Role of immune reactions in drug-induced liver injury (DILI)

Drug Metabolism Reviews

Volumn 44, Issue 1, 2012, Pages 107-115

  Ju, Cynthia ^a   Reilly, Timothy ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

acetaminophen induced liver injury; adaptive immunity; animal model; halothane induced liver injury; innate immunity; Kupffer cells; neutrophils; NK cells; NKT cells

Indexed keywords

CYTOCHROME P450; HALOTHANE; HAPTEN; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; PARACETAMOL; PEROXIDASE; PROTEIN S 100;

ADAPTIVE IMMUNITY; APOPTOSIS; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL STRESS; COVALENT BOND; DRUG PROTEIN BINDING; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; KUPFFER CELL; LYMPHOCYTE; LYMPHOID CELL; MACROPHAGE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; REVIEW; TOXIC HEPATITIS;

ADAPTIVE IMMUNITY; ANIMALS; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; LIVER; PHARMACEUTICAL PREPARATIONS;

EID: 84855889415     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2011.645579     Document Type: Review

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