Nitric oxide mediates the change of proteoglycan synthesis in the human lumbar intervertebral disc in response to hydrostatic pressure

Spine

Volumn 26, Issue 2, 2001, Pages 134-141

  Liu, Gen Zhe ^a   Ishihara, Hirokazu ^a   Osada, Ryusuke ^a   Kimura, Tomoatsu ^a   Tsuji, Haruo ^a  

^a TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Hydrostatic pressure; Intervertebral disc; Nitric oxide; Proteoglycan

Indexed keywords

N(G) METHYLARGININE; NITRIC OXIDE; SNARE PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; AUTOCRINE EFFECT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYDROSTATIC PRESSURE; LUMBAR DISK; MALE; MECHANICAL STRESS; METABOLIC REGULATION; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; SHEAR STRESS;

ADOLESCENT; ADULT; AGED; FEMALE; HUMANS; HYDROSTATIC PRESSURE; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; NITRIC OXIDE; PROTEOGLYCANS;

EID: 0035863431     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200101150-00005     Document Type: Article

References (45)

1. In vitro method for measuring synthesis rates in the intervertebral disc
2. IL-1 beta induces the degradation of equine articular cartilage by a mechanism that is not mediated by nitric oxide
3. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression
4. Spine Update. Aging and degeneration of the human intervertebral disc
5. The response of the canine intervertebral disc to immobilization produced by spinal arthrodesis is dependent on constitutional factors
6. Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear
7. Nitric oxide and cartilage metabolism
8. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures
9. Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation
10. Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis
11. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
12. The effects of hydrostatic pressure on matrix synthesis in articular cartilage
13. Effects of hydrostatic pressure on matrix synthesis and matrix metalloproteinase production in the human lumbar intervertebral disc
14. Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture
15. Variations in the nutrition of the canine intervertebral disc induced by motion
16. Nutritional changes in the canine intervertebral disc after spinal fusion
17. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
18. Effects of continuous quantitative vibration on rheologic and biological behaviors of the intervertebral disc
19. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk
20. Proteoglycan synthesis in the intervertebral disk nucleus: The role of extracellular osmolality
21. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2
22. Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases
23. Sensitivity of osteocytes to biomechanical stress in vitro
24. Compression-induced degeneration of the intervertebral disc: An in vivo mouse model and finite-element study
25. Nitric oxide activates metalloprotease enzymes in articular cartilage
26. Intravital dynamic pressure measurements in lumbar discs
27. Effects of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique
28. Autocrine/paractine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs
29. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
30. Effects of microgravity on the composition of the intervertebral disk
31. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase
32. Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone re modeling?
33. The inducible production of nitric oxide by articular cell types
34. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
35. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides
36. Biochemical changes of intervertebral discs in patients with spondylolisthesis or with tears of the posterior annulus fibrosus
37. The role of interleukin-1 on proteoglycan metabolism of rabbit annulus fibrosus cells cultured in vitro
38. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide
39. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures
40. Nitric oxide and proteoglycan turnover in rabbit articular cartilage
41. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1
42. Effects of axial traction stress on solute transport and proteoglycan synthesis in the porcine intervertebral disc in vitro
43. Nutrition of the intervertebral disk
44. Intragenic polymorphisms of the vitamin D receptor gene associated with intervertebral disc degeneration