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Volumn 16, Issue 2, 2014, Pages 192-202

Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment

Author keywords

Hypogonadism; Male ageing; Obesity; Testicular function; Testosterone

Indexed keywords

LUTEINIZING HORMONE; TESTOSTERONE;

EID: 84896750181     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.4103/1008-682X.122336     Document Type: Review
Times cited : (160)

References (114)
  • 3
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men
    • DOI 10.1210/jc.86.2.724
    • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001; 86: 724-31. (Pubitemid 32207487)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.2 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 5
    • 84860751541 scopus 로고    scopus 로고
    • Characteristics of androgen deficiency in late-onset hypogonadism: Results from the European Male Aging Study (EMAS)
    • EMAS Group
    • Tajar A, Huhtaniemi IT, O'Neill TW, Finn JD, Pye SR, et al. EMAS Group. Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS). J Clin Endocrinol Metab 2012; 97: 1508-16.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1508-1516
    • Tajar, A.1    Huhtaniemi, I.T.2    O'Neill, T.W.3    Finn, J.D.4    Pye, S.R.5
  • 6
    • 77954414397 scopus 로고    scopus 로고
    • Identification of late-onset hypogonadism in middle-aged and elderly men
    • EMAS Group
    • Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, et al. EMAS Group. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010; 363: 123-35.
    • (2010) N Engl J Med , vol.363 , pp. 123-135
    • Wu, F.C.1    Tajar, A.2    Beynon, J.M.3    Pye, S.R.4    Silman, A.J.5
  • 7
    • 58149302752 scopus 로고    scopus 로고
    • Investigation, treatment and monitoring of late-onset hypogonadism in males
    • Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males. Int J Androl 2009; 32: 1-10.
    • (2009) Int J Androl , vol.32 , pp. 1-10
    • Wang, C.1    Nieschlag, E.2    Swerdloff, R.3    Behre, H.M.4    Hellstrom, W.J.5
  • 8
    • 84863292535 scopus 로고    scopus 로고
    • Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities
    • Sun K, Liang GQ, Chen XF, Ping P, Yao WL, et al. Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities. Asian J Androl 2012; 14: 338-40.
    • (2012) Asian J Androl , vol.14 , pp. 338-340
    • Sun, K.1    Liang, G.Q.2    Chen, X.F.3    Ping, P.4    Yao, W.L.5
  • 9
    • 79960048496 scopus 로고    scopus 로고
    • Testosterone replacement therapy for late-onset hypogonadism: Current trends in Korea
    • Ko YH, Kim JJ. Testosterone replacement therapy for late-onset hypogonadism: current trends in Korea. Asian J Androl 2011; 13: 563-8.
    • (2011) Asian J Androl , vol.13 , pp. 563-568
    • Ko, Y.H.1    Kim, J.J.2
  • 10
    • 79960046175 scopus 로고    scopus 로고
    • Recent topics related to testosterone deficiency syndrome in Japan
    • Tsujimura A, Nonomura N. Recent topics related to testosterone deficiency syndrome in Japan. Asian J Androl 2011; 13: 558-62.
    • (2011) Asian J Androl , vol.13 , pp. 558-562
    • Tsujimura, A.1    Nonomura, N.2
  • 11
    • 77449093905 scopus 로고    scopus 로고
    • Proportion and acceptance of andropause symptoms among elderly men: A Study in Jakarta
    • Taher A. Proportion and acceptance of andropause symptoms among elderly men: a Study in Jakarta. Acta Med Indones 2005; 37: 82-6.
    • (2005) Acta Med Indones , vol.37 , pp. 82-86
    • Taher, A.1
  • 12
    • 84865077426 scopus 로고    scopus 로고
    • Pharmacoepidemiology of testosterone prescribing in Australia, 1992-2010
    • Handelsman DJ. Pharmacoepidemiology of testosterone prescribing in Australia, 1992-2010. Med J Aust 2012; 196: 642-5.
    • (2012) Med J Aust , vol.196 , pp. 642-645
    • Handelsman, D.J.1
  • 13
    • 65549104191 scopus 로고    scopus 로고
    • Oral testosterone replacement in symptomatic late-onset hypogonadism: Effects on rating scales and general safety in a randomized, placebo-controlled study
    • Legros JJ, Meuleman EJ, Elbers JM, Geurts TB, Kaspers MJ, et al. Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study. Eur J Endocrinol 2009; 160: 821-31.
    • (2009) Eur J Endocrinol , vol.160 , pp. 821-831
    • Legros, J.J.1    Meuleman, E.J.2    Elbers, J.M.3    Geurts, T.B.4    Kaspers, M.J.5
  • 14
    • 66149143224 scopus 로고    scopus 로고
    • Time for international action on treating testosterone deficiency syndrome
    • Carruthers M. Time for international action on treating testosterone deficiency syndrome. Aging Male 2009; 12: 21-8.
    • (2009) Aging Male , vol.12 , pp. 21-28
    • Carruthers, M.1
  • 15
    • 77954699155 scopus 로고    scopus 로고
    • The role of testosterone in type 2 diabetes and metabolic syndrome in men
    • Saad F. The role of testosterone in type 2 diabetes and metabolic syndrome in men. Arq Bras Endocrinol Metabol 2009; 53: 901-7.
    • (2009) Arq Bras Endocrinol Metabol , vol.53 , pp. 901-907
    • Saad, F.1
  • 16
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline
    • Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010; 95: 2536-59.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3    Matsumoto, A.M.4    Snyder, P.J.5
  • 19
  • 21
    • 0035140143 scopus 로고    scopus 로고
    • Effects of male age on semen quality and fertility: A review of the literature
    • DOI 10.1016/S0015-0282(00)01679-4, PII S0015028200016794
    • Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001; 75: 237-48. (Pubitemid 32112097)
    • (2001) Fertility and Sterility , vol.75 , Issue.2 , pp. 237-248
    • Kidd, S.A.1    Eskenazi, B.2    Wyrobek, A.J.3
  • 22
    • 0038172610 scopus 로고    scopus 로고
    • Effect of male age on fertility: Evidence for the decline in male fertility with increasing age
    • DOI 10.1016/S0015-0282(03)00366-2
    • Hassan MA, Killick SR. Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Fertil Steril 2003; 79 Suppl 3: 1520-7. (Pubitemid 36687928)
    • (2003) Fertility and Sterility , vol.79 , Issue.SUPPL. 3 , pp. 1520-1527
    • Hassan, M.A.M.1    Killick, S.R.2
  • 23
    • 0021123879 scopus 로고
    • Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men
    • Neaves WB, Johnson L, Porter JC, Parker CR Jr, Petty CS. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 1984; 59: 756-63. (Pubitemid 14012503)
    • (1984) Journal of Clinical Endocrinology and Metabolism , vol.59 , Issue.4 , pp. 756-763
    • Neaves, W.B.1    Johnson, L.2    Porter, J.C.3
  • 24
    • 0021746092 scopus 로고
    • Quantification of the human Sertoli cell population: Its distribution, relation to germ cell numbers, and age-related decline
    • DOI 10.1095/biolreprod31.4.785
    • Johnson L, Zane RS, Petty CS, Neaves WB. Quantification of the human Sertoli cell population: its distribution, relation to germ cell numbers, and age-related decline. Biol Reprod 1984; 31: 785-95. (Pubitemid 15184943)
    • (1984) Biology of Reproduction , vol.31 , Issue.4 , pp. 785-795
    • Johnson, L.1    Zane, R.S.2    Petty, C.S.3    Neaves, W.B.4
  • 25
  • 26
    • 26444515048 scopus 로고    scopus 로고
    • The decline of androgen levels in elderly men and its clinical and therapeutic implications
    • DOI 10.1210/er.2004-0013
    • Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005; 26: 833-76. (Pubitemid 41428540)
    • (2005) Endocrine Reviews , vol.26 , Issue.6 , pp. 833-876
    • Kaufman, J.M.1    Vermeulen, A.2
  • 28
    • 84879871219 scopus 로고    scopus 로고
    • Implications of leptin in neuroendocrine regulation of male reproduction
    • Landry D, Cloutier F, Martin LJ. Implications of leptin in neuroendocrine regulation of male reproduction. Reprod Biol 2013; 13: 1-14.
    • (2013) Reprod Biol , vol.13 , pp. 1-14
    • Landry, D.1    Cloutier, F.2    Martin, L.J.3
  • 29
  • 31
    • 1442327856 scopus 로고    scopus 로고
    • Measurement of total serum testosterone in adult men: Comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry
    • DOI 10.1210/jc.2003-031287
    • Wang C, Catlin DH, Demers LM, Starcevic B, Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 2004; 89: 534-43. (Pubitemid 38269854)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.2 , pp. 534-543
    • Wang, C.1    Catlin, D.H.2    Demers, L.M.3    Starcevic, B.4    Swerdloff, R.S.5
  • 32
    • 34548678669 scopus 로고    scopus 로고
    • Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques
    • DOI 10.1016/j.cca.2007.07.013, PII S0009898107003774
    • Moal V, Mathieu E, Reynier P, Malthiery Y, Gallois Y. Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques. Clin Chim Acta 2007; 386: 12-9. (Pubitemid 47417956)
    • (2007) Clinica Chimica Acta , vol.386 , Issue.1-2 , pp. 12-19
    • Moal, V.1    Mathieu, E.2    Reynier, P.3    Malthiery, Y.4    Gallois, Y.5
  • 33
    • 77957770494 scopus 로고    scopus 로고
    • Toward excellence in testosterone testing: A consensus statement
    • Endocrine Society American Association for Clinical Chemistry, American Association of Clinical Endocrinologists, Androgen Excess/PCOS Society, American Society for Bone and Mineral Research, American Society for Reproductive Medicine, et al
    • Rosner W, Vesper H. Endocrine Society, American Association for Clinical Chemistry, American Association of Clinical Endocrinologists, Androgen Excess/PCOS Society, American Society for Bone and Mineral Research, American Society for Reproductive Medicine, et al. Toward excellence in testosterone testing: a consensus statement. J Clin Endocrinol Metab 2010; 95: 4542-8.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4542-4548
    • Rosner, W.1    Vesper, H.2
  • 34
    • 77955428229 scopus 로고    scopus 로고
    • Standardization of testosterone measurements in humans
    • Vesper HW, Botelho JC. Standardization of testosterone measurements in humans. J Steroid Biochem Mol Biol 2010; 121: 513-9.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 513-519
    • Vesper, H.W.1    Botelho, J.C.2
  • 37
    • 77949263021 scopus 로고    scopus 로고
    • Analysis of estrogens in serum and plasma from postmenopausal women: Past present, and future
    • Blair IA. Analysis of estrogens in serum and plasma from postmenopausal women: past present, and future. Steroids 2010; 75: 297-306.
    • (2010) Steroids , vol.75 , pp. 297-306
    • Blair, I.A.1
  • 38
    • 78650052374 scopus 로고    scopus 로고
    • Standardization of hormonal assays for the 21st century
    • Wartofsky L, Handelsman DJ. Standardization of hormonal assays for the 21st century. J Clin Endocrinol Metab 2010; 95: 5141-3.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5141-5143
    • Wartofsky, L.1    Handelsman, D.J.2
  • 39
    • 54149084920 scopus 로고    scopus 로고
    • The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders
    • Bhasin S, Zhang A, Coviello A, Jasuja R, Ulloor J, et al. The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders. Steroids 2008; 73: 1311-7.
    • (2008) Steroids , vol.73 , pp. 1311-1317
    • Bhasin, S.1    Zhang, A.2    Coviello, A.3    Jasuja, R.4    Ulloor, J.5
  • 40
    • 62149150656 scopus 로고    scopus 로고
    • Interlaboratory comparison study of serum total testosterone [corrected] measurements performed by mass spectrometry methods
    • Vesper HW, Bhasin S, Wang C, Tai SS, Dodge LA, et al. Interlaboratory comparison study of serum total testosterone [corrected] measurements performed by mass spectrometry methods. Steroids 2009; 74: 498-503.
    • (2009) Steroids , vol.74 , pp. 498-503
    • Vesper, H.W.1    Bhasin, S.2    Wang, C.3    Tai, S.S.4    Dodge, L.A.5
  • 41
    • 78650061172 scopus 로고    scopus 로고
    • Total testosterone assays in women with polycystic ovary syndrome: Precision and correlation with hirsutism
    • Reproductive Medicine Network
    • Legro RS, Schlaff WD, Diamond MP, Coutifaris C, Casson PR, et al. Reproductive Medicine Network. Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism. J Clin Endocrinol Metab 2010; 95: 5305-13.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5305-5313
    • Legro, R.S.1    Schlaff, W.D.2    Diamond, M.P.3    Coutifaris, C.4    Casson, P.R.5
  • 42
    • 58149289753 scopus 로고    scopus 로고
    • The European Male Ageing Study (EMAS): Design, methods and recruitment
    • EMAS study group
    • Lee DM, O'Neill TW, Pye SR, Silman AJ, Finn JD, et al. EMAS study group. The European Male Ageing Study (EMAS): design, methods and recruitment. Int J Androl 2009; 32: 11-24.
    • (2009) Int J Androl , vol.32 , pp. 11-24
    • Lee, D.M.1    O'Neill, T.W.2    Pye, S.R.3    Silman, A.J.4    Finn, J.D.5
  • 43
    • 84861331756 scopus 로고    scopus 로고
    • Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; Relevance for the diagnostics in aging men
    • EMAS study group
    • Huhtaniemi IT, Tajar A, Lee DM, O'Neill TW, Finn JD, et al. EMAS study group. Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men. Eur J Endocrinol 2012; 166: 983-91.
    • (2012) Eur J Endocrinol , vol.166 , pp. 983-991
    • Huhtaniemi, I.T.1    Tajar, A.2    Lee, D.M.3    O'Neill, T.W.4    Finn, J.D.5
  • 44
    • 80051560339 scopus 로고    scopus 로고
    • Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    • Bhasin S, Pencina M, Jasuja GK, Travison TG, Coviello A, et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab 2011; 96: 2430-9.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2430-2439
    • Bhasin, S.1    Pencina, M.2    Jasuja, G.K.3    Travison, T.G.4    Coviello, A.5
  • 45
    • 84868611284 scopus 로고    scopus 로고
    • Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    • Yeap BB, Alfonso H, Chubb SA, Handelsman DJ, Hankey GJ, et al. Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men. J Clin Endocrinol Metab 2012; 97: 4030-9.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4030-4039
    • Yeap, B.B.1    Alfonso, H.2    Chubb, S.A.3    Handelsman, D.J.4    Hankey, G.J.5
  • 46
    • 36249031484 scopus 로고    scopus 로고
    • Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men
    • DOI 10.1111/j.1365-2265.2007.02976.x
    • Brambilla DJ, O'Donnell AB, Matsumoto AM, McKinlay JB. Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men. Clin Endocrinol (Oxf) 2007; 67: 853-62. (Pubitemid 350135128)
    • (2007) Clinical Endocrinology , vol.67 , Issue.6 , pp. 853-862
    • Brambilla, D.J.1    O'Donnell, A.B.2    Matsumoto, A.M.3    McKinlay, J.B.4
  • 47
    • 40449116660 scopus 로고    scopus 로고
    • Free testosterone measurement by the analog displacement direct assay: Old concerns and new evidence
    • DOI 10.1373/clinchem.2007.101303
    • Swerdloff RS, Wang C. Free testosterone measurement by the analog displacement direct assay: old concerns and new evidence. Clin Chem 2008; 54: 458-60. (Pubitemid 351348150)
    • (2008) Clinical Chemistry , vol.54 , Issue.3 , pp. 458-460
    • Swerdloff, R.S.1    Wang, C.2
  • 50
    • 58149400587 scopus 로고    scopus 로고
    • Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats
    • European Male Ageing Study Group
    • Huhtaniemi IT, Pye SR, Limer KL, Thomson W, O'Neill TW, et al. European Male Ageing Study Group. Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats. J Clin Endocrinol Metab 2009; 94: 277-84.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 277-284
    • Huhtaniemi, I.T.1    Pye, S.R.2    Limer, K.L.3    Thomson, W.4    O'Neill, T.W.5
  • 51
    • 77951634472 scopus 로고    scopus 로고
    • Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men
    • European Male Aging Study Group
    • Huhtaniemi IT, Pye SR, Holliday KL, Thomson W, O'Neill TW, et al. European Male Aging Study Group. Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men. J Clin Endocrinol Metab 2010; 95: 1898-908.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1898-1908
    • Huhtaniemi, I.T.1    Pye, S.R.2    Holliday, K.L.3    Thomson, W.4    O'Neill, T.W.5
  • 53
    • 33751533215 scopus 로고    scopus 로고
    • Association of specific symptoms and metabolic risks with serum testosterone in older men
    • DOI 10.1210/jc.2006-0401
    • Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab 2006; 91: 4335-43. (Pubitemid 44833407)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.11 , pp. 4335-4343
    • Zitzmann, M.1    Faber, S.2    Nieschlag, E.3
  • 54
    • 77951642063 scopus 로고    scopus 로고
    • Characteristics of secondary, primary, and compensated hypogonadism in aging men: Evidence from the European Male Ageing Study
    • EMAS Group
    • Tajar A, Forti G, O'Neill TW, Lee DM, Silman AJ, et al. EMAS Group. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab 2010; 95: 1810-8.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1810-1818
    • Tajar, A.1    Forti, G.2    O'Neill, T.W.3    Lee, D.M.4    Silman, A.J.5
  • 55
    • 4744338326 scopus 로고    scopus 로고
    • Can results of the Aging Males' Symptoms (AMS) scales predict those of screening scales for androgen deficiency?
    • DOI 10.1080/13685530400004223
    • Heinemann LA, Saad F, Heinemann K, Thai DM. Can results of the Aging Males' Symptoms (AMS) scale predict those of screening scales for androgen deficiency? Aging Male 2004; 7: 211-8. (Pubitemid 39315125)
    • (2004) Aging Male , vol.7 , Issue.3 , pp. 211-218
    • Heinemann, L.A.J.1    Saad, F.2    Heinemann, K.3    Thai, D.M.4
  • 56
    • 0033821819 scopus 로고    scopus 로고
    • Validation of a screening questionnaire for androgen deficiency in aging males
    • Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 2000; 49: 1239-42.
    • (2000) Metabolism , vol.49 , pp. 1239-1242
    • Morley, J.E.1    Charlton, E.2    Patrick, P.3    Kaiser, F.E.4    Cadeau, P.5
  • 57
    • 0034492440 scopus 로고    scopus 로고
    • Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men
    • DOI 10.1046/j.1365-2265.2000.01152.x
    • Smith KW, Feldman HA, McKinlay JB. Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men. Clin Endocrinol (Oxf) 2000; 53: 703-11. (Pubitemid 32096681)
    • (2000) Clinical Endocrinology , vol.53 , Issue.6 , pp. 703-711
    • Smith, K.W.1    Feldman, H.A.2    McKinlay, J.B.3
  • 58
    • 84872228554 scopus 로고    scopus 로고
    • The comparison of the aging male symptoms (AMS) scale and androgen deficiency in the aging male (ADAM) questionnaire to detect androgen deficiency in middle-aged men
    • Chueh KS, Huang SP, Lee YC, Wang CJ, Yeh HC, et al. The comparison of the aging male symptoms (AMS) scale and androgen deficiency in the aging male (ADAM) questionnaire to detect androgen deficiency in middle-aged men. J Androl 2012; 33: 817-23.
    • (2012) J Androl , vol.33 , pp. 817-823
    • Chueh, K.S.1    Huang, S.P.2    Lee, Y.C.3    Wang, C.J.4    Yeh, H.C.5
  • 59
  • 61
    • 85027927816 scopus 로고    scopus 로고
    • Male late-onset hypogonadism: Pathogenesis, diagnosis and treatment
    • Huhtaniemi I, Forti G. Male late-onset hypogonadism: pathogenesis, diagnosis and treatment. Nat Rev Urol 2011; 8: 335-44.
    • (2011) Nat Rev Urol , vol.8 , pp. 335-344
    • Huhtaniemi, I.1    Forti, G.2
  • 65
    • 84884417329 scopus 로고    scopus 로고
    • Diagnostic and treatment of late-onset hypoginadism. Systematic review and meta-analysis of TRT outcomes
    • Corona G, Rastrelli G, Maggi M. Diagnostic and treatment of late-onset hypoginadism. Systematic review and meta-analysis of TRT outcomes. Best Pact Expt Clin Endocrinol 2013; 27: 557-79.
    • (2013) Best Pact Expt Clin Endocrinol , vol.27 , pp. 557-579
    • Corona, G.1    Rastrelli, G.2    Maggi, M.3
  • 66
    • 58149493404 scopus 로고    scopus 로고
    • ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males
    • Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, et al. ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males. Int J Impot Res 2009; 21: 1-8.
    • (2009) Int J Impot Res , vol.21 , pp. 1-8
    • Wang, C.1    Nieschlag, E.2    Swerdloff, R.3    Behre, H.M.4    Hellstrom, W.J.5
  • 67
    • 84875863886 scopus 로고    scopus 로고
    • Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: Longitudinal results from the European Male Ageing Study
    • EMAS Group
    • Camacho EM, Huhtaniemi IT, O'Neill TW, Finn JD, Pye SR, et al. EMAS Group. Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. Eur J Endocrinol 2013; 168: 445-55.
    • (2013) Eur J Endocrinol , vol.168 , pp. 445-455
    • Camacho, E.M.1    Huhtaniemi, I.T.2    O'Neill, T.W.3    Finn, J.D.4    Pye, S.R.5
  • 68
    • 35349019230 scopus 로고    scopus 로고
    • Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men
    • DOI 10.1210/jc.2007-0620
    • Zitzmann M, Nieschlag E. Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J Clin Endocrinol Metab 2007; 92: 3844-53. (Pubitemid 47607632)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.10 , pp. 3844-3853
    • Zitzmann, M.1    Nieschlag, E.2
  • 69
    • 78650909514 scopus 로고    scopus 로고
    • Why is androgen replacement in males controversial?
    • Cunningham GR, Toma SM. Why is androgen replacement in males controversial? J Clin Endocrinol Metab 2011; 96: 38-52.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 38-52
    • Cunningham, G.R.1    Toma, S.M.2
  • 70
    • 75949087002 scopus 로고    scopus 로고
    • The role of testosterone in erectile dysfunction
    • Corona G, Maggi M. The role of testosterone in erectile dysfunction. Nat Rev Urol 2010; 7: 46-56.
    • (2010) Nat Rev Urol , vol.7 , pp. 46-56
    • Corona, G.1    Maggi, M.2
  • 71
    • 33646138925 scopus 로고    scopus 로고
    • Does testosterone have a role in erectile function?
    • Mikhail N. Does testosterone have a role in erectile function? Am J Med 2006; 119: 373-82.
    • (2006) Am J Med , vol.119 , pp. 373-382
    • Mikhail, N.1
  • 72
    • 0036126770 scopus 로고    scopus 로고
    • The relationship of serum testosterone to erectile function in normal aging men
    • Rhoden EL, Teloken C, Sogari PR, Souto CA. The relationship of serum testosterone to erectile function in normal aging men. J Urol 2002; 167: 1745-8. (Pubitemid 34240718)
    • (2002) Journal of Urology , vol.167 , Issue.4 , pp. 1745-1748
    • Rhoden, E.L.1    Teloken, C.2    Sogari, P.R.3    Vargas Souto, C.A.4
  • 76
    • 84872546745 scopus 로고    scopus 로고
    • Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: A parallel, randomized trial
    • Spitzer M, Basaria S, Travison TG, Davda MN, Paley A, et al. Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial. Ann Intern Med 2012; 157: 681-91.
    • (2012) Ann Intern Med , vol.157 , pp. 681-691
    • Spitzer, M.1    Basaria, S.2    Travison, T.G.3    Davda, M.N.4    Paley, A.5
  • 77
    • 76149135996 scopus 로고    scopus 로고
    • Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: A randomized, double-blind, placebo-controlled study
    • Srinivas-Shankar U, Roberts SA, Connolly MJ, O'Connell MD, Adams JE, et al. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010; 95: 639-50.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 639-650
    • Srinivas-Shankar, U.1    Roberts, S.A.2    Connolly, M.J.3    O'Connell, M.D.4    Adams, J.E.5
  • 78
    • 84877719155 scopus 로고    scopus 로고
    • Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels
    • Hildreth KL, Barry DW, Moreau KL, Vande Griend J, Meacham RB, et al. Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels. J Clin Endocrinol Metab 2013; 98: 1891-900.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1891-1900
    • Hildreth, K.L.1    Barry, D.W.2    Moreau, K.L.3    Vande Griend, J.4    Meacham, R.B.5
  • 83
    • 0344874544 scopus 로고    scopus 로고
    • Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: The MINOS study
    • DOI 10.1210/jc.2003-030200
    • Szulc P, Claustrat B, Marchand F, Delmas PD. Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study. J Clin Endocrinol Metab 2003; 88: 5240-7. (Pubitemid 37452722)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.11 , pp. 5240-5247
    • Szulc, P.1    Claustrat, B.2    Marchand, F.3    Delmas, P.D.4
  • 84
    • 23244433166 scopus 로고    scopus 로고
    • The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women
    • DOI 10.1111/j.1365-2265.2005.02315.x
    • Schaap LA, Pluijm SM, Smit JH, van Schoor NM, Visser M, et al. The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. Clin Endocrinol (Oxf) 2005; 63: 152-60. (Pubitemid 41097983)
    • (2005) Clinical Endocrinology , vol.63 , Issue.2 , pp. 152-160
    • Schaap, L.A.1    Pluijm, S.M.F.2    Smitt, J.H.3    Van Schoor, N.M.4    Visser, M.5    Gooren, L.J.G.6    Lips, P.7
  • 85
    • 79951697311 scopus 로고    scopus 로고
    • Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men?
    • O'Connell MD, Roberts SA, Srinivas-Shankar U, Tajar A, Connolly MJ, et al. Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men? J Clin Endocrinol Metab 2010.
    • (2010) J Clin Endocrinol Metab
    • O'Connell, M.D.1    Roberts, S.A.2    Srinivas-Shankar, U.3    Tajar, A.4    Connolly, M.J.5
  • 87
    • 55349088602 scopus 로고    scopus 로고
    • Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men
    • Storer TW, Woodhouse L, Magliano L, Singh AB, Dzekov C, et al. Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men. J Am Geriatr Soc 2008; 56: 1991-9.
    • (2008) J Am Geriatr Soc , vol.56 , pp. 1991-1999
    • Storer, T.W.1    Woodhouse, L.2    Magliano, L.3    Singh, A.B.4    Dzekov, C.5
  • 92
  • 93
    • 79961243360 scopus 로고    scopus 로고
    • Low testosterone in men with type 2 diabetes: Significance and treatment
    • Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab 2011; 96: 2341-53.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2341-2353
    • Grossmann, M.1
  • 95
    • 84860877671 scopus 로고    scopus 로고
    • Testosterone and cardiovascular disease in men
    • Morris PD, Channer KS. Testosterone and cardiovascular disease in men. Asian J Androl 2012; 14: 428-35.
    • (2012) Asian J Androl , vol.14 , pp. 428-435
    • Morris, P.D.1    Channer, K.S.2
  • 96
    • 0033584717 scopus 로고    scopus 로고
    • Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease
    • Webb CM, McNeill JG, Hayward CS, de Zeigler D, Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 1999; 100: 1690-6. (Pubitemid 29485250)
    • (1999) Circulation , vol.100 , Issue.16 , pp. 1690-1696
    • Webb, C.M.1    McNeill, J.G.2    Hayward, C.S.3    De Zeigler, D.4    Collins, P.5
  • 97
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 2000; 102: 1906-11.
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 98
    • 74049152290 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease during androgen deprivation therapy: Observational study of veterans with prostate cancer
    • Keating NL, O'Malley AJ, Freedland SJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. J Natl Cancer Inst 2010; 102: 39-46.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 39-46
    • Keating, N.L.1    O'Malley, A.J.2    Freedland, S.J.3    Smith, M.R.4
  • 99
    • 79955906626 scopus 로고    scopus 로고
    • Endogenous testosterone and cardiovascular disease in healthy men: A meta-analysis
    • Ruige JB, Mahmoud AM, De Bacquer D, Kaufman JM. Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysis. Heart 2011; 97: 870-5.
    • (2011) Heart , vol.97 , pp. 870-875
    • Ruige, J.B.1    Mahmoud, A.M.2    De Bacquer, D.3    Kaufman, J.M.4
  • 101
    • 28944442442 scopus 로고    scopus 로고
    • Testosterone therapy in men with moderate severity heart failure: A double-blind randomized placebo controlled trial
    • DOI 10.1093/eurheartj/ehi443
    • Malkin CJ, Pugh PJ, West JN, van Beek EJ, Jones TH, et al. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 2006; 27: 57-64. (Pubitemid 41785933)
    • (2006) European Heart Journal , vol.27 , Issue.1 , pp. 57-64
    • Malkin, C.J.1    Pugh, P.J.2    West, J.N.3    Van Beek, E.J.R.4    Jones, T.H.5    Channer, K.S.6
  • 102
    • 68949172537 scopus 로고    scopus 로고
    • Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study
    • Caminiti G, Volterrani M, Iellamo F, Marazzi G, Massaro R, et al. Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 2009; 54: 919-27.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 919-927
    • Caminiti, G.1    Volterrani, M.2    Iellamo, F.3    Marazzi, G.4    Massaro, R.5
  • 105
    • 79959969392 scopus 로고    scopus 로고
    • Testosterone levels and cognition in elderly men: A review
    • Holland J, Bandelow S, Hogervorst E. Testosterone levels and cognition in elderly men: a review. Maturitas 2011; 69: 322-37.
    • (2011) Maturitas , vol.69 , pp. 322-337
    • Holland, J.1    Bandelow, S.2    Hogervorst, E.3
  • 107
    • 77954394453 scopus 로고    scopus 로고
    • Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis
    • Fernandez-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, et al. Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab 2010; 95: 2560-75.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2560-2575
    • Fernandez-Balsells, M.M.1    Murad, M.H.2    Lane, M.3    Lampropulos, J.F.4    Albuquerque, F.5
  • 109
    • 77957779215 scopus 로고    scopus 로고
    • Testosterone suppresses hepcidin in men: A potential mechanism for testosterone-induced erythrocytosis
    • Bachman E, Feng R, Travison T, Li M, Olbina G, et al. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab 2010; 95: 4743-7.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4743-4747
    • Bachman, E.1    Feng, R.2    Travison, T.3    Li, M.4    Olbina, G.5
  • 110
    • 0242390083 scopus 로고    scopus 로고
    • Managing the risks of prostate disease during testosterone replacement therapy in older men: Recommendations for a standardized monitoring plan
    • Bhasin S, Singh AB, Mac RP, Carter B, Lee MI, et al. Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan. J Androl 2003; 24: 299-311. (Pubitemid 39571784)
    • (2003) Journal of Andrology , vol.24 , Issue.3 , pp. 299-311
    • Bhasin, S.1    Singh, A.B.2    Mac, R.P.3    Carter, B.4    Lee, M.I.5    Cunningham, G.R.6
  • 111
    • 24144489427 scopus 로고    scopus 로고
    • Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: A meta-analysis
    • DOI 10.1111/j.1365-2265.2005.02339.x
    • Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, et al. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf) 2005; 63: 280-93. (Pubitemid 41233445)
    • (2005) Clinical Endocrinology , vol.63 , Issue.3 , pp. 280-293
    • Isidori, A.M.1    Giannetta, E.2    Greco, E.A.3    Gianfrilli, D.4    Bonifacio, V.5    Isidori, A.6    Lenzi, A.7    Fabbri, A.8
  • 112
    • 41649087796 scopus 로고    scopus 로고
    • Gynaecomastia and breast cancer in men
    • DOI 10.1136/bmj.39511.493391.BE
    • Niewoehner CB, Schorer AE. Gynaecomastia and breast cancer in men. BMJ 2008; 336: 709-13. (Pubitemid 351481214)
    • (2008) BMJ , vol.336 , Issue.7646 , pp. 709-713
    • Niewoehner, C.B.1    Schorer, A.E.2
  • 113
    • 0032931818 scopus 로고    scopus 로고
    • Long-term substitution therapy of hypogonadal men with transscrotal testosterone over 7-10 years
    • DOI 10.1046/j.1365-2265.1999.00705.x
    • Behre HM, von Eckardstein S, Kliesch S, Nieschlag E. Long-term substitution therapy of hypogonadal men with transscrotal testosterone over 7-10 years. Clin Endocrinol (Oxf) 1999; 50: 629-35. (Pubitemid 29236340)
    • (1999) Clinical Endocrinology , vol.50 , Issue.5 , pp. 629-635
    • Behre, H.M.1    Von Eckardstein, S.2    Kliesch, S.3    Nieschlag, E.4
  • 114
    • 0028360993 scopus 로고
    • A ten-year safety study of the oral androgen testosterone undecanoate
    • Gooren LJ. A ten-year safety study of the oral androgen testosterone undecanoate. J Androl 1994; 15: 212-5. (Pubitemid 24218140)
    • (1994) Journal of Andrology , vol.15 , Issue.3 , pp. 212-215
    • Gooren, L.J.G.1


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