-
2
-
-
84882245384
-
Scaling and systems biology for integrating multiple organs-on-a-chip
-
Wikswo JP,Curtis EL,Eagleton ZE,Evans BC,Kole A,Hofmeister LH,Matloff WJ.Scaling and systems biology for integrating multiple organs-on-a-chip.Lab Chip. 2013;13:3496-511
-
(2013)
Lab Chip
, vol.13
, pp. 3496-3511
-
-
Wikswo, J.P.1
Curtis, E.L.2
Eagleton, Z.E.3
Evans, B.C.4
Kole, A.5
Hofmeister, L.H.6
Matloff, W.J.7
-
3
-
-
84907014643
-
The relevance and potential roles of microphysiological systems in biology and medicine
-
Wikswo JP.The relevance and potential roles of microphysiological systems in biology and medicine.Exp Biol Med. 2014;239:1061-72
-
(2014)
Exp Biol Med
, vol.239
, pp. 1061-1072
-
-
Wikswo, J.P.1
-
4
-
-
84857125662
-
Modeling hepatitis C virus infection using human induced pluripotent stem cells
-
Schwartz RE,Trehan K,Andrus L,Sheahan TP,Ploss A,Duncan SA,Rice CM,Bhatia SN.Modeling hepatitis C virus infection using human induced pluripotent stem cells.Proc Natl Acad Sci USA. 2012;109:2544-8
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 2544-2548
-
-
Schwartz, R.E.1
Trehan, K.2
Andrus, L.3
Sheahan, T.P.4
Ploss, A.5
Duncan, S.A.6
Rice, C.M.7
Bhatia, S.N.8
-
5
-
-
84907014643
-
Annual thematic issue: the biology and medicine of microphysiological systems [Special Issue]
-
Wikswo JP (ed). Annual thematic issue: the biology and medicine of microphysiological systems [Special Issue]. Exp Biol Med 2014;239:1061–1072.
-
(2014)
Exp Biol Med
, vol.239
, pp. 1061-1072
-
-
Wikswo, J.P.1
-
7
-
-
84930789065
-
-
Giuliano KA, Taylor DL, Waggoner AS. Reagents to measure and manipulate cell functions. High content screening. Springer, New York, NY, 2006, pp.141–63.
-
(2006)
New York, NY
, pp. 141-163
-
-
Giuliano, K.A.1
Taylor, D.L.2
-
8
-
-
70349337796
-
The photochemistry of fluorescent proteins: implications for their biological applications
-
Seward HE,Bagshaw CR.The photochemistry of fluorescent proteins: implications for their biological applications.Chem Soc Rev. 2009;38:2842-51
-
(2009)
Chem Soc Rev
, vol.38
, pp. 2842-2851
-
-
Seward, H.E.1
Bagshaw, C.R.2
-
10
-
-
62449171854
-
Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment
-
Provenzano PP,Eliceiri KW,Keely PJ.Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment.Clin Exp Metastasis. 2009;26:357-70
-
(2009)
Clin Exp Metastasis
, vol.26
, pp. 357-370
-
-
Provenzano, P.P.1
Eliceiri, K.W.2
Keely, P.J.3
-
11
-
-
80053099964
-
Recent advances in dynamic intravital multi-photon microscopy
-
Niesner RA,Hauser AE.Recent advances in dynamic intravital multi-photon microscopy.Cytometry A. 2011;79:789-98
-
(2011)
Cytometry A
, vol.79
, pp. 789-798
-
-
Niesner, R.A.1
Hauser, A.E.2
-
12
-
-
1642282158
-
First dose of potential new medicines to humans: how animals help
-
Greaves P,Williams A,Eve M.First dose of potential new medicines to humans: how animals help.Nat Rev Drug Discov. 2004;3:226-36
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 226-236
-
-
Greaves, P.1
Williams, A.2
Eve, M.3
-
13
-
-
33645799020
-
Mechanisms of drug-induced liver injury
-
Holt MP,Ju C.Mechanisms of drug-induced liver injury.AAPS J. 2006;8:E48-54
-
(2006)
AAPS J
, vol.8
, pp. 48-54
-
-
Holt, M.P.1
Ju, C.2
-
14
-
-
84907016464
-
In vitro platforms for evaluating liver toxicity
-
Bale SS,Vernetti L,Senutovitch N,Jindal R,Hegde M,Gough A,McCarty WJ,Bakan A,Bhushan A,Shun TY,Golberg I,DeBiasio R,Usta OB,Taylor DL,Yarmush ML.In vitro platforms for evaluating liver toxicity.Exp Biol Med. 2014;239:1180-91
-
(2014)
Exp Biol Med
, vol.239
, pp. 1180-1191
-
-
Bale, S.S.1
Vernetti, L.2
Senutovitch, N.3
Jindal, R.4
Hegde, M.5
Gough, A.6
McCarty, W.J.7
Bakan, A.8
Bhushan, A.9
Shun, T.Y.10
Golberg, I.11
DeBiasio, R.12
Usta, O.B.13
Taylor, D.L.14
Yarmush, M.L.15
-
15
-
-
84930792656
-
-
Vernetti LA, Senutovtich N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Exp Bio Med 2015; epub ahead of print
-
Vernetti LA, Senutovtich N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Exp Bio Med 2015; epub ahead of print.
-
-
-
-
16
-
-
84891364200
-
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans
-
Bhushan A,Senutovitch N,Bale SS,McCarty WJ,Hegde M,Jindal R,Golberg I,Berk Usta O,Yarmush ML,Vernetti L,Gough A,Bakan A,Shun TY,DeBiasio R,Lansing Taylor D.Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans.Stem Cell Res Ther. 2013;4:S16-S16
-
(2013)
Stem Cell Res Ther
, vol.4
, pp. 16
-
-
Bhushan, A.1
Senutovitch, N.2
Bale, S.S.3
McCarty, W.J.4
Hegde, M.5
Jindal, R.6
Golberg, I.7
Berk Usta, O.8
Yarmush, M.L.9
Vernetti, L.10
Gough, A.11
Bakan, A.12
Shun, T.Y.13
DeBiasio, R.14
Lansing Taylor, D.15
-
17
-
-
0017817822
-
Molecular cytochemistry: incorporation of fluorescently labeled actin into living cells
-
Taylor DL,Wang YL.Molecular cytochemistry: incorporation of fluorescently labeled actin into living cells.Proc Natl Acad Sci USA. 1978;75:857-61
-
(1978)
Proc Natl Acad Sci USA
, vol.75
, pp. 857-861
-
-
Taylor, D.L.1
Wang, Y.L.2
-
18
-
-
0024231304
-
Centripetal transport of cytoplasm, actin, and the cell surface in lamellipodia of fibroblasts
-
Fisher GW,Conrad PA,DeBiasio RL,Taylor DL.Centripetal transport of cytoplasm, actin, and the cell surface in lamellipodia of fibroblasts.Cell Motil Cytoskeleton. 1988;11:235-47
-
(1988)
Cell Motil Cytoskeleton
, vol.11
, pp. 235-247
-
-
Fisher, G.W.1
Conrad, P.A.2
DeBiasio, R.L.3
Taylor, D.L.4
-
20
-
-
0018852273
-
Fluorescently labelled molecules as probes of the structure and function of living cells
-
Taylor DL,Wang YL.Fluorescently labelled molecules as probes of the structure and function of living cells.Nature. 1980;284:405-10
-
(1980)
Nature
, vol.284
, pp. 405-410
-
-
Taylor, D.L.1
Wang, Y.L.2
-
22
-
-
0342812081
-
-
,,,,,. Herman BJacobson K, ed. New York: Wiley-Liss
-
Giuliano K,Nederlof M,DeBiasio R,Lanni F,Waggoner A,Taylor DOptical microscopy for biology. Herman BJacobson K, ed. New York: Wiley-Liss; 1990:543-57.
-
(1990)
Optical microscopy for biology
, pp. 543-557
-
-
Giuliano, K.1
Nederlof, M.2
DeBiasio, R.3
Lanni, F.4
Waggoner, A.5
Taylor, D.6
-
24
-
-
0000568844
-
Fluorophores for confocal microscopy
-
New York, NY: US
-
Tsien R, Waggoner A. Fluorophores for confocal microscopy. In: Pawley J (ed) Handbook of biological confocal microscopy. Springer, New York, NY, US, 1995, pp.267–79.
-
(1995)
Handbook of biological confocal microscopy. Springer
, pp. 267-279
-
-
Tsien, R.1
Waggoner, A.2
Pawley, J.3
-
25
-
-
78149498081
-
Fluorescence anisotropy and resonance energy transfer: powerful tools for measuring real time protein dynamics in a physiological environment
-
Yengo CM,Berger CL.Fluorescence anisotropy and resonance energy transfer: powerful tools for measuring real time protein dynamics in a physiological environment.Curr Opin Pharmacol. 2010;10:731-7
-
(2010)
Curr Opin Pharmacol
, vol.10
, pp. 731-737
-
-
Yengo, C.M.1
Berger, C.L.2
-
27
-
-
84873373484
-
Advances in multiphoton microscopy technology
-
Hoover EE,Squier JA.Advances in multiphoton microscopy technology.Nat Photon. 2013;7:93-101
-
(2013)
Nat Photon
, vol.7
, pp. 93-101
-
-
Hoover, E.E.1
Squier, J.A.2
-
28
-
-
84860255190
-
Advanced fluorescence microscopy techniques—FRAP, FLIP, FLAP, FRET and FLIM
-
Ishikawa-Ankerhold HC,Ankerhold R,Drummen GP.Advanced fluorescence microscopy techniques—FRAP, FLIP, FLAP, FRET and FLIM.Molecules. 2012;17:4047-132
-
(2012)
Molecules
, vol.17
, pp. 4047-4132
-
-
Ishikawa-Ankerhold, H.C.1
Ankerhold, R.2
Drummen, G.P.3
-
29
-
-
84872308143
-
Single-molecule monitoring in living cells by use of fluorescence microscopy
-
Luo W,He K,Xia T,Fang X.Single-molecule monitoring in living cells by use of fluorescence microscopy.Anal Bioanal Chem. 2013;405:43-9
-
(2013)
Anal Bioanal Chem
, vol.405
, pp. 43-49
-
-
Luo, W.1
He, K.2
Xia, T.3
Fang, X.4
-
30
-
-
84930791746
-
Quantitative measurement of intracellular protein dynamics using photobleaching or photoactivation of fluorescent proteins
-
Matsuda T,Nagai T.Quantitative measurement of intracellular protein dynamics using photobleaching or photoactivation of fluorescent proteins.Microscopy. 2014;63:403-8
-
(2014)
Microscopy
, vol.63
, pp. 403-408
-
-
Matsuda, T.1
Nagai, T.2
-
31
-
-
79959458043
-
Development of probes for cellular functions using fluorescent proteins and fluorescence resonance energy transfer
-
Miyawaki A.Development of probes for cellular functions using fluorescent proteins and fluorescence resonance energy transfer.Ann Rev Biochem. 2011;80:357-73
-
(2011)
Ann Rev Biochem
, vol.80
, pp. 357-373
-
-
Miyawaki, A.1
-
32
-
-
84859848908
-
FRET microscopy in the living cell: different approaches, strengths and weaknesses
-
Padilla-Parra S,Tramier M.FRET microscopy in the living cell: different approaches, strengths and weaknesses.Bioessays. 2012;34:369-76
-
(2012)
Bioessays
, vol.34
, pp. 369-376
-
-
Padilla-Parra, S.1
Tramier, M.2
-
33
-
-
0023266426
-
Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH
-
Bright GR,Fisher GW,Rogowska J,Taylor DL.Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH.J Cell Biol. 1987;104:1019-33
-
(1987)
J Cell Biol
, vol.104
, pp. 1019-1033
-
-
Bright, G.R.1
Fisher, G.W.2
Rogowska, J.3
Taylor, D.L.4
-
34
-
-
0026793336
-
Patterns of elevated free calcium and calmodulin activation in living cells
-
Hahn K,DeBiasio R,Taylor DL.Patterns of elevated free calcium and calmodulin activation in living cells.Nature. 1992;359:736-8
-
(1992)
Nature
, vol.359
, pp. 736-738
-
-
Hahn, K.1
DeBiasio, R.2
Taylor, D.L.3
-
35
-
-
0035823254
-
Real-time molecular and cellular analysis: the new frontier of drug discovery
-
Taylor DL,Woo ES,Giuliano KA.Real-time molecular and cellular analysis: the new frontier of drug discovery.Curr Opin Biotechnol. 2001;12:75-81
-
(2001)
Curr Opin Biotechnol
, vol.12
, pp. 75-81
-
-
Taylor, D.L.1
Woo, E.S.2
Giuliano, K.A.3
-
36
-
-
33645283923
-
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
-
Belousov VV,Fradkov AF,Lukyanov KA,Staroverov DB,Shakhbazov KS,Terskikh AV,Lukyanov S.Genetically encoded fluorescent indicator for intracellular hydrogen peroxide.Nat Methods. 2006;3:281-6
-
(2006)
Nat Methods
, vol.3
, pp. 281-286
-
-
Belousov, V.V.1
Fradkov, A.F.2
Lukyanov, K.A.3
Staroverov, D.B.4
Shakhbazov, K.S.5
Terskikh, A.V.6
Lukyanov, S.7
-
37
-
-
84902772267
-
Tracking single molecules at work in living cells
-
Kusumi A,Tsunoyama TA,Hirosawa KM,Kasai RS,Fujiwara TK.Tracking single molecules at work in living cells.Nat Chem Biol. 2014;10:524-32
-
(2014)
Nat Chem Biol
, vol.10
, pp. 524-532
-
-
Kusumi, A.1
Tsunoyama, T.A.2
Hirosawa, K.M.3
Kasai, R.S.4
Fujiwara, T.K.5
-
38
-
-
84930792740
-
Past, present, and future of high content screening and the field of cellomics. High content screening. Springer, New York
-
Taylor DL. Past, present, and future of high content screening and the field of cellomics. High content screening. Springer, New York, NY, 2006, pp.3–18.
-
(2006)
NY
, pp. 3-18
-
-
Taylor, D.L.1
-
39
-
-
0001341562
-
High-content screening: a new approach to easing key bottlenecks in the drug discovery process
-
Giuliano KA,DeBiasio RL,Dunlay RT,Gough A,Volosky JM,Zock J,Pavlakis GN,Taylor DL.High-content screening: a new approach to easing key bottlenecks in the drug discovery process.J Biomol Screen. 1997;2:249-59
-
(1997)
J Biomol Screen
, vol.2
, pp. 249-259
-
-
Giuliano, K.A.1
DeBiasio, R.L.2
Dunlay, R.T.3
Gough, A.4
Volosky, J.M.5
Zock, J.6
Pavlakis, G.N.7
Taylor, D.L.8
-
40
-
-
77956046289
-
Early safety assessment using cellular systems biology yields insights into mechanisms of action
-
Giuliano KA,Gough AH,Taylor DL,Vernetti LA,Johnston PA.Early safety assessment using cellular systems biology yields insights into mechanisms of action.J Biomol Screen. 2010;15:783-97
-
(2010)
J Biomol Screen
, vol.15
, pp. 783-797
-
-
Giuliano, K.A.1
Gough, A.H.2
Taylor, D.L.3
Vernetti, L.A.4
Johnston, P.A.5
-
42
-
-
77956029024
-
A personal perspective on high-content screening (HCS): from the beginning
-
Taylor DL.A personal perspective on high-content screening (HCS): from the beginning.J Biomol Screen. 2010;15:720-5
-
(2010)
J Biomol Screen
, vol.15
, pp. 720-725
-
-
Taylor, D.L.1
-
43
-
-
84904497596
-
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery
-
Gough AH,Chen N,Shun TY,Lezon TR,Boltz RC,Reese CE,Wagner J,Vernetti LA,Grandis JR,Lee AV,Stern AM,Schurdak ME,Taylor DL.Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.PLoS One. 2014;9:e102678-e102678
-
(2014)
PLoS One
, vol.9
, pp. 102678
-
-
Gough, A.H.1
Chen, N.2
Shun, T.Y.3
Lezon, T.R.4
Boltz, R.C.5
Reese, C.E.6
Wagner, J.7
Vernetti, L.A.8
Grandis, J.R.9
Lee, A.V.10
Stern, A.M.11
Schurdak, M.E.12
Taylor, D.L.13
-
44
-
-
84930797973
-
-
,,,,,,. 4th ed. New York, NY: Elsevier, 2014.Mendelsohn JHowley PMIsrael MAGray JWThompson CB, ed. New York, NY: ; :, Elsevier
-
Gough A,Lezon T,Faeder JR,Chennubhotla C,Murphy RF,Critchley-Thorne R,Taylor DLThe molecular basis of cancer. 4th ed. New York, NY: Elsevier, 2014.Mendelsohn JHowley PMIsrael MAGray JWThompson CB, ed. New York, NY: Elsevier; 2014:
-
(2014)
The molecular basis of cancer
-
-
Gough, A.1
Lezon, T.2
Faeder, J.R.3
Chennubhotla, C.4
Murphy, R.F.5
Critchley-Thorne, R.6
Taylor, D.L.7
-
45
-
-
84930798565
-
Protein-based biosensors with polarization transduction
-
New York, NY: US
-
Thompson R. Protein-based biosensors with polarization transduction. In: Geddes C, Lakowicz J (eds) Advanced concepts in fluorescence sensing. Topics in fluorescence spectroscopy. 10: Springer, New York, NY, US, 2005, pp.1–19.
-
(2005)
Advanced concepts in fluorescence sensing. Topics in fluorescence spectroscopy. 10: Springer
, pp. 1-19
-
-
Thompson, R.1
Geddes, C.2
Lakowicz, J.3
-
46
-
-
0028864440
-
A fluorescent protein biosensor of myosin II regulatory light chain phosphorylation reports a gradient of phosphorylated myosin II in migrating cells
-
Post PL,DeBiasio RL,Taylor DL.A fluorescent protein biosensor of myosin II regulatory light chain phosphorylation reports a gradient of phosphorylated myosin II in migrating cells.Mol Biol Cell. 1995;6:1755-68
-
(1995)
Mol Biol Cell
, vol.6
, pp. 1755-1768
-
-
Post, P.L.1
DeBiasio, R.L.2
Taylor, D.L.3
-
47
-
-
0029779538
-
Myosin II transport, organization, and phosphorylation: evidence for cortical flow/solation-contraction coupling during cytokinesis and cell locomotion
-
DeBiasio RL,LaRocca GM,Post PL,Taylor DL.Myosin II transport, organization, and phosphorylation: evidence for cortical flow/solation-contraction coupling during cytokinesis and cell locomotion.Mol Biol Cell. 1996;7:1259-82
-
(1996)
Mol Biol Cell
, vol.7
, pp. 1259-1282
-
-
DeBiasio, R.L.1
LaRocca, G.M.2
Post, P.L.3
Taylor, D.L.4
-
48
-
-
0025251786
-
A calcium-sensitive fluorescent analog of calmodulin based on a novel calmodulin-binding fluorophore
-
Hahn KM,Waggoner AS,Taylor DL.A calcium-sensitive fluorescent analog of calmodulin based on a novel calmodulin-binding fluorophore.J Biol Chem. 1990;265:20335-45
-
(1990)
J Biol Chem
, vol.265
, pp. 20335-20345
-
-
Hahn, K.M.1
Waggoner, A.S.2
Taylor, D.L.3
-
50
-
-
84889493659
-
-
,,. Hoboken, NJ: John Wiley
-
Giuliano K,Premkumar D,Taylor DLOptimal characteristics of protein-protein interaction biosensors for cellular systems biology profiling. High content screening: science, techniques and applications. Hoboken, NJ: John Wiley; 2007:371-87.
-
(2007)
Optimal characteristics of protein-protein interaction biosensors for cellular systems biology profiling. High content screening: science, techniques and applications
, pp. 371-387
-
-
Giuliano, K.1
Premkumar, D.2
Taylor, D.L.3
-
51
-
-
23444431611
-
Green fluorescent protein as a marker for gene expression
-
Chalfie M,Tu Y,Euskirchen G,Ward WW,Prasher DC.Green fluorescent protein as a marker for gene expression.Science. 1994;263:802-5
-
(1994)
Science
, vol.263
, pp. 802-805
-
-
Chalfie, M.1
Tu, Y.2
Euskirchen, G.3
Ward, W.W.4
Prasher, D.C.5
-
52
-
-
70349331596
-
Genetically encoded biosensors based on engineered fluorescent proteins
-
Frommer WB,Davidson MW,Campbell RE.Genetically encoded biosensors based on engineered fluorescent proteins.Chem Soc Rev. 2009;38:2833-41
-
(2009)
Chem Soc Rev
, vol.38
, pp. 2833-2841
-
-
Frommer, W.B.1
Davidson, M.W.2
Campbell, R.E.3
-
53
-
-
0030610646
-
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin
-
Miyawaki A,Llopis J,Heim R,McCaffery JM,Adams JA,Ikura M,Tsien RY.Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin.Nature. 1997;388:882-7
-
(1997)
Nature
, vol.388
, pp. 882-887
-
-
Miyawaki, A.1
Llopis, J.2
Heim, R.3
McCaffery, J.M.4
Adams, J.A.5
Ikura, M.6
Tsien, R.Y.7
-
54
-
-
75849129809
-
Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states
-
Subach FV,Malashkevich VN,Zencheck WD,Xiao H,Filonov GS,Almo SC,Verkhusha VV.Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states.Proc Natl Acad Sci USA. 2009;106:21097-102
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 21097-21102
-
-
Subach, F.V.1
Malashkevich, V.N.2
Zencheck, W.D.3
Xiao, H.4
Filonov, G.S.5
Almo, S.C.6
Verkhusha, V.V.7
-
55
-
-
44449096254
-
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
-
Maurel D,Comps-Agrar L,Brock C,Rives ML,Bourrier E,Ayoub MA,Bazin H,Tinel N,Durroux T,Prezeau L,Trinquet E,Pin JP.Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization.Nat Methods. 2008;5:561-7
-
(2008)
Nat Methods
, vol.5
, pp. 561-567
-
-
Maurel, D.1
Comps-Agrar, L.2
Brock, C.3
Rives, M.L.4
Bourrier, E.5
Ayoub, M.A.6
Bazin, H.7
Tinel, N.8
Durroux, T.9
Prezeau, L.10
Trinquet, E.11
Pin, J.P.12
-
56
-
-
38849199681
-
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
-
Sakaue-Sawano A,Kurokawa H,Morimura T,Hanyu A,Hama H,Osawa H,Kashiwagi S,Fukami K,Miyata T,Miyoshi H,Imamura T,Ogawa M,Masai H,Miyawaki A.Visualizing spatiotemporal dynamics of multicellular cell-cycle progression.Cell. 2008;132:487-98
-
(2008)
Cell
, vol.132
, pp. 487-498
-
-
Sakaue-Sawano, A.1
Kurokawa, H.2
Morimura, T.3
Hanyu, A.4
Hama, H.5
Osawa, H.6
Kashiwagi, S.7
Fukami, K.8
Miyata, T.9
Miyoshi, H.10
Imamura, T.11
Ogawa, M.12
Masai, H.13
Miyawaki, A.14
-
57
-
-
14644393547
-
Green fluorescent protein is a quantitative reporter of gene expression in individual eukaryotic cells
-
Soboleski MR,Oaks J,Halford WP.Green fluorescent protein is a quantitative reporter of gene expression in individual eukaryotic cells.FASEB J. 2005;19:440-2
-
(2005)
FASEB J
, vol.19
, pp. 440-442
-
-
Soboleski, M.R.1
Oaks, J.2
Halford, W.P.3
-
58
-
-
84880903228
-
A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space
-
Fritz RD,Letzelter M,Reimann A,Martin K,Fusco L,Ritsma L,Ponsioen B,Fluri E,Schulte-Merker S,van Rheenen J,Pertz O.A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space.Science Signal. 2013;6:rs12-rs12
-
(2013)
Science Signal
, vol.6
, pp. 12
-
-
Fritz, R.D.1
Letzelter, M.2
Reimann, A.3
Martin, K.4
Fusco, L.5
Ritsma, L.6
Ponsioen, B.7
Fluri, E.8
Schulte-Merker, S.9
van Rheenen, J.10
Pertz, O.11
-
59
-
-
77951211821
-
Fluorescent biosensors of intracellular targets from genetically encoded reporters to modular polypeptide probes
-
Morris MC.Fluorescent biosensors of intracellular targets from genetically encoded reporters to modular polypeptide probes.Cell Biochem Biophys. 2010;56:19-37
-
(2010)
Cell Biochem Biophys
, vol.56
, pp. 19-37
-
-
Morris, M.C.1
-
60
-
-
0033613235
-
Circular permutation and receptor insertion within green fluorescent proteins
-
Baird GS,Zacharias DA,Tsien RY.Circular permutation and receptor insertion within green fluorescent proteins.Proc Natl Acad Sci USA. 1999;96:11241-6
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11241-11246
-
-
Baird, G.S.1
Zacharias, D.A.2
Tsien, R.Y.3
-
61
-
-
84865094135
-
In vivo application of optogenetics for neural circuit analysis
-
Han X.In vivo application of optogenetics for neural circuit analysis.ACS Chem Neurosci. 2012;3:577-84
-
(2012)
ACS Chem Neurosci
, vol.3
, pp. 577-584
-
-
Han, X.1
-
62
-
-
26444621497
-
Millisecond-timescale, genetically targeted optical control of neural activity
-
Boyden ES,Zhang F,Bamberg E,Nagel G,Deisseroth K.Millisecond-timescale, genetically targeted optical control of neural activity.Nat Neurosci. 2005;8:1263-8
-
(2005)
Nat Neurosci
, vol.8
, pp. 1263-1268
-
-
Boyden, E.S.1
Zhang, F.2
Bamberg, E.3
Nagel, G.4
Deisseroth, K.5
-
63
-
-
0345133280
-
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
-
Nagel G,Szellas T,Huhn W,Kateriya S,Adeishvili N,Berthold P,Ollig D,Hegemann P,Bamberg E.Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.Proc Natl Acad Sci USA. 2003;100:13940-5
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 13940-13945
-
-
Nagel, G.1
Szellas, T.2
Huhn, W.3
Kateriya, S.4
Adeishvili, N.5
Berthold, P.6
Ollig, D.7
Hegemann, P.8
Bamberg, E.9
-
64
-
-
55849136898
-
Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution
-
Han X,Boyden ES.Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution.PLoS One. 2007;2:e299-e299
-
(2007)
PLoS One
, vol.2
, pp. 299
-
-
Han, X.1
Boyden, E.S.2
-
65
-
-
73849143150
-
High-performance genetically targetable optical neural silencing by light-driven proton pumps
-
Chow BY,Han X,Dobry AS,Qian X,Chuong AS,Li M,Henninger MA,Belfort GM,Lin Y,Monahan PE,Boyden ES.High-performance genetically targetable optical neural silencing by light-driven proton pumps.Nature. 2010;463:98-102
-
(2010)
Nature
, vol.463
, pp. 98-102
-
-
Chow, B.Y.1
Han, X.2
Dobry, A.S.3
Qian, X.4
Chuong, A.S.5
Li, M.6
Henninger, M.A.7
Belfort, G.M.8
Lin, Y.9
Monahan, P.E.10
Boyden, E.S.11
-
66
-
-
84867026349
-
Optimization of a GCaMP calcium indicator for neural activity imaging
-
Akerboom J,Chen TW,Wardill TJ,Tian L,Marvin JS,Mutlu S,Calderon NC,Esposti F,Borghuis BG,Sun XR,Gordus A,Orger MB,Portugues R,Engert F,Macklin JJ,Filosa A,Aggarwal A,Kerr RA,Takagi R,Kracun S,Shigetomi E,Khakh BS,Baier H,Lagnado L,Wang SS,Bargmann CI,Kimmel BE,Jayaraman V,Svoboda K,Kim DS,Schreiter ER,Looger LL.Optimization of a GCaMP calcium indicator for neural activity imaging.J Neurosci. 2012;32:13819-40
-
(2012)
J Neurosci
, vol.32
, pp. 13819-13840
-
-
Akerboom, J.1
Chen, T.W.2
Wardill, T.J.3
Tian, L.4
Marvin, J.S.5
Mutlu, S.6
Calderon, N.C.7
Esposti, F.8
Borghuis, B.G.9
Sun, X.R.10
Gordus, A.11
Orger, M.B.12
Portugues, R.13
Engert, F.14
Macklin, J.J.15
Filosa, A.16
Aggarwal, A.17
Kerr, R.A.18
Takagi, R.19
Kracun, S.20
Shigetomi, E.21
Khakh, B.S.22
Baier, H.23
Lagnado, L.24
Wang, S.S.25
Bargmann, C.I.26
Kimmel, B.E.27
Jayaraman, V.28
Svoboda, K.29
Kim, D.S.30
Schreiter, E.R.31
Looger, L.L.32
more..
-
67
-
-
0036221893
-
A genetically targetable fluorescent probe of channel gating with rapid kinetics
-
Ataka K,Pieribone VA.A genetically targetable fluorescent probe of channel gating with rapid kinetics.Biophys J. 2002;82:509-16
-
(2002)
Biophys J
, vol.82
, pp. 509-516
-
-
Ataka, K.1
Pieribone, V.A.2
-
68
-
-
0034912282
-
Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein
-
Sakai R,Repunte-Canonigo V,Raj CD,Knopfel T.Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein.Eur J Neurosci. 2001;13:2314-8
-
(2001)
Eur J Neurosci
, vol.13
, pp. 2314-2318
-
-
Sakai, R.1
Repunte-Canonigo, V.2
Raj, C.D.3
Knopfel, T.4
-
69
-
-
78650093725
-
Optogenetic monitoring of membrane potentials
-
Mutoh H,Perron A,Akemann W,Iwamoto Y,Knopfel T.Optogenetic monitoring of membrane potentials.Exp Physiol. 2011;96:13-8
-
(2011)
Exp Physiol
, vol.96
, pp. 13-18
-
-
Mutoh, H.1
Perron, A.2
Akemann, W.3
Iwamoto, Y.4
Knopfel, T.5
-
70
-
-
0037072602
-
A photoactivatable GFP for selective photolabeling of proteins and cells
-
Patterson GH,Lippincott-Schwartz J.A photoactivatable GFP for selective photolabeling of proteins and cells.Science. 2002;297:1873-7
-
(2002)
Science
, vol.297
, pp. 1873-1877
-
-
Patterson, G.H.1
Lippincott-Schwartz, J.2
-
71
-
-
0029784190
-
Diffusional mobility of Golgi proteins in membranes of living cells
-
Cole NB,Smith CL,Sciaky N,Terasaki M,Edidin M,Lippincott-Schwartz J.Diffusional mobility of Golgi proteins in membranes of living cells.Science. 1996;273:797-801
-
(1996)
Science
, vol.273
, pp. 797-801
-
-
Cole, N.B.1
Smith, C.L.2
Sciaky, N.3
Terasaki, M.4
Edidin, M.5
Lippincott-Schwartz, J.6
-
72
-
-
0036241055
-
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation
-
Hu CD,Chinenov Y,Kerppola TK.Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation.Mol Cell. 2002;9:789-98
-
(2002)
Mol Cell
, vol.9
, pp. 789-798
-
-
Hu, C.D.1
Chinenov, Y.2
Kerppola, T.K.3
-
73
-
-
0035853040
-
Circularly permuted green fluorescent proteins engineered to sense Ca2+
-
Nagai T,Sawano A,Park ES,Miyawaki A.Circularly permuted green fluorescent proteins engineered to sense Ca2+.Proc Natl Acad Sci USA. 2001;98:3197-202
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3197-3202
-
-
Nagai, T.1
Sawano, A.2
Park, E.S.3
Miyawaki, A.4
-
74
-
-
0032500053
-
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
-
Miesenbock G,De Angelis DA,Rothman JE.Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins.Nature. 1998;394:192-5
-
(1998)
Nature
, vol.394
, pp. 192-195
-
-
Miesenbock, G.1
De Angelis, D.A.2
Rothman, J.E.3
-
75
-
-
84858977397
-
pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein
-
Mahon MJ.pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein.Adv Biosci Biotechnol. 2011;2:132-7
-
(2011)
Adv Biosci Biotechnol
, vol.2
, pp. 132-137
-
-
Mahon, M.J.1
-
76
-
-
84860849817
-
Genetically encoded pH sensor for tracking surface proteins through endocytosis
-
Grover A,Schmidt BF,Salter RD,Watkins SC,Waggoner AS,Bruchez MP.Genetically encoded pH sensor for tracking surface proteins through endocytosis.Angewandte Chem. 2012;51:4838-42
-
(2012)
Angewandte Chem
, vol.51
, pp. 4838-4842
-
-
Grover, A.1
Schmidt, B.F.2
Salter, R.D.3
Watkins, S.C.4
Waggoner, A.S.5
Bruchez, M.P.6
-
77
-
-
84905586833
-
Self-checking cell-based assays for GPCR desensitization and resensitization
-
Fisher GW,Fuhrman MH,Adler SA,Szent-Gyorgyi C,Waggoner AS,Jarvik JW.Self-checking cell-based assays for GPCR desensitization and resensitization.J Biomol Screen. 2014;19:1220-6
-
(2014)
J Biomol Screen
, vol.19
, pp. 1220-1226
-
-
Fisher, G.W.1
Fuhrman, M.H.2
Adler, S.A.3
Szent-Gyorgyi, C.4
Waggoner, A.S.5
Jarvik, J.W.6
-
78
-
-
0032780959
-
Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells
-
Minamikawa T,Sriratana A,Williams DA,Bowser DN,Hill JS,Nagley P.Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells.J Cell Sci. 1999;112:2419-30
-
(1999)
J Cell Sci
, vol.112
, pp. 2419-2430
-
-
Minamikawa, T.1
Sriratana, A.2
Williams, D.A.3
Bowser, D.N.4
Hill, J.S.5
Nagley, P.6
-
80
-
-
84899869963
-
Development of a doxycycline-inducible lentiviral plasmid with an instant regulatory feature
-
Yang T,Burrows C,Park JH.Development of a doxycycline-inducible lentiviral plasmid with an instant regulatory feature.Plasmid. 2014;72:29-35
-
(2014)
Plasmid
, vol.72
, pp. 29-35
-
-
Yang, T.1
Burrows, C.2
Park, J.H.3
-
81
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen M,Bujard H.Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.Proc Natl Acad Sci USA. 1992;89:5547-51
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
82
-
-
84934443646
-
Evaluation of promoters for use in tissue-specific gene delivery
-
Zheng C,Baum BJ.Evaluation of promoters for use in tissue-specific gene delivery.Methods Mol Biol. 2008;434:205-19
-
(2008)
Methods Mol Biol
, vol.434
, pp. 205-219
-
-
Zheng, C.1
Baum, B.J.2
-
83
-
-
77956058093
-
Mammalian cell transfection: the present and the future
-
Kim TK,Eberwine JH.Mammalian cell transfection: the present and the future.Anal Bioanal Chem. 2010;397:3173-8
-
(2010)
Anal Bioanal Chem
, vol.397
, pp. 3173-3178
-
-
Kim, T.K.1
Eberwine, J.H.2
-
84
-
-
18044385346
-
Gene delivery to embryonic stem cells
-
Kobayashi N,Rivas-Carrillo JD,Soto-Gutierrez A,Fukazawa T,Chen Y,Navarro-Alvarez N,Tanaka N.Gene delivery to embryonic stem cells.Birth Defects Res Part C Embryo Today Rev. 2005;75:10-8
-
(2005)
Birth Defects Res Part C Embryo Today Rev
, vol.75
, pp. 10-18
-
-
Kobayashi, N.1
Rivas-Carrillo, J.D.2
Soto-Gutierrez, A.3
Fukazawa, T.4
Chen, Y.5
Navarro-Alvarez, N.6
Tanaka, N.7
-
85
-
-
84860133437
-
Lentiviral vectors: basic to translational
-
Sakuma T,Barry MA,Ikeda Y.Lentiviral vectors: basic to translational.Biochem J. 2012;443:603-18
-
(2012)
Biochem J
, vol.443
, pp. 603-618
-
-
Sakuma, T.1
Barry, M.A.2
Ikeda, Y.3
-
86
-
-
22944458202
-
Altering the tropism of lentiviral vectors through pseudotyping
-
Cronin J,Zhang XY,Reiser J.Altering the tropism of lentiviral vectors through pseudotyping.Curr Gene Ther. 2005;5:387-98
-
(2005)
Curr Gene Ther
, vol.5
, pp. 387-398
-
-
Cronin, J.1
Zhang, X.Y.2
Reiser, J.3
-
87
-
-
84879264708
-
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
-
Gaj T,Gersbach CA,Barbas CF.ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.Trends Biotechnol. 2013;31:397-405
-
(2013)
Trends Biotechnol
, vol.31
, pp. 397-405
-
-
Gaj, T.1
Gersbach, C.A.2
Barbas, C.F.3
-
88
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
Hsu PD,Lander ES,Zhang F.Development and applications of CRISPR-Cas9 for genome engineering.Cell. 2014;157:1262-78
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
89
-
-
36849043025
-
Genetic modification of stem cells for transplantation
-
Phillips MI,Tang YL.Genetic modification of stem cells for transplantation.Adv Drug Deliv Rev. 2008;60:160-72
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 160-172
-
-
Phillips, M.I.1
Tang, Y.L.2
-
90
-
-
84922017104
-
Gene targeting of human pluripotent stem cells by homologous recombination
-
Howden SE,Thomson JA.Gene targeting of human pluripotent stem cells by homologous recombination.Methods Mol Biol. 2014;1114:37-55
-
(2014)
Methods Mol Biol
, vol.1114
, pp. 37-55
-
-
Howden, S.E.1
Thomson, J.A.2
-
91
-
-
84930787068
-
-
Tissue Eng Part C Methods, Epub ahead of print:
-
Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur AA, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka A, Russell CR, So PL, Conklin BR, Healy KE. Automated video-based analysis of contractility and calcium flux in human iPS-derived cardiomyocytes cultured over different spatial scales. Tissue Eng Part C Methods 2014. Epub ahead of print.
-
(2014)
Automated video-based analysis of contractility and calcium flux in human iPS-derived cardiomyocytes cultured over different spatial scales
-
-
Huebsch, N.1
Loskill, P.2
Mandegar, M.A.3
Marks, N.C.4
Sheehan, A.S.5
Ma, Z.6
Mathur, A.A.7
Nguyen, T.N.8
Yoo, J.C.9
Judge, L.M.10
Spencer, C.I.11
Chukka, A.12
Russell, C.R.13
So, P.L.14
Conklin, B.R.15
Healy, K.E.16
-
92
-
-
79960833952
-
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
-
Soldner F,Laganiere J,Cheng AW,Hockemeyer D,Gao Q,Alagappan R,Khurana V,Golbe LI,Myers RH,Lindquist S,Zhang L,Guschin D,Fong LK,Vu BJ,Meng X,Urnov FD,Rebar EJ,Gregory PD,Zhang HS,Jaenisch R.Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.Cell. 2011;146:318-31
-
(2011)
Cell
, vol.146
, pp. 318-331
-
-
Soldner, F.1
Laganiere, J.2
Cheng, A.W.3
Hockemeyer, D.4
Gao, Q.5
Alagappan, R.6
Khurana, V.7
Golbe, L.I.8
Myers, R.H.9
Lindquist, S.10
Zhang, L.11
Guschin, D.12
Fong, L.K.13
Vu, B.J.14
Meng, X.15
Urnov, F.D.16
Rebar, E.J.17
Gregory, P.D.18
Zhang, H.S.19
Jaenisch, R.20
more..
-
93
-
-
79960836456
-
Genetic engineering of human pluripotent cells using TALE nucleases
-
Hockemeyer D,Wang H,Kiani S,Lai CS,Gao Q,Cassady JP,Cost GJ,Zhang L,Santiago Y,Miller JC,Zeitler B,Cherone JM,Meng X,Hinkley SJ,Rebar EJ,Gregory PD,Urnov FD,Jaenisch R.Genetic engineering of human pluripotent cells using TALE nucleases.Nat Biotechnol. 2011;29:731-4
-
(2011)
Nat Biotechnol
, vol.29
, pp. 731-734
-
-
Hockemeyer, D.1
Wang, H.2
Kiani, S.3
Lai, C.S.4
Gao, Q.5
Cassady, J.P.6
Cost, G.J.7
Zhang, L.8
Santiago, Y.9
Miller, J.C.10
Zeitler, B.11
Cherone, J.M.12
Meng, X.13
Hinkley, S.J.14
Rebar, E.J.15
Gregory, P.D.16
Urnov, F.D.17
Jaenisch, R.18
-
94
-
-
84884663630
-
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
-
Hou Z,Zhang Y,Propson NE,Howden SE,Chu LF,Sontheimer EJ,Thomson JA.Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis.Proc Natl Acad Sci USA. 2013;110:15644-9
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 15644-15649
-
-
Hou, Z.1
Zhang, Y.2
Propson, N.E.3
Howden, S.E.4
Chu, L.F.5
Sontheimer, E.J.6
Thomson, J.A.7
-
95
-
-
84900314611
-
CRISPR-Cas systems for editing, regulating and targeting genomes
-
Sander JD,Joung JK.CRISPR-Cas systems for editing, regulating and targeting genomes.Nat Biotechnol. 2014;32:347-55
-
(2014)
Nat Biotechnol
, vol.32
, pp. 347-355
-
-
Sander, J.D.1
Joung, J.K.2
-
96
-
-
84891710947
-
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
-
Cho SW,Kim S,Kim Y,Kweon J,Kim HS,Bae S,Kim JS.Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.Genome Res. 2014;24:132-41
-
(2014)
Genome Res
, vol.24
, pp. 132-141
-
-
Cho, S.W.1
Kim, S.2
Kim, Y.3
Kweon, J.4
Kim, H.S.5
Bae, S.6
Kim, J.S.7
-
97
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem O,Sanjana NE,Hartenian E,Shi X,Scott DA,Mikkelsen TS,Heckl D,Ebert BL,Root DE,Doench JG,Zhang F.Genome-scale CRISPR-Cas9 knockout screening in human cells.Science. 2014;343:84-7
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
Sanjana, N.E.2
Hartenian, E.3
Shi, X.4
Scott, D.A.5
Mikkelsen, T.S.6
Heckl, D.7
Ebert, B.L.8
Root, D.E.9
Doench, J.G.10
Zhang, F.11
-
98
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran FA,Hsu PD,Lin CY,Gootenberg JS,Konermann S,Trevino AE,Scott DA,Inoue A,Matoba S,Zhang Y,Zhang F.Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.Cell. 2013;154:1380-9
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
Hsu, P.D.2
Lin, C.Y.3
Gootenberg, J.S.4
Konermann, S.5
Trevino, A.E.6
Scott, D.A.7
Inoue, A.8
Matoba, S.9
Zhang, Y.10
Zhang, F.11
-
99
-
-
0036163759
-
Mechanisms of hepatotoxicity
-
Jaeschke H,Gores GJ,Cederbaum AI,Hinson JA,Pessayre D,Lemasters JJ.Mechanisms of hepatotoxicity.Toxicol Sci. 2002; 65:166-76
-
(2002)
Toxicol Sci
, vol.65
, pp. 166-176
-
-
Jaeschke, H.1
Gores, G.J.2
Cederbaum, A.I.3
Hinson, J.A.4
Pessayre, D.5
Lemasters, J.J.6
-
100
-
-
17644394600
-
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence
-
Zhao H,Joseph J,Fales HM,Sokoloski EA,Levine RL,Vasquez-Vivar J,Kalyanaraman B.Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence.Proc Natl Acad Sci USA. 2005;102:5727-32
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 5727-5732
-
-
Zhao, H.1
Joseph, J.2
Fales, H.M.3
Sokoloski, E.A.4
Levine, R.L.5
Vasquez-Vivar, J.6
Kalyanaraman, B.7
-
101
-
-
84912527851
-
The virtual liver: state of the art and future perspectives
-
Drasdo D, Bode J, Dahmen U, Dirsch O, Dooley S, Gebhardt R, Ghallab A, Godoy P, Haussinger D, Hammad S, Hoehme S, Holzhutter HG, Klingmuller U, Kuepfer L, Timmer J, Zerial M, Hengstler JG. The virtual liver: state of the art and future perspectives. Arch Toxicol 2014;88:2071–2075.
-
(2014)
Arch Toxicol
, vol.88
, pp. 2071-2075
-
-
Drasdo, D.1
Bode, J.2
Dahmen, U.3
Dirsch, O.4
Dooley, S.5
Gebhardt, R.6
Ghallab, A.7
Godoy, P.8
Haussinger, D.9
Hammad, S.10
Hoehme, S.11
Holzhutter, H.G.12
Klingmuller, U.13
Kuepfer, L.14
Timmer, J.15
Zerial, M.16
Hengstler, J.G.17
-
102
-
-
84878509841
-
Analysis of kinetics of dihydroethidium fluorescence with superoxide using xanthine oxidase and hypoxanthine assay
-
Chen J,Rogers SC,Kavdia M.Analysis of kinetics of dihydroethidium fluorescence with superoxide using xanthine oxidase and hypoxanthine assay.Ann Biomed Eng. 2013;41:327-37
-
(2013)
Ann Biomed Eng
, vol.41
, pp. 327-337
-
-
Chen, J.1
Rogers, S.C.2
Kavdia, M.3
-
103
-
-
84855889415
-
Role of immune reactions in drug-induced liver injury (DILI)
-
Ju C,Reilly T.Role of immune reactions in drug-induced liver injury (DILI).Drug Metab Rev. 2012;44:107-15
-
(2012)
Drug Metab Rev
, vol.44
, pp. 107-115
-
-
Ju, C.1
Reilly, T.2
-
104
-
-
0344142396
-
Emerging roles of caspase-3 in apoptosis
-
Porter AG,Janicke RU.Emerging roles of caspase-3 in apoptosis.Cell Death Differ. 1999;6:99-104
-
(1999)
Cell Death Differ
, vol.6
, pp. 99-104
-
-
Porter, A.G.1
Janicke, R.U.2
-
105
-
-
33744500237
-
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL
-
Meyer LH,Karawajew L,Schrappe M,Ludwig WD,Debatin KM,Stahnke K.Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.Blood. 2006;107:4524-31
-
(2006)
Blood
, vol.107
, pp. 4524-4531
-
-
Meyer, L.H.1
Karawajew, L.2
Schrappe, M.3
Ludwig, W.D.4
Debatin, K.M.5
Stahnke, K.6
-
106
-
-
79955661144
-
Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death
-
Kuznetsov AV,Margreiter R,Amberger A,Saks V,Grimm M.Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death.Biochim Biophys Acta. 2011;1813:1144-52
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1144-1152
-
-
Kuznetsov, A.V.1
Margreiter, R.2
Amberger, A.3
Saks, V.4
Grimm, M.5
-
107
-
-
34547133010
-
Single fluorescent protein-based Ca2+ sensors with increased dynamic range
-
Souslova EA,Belousov VV,Lock JG,Stromblad S,Kasparov S,Bolshakov AP,Pinelis VG,Labas YA,Lukyanov S,Mayr LM,Chudakov DM.Single fluorescent protein-based Ca2+ sensors with increased dynamic range.BMC Biotechnol. 2007;7:37-37
-
(2007)
BMC Biotechnol
, vol.7
, pp. 37
-
-
Souslova, E.A.1
Belousov, V.V.2
Lock, J.G.3
Stromblad, S.4
Kasparov, S.5
Bolshakov, A.P.6
Pinelis, V.G.7
Labas, Y.A.8
Lukyanov, S.9
Mayr, L.M.10
Chudakov, D.M.11
-
108
-
-
77957999166
-
The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations
-
Leder L,Stark W,Freuler F,Marsh M,Meyerhofer M,Stettler T,Mayr LM,Britanova OV,Strukova LA,Chudakov DM,Souslova EA.The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations.Sensors. 2010;10:8143-60
-
(2010)
Sensors
, vol.10
, pp. 8143-8160
-
-
Leder, L.1
Stark, W.2
Freuler, F.3
Marsh, M.4
Meyerhofer, M.5
Stettler, T.6
Mayr, L.M.7
Britanova, O.V.8
Strukova, L.A.9
Chudakov, D.M.10
Souslova, E.A.11
-
109
-
-
84866479079
-
Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity
-
Kim JA,Han E,Eun CJ,Tak YK,Song JM.Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity.Toxicol Lett. 2012;214:175-81
-
(2012)
Toxicol Lett
, vol.214
, pp. 175-181
-
-
Kim, J.A.1
Han, E.2
Eun, C.J.3
Tak, Y.K.4
Song, J.M.5
-
110
-
-
65549091909
-
Practical and reliable FRET/FLIM pair of fluorescent proteins
-
Shcherbo D,Souslova EA,Goedhart J,Chepurnykh TV,Gaintzeva A,Shemiakina II,Gadella TW,Lukyanov S,Chudakov DM.Practical and reliable FRET/FLIM pair of fluorescent proteins.BMC Biotechnol. 2009;9:24-24
-
(2009)
BMC Biotechnol
, vol.9
, pp. 24
-
-
Shcherbo, D.1
Souslova, E.A.2
Goedhart, J.3
Chepurnykh, T.V.4
Gaintzeva, A.5
Shemiakina, I.I.6
Gadella, T.W.7
Lukyanov, S.8
Chudakov, D.M.9
-
111
-
-
53649100738
-
Conversion of red fluorescent protein into a bright blue probe
-
Subach OM,Gundorov IS,Yoshimura M,Subach FV,Zhang J,Gruenwald D,Souslova EA,Chudakov DM,Verkhusha VV.Conversion of red fluorescent protein into a bright blue probe.Chem Biol. 2008;15:1116-24
-
(2008)
Chem Biol
, vol.15
, pp. 1116-1124
-
-
Subach, O.M.1
Gundorov, I.S.2
Yoshimura, M.3
Subach, F.V.4
Zhang, J.5
Gruenwald, D.6
Souslova, E.A.7
Chudakov, D.M.8
Verkhusha, V.V.9
-
112
-
-
10044295010
-
Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells
-
Bova MP,Tam D,McMahon G,Mattson MN.Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.Toxicol Lett. 2005;155:41-50
-
(2005)
Toxicol Lett
, vol.155
, pp. 41-50
-
-
Bova, M.P.1
Tam, D.2
McMahon, G.3
Mattson, M.N.4
-
113
-
-
84887152893
-
Accurate prediction of drug-induced liver injury using stem cell-derived populations
-
Szkolnicka D,Farnworth SL,Lucendo-Villarin B,Storck C,Zhou W,Iredale JP,Flint O,Hay DC.Accurate prediction of drug-induced liver injury using stem cell-derived populations.Stem Cells Translat Med. 2014;3:141-8
-
(2014)
Stem Cells Translat Med
, vol.3
, pp. 141-148
-
-
Szkolnicka, D.1
Farnworth, S.L.2
Lucendo-Villarin, B.3
Storck, C.4
Zhou, W.5
Iredale, J.P.6
Flint, O.7
Hay, D.C.8
-
114
-
-
0028022558
-
Potential of machine-vision light microscopy in toxicologic pathology
-
Taylor DL,DeBiasio R,LaRocca G,Pane D,Post P,Kolega J,Giuliano K,Burton K,Gough B,Dow A,Yu J,Waggoner AS,Farkas D.Potential of machine-vision light microscopy in toxicologic pathology.Toxicol Pathol. 1994;22:145-59
-
(1994)
Toxicol Pathol
, vol.22
, pp. 145-159
-
-
Taylor, D.L.1
DeBiasio, R.2
LaRocca, G.3
Pane, D.4
Post, P.5
Kolega, J.6
Giuliano, K.7
Burton, K.8
Gough, B.9
Dow, A.10
Yu, J.11
Waggoner, A.S.12
Farkas, D.13
-
115
-
-
84870803043
-
Mitochondria-targeted cpYFP: pH or superoxide sensor?
-
Quatresous E,Legrand C,Pouvreau S.Mitochondria-targeted cpYFP: pH or superoxide sensor?.J Gen Physiol. 2012;140:567-70
-
(2012)
J Gen Physiol
, vol.140
, pp. 567-570
-
-
Quatresous, E.1
Legrand, C.2
Pouvreau, S.3
-
116
-
-
84876213335
-
Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity
-
Wei-LaPierre L,Gong G,Gerstner BJ,Ducreux S,Yule DI,Pouvreau S,Wang X,Sheu SS,Cheng H,Dirksen RT,Wang W.Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity.J Biol Chem. 2013;288:10567-77
-
(2013)
J Biol Chem
, vol.288
, pp. 10567-10577
-
-
Wei-LaPierre, L.1
Gong, G.2
Gerstner, B.J.3
Ducreux, S.4
Yule, D.I.5
Pouvreau, S.6
Wang, X.7
Sheu, S.S.8
Cheng, H.9
Dirksen, R.T.10
Wang, W.11
-
117
-
-
79951571474
-
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
-
Perry SW,Norman JP,Barbieri J,Brown EB,Gelbard HA.Mitochondrial membrane potential probes and the proton gradient: a practical usage guide.BioTechniques. 2011;50:98-115
-
(2011)
BioTechniques
, vol.50
, pp. 98-115
-
-
Perry, S.W.1
Norman, J.P.2
Barbieri, J.3
Brown, E.B.4
Gelbard, H.A.5
-
118
-
-
79961133920
-
Fluorescent proteins at a glance
-
Kremers GJ,Gilbert SG,Cranfill PJ,Davidson MW,Piston DW.Fluorescent proteins at a glance.J Cell Sci. 2011;124:157-60
-
(2011)
J Cell Sci
, vol.124
, pp. 157-160
-
-
Kremers, G.J.1
Gilbert, S.G.2
Cranfill, P.J.3
Davidson, M.W.4
Piston, D.W.5
-
120
-
-
70349304323
-
The structure and function of fluorescent proteins
-
Sample V,Newman RH,Zhang J.The structure and function of fluorescent proteins.Chem Soc Rev. 2009;38:2852-64
-
(2009)
Chem Soc Rev
, vol.38
, pp. 2852-2864
-
-
Sample, V.1
Newman, R.H.2
Zhang, J.3
-
121
-
-
0032499784
-
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins
-
Llopis J,McCaffery JM,Miyawaki A,Farquhar MG,Tsien RY.Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins.Proc Natl Acad Sci USA. 1998;95:6803-8
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6803-6808
-
-
Llopis, J.1
McCaffery, J.M.2
Miyawaki, A.3
Farquhar, M.G.4
Tsien, R.Y.5
-
122
-
-
3442888534
-
Fluorescence photoconversion kinetics in novel green fluorescent protein pH sensors (pHluorins)
-
Hess ST,Heikal AA,Webb WW.Fluorescence photoconversion kinetics in novel green fluorescent protein pH sensors (pHluorins).J Phys Chem B. 2004;108:10138-48
-
(2004)
J Phys Chem B
, vol.108
, pp. 10138-10148
-
-
Hess, S.T.1
Heikal, A.A.2
Webb, W.W.3
-
123
-
-
33745785300
-
Visualization of molecular interactions by fluorescence complementation
-
Kerppola TK.Visualization of molecular interactions by fluorescence complementation.Nat Rev Mol Cell Biol. 2006;7:449-56
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 449-456
-
-
Kerppola, T.K.1
-
125
-
-
84859593977
-
A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes
-
Watts SD,Suchland KL,Amara SG,Ingram SL.A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes.PLoS One. 2012;7:e35373-e35373
-
(2012)
PLoS One
, vol.7
, pp. 35373
-
-
Watts, S.D.1
Suchland, K.L.2
Amara, S.G.3
Ingram, S.L.4
-
126
-
-
77649184827
-
Ultrafast optogenetic control
-
Gunaydin LA,Yizhar O,Berndt A,Sohal VS,Deisseroth K,Hegemann P.Ultrafast optogenetic control.Nat Neurosci. 2010;13:387-92
-
(2010)
Nat Neurosci
, vol.13
, pp. 387-392
-
-
Gunaydin, L.A.1
Yizhar, O.2
Berndt, A.3
Sohal, V.S.4
Deisseroth, K.5
Hegemann, P.6
-
127
-
-
84874185263
-
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics
-
Akerboom J,Carreras Calderon N,Tian L,Wabnig S,Prigge M,Tolo J,Gordus A,Orger MB,Severi KE,Macklin JJ,Patel R,Pulver SR,Wardill TJ,Fischer E,Schuler C,Chen TW,Sarkisyan KS,Marvin JS,Bargmann CI,Kim DS,Kugler S,Lagnado L,Hegemann P,Gottschalk A,Schreiter ER,Looger LL.Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.Front Mol Neurosci. 2013;6:2-2
-
(2013)
Front Mol Neurosci
, vol.6
, pp. 2
-
-
Akerboom, J.1
Carreras Calderon, N.2
Tian, L.3
Wabnig, S.4
Prigge, M.5
Tolo, J.6
Gordus, A.7
Orger, M.B.8
Severi, K.E.9
Macklin, J.J.10
Patel, R.11
Pulver, S.R.12
Wardill, T.J.13
Fischer, E.14
Schuler, C.15
Chen, T.W.16
Sarkisyan, K.S.17
Marvin, J.S.18
Bargmann, C.I.19
Kim, D.S.20
Kugler, S.21
Lagnado, L.22
Hegemann, P.23
Gottschalk, A.24
Schreiter, E.R.25
Looger, L.L.26
more..
-
128
-
-
77955799478
-
Detection and quantification of beta2AR internalization in living cells using FAP-based biosensor technology
-
Fisher GW,Adler SA,Fuhrman MH,Waggoner AS,Bruchez MP,Jarvik JW.Detection and quantification of beta2AR internalization in living cells using FAP-based biosensor technology.J Biomol Screen. 2010;15:703-9
-
(2010)
J Biomol Screen
, vol.15
, pp. 703-709
-
-
Fisher, G.W.1
Adler, S.A.2
Fuhrman, M.H.3
Waggoner, A.S.4
Bruchez, M.P.5
Jarvik, J.W.6
-
129
-
-
84907943065
-
From fluorescence polarization to Quenchbody: recent progress in fluorescent reagentless biosensors based on antibody and other binding proteins
-
Ueda H,Dong J.From fluorescence polarization to Quenchbody: recent progress in fluorescent reagentless biosensors based on antibody and other binding proteins.Biochim Biophys Acta. 2014;1844:1951-9
-
(2014)
Biochim Biophys Acta
, vol.1844
, pp. 1951-1959
-
-
Ueda, H.1
Dong, J.2
-
130
-
-
84901044155
-
Live-cell reporters for fluorescence imaging
-
Correa IR.Live-cell reporters for fluorescence imaging.Curr Opin Chem Biol. 2014;20:36-45
-
(2014)
Curr Opin Chem Biol
, vol.20
, pp. 36-45
-
-
Correa, I.R.1
-
131
-
-
48049092838
-
HaloTag: a novel protein labeling technology for cell imaging and protein analysis
-
Los GV,Encell LP,McDougall MG,Hartzell DD,Karassina N,Zimprich C,Wood MG,Learish R,Ohana RF,Urh M,Simpson D,Mendez J,Zimmerman K,Otto P,Vidugiris G,Zhu J,Darzins A,Klaubert DH,Bulleit RF,Wood KV.HaloTag: a novel protein labeling technology for cell imaging and protein analysis.ACS Chem Biol. 2008;3:373-82
-
(2008)
ACS Chem Biol
, vol.3
, pp. 373-382
-
-
Los, G.V.1
Encell, L.P.2
McDougall, M.G.3
Hartzell, D.D.4
Karassina, N.5
Zimprich, C.6
Wood, M.G.7
Learish, R.8
Ohana, R.F.9
Urh, M.10
Simpson, D.11
Mendez, J.12
Zimmerman, K.13
Otto, P.14
Vidugiris, G.15
Zhu, J.16
Darzins, A.17
Klaubert, D.H.18
Bulleit, R.F.19
Wood, K.V.20
more..
-
132
-
-
84875871080
-
Chemical biology-based approaches on fluorescent labeling of proteins in live cells
-
Jung D,Min K,Jung J,Jang W,Kwon Y.Chemical biology-based approaches on fluorescent labeling of proteins in live cells.Mol Biosyst. 2013;9:862-72
-
(2013)
Mol Biosyst
, vol.9
, pp. 862-872
-
-
Jung, D.1
Min, K.2
Jung, J.3
Jang, W.4
Kwon, Y.5
-
133
-
-
13844276672
-
Site-specific labeling of proteins with small molecules in live cells
-
Chen I,Ting AY.Site-specific labeling of proteins with small molecules in live cells.Curr Opin Biotechnol. 2005;16:35-40
-
(2005)
Curr Opin Biotechnol
, vol.16
, pp. 35-40
-
-
Chen, I.1
Ting, A.Y.2
-
134
-
-
78349261856
-
Cyto-Tracers™: novel lentiviral-based molecular imaging tools
-
Fong M,Lesnik J,Li G,Antes TJ,Lu B.Cyto-Tracers™: novel lentiviral-based molecular imaging tools.BioTechniques. 2010;49:839-40
-
(2010)
BioTechniques
, vol.49
, pp. 839-840
-
-
Fong, M.1
Lesnik, J.2
Li, G.3
Antes, T.J.4
Lu, B.5
-
135
-
-
75149149167
-
Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage
-
Tang JB,Goellner EM,Wang XH,Trivedi RN,St Croix CM,Jelezcova E,Svilar D,Brown AR,Sobol RW.Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage.Mol Cancer Res. 2010;8:67-79
-
(2010)
Mol Cancer Res
, vol.8
, pp. 67-79
-
-
Tang, J.B.1
Goellner, E.M.2
Wang, X.H.3
Trivedi, R.N.4
St Croix, C.M.5
Jelezcova, E.6
Svilar, D.7
Brown, A.R.8
Sobol, R.W.9
-
136
-
-
0026158432
-
Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration
-
Dunn JC,Tompkins RG,Yarmush ML.Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration.Biotechnol Prog. 1991;7:237-45
-
(1991)
Biotechnol Prog
, vol.7
, pp. 237-245
-
-
Dunn, J.C.1
Tompkins, R.G.2
Yarmush, M.L.3
-
137
-
-
84907011121
-
Tissue-engineered microenvironment systems for modeling human vasculature
-
Tourovskaia A,Fauver M,Kramer G,Simonson S,Neumann T.Tissue-engineered microenvironment systems for modeling human vasculature.Exp Biol Med. 2014;239:1264-71
-
(2014)
Exp Biol Med
, vol.239
, pp. 1264-1271
-
-
Tourovskaia, A.1
Fauver, M.2
Kramer, G.3
Simonson, S.4
Neumann, T.5
|