479-485, http://dx.doi.org/10.1016/j.autrev. 2011.11.022.
    • (2012) Autoimmun. Rev. , vol.11 , pp. A479-485
    • Oertelt-Prigione, S.1
  • 64
    • 84876544047 scopus 로고    scopus 로고
    • Sex bias in infectious disease epidemiology: patterns and processes
    • F. Guerra-Silveira, F. Abad-Franch, Sex bias in infectious disease epidemiology: patterns and processes, PLoS One 8 (2013) e62390, http://dx.doi.org/10.1371/journal.pone.0062390.
    • (2013) PLoS One , vol.8
    • Guerra-Silveira, F.1    Abad-Franch, F.2
  • 65
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccination in the elderly: a quantitative review
    • K. Goodwin, C. Viboud, L. Simonsen, Antibody response to influenza vaccination in the elderly: a quantitative review, Vaccine 24 (2006) 1159-1169, http://dx.doi.org/10.1016/j.vaccine.2005.08.105.
    • (2006) Vaccine , vol.24 , pp. 1159-1169
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 66
    • 0034463126 scopus 로고    scopus 로고
    • Epidemiology and unique aspects of aging and infectious diseases
    • T.T. Yoshikawa, Epidemiology and unique aspects of aging and infectious diseases, Clin. Infect. Dis. 30 (2000) 931-933, http://dx.doi.org/10.1086/313792.
    • (2000) Clin. Infect. Dis. , vol.30 , pp. 931-933
    • Yoshikawa, T.T.1
  • 67
    • 84904664731 scopus 로고    scopus 로고
    • On the immunological theory of aging
    • in: L. Robert, T. Fulop (Eds.), S. KARGER AG, Basel accessed 17.12.14
    • T. Fulop, J.M. Witkowski, G. Pawelec, C. Alan, A. Larbi, On the immunological theory of aging, in: L. Robert, T. Fulop (Eds.), Interdiscip. Top. Gerontol., S. KARGER AG, Basel, 2014, pp. 163-176. (accessed 17.12.14).
    • (2014) Interdiscip. Top. Gerontol , pp. 163-176
    • Fulop, T.1    Witkowski, J.M.2    Pawelec, G.3    Alan, C.4    Larbi, A.5
  • 68
    • 84888320636 scopus 로고    scopus 로고
    • Age-dependent dysregulation of innate immunity
    • A.C. Shaw, D.R. Goldstein, R.R. Montgomery, Age-dependent dysregulation of innate immunity, Nat. Rev. Immunol. 13 (2013) 875-887, http://dx.doi.org/10.1038/nri3547.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 875-887
    • Shaw, A.C.1    Goldstein, D.R.2    Montgomery, R.R.3
  • 69
    • 84866436856 scopus 로고    scopus 로고
    • The age-related increase in low-grade systemic inflammation (inflammaging) is not driven by cytomegalovirus infection
    • D.B. Bartlett, C.M. Firth, A.C. Phillips, P. Moss, D. Baylis, H. Syddall, et al., The age-related increase in low-grade systemic inflammation (inflammaging) is not driven by cytomegalovirus infection, Aging Cell 11 (2012) 912-915, http://dx.doi.org/10.1111/j.1474-9726.2012.00849.x.
    • (2012) Aging Cell , vol.11 , pp. 912-915
    • Bartlett, D.B.1    Firth, C.M.2    Phillips, A.C.3    Moss, P.4    Baylis, D.5    Syddall, H.6
  • 70
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: the lesson of centenarians
    • C. Franceschi, D. Monti, P. Sansoni, A. Cossarizza, The immunology of exceptional individuals: the lesson of centenarians, Immunol. Today 16 (1995) 12-16.
    • (1995) Immunol. Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 71
    • 84871398447 scopus 로고    scopus 로고
    • NK cells in healthy aging and ageassociated diseases
    • X. Camous, A. Pera, R. Solana, A. Larbi, NK cells in healthy aging and ageassociated diseases, J. Biomed. Biotechnol. 2012 (2012) 195956, http://dx.doi.org/10.1155/2012/195956.
    • (2012) J. Biomed. Biotechnol. , vol.2012
    • Camous, X.1    Pera, A.2    Solana, R.3    Larbi, A.4
  • 72
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
    • R. Solana, R. Tarazona, I. Gayoso, O. Lesur, G. Dupuis, T. Fulop, Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans, Semin. Immunol. 24 (2012) 331-341, http://dx.doi.org/10.1016/j.smim.2012.04.008.
    • (2012) Semin. Immunol. , vol.24 , pp. 331-341
    • Solana, R.1    Tarazona, R.2    Gayoso, I.3    Lesur, O.4    Dupuis, G.5    Fulop, T.6
  • 73
    • 0035216133 scopus 로고    scopus 로고
    • Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
    • S.K. Butcher, H. Chahal, L. Nayak, A. Sinclair, N.V. Henriquez, E. Sapey, et al., Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans, J. Leukoc. Biol. 70 (2001) 881-886.
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 881-886
    • Butcher, S.K.1    Chahal, H.2    Nayak, L.3    Sinclair, A.4    Henriquez, N.V.5    Sapey, E.6
  • 74
    • 0021850379 scopus 로고
    • Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes
    • T. Fülöp, G. Fóris, I. Wórum, A. Leövey, Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes, Clin. Exp. Immunol. 61 (1985) 425-432.
    • (1985) Clin. Exp. Immunol. , vol.61 , pp. 425-432
    • Fülöp, T.1    Fóris, G.2    Wórum, I.3    Leövey, A.4
  • 75
    • 5644265023 scopus 로고    scopus 로고
    • Signal transduction and functional changes in neutrophils with aging
    • T. Fulop, A. Larbi, N. Douziech, C. Fortin, K.-P. Guérard, O. Lesur, et al., Signal transduction and functional changes in neutrophils with aging, Aging Cell 3 (2004) 217-226, http://dx.doi.org/10.1111/j.1474-9728.2004.00110.x.
    • (2004) Aging Cell , vol.3 , pp. 217-226
    • Fulop, T.1    Larbi, A.2    Douziech, N.3    Fortin, C.4    Guérard, K.-P.5    Lesur, O.6
  • 76
    • 45149089630 scopus 로고    scopus 로고
    • Influence of aging on murine neutrophil and macrophage function against Candida albicans
    • C. Murciano, A. Yáñez, J.E. O'Connor, D. Gozalbo, M.L. Gil, Influence of aging on murine neutrophil and macrophage function against Candida albicans, FEMS Immunol. Med. Microbiol. 53 (2008) 214-221, http://dx.doi.org/10.1111/j.1574-695X.2008.00418.x.
    • (2008) FEMS Immunol. Med. Microbiol. , vol.53 , pp. 214-221
    • Murciano, C.1    Yáñez, A.2    O'Connor, J.E.3    Gozalbo, D.4    Gil, M.L.5
  • 77
    • 0024397502 scopus 로고
    • Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies
    • Y. Niwa, T. Kasama, Y. Miyachi, T. Kanoh, Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies, Life Sci. 44 (1989) 1655-1664.
    • (1989) Life Sci. , vol.44 , pp. 1655-1664
    • Niwa, Y.1    Kasama, T.2    Miyachi, Y.3    Kanoh, T.4
  • 78
    • 79951722208 scopus 로고    scopus 로고
    • Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
    • B. Simell, A. Vuorela, N. Ekström, A. Palmu, A. Reunanen, S. Meri, et al., Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis, Vaccine 29 (2011) 1929-1934, http://dx.doi.org/10.1016/j.vaccine.2010.12.121.
    • (2011) Vaccine , vol.29 , pp. 1929-1934
    • Simell, B.1    Vuorela, A.2    Ekström, N.3    Palmu, A.4    Reunanen, A.5    Meri, S.6
  • 79
    • 73949091048 scopus 로고    scopus 로고
    • Impaired immune responses in the lungs of aged mice following influenza infection
    • F.R. Toapanta, T.M. Ross, Impaired immune responses in the lungs of aged mice following influenza infection, Respir. Res. 10 (2009) 112, http://dx.doi.org/10.1186/1465-9921-10-112.
    • (2009) Respir. Res. , vol.10 , pp. 112
    • Toapanta, F.R.1    Ross, T.M.2
  • 80
    • 84864378864 scopus 로고    scopus 로고
    • Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus
    • C.W. Tseng, P.A. Kyme, A. Arruda, V.K. Ramanujan, W. Tawackoli, G.Y. Liu, Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus, PLoS One 7 (2012) e41454, http://dx.doi.org/10.1371/journal.pone.0041454.
    • (2012) PLoS One , vol.7
    • Tseng, C.W.1    Kyme, P.A.2    Arruda, A.3    Ramanujan, V.K.4    Tawackoli, W.5    Liu, G.Y.6
  • 82
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • A. Agrawal, S. Agrawal, J.-N. Cao, H. Su, K. Osann, S. Gupta, Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway, J. Immunol. (Baltim. Md 1950) 178 (2007) 6912-6922.
    • (2007) J. Immunol. (Baltim. Md 1950) , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.-N.3    Su, H.4    Osann, K.5    Gupta, S.6
  • 83
    • 43349104959 scopus 로고    scopus 로고
    • Ageing is associated with diminished apoptotic cell clearance in vivo
    • T. Aprahamian, Y. Takemura, D. Goukassian, K. Walsh, Ageing is associated with diminished apoptotic cell clearance in vivo, Clin. Exp. Immunol. 152 (2008) 448-455, http://dx.doi.org/10.1111/j.1365-2249.2008.03658.x.
    • (2008) Clin. Exp. Immunol. , vol.152 , pp. 448-455
    • Aprahamian, T.1    Takemura, Y.2    Goukassian, D.3    Walsh, K.4
  • 84
    • 71849099712 scopus 로고    scopus 로고
    • Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen
    • M.M. Moretto, E.M. Lawlor, I.A. Khan, Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen, J. Immunol. (Baltim. Md 1950) 181 (2008) 7977-7984.
    • (2008) J. Immunol. (Baltim. Md 1950) , vol.181 , pp. 7977-7984
    • Moretto, M.M.1    Lawlor, E.M.2    Khan, I.A.3
  • 85
    • 58149177781 scopus 로고    scopus 로고
    • Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation
    • H.W. Stout-Delgado, X. Yang, W.E. Walker, B.M. Tesar, D.R. Goldstein, Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation, J. Immunol. (Baltim. Md 1950) 181 (2008) 6747-6756.
    • (2008) J. Immunol. (Baltim. Md 1950) , vol.181 , pp. 6747-6756
    • Stout-Delgado, H.W.1    Yang, X.2    Walker, W.E.3    Tesar, B.M.4    Goldstein, D.R.5
  • 87
    • 77951886965 scopus 로고    scopus 로고
    • Ageassociated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response
    • A. Panda, F. Qian, S. Mohanty, D. van Duin, F.K. Newman, L. Zhang, et al., Ageassociated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response, J. Immunol. (Baltim. Md 1950) 184 (2010) 2518-2527, http://dx.doi.org/10.4049/jimmunol.0901022.
    • (2010) J. Immunol. (Baltim. Md 1950) , vol.184 , pp. 2518-2527
    • Panda, A.1    Qian, F.2    Mohanty, S.3    van Duin, D.4    Newman, F.K.5    Zhang, L.6
  • 88
    • 17644425982 scopus 로고    scopus 로고
    • CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances
    • Y. Chong, H. Ikematsu, K. Yamaji, M. Nishimura, S. Nabeshima, S. Kashiwagi, et al., CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances, Int. Immunol. 17 (2005) 383-390, http://dx.doi.org/10.1093/intimm/dxh218.
    • (2005) Int. Immunol. , vol.17 , pp. 383-390
    • Chong, Y.1    Ikematsu, H.2    Yamaji, K.3    Nishimura, M.4    Nabeshima, S.5    Kashiwagi, S.6
  • 89
    • 59049088629 scopus 로고    scopus 로고
    • Bcell diversity decreases in old age and is correlated with poor health status
    • K.L. Gibson, Y.-C. Wu, Y. Barnett, O. Duggan, R. Vaughan, E. Kondeatis, et al., Bcell diversity decreases in old age and is correlated with poor health status, Aging Cell 8 (2009) 18-25, http://dx.doi.org/10.1111/j.1474-9726.2008. 00443.x.
    • (2009) Aging Cell , vol.8 , pp. 18-25
    • Gibson, K.L.1    Wu, Y.-C.2    Barnett, Y.3    Duggan, O.4    Vaughan, R.5    Kondeatis, E.6
  • 90
    • 0037094083 scopus 로고    scopus 로고
    • Aging-dependent exclusion of antigeninexperienced cells from the peripheral B cell repertoire
    • S.A. Johnson, S.J. Rozzo, J.C. Cambier, Aging-dependent exclusion of antigeninexperienced cells from the peripheral B cell repertoire, J. Immunol. (Baltim. Md 1950) 168 (2002) 5014-5023.
    • (2002) J. Immunol. (Baltim. Md 1950) , vol.168 , pp. 5014-5023
    • Johnson, S.A.1    Rozzo, S.J.2    Cambier, J.C.3
  • 91
    • 79960997012 scopus 로고    scopus 로고
    • Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
    • S. Sasaki, M. Sullivan, C.F. Narvaez, T.H. Holmes, D. Furman, N.-Y. Zheng, et al., Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies, J. Clin. Invest. 121 (2011) 3109-3119, http://dx.doi.org/10.1172/JCI57834.
    • (2011) J. Clin. Invest. , vol.121 , pp. 3109-3119
    • Sasaki, S.1    Sullivan, M.2    Narvaez, C.F.3    Holmes, T.H.4    Furman, D.5    Zheng, N.-Y.6
  • 92
    • 52149084988 scopus 로고    scopus 로고
    • Pneumococcal vaccination in older adults induces antibodies with low opsonic capacity and reduced antibody potency
    • J.G. Schenkein, S. Park, M.H. Nahm, Pneumococcal vaccination in older adults induces antibodies with low opsonic capacity and reduced antibody potency, Vaccine 26 (2008) 5521-5526, http://dx.doi.org/10.1016/j.vaccine.2008.07.071.
    • (2008) Vaccine , vol.26 , pp. 5521-5526
    • Schenkein, J.G.1    Park, S.2    Nahm, M.H.3
  • 93
    • 0022377731 scopus 로고
    • The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study
    • G.G. Steinmann, B. Klaus, H.K. Müller-Hermelink, The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study, Scand. J. Immunol. 22 (1985) 563-575.
    • (1985) Scand. J. Immunol. , vol.22 , pp. 563-575
    • Steinmann, G.G.1    Klaus, B.2    Müller-Hermelink, H.K.3
  • 94
  • 95
    • 33846487547 scopus 로고    scopus 로고
    • Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice
    • K. Clise-Dwyer, G.E. Huston, A.L. Buck, D.K. Duso, S.L. Swain, Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice, J. Immunol. (Baltim. Md 1950) 178 (2007) 1321-1331.
    • (2007) J. Immunol. (Baltim. Md 1950) , vol.178 , pp. 1321-1331
    • Clise-Dwyer, K.1    Huston, G.E.2    Buck, A.L.3    Duso, D.K.4    Swain, S.L.5
  • 97
    • 68149124434 scopus 로고    scopus 로고
    • Effects of aging on T cell function
    • L. Haynes, A.C. Maue, Effects of aging on T cell function, Curr. Opin. Immunol. 21 (2009) 414-417, http://dx.doi.org/10.1016/j.coi.2009.05.009.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 414-417
    • Haynes, L.1    Maue, A.C.2
  • 98
    • 33747789572 scopus 로고    scopus 로고
    • Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals
    • I. Messaoudi, J. Warner, J. Nikolich-Zugich, Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals, J. Immunol. (Baltim. Md 1950) 177 (2006) 2784-2792.
    • (2006) J. Immunol. (Baltim. Md 1950) , vol.177 , pp. 2784-2792
    • Messaoudi, I.1    Warner, J.2    Nikolich-Zugich, J.3
  • 100
    • 84886033654 scopus 로고    scopus 로고
    • Human T cell aging and the impact of persistent viral infections
    • T. Fülöp, A. Larbi, G. Pawelec, Human T cell aging and the impact of persistent viral infections, Front. Immunol. 4 (2013) 271, http://dx.doi.org/10.3389/fimmu.2013.00271.
    • (2013) Front. Immunol. , vol.4 , pp. 271
    • Fülöp, T.1    Larbi, A.2    Pawelec, G.3
  • 101
    • 79953159005 scopus 로고    scopus 로고
    • Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
    • A.N. Akbar, S.M. Henson, Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?, Nat Rev. Immunol. 11 (2011) 289-295, http://dx.doi.org/10.1038/nri2959.
    • (2011) Nat Rev. Immunol. , vol.11 , pp. 289-295
    • Akbar, A.N.1    Henson, S.M.2
  • 102
    • 79551614790 scopus 로고    scopus 로고
    • HIV infection, inflammation, immunosenescence, and aging
    • S.G. Deeks, HIV infection, inflammation, immunosenescence, and aging, Annu. Rev. Med. 62 (2011) 141-155, http://dx.doi.org/10.1146/annurev-med-042909-093756.
    • (2011) Annu. Rev. Med. , vol.62 , pp. 141-155
    • Deeks, S.G.1
  • 103
    • 33646518593 scopus 로고    scopus 로고
    • Inflammation markers predicting frailty and mortality in the elderly
    • M. De Martinis, C. Franceschi, D. Monti, L. Ginaldi, Inflammation markers predicting frailty and mortality in the elderly, Exp. Mol. Pathol. 80 (2006) 219-227, http://dx.doi.org/10.1016/j.yexmp.2005.11.004.
    • (2006) Exp. Mol. Pathol. , vol.80 , pp. 219-227
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 104
    • 33847675339 scopus 로고    scopus 로고
    • Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease
    • A.N. Vallejo, Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease, Trends Mol. Med. 13 (2007) 94-102, http://dx.doi.org/10.1016/j.molmed.2007.01.005.
    • (2007) Trends Mol. Med. , vol.13 , pp. 94-102
    • Vallejo, A.N.1
  • 105
    • 84881526076 scopus 로고    scopus 로고
    • Slower immune system aging in women versus men in the Japanese population
    • K. Hirokawa, M. Utsuyama, Y. Hayashi, M. Kitagawa, T. Makinodan, T. Fulop, Slower immune system aging in women versus men in the Japanese population, Immun. Ageing A 10 (2013) 19, http://dx.doi.org/10.1186/1742-4933-10-19.
    • (2013) Immun. Ageing A , vol.10 , pp. 19
    • Hirokawa, K.1    Utsuyama, M.2    Hayashi, Y.3    Kitagawa, M.4    Makinodan, T.5    Fulop, T.6
  • 106
    • 84889609822 scopus 로고    scopus 로고
    • Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults
    • O.-J. Lee, Y.-N. Cho, S.-J. Kee, M.-J. Kim, H.-M. Jin, S.-J. Lee, et al., Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults, Exp. Gerontol. 49 (2014) 47-54, http://dx.doi.org/10.1016/j.exger.2013.11.003.
    • (2014) Exp. Gerontol. , vol.49 , pp. 47-54
    • Lee, O.-J.1    Cho, Y.-N.2    Kee, S.-J.3    Kim, M.-J.4    Jin, H.-M.5    Lee, S.-J.6
  • 107
    • 84880571275 scopus 로고    scopus 로고
    • The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study
    • J. Strindhall, M. Skog, J. Ernerudh, M. Bengner, S. Löfgren, A. Matussek, et al., The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study, Age (Dordr. Neth.) 35 (2013) 985-991, http://dx.doi.org/10.1007/s11357-012-9400-3.
    • (2013) Age (Dordr. Neth.) , vol.35 , pp. 985-991
    • Strindhall, J.1    Skog, M.2    Ernerudh, J.3    Bengner, M.4    Löfgren, S.5    Matussek, A.6
  • 108
    • 77956621724 scopus 로고    scopus 로고
    • Gender specificity of altered human immune cytokine profiles in aging
    • E.J. Goetzl, M.-C. Huang, J. Kon, K. Patel, J.B. Schwartz, K. Fast, et al., Gender specificity of altered human immune cytokine profiles in aging, FASEB J. 24 (2010) 3580-3589, http://dx.doi.org/10.1096/fj.10-160911.
    • (2010) FASEB J. , vol.24 , pp. 3580-3589
    • Goetzl, E.J.1    Huang, M.-C.2    Kon, J.3    Patel, K.4    Schwartz, J.B.5    Fast, K.6
  • 109
    • 32044433093 scopus 로고    scopus 로고
    • Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly
    • S.R. Hadrup, J. Strindhall, T. Køllgaard, T. Seremet, B. Johansson, G. Pawelec, et al., Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly, J. Immunol. (Baltim. Md 1950) 176 (2006) 2645-2653.
    • (2006) J. Immunol. (Baltim. Md 1950) , vol.176 , pp. 2645-2653
    • Hadrup, S.R.1    Strindhall, J.2    Køllgaard, T.3    Seremet, T.4    Johansson, B.5    Pawelec, G.6
  • 111
    • 84871935156 scopus 로고    scopus 로고
    • Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    • E. Derhovanessian, H. Theeten, K. Hähnel, P. Van Damme, N. Cools, G. Pawelec, Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination, Vaccine 31 (2013) 685-690, http://dx.doi.org/10.1016/j.vaccine.2012.11.041.
    • (2013) Vaccine , vol.31 , pp. 685-690
    • Derhovanessian, E.1    Theeten, H.2    Hähnel, K.3    van Damme, P.4    Cools, N.5    Pawelec, G.6
  • 112
    • 84907223820 scopus 로고    scopus 로고
    • Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly
    • E. Derhovanessian, A.B. Maier, K. Hähnel, J.E. McElhaney, E.P. Slagboom, G. Pawelec, Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly, J. Immunol. (Baltim. Md 1950) 193 (2014) 3624-3631, http://dx.doi.org/10.4049/jimmunol.1303361.
    • (2014) J. Immunol. (Baltim. Md 1950) , vol.193 , pp. 3624-3631
    • Derhovanessian, E.1    Maier, A.B.2    Hähnel, K.3    McElhaney, J.E.4    Slagboom, E.P.5    Pawelec, G.6
  • 113
    • 0027284355 scopus 로고
    • Ethnic and gender differences in the prevalence of anti-cytomegalovirus antibodies among young adults in Israel
    • M.S. Green, D. Cohen, R. Slepon, G. Robin, M. Wiener, Ethnic and gender differences in the prevalence of anti-cytomegalovirus antibodies among young adults in Israel, Int. J. Epidemiol. 22 (1993) 720-723.
    • (1993) Int. J. Epidemiol. , vol.22 , pp. 720-723
    • Green, M.S.1    Cohen, D.2    Slepon, R.3    Robin, G.4    Wiener, M.5
  • 116
    • 2542480663 scopus 로고    scopus 로고
    • Predominant type 1 CMVspecific memory T-helper response in humans: evidence for gender differences in cytokine secretion
    • M.C. Villacres, J. Longmate, C. Auge, D.J. Diamond, Predominant type 1 CMVspecific memory T-helper response in humans: evidence for gender differences in cytokine secretion, Hum. Immunol. 65 (2004) 476-485, http://dx.doi.org/10.1016/j.humimm.2004.02.021.
    • (2004) Hum. Immunol. , vol.65 , pp. 476-485
    • Villacres, M.C.1    Longmate, J.2    Auge, C.3    Diamond, D.J.4
  • 117
    • 77955661281 scopus 로고    scopus 로고
    • Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly
    • T.M. Kao, S.M. Hsieh, H.C. Kung, Y.C. Lee, K.C. Huang, L.M. Huang, Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly, Vaccine 28 (2010) (2009) 6159-6163, http://dx.doi.org/10.1016/j.vaccine.2010.07.026.
    • (2009) Vaccine , vol.28 , pp. 6159-6163
    • Kao, T.M.1    Hsieh, S.M.2    Kung, H.C.3    Lee, Y.C.4    Huang, K.C.5    Huang, L.M.6
  • 118
    • 78649522730 scopus 로고    scopus 로고
    • Menopause and aging: changes in the immune system -a review
    • C.M. Gameiro, F. Romão, C. Castelo-Branco, Menopause and aging: changes in the immune system -a review, Maturitas 67 (2010) 316-320, http://dx.doi.org/10.1016/j.maturitas.2010.08.003.
    • (2010) Maturitas , vol.67 , pp. 316-320
    • Gameiro, C.M.1    Romão, F.2    Castelo-Branco, C.3
  • 119
    • 84886243127 scopus 로고    scopus 로고
    • Effect of age on atherogenicity of LDL and inflammatory markers in healthy women
    • J.K. Paik, J.S. Chae, R. Kang, N. Kwon, S.-H. Lee, J.H. Lee, Effect of age on atherogenicity of LDL and inflammatory markers in healthy women, Nutr. Metab. Cardiovasc. Dis. 23 (2013) 967-972, http://dx.doi.org/10.1016/j.numecd.2012.08.002.
    • (2013) Nutr. Metab. Cardiovasc. Dis. , vol.23 , pp. 967-972
    • Paik, J.K.1    Chae, J.S.2    Kang, R.3    Kwon, N.4    Lee, S.-H.5    Lee, J.H.6
  • 120
    • 0042354826 scopus 로고    scopus 로고
    • Age-and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts
    • DECODE Study Group, Age-and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts, Diabetes Care 26 (2003) 61-69.
    • (2003) Diabetes Care , vol.26 , pp. 61-69
  • 121
    • 70349859846 scopus 로고    scopus 로고
    • Gender differences in the cardiovascular effect of sex hormones
    • C. Vitale, M.E. Mendelsohn, G.M.C. Rosano, Gender differences in the cardiovascular effect of sex hormones, Nat. Rev. Cardiol. 6 (2009) 532-542, http://dx.doi.org/10.1038/nrcardio.2009.105.
    • (2009) Nat. Rev. Cardiol. , vol.6 , pp. 532-542
    • Vitale, C.1    Mendelsohn, M.E.2    Rosano, G.M.C.3
  • 122
    • 0034463905 scopus 로고    scopus 로고
    • Loss of atheroprotective effect of estradiol in immunodeficient mice
    • R. Elhage, S. Clamens, C. Reardon-Alulis, G.S. Getz, C. Fievet, A. Maret, et al., Loss of atheroprotective effect of estradiol in immunodeficient mice, Endocrinology 141 (2000) 462-465, http://dx.doi.org/10.1210/endo.141.1.7377.
    • (2000) Endocrinology , vol.141 , pp. 462-465
    • Elhage, R.1    Clamens, S.2    Reardon-Alulis, C.3    Getz, G.S.4    Fievet, C.5    Maret, A.6
  • 123
    • 82355163442 scopus 로고    scopus 로고
    • Minireview: recent advances in extranuclear steroid receptor actions
    • S.R. Hammes, E.R. Levin, Minireview: recent advances in extranuclear steroid receptor actions, Endocrinology 152 (2011) 4489-4495, http://dx.doi.org/10.1210/en.2011-1470.
    • (2011) Endocrinology , vol.152 , pp. 4489-4495
    • Hammes, S.R.1    Levin, E.R.2
  • 124
    • 0035132187 scopus 로고    scopus 로고
    • Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice
    • J.B. Hodgin, J.H. Krege, R.L. Reddick, K.S. Korach, O. Smithies, N. Maeda, Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/-mice, J. Clin. Invest. 107 (2001) 333-340, http://dx.doi.org/10.1172/JCI11320.
    • (2001) J. Clin. Invest. , vol.107 , pp. 333-340
    • Hodgin, J.B.1    Krege, J.H.2    Reddick, R.L.3    Korach, K.S.4    Smithies, O.5    Maeda, N.6
  • 125
    • 84864851512 scopus 로고    scopus 로고
    • Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?
    • M. Alemany, Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?, Front Endocrinol. 3 (2012) 27, http://dx.doi.org/10.3389/fendo.2012.00027.
    • (2012) Front Endocrinol. , vol.3 , pp. 27
    • Alemany, M.1
  • 126
    • 84873742735 scopus 로고    scopus 로고
    • 11b-Hydroxysteroid dehydrogenase type 1: potential therapeutic target for metabolic syndrome
    • A. Joharapurkar, N. Dhanesha, G. Shah, R. Kharul, M. Jain, 11b-Hydroxysteroid dehydrogenase type 1: potential therapeutic target for metabolic syndrome, Pharmacol. Rep. 64 (2012) 1055-1065.
    • (2012) Pharmacol. Rep. , vol.64 , pp. 1055-1065
    • Joharapurkar, A.1    Dhanesha, N.2    Shah, G.3    Kharul, R.4    Jain, M.5
  • 128
    • 0141819043 scopus 로고    scopus 로고
    • The epidemiology of autoimmune diseases
    • G.S. Cooper, B.C. Stroehla, The epidemiology of autoimmune diseases, Autoimmun. Rev. 2 (2003) 119-125.
    • (2003) Autoimmun. Rev. , vol.2 , pp. 119-125
    • Cooper, G.S.1    Stroehla, B.C.2
  • 129
    • 0022656719 scopus 로고
    • Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population
    • D.J. Lerner, W.B. Kannel, Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population, Am. Heart J. 111 (1986) 383-390, http://dx.doi.org/10.1016/0002-8703(86)90155-9.
    • (1986) Am. Heart J. , vol.111 , pp. 383-390
    • Lerner, D.J.1    Kannel, W.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.