Effect of microgravity on the biomechanical properties of lumbar and caudal intervertebral discs in mice

Journal of Biomechanics

Volumn 47, Issue 12, 2014, Pages 2983-2988

  Bailey, Jeannie F ^a,c   Hargens, Alan R ^b   Cheng, Kevin K ^a   Lotz, Jeffrey C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Compressive creep; Disc degeneration; Disc herniation; Intervertebral disc; Microgravity

Indexed keywords

BIOMECHANICS; CREEP; IMPLANTS (SURGICAL); MAMMALS; MANNED SPACE FLIGHT; MICROGRAVITY PROCESSING; OSMOSIS;

BIOMECHANICAL PROPERTIES; COMPRESSIVE CREEP; COMPRESSIVE CREEP TESTS; DISC DEGENERATION; DISC HERNIATION; GROUND BASED CONTROL; INTERVERTEBRAL DISCS; LUMBAR DISC HERNIATION;

MICROGRAVITY;

ANIMAL EXPERIMENT; ARTICLE; BIOMECHANICS; CAUDAL INTERVERTEBRAL DISC; COMPRESSIVE CREEP TEST; CONTROLLED STUDY; EXPERIMENTAL TEST; FEMALE; GROUND REACTION FORCE; INTERVERTEBRAL DISK; LUMBAR DISK; MICROGRAVITY; MOUSE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSMOTIC PRESSURE; PERMEABILITY; PHYSIOLOGICAL DISC HEIGHT; RANGE OF MOTION; SPACE FLIGHT; VISCOELASTICITY; WEIGHTLESSNESS; YOUNG MODULUS; ANIMAL; BACK; C57BL MOUSE; LUMBAR VERTEBRA; PHYSIOLOGY;

ANIMALS; FEMALE; INTERVERTEBRAL DISC; LUMBAR VERTEBRAE; LUMBOSACRAL REGION; MICE, INBRED C57BL; OSMOTIC PRESSURE; SPACE FLIGHT; WEIGHTLESSNESS;

EID: 84908075449     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2014.07.005     Document Type: Article

References (25)

1. Adams M.A., Hutton W.C. The effect of posture on the fluid content of lumbar intervertebral discs. Spine 1983, 8:665-671.
2. Adams M.A., Dolan P., Hutton W.C., Porter R.W. Diurnal changes in spinal mechanics and their clinical significance. J. Bone Joint Surg. 1990, 72:266-270.
3. Antoniou J., Demers C.N., Beaudoin G., Goswami T., Mwale F., Aebi M., Alini M. Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn. Reson. Imaging 2004, 22:963-972.
4. Botsford D.J., Esses S.I., Ogilvie-Harris D.J. In vivo diurnal variation in intervertebral disc volume and morphology. Spine 1994, 19:935-940.
5. Burns M.L., Kaleps I., Kazarian L.E. Analysis of compressive creep behavior of the vertebral unit subjected to a uniform axial loading using exact parametric solution equations of Kelvin-solid models-Part I. Human intervertebral joints. J. Biomech. 1984, 17:113-130.
6. Cassidy J.J., Silverstein M.S., Hiltner A. A water transport model for the creep response of the intervertebral disc. J. Mater. Sci.: Mater. Med. 1990, 1:81-89.
7. Chen J., Baer A.E., Paik P.Y., Yan W., Setton L.A. Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity. Biochem. Biophys. Res. Commun. 2002, 293:932-938.
8. Chiu E. Characterization of the human intervertebral disc with magnetic resonance imaging 1998, UMI Dissertations Publishing, University of California, San Francisco, (PhD thesis).
9. Elliott D.M., Sarver J.J. Young investigator award winner: validation of the mouse and rat disc as mechanical models of the human lumbar disc. Spine 2004, 29:713-722.
10. Hargens A.R., Richardson S. Cardiovascular adaptations, fluid shifts, and countermeasures related to space flight. Respir. Physiol. Neurobiol. 2009, 169(Suppl 1):S30-S33.
11. Johnston S.L., Campbell M.R. Risk of herniated nucleus pulposus among US astronauts. Aviation 2010, 81:566-574.
12. LeBlanc A., Schneider V., Shackelford L., West S., Oganov V., Bakulin A., Voronin L. Bone mineral and lean tissue loss after long duration space flight. J. Musculoskelet. Neuronal Interact. 2000, 1:157-160.
13. Lee S.-U., Hargens A.R., Fredericson M., Lang P.K. Lumbar spine disc heights and curvature: upright posture vs. supine compression harness. Aviat. Space, Environ. Med. 2003, 74:512-516.
14. Maynard J.A The effects of space flight on the composition of the intervertebral disc. Iowa Orthop. J. 1994, 14:125-133.
15. Ohshima H., Urban J.P. The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc. Spine 1992, 17:1079-1082.
16. Ohshima H., Urban J.P., Bergel D.H. Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique. J. Orthop. Res. 1995, 13:22-29.
17. Palmer E.I., Lotz J.C. The compressive creep properties of normal and degenerated murine intervertebral discs. J. Orthop. Res. 2004, 22:164-169.
18. Pedrini-Mille A., Maynard J.A., Durnova G.N., Kaplansky A.S., Pedrini V.A., Chung C.B., Fedler-Troester J Effects of microgravity on the composition of the intervertebral disk. J. Appl. Physiol. 1992, 73:26S-32S.
19. Sarver J.J., Elliott D.M. Mechanical differences between lumbar and tail discs in the mouse. J. Orthop. Res. 2005, 23:150-155.
20. Sayson J.V., Hargens A.R. Pathophysiology of low back pain during exposure to microgravity. Aviat. Space, Environ. Med. 2008, 79:365-373.
21. Sinha R.K., Shan S.A., Hume E.L, Tuan R.S. The effect of a 5-day spaceflight on the immature rate spine. Spine J. 2002, 2:239-243.
22. Smit T.H. The use of a quadruped as an in vivo model for the study of the spine - biomechanical considerations. Eur. Spine J. 2002, 11:137-144.
23. White A.A., Panjabi M.M. Clinical Biomechanics of the Spine 1990, Lippincott Williams & Wilkins, Philadelphia.
24. Wilke H.J., Neef P., Caimi M., Hoogland T., Claes L.E. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 1999, 24:755-762.
25. Wing P.C., Tsang I.K., Susak L., Gagnon F., Gagnon R., Potts J.E. Back pain and spinal changes in microgravity. Orthop. Clin. N. Am. 1991, 22:255-262.