New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration

Spine

Volumn 27, Issue 23, 2002, Pages 2684-2690

  Kroeber, Markus W ^a   Unglaub, Frank ^a   Wang, Haili ^a   Schmid, Carsten ^a   Thomsen, Marc ^a   Nerlich, Andreas ^b   Richter, Wiltrud ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b KLINIKUM BOGENHAUSEN   (Germany)

Author keywords

Animal model; Disc degeneration; Gene transfer

Indexed keywords

BETA GALACTOSIDASE; LUCIFERASE; PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; FOLLOW UP; GENE TRANSFER; HISTOPATHOLOGY; IMAGE ANALYSIS; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; LOADING TEST; MARKER GENE; NERVE ENDING; NONHUMAN; NUCLEUS PULPOSUS; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIGIDITY; SPECIES COMPARISON; SPINAL CORD COMPRESSION; TISSUE REGENERATION; TISSUE REPAIR; TREATMENT OUTCOME;

ADENOVIRIDAE; ANIMALS; BIOMECHANICS; CARTILAGE; CELL DIVISION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; IN SITU NICK-END LABELING; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBOSACRAL REGION; RABBITS; REGENERATION; SPINE; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 0036894339     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200212010-00007     Document Type: Article

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