A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: Correlation between the degree of disc injury and radiological and histological appearances of disc degeneration

Spine

Volumn 30, Issue 1, 2005, Pages 5-14

  Masuda, Koichi ^a   Aota, Yoichi ^a   Muehleman, Carol ^a   Imai, Yoshiyuki ^a   Okuma, Masahiko ^a   Thonar, Eugene J ^a   Andersson, Gunnar B ^a   An, Howard S ^a  

^a RUSH MEDICAL COLLEGE   (United States)

Author keywords

Animal model; Anulus fibrosus; Disc degeneration; Intervertebral disc; Rabbit

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; HISTOPATHOLOGY; IMAGE ANALYSIS; INTERVERTEBRAL DISK DEGENERATION; NEEDLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVER VARIATION; PRIORITY JOURNAL; RABBIT; RELIABILITY; REPRODUCIBILITY; STAB WOUND;

EID: 13444302219     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.brs.0000148152.04401.20     Document Type: Article

References (42)

1. Praemer A, Furner S, Rice DP. Musculoskeletal Conditions in the United States. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1999.
2. An YH, Friedman RJ. Animal Models in Orthopaedic Research. Boca Raton, FL: CRC Press; 1999;604.
3. Hulth A, Lindberg L, Telhag H. Experimental osteoarthritis in rabbits. Acta Orthop Scand 1970;41:522-30.
4. Pond MJ, Nuki G. Experimentally induced osteoarthritis in the dog. Ann Rheum Dis 1973;32:387-8.
5. Williams JM, Downey C, Thonar EJ. Increase in levels of serum keratan sulfate following cartilage proteoglycan degradation in the rabbit knee joint. Arthritis Rheum 1988;31:557-60.
6. Homandberg GA, Meyers R, Williams JM. Intraarticular injection of fibronectin fragments causes severe depletion of cartilage proteoglycans in vivo. J Rheumatol 1993;20:1378-82.
7. Pearson CM, Wood FD. Inhibition of adjuvant arthritis by protein antigens. I. Inhibitory capacities and dose relationships of different proteins Immunology 1969;16:157-65.
8. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 1977;146:857-68.
9. Lauerman WC, Platenberg RC, Cain JE, et al. Age-related disk degeneration: preliminary report of a naturally occurring baboon model. J Spinal Disord 1992;5:170-4.
10. Silberberg R, Gerritsen G. Aging changes in intervertebral discs and spondylosis in Chinese hamsters. Diabetes 1976;25:477-83.
11. Silberberg R. Histologic and morphometric observations on vertebral bone of aging sand rats. Spine 1988;13:202-8.
12. Silberberg R, Aufdermaur M, Adler JH. Degeneration of the intervertebral disks and spondylosis in aging sand rats. Arch Pathol Lab Med 1979;103:231-5.
13. Nguyen CM, Haughton VM, Ho KC, et al. A model for studying intervertebral disc degeneration with magnetic resonance and a nucleotome. Invest Radiol 1989;24:407-9.
14. Gillett NA, Gerlach R, Cassidy JJ, et al. Age-related changes in the beagle spine. Acta Orthop Scand 1988;59:503-7.
15. Green PW, Fox RR, Sokoloff L. Spontaneous degenerative spinal disease in the laboratory rabbit. J Orthop Res 1984;2:161-8.
16. Kroeber MW, Unglaub F, Wang H, et al. New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration. Spine 2002;27:2684-90.
17. Hutton WC, Ganey TM, Elmer WA, et al. Does long-term compressive loading on the intervertebral disc cause degeneration? Spine 2000;25:2993-3004.
18. Iatridis JC, Mente PL, Stokes IA, et al. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine 1999;24:996-1002.
19. Hadjipavlou AG, Simmons JW, Yang JP, et al. Torsional injury resulting in disc degeneration: I. An in vivo rabbit model. J Spinal Disord 1998;11:312-7.
20. Eurell JC, Brown MD, Ramos M. The effects of chondroitinase ABC on the rabbit intervertebral disc. A roentgenographic and histologic study. Clin Orthop 1990;256:238-43.
21. Kato F, Iwata H, Mimatsu K, et al. Experimental chemonucleolysis with chondroitinase ABC. Clin Orthop 1990;301-8.
22. Norcross JP, Lester GE, Weinhold P, et al. An in vivo model of degenerative disc disease. J Orthop Res 2003;21:183-8.
23. Kaigle AM, Holm SH, Hansson TH. Experimental instability in the lumbar spine. Spine 1995;20:421-30.
24. Key A, Ford L. Experimental intervertebral-disc lesions. J Bone Joints Surg Am 1948;30A:621-30.
25. Smith J, Walmsley R. Experimental incision of the intervertebral disc. J Bone Joint Surg Br 1954;33B:612-25.
26. Lipson SJ, Muir H. 1980 Volvo award in basic science. Proteoglycans in experimental intervertebral disc degeneration. Spine 1981;6:194-210.
27. Lipson SJ, Muir H. Experimental intervertebral disc degeneration: morphologic and proteoglycan changes over time. Arthritis Rheum 1981;24:12-21.
28. Osti OL, Vernon RB, Fraser RD. 1990 Volvo Award in experimental studies. Anulus tears and intervertebral disc degeneration. An experimental study using an animal model. Spine 1990;15:762-7.
29. Lu DS, Shono Y, Oda I, et al. Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study. Spine 1997;22:1828-34; discussion 34-5.
30. Bland JM, Altman DG. Measurement error. Br Med J 1996;313:744.
31. Brennan P, Silman A. Statistical methods for assessing observer variability in clinical measures. Br Med J 1992;304:1491-4.
32. Rosenberg L. Chemical basis for the histological use of safranin O in the study of articular cartilage. J Bone Joint Surg Am 1971;53:69-82.
33. Junqueira LC, Bignolas G, Brentani RR. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 1979;11:447-55.
34. Scott NA, Harris PF, Bagnall KM. A morphological and histological study of the postnatal development of intervertebral discs in the lumbar spine of the rabbit. J Anat 1980;130:75-81.
35. Poiraudeau S, Monteiro I, Anract P, et al. Phenotypic characteristics of rabbit intervertebral disc cells. Comparison with cartilage cells from the same animals. Spine 1999;24:837-44.
36. Takahashi T, Kurihara H, Nakajima S, et al. Chemonucleolytic effects of chondroitinase ABC on normal rabbit intervertebral discs. Course of action up to 10 days postinjection and minimum effective dose. Spine 1996;21:2405-11.
37. Boos N, Weissbach S, Rohrbach H, et al. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 2002;27:2631-44.
38. Horner HA, Roberts S, Bielby RC, et al. Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype. Spine 2002;27:1018-28.
39. Hunter CJ, Matyas JR, Duncan NA. The comparative cytomorphology of nucleus pulposus cells. Trans Orthop Res Soc 2003;87.
40. An H, Takegami K, Kamada H, et al. Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine 2004. In press.
41. Macnab I. Backached. Baltimore, MD: Williams & Wilkins; 1977.
42. Kim KW, Lim TH, Kim JG, et al. The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Spine 2003;28:982-90.