Regulated stability of Eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

Biochemical Journal

Volumn 467, Issue 2, 2015, Pages 321-331

  Wang, Xuemin ^a,b   Xie, Jianling ^a,b   Da Mota, Sergio Regufe ^a,c   Moore, Claire E ^a   Proud, Christopher G ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Autophosphorylation; Degradation; Eukaryotic elongation factor 2 kinase (eEF2K); Phosphodegron; kinase

Indexed keywords

DEOXYGLUCOSE; ELONGATION FACTOR 2 KINASE; PHOSPHOTRANSFERASE; PROTEASOME; THREONINE; UBIQUITIN PROTEIN LIGASE E3; ANTIMETABOLITE; EEF2K PROTEIN, HUMAN; EEF2K PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR;

ACIDOSIS; ARTICLE; AUTOPHOSPHORYLATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SOLID TUMOR; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGICAL STRESS;

EUKARYOTA;

ANIMALS; ANTIMETABOLITES; DEOXYGLUCOSE; ELONGATION FACTOR 2 KINASE; ENZYME STABILITY; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; STRESS, PHYSIOLOGICAL;

EID: 84930802217     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150089     Document Type: Article

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